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  1. Article ; Online: Covalent immobilization of coagulation factor VIII on magnetic nanoparticles for aptamer development.

    Tabarzad, Maryam / Sharafi, Zeinab / Javidi, Jaber

    Journal of applied biomaterials & functional materials

    2018  Volume 16, Issue 3, Page(s) 161–170

    Abstract: Introduction: Magnetic nanoparticles (MNPs) are one of the most useful particulate systems in analytical applications such as specific aptamer selection. Proteins are the most noted targets of aptamer selection. Generally, covalently immobilized protein ...

    Abstract Introduction: Magnetic nanoparticles (MNPs) are one of the most useful particulate systems in analytical applications such as specific aptamer selection. Proteins are the most noted targets of aptamer selection. Generally, covalently immobilized protein coated MNPs are more stable structures.
    Methods: In this study, coagulation factor VIII (FVIII) was immobilized on MNPs. A silica coating provided isocyanate functional groups was considered to interact covalently with reactive groups of the protein, resulting in a stable protein immobilization. The reactions was run in dried toluene. At end, these MNPs were applied for affinity determination of a previously selected FVIII specific aptamers.
    Results: Immobilization of 1 mg FVIII (~ 3 nmol) on 5 mg particles was achieved with no significant particle aggregation. Using a fluorescence-based method, affinity measurement resulted in a calculated dissociation constant of 120 ± 5.6 nM for the FVIII-specific aptamer to the FVIII-coated MNPs.
    Conclusion: The final product could be a suitable protein-coated solid support for magnetic-based aptamer selection processes.
    MeSH term(s) Aptamers, Nucleotide/chemistry ; Aptamers, Nucleotide/metabolism ; Factor VIII/chemistry ; Factor VIII/metabolism ; Humans ; Immobilized Proteins/chemistry ; Immobilized Proteins/metabolism ; Isocyanates/chemistry ; Magnetite Nanoparticles/chemistry ; Microscopy, Electron, Transmission ; Protein Stability ; SELEX Aptamer Technique ; Silanes/chemistry ; Silicon Dioxide/chemistry ; Spectrometry, X-Ray Emission ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
    Chemical Substances 3-(triethoxysilyl)-propylisocyanate ; Aptamers, Nucleotide ; Immobilized Proteins ; Isocyanates ; Magnetite Nanoparticles ; Silanes ; Silicon Dioxide (7631-86-9) ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2018-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2673624-X
    ISSN 2280-8000 ; 1722-6899
    ISSN (online) 2280-8000
    ISSN 1722-6899
    DOI 10.1177/2280800018765046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Synthesis of Silica-coated Iron Oxide Nanoparticles: Preventing Aggregation without Using Additives or Seed Pretreatment.

    Sharafi, Zeinab / Bakhshi, Bita / Javidi, Jaber / Adrangi, Sina

    Iranian journal of pharmaceutical research : IJPR

    2018  Volume 17, Issue 1, Page(s) 386–395

    Abstract: The Stober process is frequently used to prepare silica-coated iron oxide nanoparticles. This is usually achieved by seeding a reaction mixture consisting of water, ethanol and a catalyst with iron oxide particles and adding a silica precursor. The ... ...

    Abstract The Stober process is frequently used to prepare silica-coated iron oxide nanoparticles. This is usually achieved by seeding a reaction mixture consisting of water, ethanol and a catalyst with iron oxide particles and adding a silica precursor. The hydrolysis and condensation of precursor monomers results in the deposition of a silica layer on iron oxide particles. However, this process is accompanied by an increase in the ionic strength of the medium which promotes the rapid aggregation of iron oxide particles. A number of methods have been developed to prevent seed aggregation during the coating process. The majority of these methods include a pretreatment step in which the surface of iron oxide particles is modified in a manner that increases their stability in aqueous solutions. Here we suggest that by decreasing the initial concentration of the catalyst for a short period to minimize nucleation by reducing precursor hydrolysis rate and then gradually increasing the concentration to the optimum level to allow silica formation to proceed normally it may be possible to prevent aggregation without surface modification. The properties of the resulting nanoparticles as analyzed by transmission electron microscopy and magnetometry as well as their efficiency at extracting genomic DNA from different bacterial strains compared to that of a commercial extraction kit are also reported.
    Language English
    Publishing date 2018-05-08
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2578271-X
    ISSN 1726-6890 ; 1735-0328 ; 1735-0328
    ISSN (online) 1726-6890 ; 1735-0328
    ISSN 1735-0328
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  3. Article: Screening for Type II L-Asparaginases: Lessons from the Genus

