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  1. Article: Phrase Depicting Immoral Behavior Dilates Its Subjective Time Judgment.

    Jia, Lina / Shao, Bingjie / Wang, Xiaocheng / Shi, Zhuanghua

    Frontiers in psychology

    2021  Volume 12, Page(s) 784752

    Abstract: Intuitive moral emotions play a major role in forming our opinions and moral decisions. However, it is not yet known how we perceive the subjective time of moral-related information. In this study, we compared subjective durations of phrases depicting ... ...

    Abstract Intuitive moral emotions play a major role in forming our opinions and moral decisions. However, it is not yet known how we perceive the subjective time of moral-related information. In this study, we compared subjective durations of phrases depicting immoral, disgust, or neutral behaviors in a duration bisection task and found that phrases depicting immoral behavior were perceived as lasting longer than the neutral and disgusting phrases. By contrast, the subjective duration of the disgusting phrase, unlike the immoral phrase, was comparable to the neutral phrase. Moreover, the lengthening effect of the immoral phrase relative to the neutral phrase was significantly correlated to the anonymously prosocial tendency of the observer. Our findings suggest that immoral phrases induce embodied moral reaction, which alters emotional state and subsequently lengthens subjective time.
    Language English
    Publishing date 2021-12-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.784752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Exploring the molecular mechanism of Gan Shuang granules for the treatment of non-alcoholic steatohepatitis using network pharmacology, molecular docking, and experimental verification.

    Zhi, Guoguo / Shao, Bingjie / Zheng, Tianyan / Mu, Jie / Li, Jingwei / Feng, Yiyuan / Zhu, Sha / Dang, Yanni / Liu, Feng / Wang, Dong

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1082451

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1082451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Surmounting Cancer Drug Resistance: New Perspective on RNA-Binding Proteins.

    Feng, Yiyuan / Zhu, Sha / Liu, Tengwen / Zhi, Guoguo / Shao, Bingjie / Liu, Jibin / Li, Baixue / Jiang, Cen / Feng, Quansheng / Wu, Peijie / Wang, Dong

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 8

    Abstract: RNA-binding proteins (RBPs), being pivotal elements in both physiological and pathological processes, possess the ability to directly impact RNA, thereby exerting a profound influence on cellular life. Furthermore, the dysregulation of RBPs not only ... ...

    Abstract RNA-binding proteins (RBPs), being pivotal elements in both physiological and pathological processes, possess the ability to directly impact RNA, thereby exerting a profound influence on cellular life. Furthermore, the dysregulation of RBPs not only induces alterations in the expression levels of genes associated with cancer but also impairs the occurrence of post-transcriptional regulatory mechanisms. Consequently, these circumstances can give rise to aberrations in cellular processes, ultimately resulting in alterations within the proteome. An aberrant proteome can disrupt the equilibrium between oncogenes and tumor suppressor genes, promoting cancer progression. Given their significant role in modulating gene expression and post-transcriptional regulation, directing therapeutic interventions towards RBPs represents a viable strategy for combating drug resistance in cancer treatment. RBPs possess significant potential as diagnostic and prognostic markers for diverse cancer types. Gaining comprehensive insights into the structure and functionality of RBPs, along with delving deeper into the molecular mechanisms underlying RBPs in tumor drug resistance, can enhance cancer treatment strategies and augment the prognostic outcomes for individuals afflicted with cancer.
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16081114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinicopathological Analysis of Acquired Melanocytic Nevi and a Preliminary Study on the Possible Origin of Nevus Cells.

    Wang, Da-Guang / Huang, Fei-Ran / Chen, Wei / Zhou, Yuan / Wang, Cong-Yang / Zhu, Feng / Shao, Bing-Jie / Luo, Dan

    The American Journal of dermatopathology

    2019  Volume 42, Issue 6, Page(s) 414–422

    Abstract: Background: The pathogenesis of acquired melanocytic nevi (AMN) is still unclear, and the origin of nevus cells has not been clarified.: Objective: To analyze the clinical features and pathological types of AMN and identify the possible origin of ... ...

    Abstract Background: The pathogenesis of acquired melanocytic nevi (AMN) is still unclear, and the origin of nevus cells has not been clarified.
    Objective: To analyze the clinical features and pathological types of AMN and identify the possible origin of nevus cells.
    Methods: A retrospective study of 2929 cases of AMN was conducted, and 96 specimens of intradermal and junctional nevi were selected. Immunohistochemical assays were performed to detect the expression of basement membrane component receptor DDR-1 and the molecular markers on epidermal melanocytes, dermal stem cells (DSCs), and hair follicle stem cells.
    Results: Junctional nevi and compound nevi were prone to occur on glabrous skin, such as the palms, soles, and vulva, and on the extremities in children, whereas intradermal nevi tended to develop on the trunk, head, and face of adults. The immunohistochemical data revealed that both junctional nevi and intradermal nevi expressed the epidermal melanocyte surface markers E-cadherin, DDR-1, and integrin α6 and the DSC molecular markers NGFRp-75 and nestin. CD34 was expressed only in junctional nevi, whereas K19 was not expressed in any type of melanocytic nevi. There was no significant difference in molecular expression at different sites or in different ages of onset. Nestin expression was markedly stronger in the intradermal nevi than in the junctional nevi, but there was no difference between the superficial and deep nevus cell nests of intradermal nevi.
    Conclusion: AMN may have a multicellular origin that commonly follows the mode of Abtropfung. Furthermore, DSCs may partly or independently participate in the formation of nevus cells.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/analysis ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Nevus, Pigmented/pathology ; Retrospective Studies ; Skin Neoplasms/pathology ; Stem Cells/pathology ; Young Adult
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-12-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000001599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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