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Article ; Online: Prenatal and early-life exposure to traffic-related air pollution and allergic rhinitis in children

Lifang Liu / Jingxuan Ma / Shanshan Peng / Linshen Xie

PLoS ONE, Vol 18, Iss

A systematic literature review

2023 Volume 4

Abstract: Background Traffic-related air pollution (TRAP) is hypothesised to play a role in the development of allergic rhinitis (AR). Prenatal and early-life exposure to traffic-related air pollution is considered critical for later respiratory health. However, ... ...

Abstract	Background Traffic-related air pollution (TRAP) is hypothesised to play a role in the development of allergic rhinitis (AR). Prenatal and early-life exposure to traffic-related air pollution is considered critical for later respiratory health. However, we could not find any articles systematically reviewing the risk of prenatal and early-life exposure to traffic-related air pollution for allergic rhinitis in children. Methods A systematic literature search of PubMed, Web of Science and Medline was conducted to identify studies focused on the association between prenatal and early-life exposure to TRAP and AR in children. Other inclusion criteria were: 1) original articles; 2) based upon prospective or retrospective studies or case-control studies; and 3) publications were restricted to English. Literature quality assessment was processed using the Newcastle-Ottawa Scale (NOS) evaluation scale. This systematic literature review has been registered on the prospero (crd.york.ac.uk/prospero) with the following registry number: CRD42022361179. Results Only eight studies met the inclusion criteria. The exposure assessment indicators included PM2.5, PM2.5 absorbance, PM10, NOx, CO, and black carbon. On the whole, exposure to TRAP during pregnancy and the first year of life were positively associated with the development of AR in children. Conclusions This systematic review presents supportive evidence about prenatal and early-life exposure to TRAP and the risk of AR in children.
Keywords	Medicine ; R ; Science ; Q
Subject code	333
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Secretion of IL-6 and IL-8 in the senescence of bone marrow mesenchymal stem cells is regulated by autophagy via FoxO3a

Yong Zheng / Shangrong Wu / Haiqiang Ke / Shanshan Peng / Chengjun Hu

Experimental Gerontology, Vol 172, Iss , Pp 112062- (2023)

2023

Abstract: Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms ...

Abstract	Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms that contribute to BMSC senescence is critical for the development of BMSC-based tissue engineering and regenerative medicine. In this study, senescent BMSCs were characterized with >80 % of BMSCs stained positive for SA-β-gal, increased expressions of senescence-related genes (p16INK4a and p21Waf1). These senescent characters were accompanied by elevated autophagic activity, up-regulation of interleukin 6 (IL-6), IL-8, and FoxO3a. Autophagic activity inhibition alleviated the senescent state with reduced levels of IL-6 and IL-8 during BMSC senescence. The enhanced autophagic activity upregulated the levels of IL-6 and IL-8 which is associated with up-regulation of FoxO3a, and knockdown of FoxO3a reduced IL-6 and IL-8 expression in senescent BMSCs. Therefore, this study indicated the pivotal role of autophagic activity in the expressions of IL-6 and IL-8 during BMSC senescence, which is regulated by FoxO3a.
Keywords	Bone marrow mesenchymal stem cells ; Senescence ; Autophagy ; Interleukin 6 ; Interleukin 8 ; FoxO3a ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between kidney function and biological age

Shanshan Peng / Rui Xu / Kai Wei / Na Liu / Yuan Lv / Yong Lin

Frontiers in Public Health, Vol

a China Health and Retirement Longitudinal Study

2023 Volume 11

Abstract: IntroductionThe chronological age (CA) cannot precisely reflect the health status. Our study aimed to establish a model of kidney biological age to evaluate kidney function more elaborately.MethodsThe modeling group was used to establish the model, ... ...

