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Article: Study on the Characteristics of Traditional Chinese Medicine Syndromes in Patients with Erosive Gastritis Based on Metabolomics.

Shixiong, Zhang / Shaowei, Liu / Zeqi, Yang / Miaochan, Xu / Pingping, Zhou / Haiyan, Bai / Jingjing, Lv / Yangang, Wang

International journal of analytical chemistry

2024 Volume 2024, Page(s) 6684677

Abstract: According to traditional Chinese medicine theory, tongue coatings reflect changes in the body. The goal of this study was to identify a metabolite or a set of metabolites capable of classifying characteristics of traditional Chinese medicine syndromes in ...

Abstract	According to traditional Chinese medicine theory, tongue coatings reflect changes in the body. The goal of this study was to identify a metabolite or a set of metabolites capable of classifying characteristics of traditional Chinese medicine syndromes in erosive gastritis. In this study, we collected tongue coatings of patients with erosive gastritis with damp-heat syndrome (DHS), liver depression and qi stagnation syndrome (LDQSS), and healthy volunteers. Then, we analyzed the differences in metabolic characteristics between the two groups based on metabolomics. We identified 14 potential biomarkers related to the DHS group, and six metabolic pathways were enriched. The differential pathways included pyrimidine metabolism, pantothenate and CoA biosynthesis, citrate cycle (TCA cycle), pyruvate metabolism, glycolysis/gluconeogenesis, and purine metabolism. Similarly, in the LDQSS group, we identified 25 potential biomarkers and 18 metabolic pathways were enriched. The top five pathways were the TCA cycle, sphingolipid metabolism, fatty acid biosynthesis, pantothenate and CoA biosynthesis, and the pentose phosphate pathway. In conclusion, the DHS group and the LDQSS group have different characteristics.
Language	English
Publishing date	2024-01-02
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2494714-3
ISSN	1687-8779 ; 1687-8760
ISSN (online)	1687-8779
ISSN	1687-8760
DOI	10.1155/2024/6684677
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reflection of Acoustic Wave through Multilayered Porous Sea Ice Sandwiched between the Water and Air Half-Spaces

Shande Li / Shaowei Liu / Shuai Yuan / Jian Wen / Zhifu Zhang

Applied Sciences, Vol 11, Iss 7411, p

2021 Volume 7411

Abstract: To establish an accurate sea ice model is a tremendous challenge in Arctic acoustic research. Regarding this matter, a multilayered porous sea ice model is proposed based on Biot’s theory in this paper. Assuming that the model is sandwiched between the ... ...

Abstract	To establish an accurate sea ice model is a tremendous challenge in Arctic acoustic research. Regarding this matter, a multilayered porous sea ice model is proposed based on Biot’s theory in this paper. Assuming that the model is sandwiched between the water and air half-spaces, the reflection coefficient of an incident wave from water into ice is deduced and contrasted with the solution calculated by impedance transfer method (ITM) to demonstrate the verification of the model. Furthermore, the influences of frequency, porosity and layering on reflection coefficients are analyzed. The results reveal that the reflection coefficient is closely associated with layering and porosity. Therefore, it is reasonable and necessary to simultaneously take the layering and porosity of ice into consideration. Different from the existing layered or porous ice model, the presented model synthesizes the layered characteristic and porous structure of ice, which better portrays the real condition of sea ice. It is an improvement of the broadly used stratified or porous sea ice model, which provides ideas for further sea ice modeling.
Keywords	layering ; porosity ; Biot’s theory ; reflection ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	290
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Asymmetric Total Synthesis of Hetiamacins A–F

Gang Wu / Ting Wang / Zhongke Jiang / Shaowei Liu / Chenghang Sun

ACS Omega, Vol 6, Iss 12, Pp 8239-

2021 Volume 8245

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characteristics of Low-Frequency Acoustic Wave Propagation in Ice-Covered Shallow Water Environment

Shande Li / Shuai Yuan / Shaowei Liu / Jian Wen / Qibai Huang / Zhifu Zhang

Applied Sciences, Vol 11, Iss 7815, p

2021 Volume 7815

Abstract: Mastering the sound propagation law of low-frequency signals in the Arctic is a major frontier basic research demand to improve the level of detection, communication, and navigation technology. It is of practical significance for long-distance sound ... ...