    Sharafi, Zeinab / Barati, Mahmood / Khoshayand, Mohammad Reza / Adrangi, Sina

    Iranian journal of pharmaceutical research : IJPR

    2018  Volume 16, Issue 4, Page(s) 1565–1573

    Abstract: Among the two types of bacterial L-asparaginases, only type II enzymes have been used in the treatment of acute lymphoblastic leukemia owing to their higher affinity for L-asparagine. However, current screening media used for the isolation of L- ... ...

    Abstract Among the two types of bacterial L-asparaginases, only type II enzymes have been used in the treatment of acute lymphoblastic leukemia owing to their higher affinity for L-asparagine. However, current screening media used for the isolation of L-asparaginase-producing microorganisms do not discriminate between the two types of L-asparaginase. During an optimization study conducted to increase L-asparaginase production by environmental
    Language English
    Publishing date 2018-01-09
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2578271-X
    ISSN 1726-6890 ; 1735-0328 ; 1735-0328
    ISSN (online) 1726-6890 ; 1735-0328
    ISSN 1735-0328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Design and synthesis of 4,5-diphenyl-imidazol-1,2,3-triazole hybrids as new anti-diabetic agents: in vitro α-glucosidase inhibition, kinetic and docking studies.

    Asgari, Mohammad Sadegh / Mohammadi-Khanaposhtani, Maryam / Sharafi, Zeinab / Faramarzi, Mohammad Ali / Rastegar, Hossein / Nasli Esfahani, Ensieh / Bandarian, Fatemeh / Ranjbar Rashidi, Parviz / Rahimi, Rahmatollah / Biglar, Mahmood / Mahdavi, Mohammad / Larijani, Bagher

    Molecular diversity

    2020  Volume 25, Issue 2, Page(s) 877–888

    Abstract: Fourteen novel 4,5-diphenyl-imidazol-1,2,3-triazole hybrids 8a-n were synthesized with good yields by performing click reaction between the 4,5-diphenyl-2-(prop-2-yn-1-ylthio)-1H-imidazole and various benzyl azides. The synthesized compounds 8a-n were ... ...

    Abstract Fourteen novel 4,5-diphenyl-imidazol-1,2,3-triazole hybrids 8a-n were synthesized with good yields by performing click reaction between the 4,5-diphenyl-2-(prop-2-yn-1-ylthio)-1H-imidazole and various benzyl azides. The synthesized compounds 8a-n were evaluated against yeast α-glucosidase, and all these compounds exhibited excellent inhibitory activity (IC
    MeSH term(s) Drug Design ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/toxicity ; Imidazoles/chemical synthesis ; Imidazoles/chemistry ; Imidazoles/pharmacokinetics ; Imidazoles/toxicity ; Kinetics ; Models, Biological ; Molecular Docking Simulation ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Triazoles/pharmacokinetics ; Triazoles/toxicity ; alpha-Glucosidases/chemistry
    Chemical Substances Hypoglycemic Agents ; Imidazoles ; Triazoles ; alpha-Glucosidases (EC 3.2.1.20)
    Language English
    Publishing date 2020-03-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-020-10072-8
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  5. Article ; Online: A new series of Schiff base derivatives bearing 1,2,3-triazole: Design, synthesis, molecular docking, and α-glucosidase inhibition.

