LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article: LYMPHO-PROLIFERATIVE RESPONSES TO VARIOUS FASCIOLA HEPATICA WORM'S ANTIGENS: AN IN VITRO STUDY.

    Sharaf, Osama F / Amir, Elamir M / Hawash, Yousry A

    Journal of the Egyptian Society of Parasitology

    2016  Volume 46, Issue 1, Page(s) 217–222

    Abstract: Fascioliasis is an important zoonotic disease with approximately 2-4 million people infected worldwide and a further 180 million at risk of infection. F. hepatica can survive within the bile ducts for many years through its ability to suppress the host ... ...

    Abstract Fascioliasis is an important zoonotic disease with approximately 2-4 million people infected worldwide and a further 180 million at risk of infection. F. hepatica can survive within the bile ducts for many years through its ability to suppress the host immunity with Fasciola cathepsin L1 cysteine protease and Glutathione S transferase playing an important role. The aim of the present study is to investigate the in vitro lympho-proliferative responses of hepatic hilar lymphocytes (HLN) of infected sheep in response to different F. hepatica antigens. The suppressive effects of Fasciola excretory/secretory (ES) and tegument (TEG) and their fractions were also investigated. Our results showed that both ES and TEG had significant suppressive effects on lympho-proliferation, up to 74% and 92%, respectively. When these antigens were fractionated, fraction 3 (MW of >10000-30000) of both ES (64%) and TEG (59%) in addition to fraction 4 (MW of ≤ 10000) of TEG (38%) inherited the suppressive effects. Identification of the potential molecule(s) with such suppressive effects on lymphocytes in TEG fraction 4 could reveal vaccine candidates.
    MeSH term(s) Animals ; Antigens, Helminth/physiology ; Cell Proliferation ; Fasciola hepatica/physiology ; Fascioliasis/immunology ; Fascioliasis/parasitology ; Fascioliasis/veterinary ; Helminth Proteins/immunology ; Helminth Proteins/physiology ; Lymphocytes/physiology ; Sheep ; Sheep Diseases/immunology ; Sheep Diseases/parasitology
    Chemical Substances Antigens, Helminth ; Helminth Proteins
    Language English
    Publishing date 2016-01-21
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 645058-1
    ISSN 1110-0583 ; 0253-5890
    ISSN 1110-0583 ; 0253-5890
    DOI 10.12816/0026167
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3282: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 617: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Modulation of mice immune responses against Schistosoma mansoni infection with anti-schistosomiasis drugs: Role of interleukin-4 and interferon-gamma.

    Sharaf, Osama F / Ahmed, Ahmed A / Ibrahim, Asmaa F / Shariq, Ali / Alkhamiss, Abdullah S / Alghsham, Ruqaih / Althwab, Sami A / Alghaniam, Sultan A / Alhumaydhi, Fahad A / Alghamdi, Rana / Alshomar, Ahmad / Alabdullatif, Tasleem / Alkhulayfi, Abdulrahman / Alghunaim, Abdulrhman A / Abdulmonem, Waleed Al

    International journal of health sciences

    2022  Volume 16, Issue 2, Page(s) 3–11

    Abstract: Objective: Schistosoma mansoni: Methods: Laboratory bred female albino mice (: Results: Anti-schistosomiasis drugs ART and ARA increased the levels of Th2 cytokine IL-4 (: Conclusions: These findings indicated that anti-schistosomiasis drugs ... ...

    Abstract Objective: Schistosoma mansoni
    Methods: Laboratory bred female albino mice (
    Results: Anti-schistosomiasis drugs ART and ARA increased the levels of Th2 cytokine IL-4 (
    Conclusions: These findings indicated that anti-schistosomiasis drugs ART, ARA, and PZQ play a role in the modulation of expression of Th2 cytokines. Whereas, only PZQ may play a role in the modulation of Th1 cytokines. These findings provide a scope for the formulation of novel anti-schistosomal drugs as well as in the therapeutic management of patients infected with
    Language English
    Publishing date 2022-03-11
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2603595-9
    ISSN 1658-3639
    ISSN 1658-3639
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Toxoplasmosis in immunocompetent Saudi women: Correlation with vitamin D.

