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  1. Article ; Online: Leptospirosis

    Sharada R Rane / Varsha Bhatia

    Journal of the Practice of Cardiovascular Sciences, Vol 5, Iss 3, Pp 217-

    A Diagnostic Challenge at Autopsy: Report of Two Cases

    2019  Volume 220

    Abstract: Leptospirosis is an important sporadic zoonotic disease. This disease is caused by the spirochete leptospira icterohemorrhagica. In India, leptospirosis has always remained a major health concern, particularly during monsoons. This disease mainly affects ...

    Abstract Leptospirosis is an important sporadic zoonotic disease. This disease is caused by the spirochete leptospira icterohemorrhagica. In India, leptospirosis has always remained a major health concern, particularly during monsoons. This disease mainly affects vital organs such as the lung, kidney, and heart. Acute respiratory distress syndrome and acute renal failure mainly contribute to the mortality in patients, but cardiac involvement leading to death still remains an underestimated critical clinical factor. We report here two autopsy cases and highlight histopathological changes in heart which helped us in diagnosing in correlation with other organ findings the final cause of death as leptospirosis.
    Keywords coronary artery endotheliitis ; heart ; leptospirosis ; Medicine ; R ; Surgery ; RD1-811 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Subtyping of Non-Small Cell Lung Carcinomas in Bronchoscopic Biopsies

    Mihir Mohan Vaidya / Sharada R Rane / Shaila C Puranik

    Journal of Clinical and Diagnostic Research, Vol 12, Iss 11, Pp EC01-EC

    A Tertiary Care Centre Experience

    2018  Volume 04

    Abstract: Introduction: The advent of promising targeted therapies against specific subtypes of Non-small Cell Lung Carcinoma (NSCLC) has made it mandatory for the pathologists to subclassify NSCLC into its subtypes, along with saving tissue for molecular studies ... ...

    Abstract Introduction: The advent of promising targeted therapies against specific subtypes of Non-small Cell Lung Carcinoma (NSCLC) has made it mandatory for the pathologists to subclassify NSCLC into its subtypes, along with saving tissue for molecular studies and work closely with the radiologists and the clinicians for effective management of the cases. Aim: To subclassify NSCLC into its subtypes using routine diagnostic techniques, to study the demographic, clinical and radiological features of lung cancer in addition to performing a limited immunohistochemistry panel on bronchoscopic samples. Materials and Methods: Clinically and radiologically suspected cases of lung cancer having non-small cell morphology were subjected to cytological and histopathological examination for subtyping. A limited immunohistochemistry (IHC) panel comprising of TTF-1, Napsin A, P63 and Neural Cell Adhesion Molecule (NCAM) was used in poorly differentiated tumours for further subtyping. Results: There were 52 cases of NSCLC with an incidence rate of 1.78 per 1000 per 1.5 years. Average age of patients was 56.13 years and there was a slight male preponderance. Breathlessness (85%) was the most frequent clinical finding followed by weight loss and cough (81% each). All cases presented with solid nodule or mass lesion. Adenocarcinoma (n=46%) was the most frequent histological type followed by Squamous cell carcinoma (n=34%). Ten poorly differentiated cases were classified on IHC as follows: three cases each of NSCLC favour Adenocarcinoma and NSCLC favour Squamous cell carcinoma, two cases each of Small cell lung carcinoma and NSCLC Not Otherwise Specified (NOS). Conclusion: Using routine diagnostic methods and a limited IHC panel comprising of TTF-1, Napsin A, P63 and NCAM in biopsies, it was possible to classify all 52 cases of NSCLC as per latest classification guidelines while restricting the number of NOS cases to just two.
    Keywords adenocarcinoma ; lung cancer ; napsin a ; p63 ; squamous cell carcinoma ; Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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