Abstract	IntroductionThe chronological age (CA) cannot precisely reflect the health status. Our study aimed to establish a model of kidney biological age to evaluate kidney function more elaborately.MethodsThe modeling group was used to establish the model, consisting of 1,303 respondents of the China Health and Retirement Longitudinal Study (CHARLS). The biological age of the kidney (BA) was constructed by principal component analysis (PCA) and Klemera and Doubal’s method (KDM) with the 1,303 health respondents.ResultsPCA was chosen as the best method for our research step by step. The test group was used to apply the model. (a) BA of the kidney can distinguish respondents with from without kidney disease. (b) BA of the kidney was significantly different in various levels of kidney function. The BA of the eGFR <60 group and 60 ≤ eGFR <90 group were older than GFR ≥90 group. (c) The group with younger BA of kidney at baseline had a lower risk of kidney function decreased. (d) The risk of decreased kidney function caused by increasing BA every additional year is higher than CA.DiscussionThe BA of the kidney is a parameter negatively correlated with decreased kidney function and fills the blank of evaluation among people in the middle of heathy and kidney diseases.
Keywords	kidney ; aging ; biological age ; CHARLS ; eGFR ; Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adipocyte-derived CCDC3 promotes tumorigenesis in epithelial ovarian cancer through the Wnt/ß-catenin signalling pathway

Fen Wang / Feng Jin / Shanshan Peng / Chen Li / Li Wang / Shubin Wang

Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101507- (2023)

2023

Abstract: Introduction: Epithelial ovarian cancer (EOC) is a highly aggressive disease whose unique metastatic site is the omentum. Coiled-coil domain containing 3 (CCDC3) is an adipocyte-derived secreted protein that is specifically elevated in omental adipose ... ...

Abstract	Introduction: Epithelial ovarian cancer (EOC) is a highly aggressive disease whose unique metastatic site is the omentum. Coiled-coil domain containing 3 (CCDC3) is an adipocyte-derived secreted protein that is specifically elevated in omental adipose tissue. However, its function is still unknown. Material and methods: Initially, a Kaplan–Meier plot was applied to evaluate the prognostic value of CCDC3 expression in patients with EOC. A bioinformatics analysis was next used to explore the biological function of CCDC3 in EOC. Western blot, quantitative real-time polymerase chain reaction, and in vitro invasion and migration assays were performed using SKOV3 cells and CCDC3 secreted by rat adipocytes to analyzes the impact of CCDC3 on EOC and the underlying mechanism. Results: Overexpression of CCDC3 was associated with poor prognosis of EOC. CCDC3 interacted with multiple key signalling pathways, including the Wnt/β-catenin pathway. EOC cellular proliferation, migration, and invasion were promoted in vitro when co-cultured with CCDC3 enriched conditioned medium, and this tumour-promoting effect was induced by activating the Wnt/β-catenin pathway. Furthermore, the epithelial-mesenchymal transition of EOC cells was reversed after CCDC3 silencing. Conclusions: Our results support that CCDC3 promotes EOC tumorigenesis through the Wnt/β-catenin pathway and that CCDC3 may serve as a novel prognostic biomarker and therapeutic target for metastatic EOC.
Keywords	CCDC3 ; Wnt/β-catenin ; Epithelial ovarian cancer ; Epithelial-mesenchymal transition ; Omental metastasis ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
Subject code	570
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chinese Herbal Medicine for the Treatment of Children and Adolescents With Refractory Mycoplasma Pneumoniae Pneumonia

Xiaoying Ling / Xun Sun / Huimin Kong / Shanshan Peng / Zheng Yu / Jiali Wen / Bin Yuan

Frontiers in Pharmacology, Vol

A Systematic Review and a Meta-Analysis

2021 Volume 12

Abstract: Objectives: Chinese herb medicine (CHM) is one of the most popular complementary and alternative therapies, which has been widely used to treat Refractory Mycoplasma Pneumoniae Pneumonia (RMPP). However, the effect and safety of CHM remain controversial. ...