Abstract	Mastering the sound propagation law of low-frequency signals in the Arctic is a major frontier basic research demand to improve the level of detection, communication, and navigation technology. It is of practical significance for long-distance sound propagation and underwater target detection in the Arctic Ocean. Therefore, how to establish an effective model to study the characteristics of the acoustic field in the Arctic area has always been a hot topic in polar acoustic research. Aimed at solving this problem, a mathematical polar acoustic field model with an elastic seafloor is developed based on a range-dependent elastic parabolic equation theory. Moreover, this method is applied to study the characteristics of polar sound propagation for the first attempt. The validity and effectiveness of the method and model are verified by the elastic normal mode method. Simultaneously, the propagation characteristics of low-frequency signals are studied in a polar sound field from three aspects, which are seafloor parameters, sea depth, and ice thickness. The results show that the elastic parabolic equation method can be well utilized to the Arctic low-frequency acoustic field. The analysis of the influence factors of the polar sound field reveals the laws of sound transmission loss of low-frequency signals, which is of great significance to provide information prediction for underwater submarine target detection and target recognition.
Keywords	low frequency ; polar shallow water environment ; elastic parabolic equation ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	621
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Determination of the protective effects of Hua‐Zhuo‐Jie‐Du in chronic atrophic gastritis by regulating intestinal microbiota and metabolites

Pingping Zhou / Xinyu Hao / Yu Liu / Zeqi Yang / Miaochan Xu / Shaowei Liu / Shixiong Zhang / Tianxiao Yang / Xiaomei Wang / Yangang Wang

Chinese Medicine, Vol 16, Iss 1, Pp 1-

combination of liquid chromatograph mass spectrometer metabolic profiling and 16S rRNA gene sequencing

2021 Volume 19

Abstract: Abstract Background Hua-Zhuo-Jie-Du (HZJD), a Chinese herbal prescription consisting of 11 herbs, is commonly used in China to treat chronic atrophic gastritis (CAG). We aimed to determine the effect of HZJD on the microbiome-associated metabolic changes ...

Abstract	Abstract Background Hua-Zhuo-Jie-Du (HZJD), a Chinese herbal prescription consisting of 11 herbs, is commonly used in China to treat chronic atrophic gastritis (CAG). We aimed to determine the effect of HZJD on the microbiome-associated metabolic changes in CAG rats. Methods The CAG rat models were induced by 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) combined with irregular fasting and 2% sodium salicylate, which was intragastrically administrated in fasted animals for 24 weeks. The CAG rats in the Chinese medicine (CM) group were administered a daily dose of 14.81 g/kg/day HZJD, and the vitacoenzyme (V) group were administered a daily dose of 0.08 g/kg/day vitacoenzyme. All animals were treated for 10 consecutive weeks, consecutively. Hematoxylin and eosin (H&E) staining was used to assess the histopathological changes in the gastric tissues. An integrated approach based on liquid chromatograph mass spectrometer (LC-MS) metabolic profiling combined with 16S rRNA gene sequencing was carried out to assess the effects of HZJD on CAG rats. Spearman analysis was used to calculate the correlation coefficient between the different intestinal microbiota and the metabolites. Results The H&E results indicated that HZJD could improve the pathological condition of CAG rats. The LC–MS results indicated that HZJD could significantly improve 21 gastric mucosal tissue perturbed metabolites in CAG rats; the affected metabolites were found to be involved in multiple metabolic pathways, such as the central carbon metabolism in cancer. The results of 16S rRNA gene sequencing indicated that HZJD could regulate the diversity, microbial composition, and abundance of the intestinal microbiota of CAG rats. Following HZJD treatment, the relative abundance of Turicibacter was increased, and the relative abundance of Desulfococcus and Escherichia were decreased in the CM group when compared with the M group. Spearman analysis revealed that perturbed intestinal microbes had a strong correlation with differential metabolites, ...
Keywords	Hua‐Zhuo‐Jie‐Du ; Chronic atrophic gastritis ; LC–MS ; 16S rRNA gene sequencing ; Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Catechol amide iron chelators produced by a mangrove-derived Bacillus subtilis

Li, Jingyan / Shaowei Liu / Zhongke Jiang / Chenghang Sun

Tetrahedron. 2017,

2017

Abstract: A novel triscatecholamide siderophore derivative, linear tribenglthin A (1), together with well known congener, bacillibactin (2) as well as mentioned monomer unit, benglthin were found in the secondary metabolites of a magrove-derived Bacillus subtilis ... ...