    Rasheed, Zafar / Shariq, Ali / AlQefari, Ghaida B / Alwahbi, Ghayda S / Aljuaythin, Amal I / Alsuhibani, Fidaa S / Alotaibi, Daliyah F / Aljohani, Shahad S / Alghasham, Ruqiah / Alsaeed, Thamir / Alharbi, Nada A / Rugaie, Osamah Al / Abdulmonem, Waleed Al / Sharaf, Osama F

    Women's health (London, England)

    2021  Volume 17, Page(s) 17455065211043844

    Abstract: Objective: Toxoplasma gondii: Methods: Blood samples were collected from 304 Saudi women from the Qassim region of Saudi Arabia. Specific immunoassays were used to determine the levels of : Results: Out of 304 women, 18.8% were found to be ... ...

    Abstract Objective: Toxoplasma gondii
    Methods: Blood samples were collected from 304 Saudi women from the Qassim region of Saudi Arabia. Specific immunoassays were used to determine the levels of
    Results: Out of 304 women, 18.8% were found to be positive for toxoplasmosis. Interestingly, the serum levels of vitamin D in toxoplasma positive cases were found to be significantly low as compared with the levels of vitamin D in toxoplasma negative cases. Moreover, sociodemographic risk factors such as age, residence location, and consumption of fruits/vegetables were also found to be associated with vitamin D deficiency and with the seroprevalence of toxoplasmosis.
    Conclusion: This study investigated a direct correlation of vitamin D deficiency with the severity of the toxoplasmosis in Saudi women. Therefore, it is predicted that vitamin D supplementation may provide protection against toxoplasma infection.
    MeSH term(s) Female ; Humans ; Risk Factors ; Saudi Arabia/epidemiology ; Seroepidemiologic Studies ; Toxoplasma ; Toxoplasmosis/epidemiology ; Toxoplasmosis/parasitology ; Vitamin D
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274503-8
    ISSN 1745-5065 ; 1745-5057
    ISSN (online) 1745-5065
    ISSN 1745-5057
    DOI 10.1177/17455065211043844
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6629: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Prevalence of Intestinal Protozoa among Saudi Patients with Chronic Renal Failure: A Case-Control Study.

    Hawash, Yousry A / Dorgham, Laila Sh / Amir, El-Amir M / Sharaf, Osama F

    Journal of tropical medicine

    2015  Volume 2015, Page(s) 563478

    Abstract: It has been hypothesized that chronic renal failure (CRF) predisposes patients to infection with intestinal protozoa. We tested this hypothesis with a matched case-control study to determine the prevalence of these protozoa and their diarrhea associated ... ...

    Abstract It has been hypothesized that chronic renal failure (CRF) predisposes patients to infection with intestinal protozoa. We tested this hypothesis with a matched case-control study to determine the prevalence of these protozoa and their diarrhea associated symptoms among 50 patients with CRF (cases) from Taif, western Saudi Arabia. Fifty diarrheal patients without CRF were recruited in the study as controls. Participants were interviewed by a structured questionnaire and stool samples were collected. Samples were thoroughly examined with microscopy and three coproantigens detection kits. Enteric protozoa were detected in 21 cases and 14 controls. Blastocystis spp. were the most predominant parasite (16% in cases versus 8% in controls), followed by Giardia duodenalis (10% in cases versus 12% in controls) and Cryptosporidium spp. (10% in cases versus 6% in controls). Cyclospora cayetanensis was identified in two cases, while Entamoeba histolytica was described in one case and one control. Intestinal parasitism was positively associated with the male gender, urban residence, and travel history. Clinical symptoms of nausea/vomiting and abdominal pain were significantly varied between the parasitized cases and controls (P value ≤ 0.05). Given the results, we recommend screening all diarrheal feces for intestinal protozoa in the study's population, particularly those with CRF.
    Language English
    Publishing date 2015-09-28
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2546526-0
    ISSN 1687-9694 ; 1687-9686
    ISSN (online) 1687-9694
    ISSN 1687-9686
    DOI 10.1155/2015/563478
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top