Abstract	Objectives: Chinese herb medicine (CHM) is one of the most popular complementary and alternative therapies, which has been widely used to treat Refractory Mycoplasma Pneumoniae Pneumonia (RMPP). However, the effect and safety of CHM remain controversial. Hence, we conducted this meta-analysis to evaluate whether CHM combination therapy could bring benefits to children and adolescents with RMPP.Methods: Seven databases were used for data searching through November 11, 2020 following the PRISMA checklist generally. Review Manager 5.3, Trial sequential analysis 0.9.5.10 Beta software and Stata16.0 were applied to perform data analyses. Mean difference or risk ratio was adopted to express the results, where a 95% confidence interval (CI) was applied.Results: In general, this research enrolled 17 trials with 1,451 participants. The overall pooled results indicated that CHM was beneficial for children and adolescents with RMPP by improving the clinical efficacy rate [RR = 1.20, 95% CI (1.15, 1.25), p < 0.00001], shortening antipyretic time [MD = −2.60, 95% CI (−3.06, −2.13), p < 0.00001], cough disappearance time [MD = −2.77, 95% CI (−3.12, −2.42), p < 0.00001], lung rale disappearance time [MD = −2.65, 95% CI (−3.15, −2.15), p < 0.00001], lung X-ray infiltrates disappearance time [MD = −2.75, 95% CI (−3.33, −2.17), p < 0.00001], reducing TNF-α level [MD = −5.49, 95% CI (−7.21, −3.77), p < 0.00001]. Moreover, subgroup results suggested that removing heat-phlegm and toxicity therapy had more advantages in shortening antipyretic time, cough disappearance time, lung X-ray infiltrates disappearance time and reducing TNF-α level. Meanwhile promoting blood circulation therapy seemed to be better at relieving lung rale. However, regarding adverse events, the two groups displayed no statistical difference [RR = 0.97, 95% CI (0.60, 1.57), p = 0.91].Conclusion: Despite of the apparently positive results in relieving clinical symptoms, physical signs and reducing inflammation, it is premature to confirm the efficacy of CHM in treating RMPP because of the limitation of quality and the number of the included studies. More large-scale, double-blind, well-designed, randomized controlled trials are needed in future research.
Keywords	refractory Mycoplasma pneumoniae pneumonia ; Chinese herbal medicine ; complementary and alternative medicine ; meta-analysis ; effectiveness ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Detection and Analysis of Sow Targets Based on Image Vision

Kaidong Lei / Chao Zong / Ting Yang / Shanshan Peng / Pengfei Zhu / Hao Wang / Guanghui Teng / Xiaodong Du

Agriculture, Vol 12, Iss 73, p

2022 Volume 73

Abstract: In large-scale sow production, real-time detection and recognition of sows is a key step towards the application of precision livestock farming techniques. In the pig house, the overlap of railings, floors, and sows usually challenge the accuracy of sow ... ...

Abstract	In large-scale sow production, real-time detection and recognition of sows is a key step towards the application of precision livestock farming techniques. In the pig house, the overlap of railings, floors, and sows usually challenge the accuracy of sow target detection. In this paper, a non-contact machine vision method was used for sow targets perception in complex scenarios, and the number position of sows in the pen could be detected. Two multi-target sow detection and recognition models based on the deep learning algorithms of Mask-RCNN and UNet-Attention were developed, and the model parameters were tuned. A field experiment was carried out. The data-set obtained from the experiment was used for algorithm training and validation. It was found that the Mask-RCNN model showed a higher recognition rate than that of the UNet-Attention model, with a final recognition rate of 96.8% and complete object detection outlines. In the process of image segmentation, the area distribution of sows in the pens was analyzed. The position of the sow’s head in the pen and the pixel area value of the sow segmentation were analyzed. The feeding, drinking, and lying behaviors of the sow have been identified on the basis of image recognition. The results showed that the average daily lying time, standing time, feeding and drinking time of sows were 12.67 h(MSE 1.08), 11.33 h(MSE 1.08), 3.25 h(MSE 0.27) and 0.391 h(MSE 0.10), respectively. The proposed method in this paper could solve the problem of target perception of sows in complex scenes and would be a powerful tool for the recognition of sows.
Keywords	computer vision ; sow ; image processing ; behavior ; precision livestock ; animal welfare ; Agriculture (General) ; S1-972
Subject code	630 ; 006
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The characteristics and trend of adverse events following immunization reported by information system in Jiangsu province, China, 2015–2018

Ran Hu / Shanshan Peng / Yuanbao Liu / Fengyang Tang / Zhiguo Wang / Lei Zhang / Jun Gao / Hongxiong Guo

BMC Public Health, Vol 21, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract Objective Adverse events following immunization is an important factor influencing public trust in vaccination. Publicizing its incidence timely can increase public trust. The aim of this study is to describe the incidence and characteristics of ...