    Nasli-Esfahani, Ensieh / Mohammadi-Khanaposhtani, Maryam / Rezaei, Sepideh / Sarrafi, Yaghoub / Sharafi, Zeinab / Samadi, Nasser / Faramarzi, Mohammad Ali / Bandarian, Fatemeh / Hamedifar, Haleh / Larijani, Bagher / Hajimiri, Mirhamed / Mahdavi, Mohammad

    Archiv der Pharmazie

    2019  Volume 352, Issue 8, Page(s) e1900034

    Abstract: A series of new Schiff bases bearing 1,2,3-triazole 12a-o was designed, synthesized, and evaluated as α-glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α-glucosidase and were more potent than the standard drug ... ...

    Abstract A series of new Schiff bases bearing 1,2,3-triazole 12a-o was designed, synthesized, and evaluated as α-glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α-glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α-glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α-glucosidase.
    MeSH term(s) Dose-Response Relationship, Drug ; Drug Design ; Glycoside Hydrolase Inhibitors/chemical synthesis ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/pharmacology ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Schiff Bases/chemical synthesis ; Schiff Bases/chemistry ; Schiff Bases/pharmacology ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Triazoles/pharmacology ; alpha-Glucosidases/metabolism
    Chemical Substances Glycoside Hydrolase Inhibitors ; Schiff Bases ; Triazoles ; alpha-Glucosidases (EC 3.2.1.20)
    Language English
    Publishing date 2019-07-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.201900034
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  6. Article ; Online: Morbidity and mortality from road injuries: results from the Global Burden of Disease Study 2017.

    James, Spencer L / Lucchesi, Lydia R / Bisignano, Catherine / Castle, Chris D / Dingels, Zachary V / Fox, Jack T / Hamilton, Erin B / Liu, Zichen / McCracken, Darrah / Nixon, Molly R / Sylte, Dillon O / Roberts, Nicholas L S / Adebayo, Oladimeji M / Aghamolaei, Teamur / Alghnam, Suliman A / Aljunid, Syed Mohamed / Almasi-Hashiani, Amir / Badawi, Alaa / Behzadifar, Masoud /
    Behzadifar, Meysam / Bekru, Eyasu Tamru / Bennett, Derrick A / Chapman, Jens Robert / Deribe, Kebede / Duko Adema, Bereket / Fatahi, Yousef / Gelaw, Belayneh K / Getahun, Eskezyiaw Agedew / Hendrie, Delia / Henok, Andualem / Hidru, Hagos de / Hosseinzadeh, Mehdi / Hu, Guoqing / Jahani, Mohammad Ali / Jakovljevic, Mihajlo / Jalilian, Farzad / Joseph, Nitin / Karami, Manoochehr / Kelbore, Abraham Getachew / Khan, Md Nuruzzaman / Kim, Yun Jin / Koul, Parvaiz A / La Vecchia, Carlo / Linn, Shai / Majdzadeh, Reza / Mehndiratta, Man Mohan / Memiah, Peter T N / Mengesha, Melkamu Merid / Merie, Hayimro Edemealem / R Miller, Ted / Mirzaei-Alavijeh, Mehdi / Mohammad Darwesh, Aso / Mohammad Gholi Mezerji, Naser / Mohammadibakhsh, Roghayeh / Moodley, Yoshan / Moradi-Lakeh, Maziar / Musa, Kamarul Imran / Nascimento, Bruno Ramos / Nikbakhsh, Rajan / Nyasulu, Peter S / Omar Bali, Ahmed / Onwujekwe, Obinna E / Pati, Sanghamitra / Pourmirza Kalhori, Reza / Salehi, Farkhonde / Shahabi, Saeed / Shallo, Seifadin Ahmed / Shamsizadeh, Morteza / Sharafi, Zeinab / Shukla, Sharvari Rahul / Sobhiyeh, Mohammad Reza / Soriano, Joan B / Sykes, Bryan L / Tabarés-Seisdedos, Rafael / Tadesse, Degena Bahray Bahrey / Tefera, Yonatal Mesfin / Tehrani-Banihashemi, Arash / Tlou, Boikhutso / Topor-Madry, Roman / Wiangkham, Taweewat / Yaseri, Mehdi / Yaya, Sanni / Yenesew, Muluken Azage / Younis, Mustafa Z / Ziapour, Arash / Zodpey, Sanjay / Pigott, David M / Reiner, Robert C / Hay, Simon I / Lopez, Alan D / Mokdad, Ali H

    Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention

    2020  Volume 26, Issue Supp 1, Page(s) i46–i56

    Abstract: Background: The global burden of road injuries is known to follow complex geographical, temporal and demographic patterns. While health loss from road injuries is a major topic of global importance, there has been no recent comprehensive assessment that ...

    Abstract Background: The global burden of road injuries is known to follow complex geographical, temporal and demographic patterns. While health loss from road injuries is a major topic of global importance, there has been no recent comprehensive assessment that includes estimates for every age group, sex and country over recent years.
    Methods: We used results from the Global Burden of Disease (GBD) 2017 study to report incidence, prevalence, years lived with disability, deaths, years of life lost and disability-adjusted life years for all locations in the GBD 2017 hierarchy from 1990 to 2017 for road injuries. Second, we measured mortality-to-incidence ratios by location. Third, we assessed the distribution of the natures of injury (eg, traumatic brain injury) that result from each road injury.
    Results: Globally, 1 243 068 (95% uncertainty interval 1 191 889 to 1 276 940) people died from road injuries in 2017 out of 54 192 330 (47 381 583 to 61 645 891) new cases of road injuries. Age-standardised incidence rates of road injuries increased between 1990 and 2017, while mortality rates decreased. Regionally, age-standardised mortality rates decreased in all but two regions, South Asia and Southern Latin America, where rates did not change significantly. Nine of 21 GBD regions experienced significant increases in age-standardised incidence rates, while 10 experienced significant decreases and two experienced no significant change.
    Conclusions: While road injury mortality has improved in recent decades, there are worsening rates of incidence and significant geographical heterogeneity. These findings indicate that more research is needed to better understand how road injuries can be prevented.
    MeSH term(s) Accidents, Traffic ; Asia ; Global Burden of Disease ; Global Health ; Humans ; Morbidity ; Mortality/trends ; Quality-Adjusted Life Years ; Wounds and Injuries/mortality
    Language English
    Publishing date 2020-01-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1433667-4
    ISSN 1475-5785 ; 1353-8047
    ISSN (online) 1475-5785
    ISSN 1353-8047
    DOI 10.1136/injuryprev-2019-043302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study.

