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  1. Article ; Online: The role of metallothionein in a dinitrofluorobenzene-induced atopic dermatitis-like murine model

    Jin-Zhu Guo / Wen-Hui Wang / Lin-Feng Li / Shao-Min Yang / Jing Wang

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Volume 9

    Abstract: Abstract Atopic dermatitis (AD), one of the most common chronic eczematous skin disorders, is associated with cutaneous hyperactivity as a response to environmental triggers. Metallothionein (MT) plays a constitutive defensive role in the response to ... ...

    Abstract Abstract Atopic dermatitis (AD), one of the most common chronic eczematous skin disorders, is associated with cutaneous hyperactivity as a response to environmental triggers. Metallothionein (MT) plays a constitutive defensive role in the response to noxious stimuli. However, the role of MT in AD development is unclear. Using an AD-like murine model created by the topical application of 2.4-dinitrofluorobenzene, we studied the dynamic pattern of MT expression on AD development. AD-like lesions were evaluated based on the development of erythema, edema, exfoliation, scaling, increased thickness, and increased weight of lesional skin. These characteristics of AD-like lesions and thymic stromal lymphopoietin (TSLP) expression peaked at Day 1 of the establishment of our model and gradually alleviated over time. The MT expression in lesional skin was increased and peaked at Day 3. By immunostaining, increased expression of MT was translocated from the cytoplasm to the nucleus. MT-1/2 knockout (MT−/−) mice and wild type (MT+/+) mice were also used to evaluate the role of MT on AD. MT−/− mice had greater edema scores, thickness, lesional skin weight, as well as more CD4+ T cells, TSLP, superoxide dismutase, and NDUFAF1. These results suggest that MT may play a protective role against AD development, and that antioxidant and nuclear protective mechanisms may be involved.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2018-07-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Food web properties of the recently constructed, deep subtropical Fei-Tsui Reservoir in comparison with the ancient Lake Biwa

    Okuda, Noboru / Yoichiro Sakai / Kayoko Fukumori / Shao-Min Yang / Chih-hao Hsieh / Fuh-Kwo Shiah

    Hydrobiologia. 2017 Nov., v. 802, no. 1

    2017  

    Abstract: Using carbon and nitrogen stable isotope analysis, we characterised food web properties of the deep subtropical Fei-Tsui Reservoir (FTR), which was recently altered from a lotic to a lentic system after dam construction. In the littoral zone, zoobenthos ... ...

    Abstract Using carbon and nitrogen stable isotope analysis, we characterised food web properties of the deep subtropical Fei-Tsui Reservoir (FTR), which was recently altered from a lotic to a lentic system after dam construction. In the littoral zone, zoobenthos showed strong reliance (83.9%) on benthic algal production. Zoobenthos were never found in the profundal zone because of anoxia. Zooplankton depleted ¹³C more than that of particulate organic matter as their putative food source, suggesting a contribution of methane-derived carbon to pelagic food webs. Excluding juveniles, non-native and fluvial species, adult fish showed strong reliance (on average 80.9%) on benthic production, weakly coupled with pelagic food webs. These results contrast low benthic production reliance (on average 27.4%) for a fish community in Lake Biwa, which is also classified as a subtropical lake. Both lakes are characterised by deep pelagic waters but quite different in their geological ages, suggesting that the aquatic communities in the FTR have fluvial origins, and their lacustrine history was too short for them to adapt to newly emerged deep pelagic habitat. Our isotope data are useful as a reference of newly established lentic food webs to monitor ongoing ecological and evolutionary dynamics as a result of anthropogenic disturbances.
    Keywords adults ; algae ; ancient lakes ; anthropogenic activities ; aquatic communities ; aquatic food webs ; carbon ; fish ; fish communities ; habitats ; juveniles ; lentic systems ; littoral zone ; lotic systems ; nitrogen ; particulate organic matter ; stable isotopes ; water reservoirs ; zooplankton
    Language English
    Dates of publication 2017-11
    Size p. 199-210.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 214428-1
    ISSN 1573-5117 ; 0018-8158
    ISSN (online) 1573-5117
    ISSN 0018-8158
    DOI 10.1007/s10750-017-3258-4
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Recurrence Factors in Giant Cell Tumors of the Spine

    Han-Qiang Ouyang / Liang Jiang / Xiao-Guang Liu / Feng Wei / Shao-Min Yang / Na Meng / Ping Jiang / Miao Yu / Feng-Liang Wu / Lei Dang / Hua Zhou / Hua Zhang / Zhong-Jun Liu

    Chinese Medical Journal, Vol 130, Iss 13, Pp 1557-

    2017  Volume 1563

    Abstract: Background: Giant cell tumors (GCTs) are benign, locally aggressive tumors. We examined the rate of local recurrence of spinal GCTs and sought to identify recurrence factors in patients who underwent surgery. Methods: Between 1995 and 2014, 94 mobile ... ...

    Abstract Background: Giant cell tumors (GCTs) are benign, locally aggressive tumors. We examined the rate of local recurrence of spinal GCTs and sought to identify recurrence factors in patients who underwent surgery. Methods: Between 1995 and 2014, 94 mobile spine GCT patients were treated at our hospital, comprising 43 male and 51 female patients with an average age of 33.4 years. Piecemeal intralesional spondylectomy and total en bloc spondylectomy (TES) were performed. Radiotherapy was suggested for recurrent or residual GCT cases. Since denosumab was not available before 2014 in our country, only interferon and/or zoledronic acid was suggested. Results: Of the 94 patients, four underwent conservative treatment and 90 underwent operations. Seventy-five patients (79.8%) were followed up for a minimum of 24 months or until death. The median follow-up duration was 75.3 months. The overall recurrence rate was 37.3%. Ten patients (13.3%) died before the last follow-up (median: 18.5 months). Two patients (2.6%) developed osteogenic sarcoma. The local recurrence rate was 80.0% (24/30) in patients who underwent intralesional curettage, 8.8% (3/34) in patients who underwent extracapsular piecemeal spondylectomy, and 0 (0/9) in patients who underwent TES. The risk factors for local recurrence were lesions located in the cervical spine (P = 0.049), intralesional curettage (P < 0.001), repeated surgeries (P = 0.014), and malignancy (P < 0.001). Malignant transformation was a significant risk factor for death (P < 0.001). Conclusions: Cervical spinal tumors, curettage, and nonintact tumors were risk factors for local recurrence. Intralesional curettage and malignancy were the most important significant factors for local recurrence and death, respectively.
    Keywords Extracapsular Spondylectomy ; Giant Cell Tumors ; Intralesional Curettage Spine ; Recurrence ; Total En bloc Spondylectomy ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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