Abstract	Abstract Objective Adverse events following immunization is an important factor influencing public trust in vaccination. Publicizing its incidence timely can increase public trust. The aim of this study is to describe the incidence and characteristics of adverse events following immunization in Jiangsu province of China from 2015 to 2018. Methods All information of adverse events following immunization (AEFIs) was gained from Jiangsu Province Vaccination Integrated Service Management Information System. The reported AEFI trend was analyzed using Chi-square test. Results A total of 77,980 AEFI cases were reported through the AEFI system; Among which, 77,731 were classified as non-serious AEFI cases and 249 were serious AEFI cases. The male to female ratio was 1.31:1, cases less than 7 years old accounted for 97.7%. The total estimated AEFI rate was 62.70/100,000 doses. By severity, 60.75/100,000, 4.46/100,000 and 0.11/100,000 AEFI cases were common vaccine reaction, rare vaccine reaction, and serious rare vaccine reaction, respectively. The top two serious AEFI were thrombocytopenic purpura and febrile. The incidence rates showed the increasing trend and the linear trend of the increasing incidence rates passed the significant test at 0.05 levels. Conclusion The sensitivity of AEFI monitoring in Jiangsu Province is increasing and higher than the national average and most countries. The majority of AEFI cases were common adverse reactions, while the serious vaccine reactions caused by vaccines were extremely low. To elevate the sensitivity of AEFI surveillance may reduce the incidence of developing serious AEFI cases.
Keywords	Adverse events following immunization ; Incidence of adverse events following immunization ; Serious vaccine reaction ; Common vaccine reaction ; Vaccine ; Categories of vaccine reaction ; Public aspects of medicine ; RA1-1270
Subject code	630
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reliability and validity of the mandarin version of the supportive care needs survey short-form (SCNS-SF34) and the head and neck cancer-specific supportive care needs (SCNS-HNC) module

Jianxia Lyu / Li Yin / Ping Cheng / Bin Li / Shanshan Peng / Chunlian Yang / Jing Yang / Haixin Liang / Qinghua Jiang

BMC Health Services Research, Vol 20, Iss 1, Pp 1-

2020 Volume 9

Abstract: Abstract Background This study aimed to translate the English version of the supportive care needs scale of head and neck cancer patients (SCNS-HNC) questionnaire into Mandarin and to test the reliability and validity of the SCNS-SF34 and SCNS-HNC module ...

Abstract	Abstract Background This study aimed to translate the English version of the supportive care needs scale of head and neck cancer patients (SCNS-HNC) questionnaire into Mandarin and to test the reliability and validity of the SCNS-SF34 and SCNS-HNC module in head and neck cancer patients. Methods The Mandarin version of the Supportive Care Needs Survey Short-Form (SCNS-SF34) and SCNS-HNC scales were used to assess 206 patients with head and neck cancer in Chengdu, China. Among them, 51 patients were re-tested 2 or 3 days after the first survey. The internal consistency of the scale was evaluated by Cronbach’s alpha coefficient, the retest reliability of the scale was evaluated by retest correlation coefficient r, the structural validity of the scale was evaluated by exploratory factor analysis, and the ceiling and floor effects of the scale were evaluated. Results The Mandarin version of the SCNS-HNC had Cronbach’s alpha coefficients greater than 0.700 (0.737 ≤ 0.962) for all of the domains. Except for the psychological demand dimension (r = 0.674) of the SCNS-SF34 scale, the retest reliability of the other domains was greater than 0.8. Three common factors were extracted by exploratory factor analysis, and the cumulative variance contribution rate was 64.39%. Conclusions The Mandarin version of the SCNS-SF34 and SCNS-HNC demonstrated satisfactory reliability and validity and is able to measure the supportive care needs of Chinese patients with head and neck cancer. Trial registration ChiCTR, ChiCTR1900026635 . Registered 16 October 2019- Retrospectively registered.
Keywords	Head and neck cancer ; Support care needs ; Reliability ; Validity ; SCNS-HNC scale ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Evaluating the Water Quality Impacts of Hydrothermal Liquefaction Assessment of Carbon, Nitrogen, and Energy Recovery