    Fitzmaurice, Christina / Abate, Degu / Abbasi, Naghmeh / Abbastabar, Hedayat / Abd-Allah, Foad / Abdel-Rahman, Omar / Abdelalim, Ahmed / Abdoli, Amir / Abdollahpour, Ibrahim / Abdulle, Abdishakur S M / Abebe, Nebiyu Dereje / Abraha, Haftom Niguse / Abu-Raddad, Laith Jamal / Abualhasan, Ahmed / Adedeji, Isaac Akinkunmi / Advani, Shailesh M / Afarideh, Mohsen / Afshari, Mahdi / Aghaali, Mohammad /
    Agius, Dominic / Agrawal, Sutapa / Ahmadi, Ayat / Ahmadian, Elham / Ahmadpour, Ehsan / Ahmed, Muktar Beshir / Akbari, Mohammad Esmaeil / Akinyemiju, Tomi / Al-Aly, Ziyad / AlAbdulKader, Assim M / Alahdab, Fares / Alam, Tahiya / Alamene, Genet Melak / Alemnew, Birhan Tamene T / Alene, Kefyalew Addis / Alinia, Cyrus / Alipour, Vahid / Aljunid, Syed Mohamed / Bakeshei, Fatemeh Allah / Almadi, Majid Abdulrahman Hamad / Almasi-Hashiani, Amir / Alsharif, Ubai / Alsowaidi, Shirina / Alvis-Guzman, Nelson / Amini, Erfan / Amini, Saeed / Amoako, Yaw Ampem / Anbari, Zohreh / Anber, Nahla Hamed / Andrei, Catalina Liliana / Anjomshoa, Mina / Ansari, Fereshteh / Ansariadi, Ansariadi / Appiah, Seth Christopher Yaw / Arab-Zozani, Morteza / Arabloo, Jalal / Arefi, Zohreh / Aremu, Olatunde / Areri, Habtamu Abera / Artaman, Al / Asayesh, Hamid / Asfaw, Ephrem Tsegay / Ashagre, Alebachew Fasil / Assadi, Reza / Ataeinia, Bahar / Atalay, Hagos Tasew / Ataro, Zerihun / Atique, Suleman / Ausloos, Marcel / Avila-Burgos, Leticia / Avokpaho, Euripide F G A / Awasthi, Ashish / Awoke, Nefsu / Ayala Quintanilla, Beatriz Paulina / Ayanore, Martin Amogre / Ayele, Henok Tadesse / Babaee, Ebrahim / Bacha, Umar / Badawi, Alaa / Bagherzadeh, Mojtaba / Bagli, Eleni / Balakrishnan, Senthilkumar / Balouchi, Abbas / Bärnighausen, Till Winfried / Battista, Robert J / Behzadifar, Masoud / Behzadifar, Meysam / Bekele, Bayu Begashaw / Belay, Yared Belete / Belayneh, Yaschilal Muche / Berfield, Kathleen Kim Sachiko / Berhane, Adugnaw / Bernabe, Eduardo / Beuran, Mircea / Bhakta, Nickhill / Bhattacharyya, Krittika / Biadgo, Belete / Bijani, Ali / Bin Sayeed, Muhammad Shahdaat / Birungi, Charles / Bisignano, Catherine / Bitew, Helen / Bjørge, Tone / Bleyer, Archie / Bogale, Kassawmar Angaw / Bojia, Hunduma Amensisa / Borzì, Antonio M / Bosetti, Cristina / Bou-Orm, Ibrahim R / Brenner, Hermann / Brewer, Jerry D / Briko, Andrey Nikolaevich / Briko, Nikolay Ivanovich / Bustamante-Teixeira, Maria Teresa / Butt, Zahid A / Carreras, Giulia / Carrero, Juan J / Carvalho, Félix / Castro, Clara / Castro, Franz / Catalá-López, Ferrán / Cerin, Ester / Chaiah, Yazan / Chanie, Wagaye Fentahun / Chattu, Vijay Kumar / Chaturvedi, Pankaj / Chauhan, Neelima Singh / Chehrazi, Mohammad / Chiang, Peggy Pei-Chia / Chichiabellu, Tesfaye Yitna / Chido-Amajuoyi, Onyema Greg / Chimed-Ochir, Odgerel / Choi, Jee-Young J / Christopher, Devasahayam J / Chu, Dinh-Toi / Constantin, Maria-Magdalena / Costa, Vera M / Crocetti, Emanuele / Crowe, Christopher