Abstract	A novel triscatecholamide siderophore derivative, linear tribenglthin A (1), together with well known congener, bacillibactin (2) as well as mentioned monomer unit, benglthin were found in the secondary metabolites of a magrove-derived Bacillus subtilis subsp. spizizenii MMB-016. The structure of 1, determined by extensive 1D and 2D NMR studies has an unusual nonproteinogenic amino acid, Z-dehydrobutyrine (Z-Dhb) residue to reveal a putative lantibiotic synthetase function involved in the iterative biosynthesis of non-ribosomal peptide (NRP). Our 1Hâ15N correlation spectroscopy of 2 resulted in a correction of previous NH assignment of bacillibactin, as well as a new evaluation of DPPH free radical scavenging potential suggested antioxidant activity. Benglthin monomer was isolated as a ferrous complex (3), unveiling an interestingly higher affinity for iron Fe(â¡) than trimers, 1 and 2. No dimeric forms were found.
Keywords	2,2-diphenyl-1-picrylhydrazyl ; Bacillus subtilis ; amino acids ; antioxidant activity ; biosynthesis ; catechol ; chelating agents ; chemical reactions ; chemical structure ; free radical scavengers ; iron ; nuclear magnetic resonance spectroscopy ; secondary metabolites ; siderophores
Language	English
Size	p. .
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2017.07.007
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanisms of Huazhuojiedu Decoction to Treat Chronic Atrophic Gastritis

Xinyu Hao / Yu Liu / Pingping Zhou / Qian Jiang / Zeqi Yang / Miaochan Xu / Shaowei Liu / Shixiong Zhang / Yangang Wang

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: Background. Chronic atrophic gastritis (CAG) is an important stage in the normal gastric mucosa’s transformation into gastric cancer. Huazhuojiedu decoction (HZJD), a Chinese herbal preparation, has proven clinically effective to treat CAG. However, few ... ...

Abstract	Background. Chronic atrophic gastritis (CAG) is an important stage in the normal gastric mucosa’s transformation into gastric cancer. Huazhuojiedu decoction (HZJD), a Chinese herbal preparation, has proven clinically effective to treat CAG. However, few studies have explored the mechanism of HZJD in CAG treatment. Purpose. This study aimed to shed light on the mechanisms underlying HZJD decoction CAG treatment using a network pharmacology approach and experimental validation. Methods. The active components of HZJD decoction were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. Their targets were predicted through the SwissTargetPrediction database. Disease targets were screened using the GeneCards database. The disease and drug prediction targets were intersected to select the common potential therapeutic targets, which then were input into the Search Tool for the Retrieval of Interacting Genes to build a protein-protein interaction network. The “herb-compound-target-disease” and the “herb-target-pathway” network diagrams were constructed in Cytoscape 3.3.0. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of effective targets were performed using the Database for Annotation, Visualization, and Integrated Discovery. Finally, the core targets were preliminarily verified by CAG rat model. The gastric mucosa’s histopathological changes were observed via hematoxylin-eosin staining. The expressions of MAPK1, AKT1, TNF, VEGFA, and EGFR were detected by western blot and quantitative real-time reverse transcription-polymerase chain reaction. Results. A total of 155 nodes, including 20 putative targets of HZJD decoction, were selected as core hubs based on topological importance and were closely associated with the regulation of cell proliferation, apoptotic process, and cancer-related pathways (AKT1, TNF, VEGFA, and EGFR) in CAG. Further animal experiments showed that the expression of AKT1 in CAG rats was significantly increased, ...
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Total Synthesis of Originally Proposed and Revised Structure of Hetiamacin A

Wu, Gang / Chenghang Sun / Kai Lv / Shaowei Liu / Ting Wang / Yucheng Wang / Zhongke Jiang

Organic letters. 2018 May 25, v. 20, no. 12

2018

Abstract: The first total synthesis of the originally proposed and correct structures of hetiamacin A has been accomplished via Wittig olefination and Sharpless asymmetric dihydroxylation reaction. These total syntheses culminated in the stereostructural ... ...

