Article ; Online: The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia.
Blood science (Baltimore, Md.)
2021 Volume 3, Issue 4, Page(s) 132–135
Abstract: In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% ...
| Abstract | In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% of patients. In this mini-review, we investigate the function of dendritic cells and T cells based on Flt3-ITD mutation and immune evasion as a result of this abnormality. Finally, we discuss some AML therapeutic strategies, including targeting Flt3 on DCs and TIM-3 on T cells as immune receptors to treat this hematopoietic malignancy. |
|---|---|
| Language | English |
| Publishing date | 2021-10-18 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 2543-6368 |
| ISSN (online) | 2543-6368 |
| DOI | 10.1097/BS9.0000000000000092 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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