Stephen / Curado, Maria Paula / Dahlawi, Saad M A / Damiani, Giovanni / Darwish, Amira Hamed / Daryani, Ahmad / das Neves, José / Demeke, Feleke Mekonnen / Demis, Asmamaw Bizuneh / Demissie, Birhanu Wondimeneh / Demoz, Gebre Teklemariam / Denova-Gutiérrez, Edgar / Derakhshani, Afshin / Deribe, Kalkidan Solomon / Desai, Rupak / Desalegn, Beruk Berhanu / Desta, Melaku / Dey, Subhojit / Dharmaratne, Samath Dhamminda / Dhimal, Meghnath / Diaz, Daniel / Dinberu, Mesfin Tadese Tadese / Djalalinia, Shirin / Doku, David Teye / Drake, Thomas M / Dubey, Manisha / Dubljanin, Eleonora / Duken, Eyasu Ejeta / Ebrahimi, Hedyeh / Effiong, Andem / Eftekhari, Aziz / El Sayed, Iman / Zaki, Maysaa El Sayed / El-Jaafary, Shaimaa I / El-Khatib, Ziad / Elemineh, Demelash Abewa / Elkout, Hajer / Ellenbogen, Richard G / Elsharkawy, Aisha / Emamian, Mohammad Hassan / Endalew, Daniel Adane / Endries, Aman Yesuf / Eshrati, Babak / Fadhil, Ibtihal / Fallah Omrani, Vahid / Faramarzi, Mahbobeh / Farhangi, Mahdieh Abbasalizad / Farioli, Andrea / Farzadfar, Farshad / Fentahun, Netsanet / Fernandes, Eduarda / Feyissa, Garumma Tolu / Filip, Irina / Fischer, Florian / Fisher, James L / Force, Lisa M / Foroutan, Masoud / Freitas, Marisa / Fukumoto, Takeshi / Futran, Neal D / Gallus, Silvano / Gankpe, Fortune Gbetoho / Gayesa, Reta Tsegaye / Gebrehiwot, Tsegaye Tewelde / Gebremeskel, Gebreamlak Gebremedhn / Gedefaw, Getnet Azeze / Gelaw, Belayneh K / Geta, Birhanu / Getachew, Sefonias / Gezae, Kebede Embaye / Ghafourifard, Mansour / Ghajar, Alireza / Ghashghaee, Ahmad / Gholamian, Asadollah / Gill, Paramjit Singh / Ginindza, Themba T G / Girmay, Alem / Gizaw, Muluken / Gomez, Ricardo Santiago / Gopalani, Sameer Vali / Gorini, Giuseppe / Goulart, Bárbara Niegia Garcia / Grada, Ayman / Ribeiro Guerra, Maximiliano / Guimaraes, Andre Luiz Sena / Gupta, Prakash C / Gupta, Rahul / Hadkhale, Kishor / Haj-Mirzaian, Arvin / Haj-Mirzaian, Arya / Hamadeh, Randah R / Hamidi, Samer / Hanfore, Lolemo Kelbiso / Haro, Josep Maria / Hasankhani, Milad / Hasanzadeh, Amir / Hassen, Hamid Yimam / Hay, Roderick J / Hay, Simon I / Henok, Andualem / Henry, Nathaniel J / Herteliu, Claudiu / Hidru, Hagos D / Hoang, Chi Linh / Hole, Michael K / Hoogar, Praveen / Horita, Nobuyuki / Hosgood, H Dean / Hosseini, Mostafa / Hosseinzadeh, Mehdi / Hostiuc, Mihaela / Hostiuc, Sorin / Househ, Mowafa / Hussen, Mohammedaman Mama / Ileanu, Bogdan / Ilic, Milena D / Innos, Kaire / Irvani, Seyed Sina Naghibi / Iseh, Kufre Robert / Islam, Sheikh Mohammed Shariful / Islami, Farhad / Jafari Balalami, Nader / Jafarinia, Morteza / Jahangiry, Leila / Jahani, Mohammad Ali / Jahanmehr, Nader / Jakovljevic, Mihajlo / James, Spencer L / Javanbakht, Mehdi / Jayaraman, Sudha / Jee, Sun Ha / Jenabi, Ensiyeh / Jha, Ravi Prakash / Jonas, Jost B / Jonnagaddala, Jitendra / Joo, Tamas / Jungari, Suresh Banayya / Jürisson, Mikk / Kabir, Ali / Kamangar, Farin / Karch, André / Karimi, Narges / Karimian, Ansar / Kasaeian, Amir / Kasahun, Gebremicheal Gebreslassie / Kassa, Belete / Kassa, Tesfaye Dessale / Kassaw, Mesfin Wudu / Kaul, Anil / Keiyoro, Peter Njenga / Kelbore, Abraham Getachew / Kerbo, Amene Abebe / Khader, Yousef Saleh / Khalilarjmandi, Maryam / Khan, Ejaz Ahmad / Khan, Gulfaraz / Khang, Young-Ho / Khatab, Khaled / Khater, Amir / Khayamzadeh, Maryam / Khazaee-Pool, Maryam / Khazaei, Salman / Khoja, Abdullah T / Khosravi, Mohammad Hossein / Khubchandani, Jagdish / Kianipour, Neda / Kim, Daniel / Kim, Yun Jin / Kisa, Adnan / Kisa, Sezer / Kissimova-Skarbek, Katarzyna / Komaki, Hamidreza / Koyanagi, Ai / Krohn, Kristopher J / Bicer, Burcu Kucuk / Kugbey, Nuworza / Kumar, Vivek / Kuupiel, Desmond / La Vecchia, Carlo / Lad, Deepesh P / Lake, Eyasu Alem / Lakew, Ayenew Molla / Lal, Dharmesh Kumar / Lami, Faris Hasan / Lan, Qing / Lasrado, Savita / Lauriola, Paolo / Lazarus, Jeffrey V / Leigh, James / Leshargie, Cheru Tesema / Liao, Yu / Limenih, Miteku Andualem / Listl, Stefan / Lopez, Alan D / Lopukhov, Platon D / Lunevicius, Raimundas / Madadin, Mohammed / Magdeldin, Sameh / El Razek, Hassan Magdy Abd / Majeed, Azeem / Maleki, Afshin / Malekzadeh, Reza / Manafi, Ali / Manafi, Navid / Manamo, Wondimu Ayele / Mansourian, Morteza / Mansournia, Mohammad Ali / Mantovani, Lorenzo Giovanni / Maroufizadeh, Saman / Martini, Santi Martini S / Mashamba-Thompson, Tivani Phosa / Massenburg, Benjamin Ballard / Maswabi, Motswadi Titus / Mathur, Manu Raj / McAlinden, Colm / McKee, Martin / Meheretu, Hailemariam Abiy Alemu / Mehrotra, Ravi / Mehta, Varshil / Meier, Toni / Melaku, Yohannes A / Meles, Gebrekiros Gebremichael / Meles, Hagazi Gebre / Melese, Addisu / Melku, Mulugeta / Memiah, Peter T N / Mendoza, Walter / Menezes, Ritesh G / Merat, Shahin / Meretoja, Tuomo J / Mestrovic, Tomislav / Miazgowski, Bartosz / Miazgowski, Tomasz / Mihretie, Kebadnew Mulatu M / Miller, Ted R / Mills, Edward J / Mir, Seyed Mostafa / Mirzaei, Hamed / Mirzaei, Hamid Reza / Mishra, Rashmi / Moazen, Babak / Mohammad, Dara K / Mohammad, Karzan Abdulmuhsin / Mohammad, Yousef / Darwesh, Aso Mohammad / Mohammadbeigi, Abolfazl / Mohammadi, Hiwa / Mohammadi, Moslem / Mohammadian, Mahdi / Mohammadian-Hafshejani, Abdollah / Mohammadoo-Khorasani, Milad / Mohammadpourhodki, Reza / Mohammed, Ammas Siraj / Mohammed, Jemal Abdu / Mohammed, Shafiu / Mohebi, Farnam / Mokdad, Ali H / Monasta, Lorenzo / Moodley, Yoshan / Moosazadeh, Mahmood / Moossavi, Maryam / Moradi, Ghobad / Moradi-Joo, Mohammad / Moradi-Lakeh, Maziar / Moradpour, Farhad / Morawska, Lidia / Morgado-da-Costa, Joana / Morisaki, Naho / Morrison, Shane Douglas / Mosapour, Abbas / Mousavi, Seyyed Meysam / Muche, Achenef Asmamaw / Muhammed, Oumer Sada S / Musa, Jonah / Nabhan, Ashraf F / Naderi, Mehdi / Nagarajan, Ahamarshan Jayaraman / Nagel, Gabriele / Nahvijou, Azin / Naik, Gurudatta / Najafi, Farid / Naldi, Luigi / Nam, Hae