Abstract	The first total synthesis of the originally proposed and correct structures of hetiamacin A has been accomplished via Wittig olefination and Sharpless asymmetric dihydroxylation reaction. These total syntheses culminated in the stereostructural confirmation of the reassignment of hetiamacin A.
Keywords	chemical structure ; dihydroxylation ; organic compounds
Language	English
Dates of publication	2018-0525
Size	p. 3566-3569.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.8b01350
Database	NAL-Catalogue (AGRICOLA)

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Article: Laponite crosslinked starch/polyvinyl alcohol hydrogels by freezing/thawing process and studying their cadmium ion absorption

Yu, Chen / Chengcheng Gao / Shaowei Liu / Xiaozhi Tang / Xinchun Shen / Yuling Yang

International journal of biological macromolecules. 2018 Oct. 01, v. 117

2018

Abstract: In this study, Laponite RD (LRD) cross-linked hydrogels consisting of starch, polyvinyl alcohol (PVA) were prepared by freezing/thawing process and the influence of LRD content on structure and properties of hydrogels was investigated. FTIR showed a new ... ...

Abstract	In this study, Laponite RD (LRD) cross-linked hydrogels consisting of starch, polyvinyl alcohol (PVA) were prepared by freezing/thawing process and the influence of LRD content on structure and properties of hydrogels was investigated. FTIR showed a new structure of hydrogen bonding might result from cross-linking reactions between LRD and polymers. X-ray diffraction (XRD) analysis showed that high degree of exfoliation of LRD clay layers had occurred during the preparation of hydrogels. The synergistic effect of physical cross-linking by freeze/thaw cycles and by LRD led to more porous, uniform and stable network, which was shown in SEM images. The melting temperature decreased and thermal stability got improved with the increase of LRD content. Reswelling ratios of hydrogels had the highest value when LRD content was 10%. Additionally, cadmium ion absorption capacity of the hydrogel was studied and the results showed that increasing the concentration of LRD increased absorption ratio and amount of Cd2+ ion in the solution. In a word, LRD could be used as a physical crosslinker and reinforced agent for starch-PVA based hydrogels and the formed hydrogels could be used as novel type and high capacity absorbent materials in heavy metal removing processes.
Keywords	absorbents ; absorption ; cadmium ; clay ; crosslinking ; Fourier transform infrared spectroscopy ; freezing ; heavy metals ; hydrogels ; hydrogen bonding ; laponite ; melting point ; polyvinyl alcohol ; scanning electron microscopy ; starch ; thawing ; thermal stability ; X-ray diffraction
Language	English
Dates of publication	2018-1001
Size	p. 1-6.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2018.05.159
Database	NAL-Catalogue (AGRICOLA)

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Article: Metabolic Engineering of Saccharomyces cerevisiae for High-Level Production of Salidroside from Glucose

Jiang, Jingjie / Hua Yin / Shaowei Liu / Shuai Wang / Tao Liu / Yanhe Ma / Yibin Zhuang

Journal of agricultural and food chemistry. 2018 Apr. 19, v. 66, no. 17

2018

Abstract: Salidroside is an important plant-derived aromatic compound with diverse biological properties. Because of inadequate natural resources, the supply of salidroside is currently limited. In this work, we engineered the production of salidroside in yeast. ... ...

Abstract	Salidroside is an important plant-derived aromatic compound with diverse biological properties. Because of inadequate natural resources, the supply of salidroside is currently limited. In this work, we engineered the production of salidroside in yeast. First, the aromatic aldehyde synthase (AAS) from Petroselinum crispum was overexpressed in Saccharomyces cerevisiae when combined with endogenous Ehrlich pathway to produce tyrosol from tyrosine. Glucosyltransferases from different resources were tested for ideal production of salidroside in the yeast. Metabolic flux was enhanced toward tyrosine biosynthesis by overexpressing pathway genes and eliminating feedback inhibition. The pathway genes were integrated into yeast chromosome, leading to a recombinant strain that produced 239.5 mg/L salidroside and 965.4 mg/L tyrosol. The production of salidroside and tyrosol reached up to 732.5 and 1394.6 mg/L, respectively, by fed-batch fermentation. Our work provides an alternative way for industrial large-scale production of salidroside and tyrosol from S. cerevisiae.
Keywords	aldehydes ; batch fermentation ; biosynthesis ; chromosomes ; gene overexpression ; genes ; glucose ; glucosyltransferases ; metabolic engineering ; Petroselinum crispum ; Saccharomyces cerevisiae ; tyrosine ; yeasts
Language	English
Dates of publication	2018-0419
Size	p. 4431-4438.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.8b01272
Database	NAL-Catalogue (AGRICOLA)

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