Bauer, Sarah K / Catherine F. Reynolds / Shanshan Peng / Lisa M. Colosi

Bioresource technology reports. 2018 June, v. 2

2018

Abstract: This research evaluates possible water impacts arising from creation of potent wastewaters during hydrothermal liquefaction (HTL) of organic wastes. Aqueous co-products (ACPs) arising from HTL of eight feedstocks contained very high concentrations of ... ...

Abstract	This research evaluates possible water impacts arising from creation of potent wastewaters during hydrothermal liquefaction (HTL) of organic wastes. Aqueous co-products (ACPs) arising from HTL of eight feedstocks contained very high concentrations of traditional wastewater pollutants: 100–3300 mg/L total nitrogen (N), 45–3600 mg/L total phosphorus (P), and 16,000–234,000 mg/L chemical oxygen demand (COD). pH was 4.4–8.8. These characteristics render ACP more noxious than relevant benchmark wastewaters. Adjustment of published energy ratio metrics to account for ACP treatment reveals that energy yield is moderately decreased, and energy consumption for COD, TN, and TP removal is of the same order of magnitude as liquefaction. Recovery of valuable nutrients (i.e., N and P) from ACP via precipitation could reduce the energy intensity of ACP management and mitigate its impact on energy recovery. In particular, precipitation-based nutrient recovery could enhance HTL's appeal as means to valorize waste into renewable energy and valuable scarce materials.
Keywords	carbon ; chemical oxygen demand ; coproducts ; energy ; energy recovery ; feedstocks ; hydrothermal liquefaction ; nutrients ; organic wastes ; pH ; pollutants ; renewable energy sources ; total nitrogen ; total phosphorus ; wastewater ; water quality
Language	English
Dates of publication	2018-06
Size	p. 115-120.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2589-014X
DOI	10.1016/j.biteb.2018.04.010
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Impact of Ownership Structure on the Level of Financial Risk of SME in China

Tuanye Yu / Wei Yuan / Shanshan Peng Rui / Xiaoman Song

Asian Journal of Business Management, Vol 7, Iss 2, Pp 19-

2015 Volume 27

Abstract: The level of financial risk has great significance to the sound operation of enterprises and the healthy development of economics. Based on the data from 2009 to 2011 of 205 small and medium manufacturing enterprises listed before 2009, this study ... ...

Abstract	The level of financial risk has great significance to the sound operation of enterprises and the healthy development of economics. Based on the data from 2009 to 2011 of 205 small and medium manufacturing enterprises listed before 2009, this study studies the impact of ownership structure on the level of financial risk, especially the relationship between financial risk to firms on small board and one-share dominance as well as the family characteristics of family business. The empirical result shows that: the proportion of tradable shares and the degree of equity balance are negatively correlated with the financial risk level; while the ownership concentration is positively correlated with the financial risk level; and the proportion of state-owned shares or legal person shares and CEO share-holding rate have no significant effect on the financial risk level of SME (small and medium enterprises).
Keywords	Financial risk ; ownership structure ; SME ; Management. Industrial management ; HD28-70 ; Industries. Land use. Labor ; HD28-9999 ; Social Sciences ; H
Subject code	332
Language	English
Publishing date	2015-05-01T00:00:00Z
Publisher	Maxwell Science Publication
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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