Sung / Nasiri, Naser / Nazari, Javad / Negoi, Ionut / Neupane, Subas / Newcomb, Polly A / Nggada, Haruna Asura / Ngunjiri, Josephine W / Nguyen, Cuong Tat / Nikniaz, Leila / Ningrum, Dina Nur Anggraini / Nirayo, Yirga Legesse / Nixon, Molly R / Nnaji, Chukwudi A / Nojomi, Marzieh / Nosratnejad, Shirin / Shiadeh, Malihe Nourollahpour / Obsa, Mohammed Suleiman / Ofori-Asenso, Richard / Ogbo, Felix Akpojene / Oh, In-Hwan / Olagunju, Andrew T / Olagunju, Tinuke O / Oluwasanu, Mojisola Morenike / Omonisi, Abidemi E / Onwujekwe, Obinna E / Oommen, Anu Mary / Oren, Eyal / Ortega-Altamirano, 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Safiri, Saeid / Sahebkar, Amirhossein / Salahshoor, Mohammad Reza / Salehi, Farkhonde / Salem, Hosni / Salem, Marwa Rashad / Salimzadeh, Hamideh / Salomon, Joshua A / Samy, Abdallah M / Sanabria, Juan / Santric Milicevic, Milena M / Sartorius, Benn / Sarveazad, Arash / Sathian, Brijesh / Satpathy, Maheswar / Savic, Miloje / Sawhney, Monika / Sayyah, Mehdi / Schneider, Ione J C / Schöttker, Ben / Sekerija, Mario / Sepanlou, Sadaf G / Sepehrimanesh, Masood / Seyedmousavi, Seyedmojtaba / Shaahmadi, Faramarz / Shabaninejad, Hosein / Shahbaz, Mohammad / Shaikh, Masood Ali / Shamshirian, Amir / Shamsizadeh, Morteza / Sharafi, Heidar / Sharafi, Zeinab / Sharif, Mehdi / Sharifi, Ali / Sharifi, Hamid / Sharma, Rajesh / Sheikh, Aziz / Shirkoohi, Reza / Shukla, Sharvari Rahul / Si, Si / Siabani, Soraya / Silva, Diego Augusto Santos / Silveira, Dayane Gabriele Alves / Singh, Ambrish / Singh, Jasvinder A / Sisay, Solomon / Sitas, Freddy / Sobngwi, Eugène / Soofi, Moslem / Soriano, Joan B / 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    JAMA oncology

    2019  Volume 5, Issue 12, Page(s) 1749–1768

    Abstract: Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting ... ...

    Abstract Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.
    Objective: To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning.
    Evidence review: We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence.
    Findings: In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572 000 deaths and 15.2 million DALYs), and stomach cancer (542 000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819 000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601 000 deaths and 17.4 million DALYs), TBL cancer (596 000 deaths and 12.6 million DALYs), and colorectal cancer (414 000 deaths and 8.3 million DALYs).
    Conclusions and relevance: The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care.
    MeSH term(s) Disabled Persons ; Global Burden of Disease ; Global Health ; Humans ; Incidence ; Neoplasms/epidemiology ; Quality-Adjusted Life Years
    Language English
    Publishing date 2019-11-02
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.2996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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