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  1. Article: Investigation of Artery Wall Elasticity Effect on the Prediction of Atherosclerosis by Hemodynamic Factors.

    Kalbasi, Rasool / Sharifzadeh, Bahador / Jahangiri, Mehdi

    Applied bionics and biomechanics

    2022  Volume 2022, Page(s) 3446166

    Abstract: Atherosclerosis is a vascular disease in which some parts of the artery undergo stenosis due to the aggregation of fat. The causes and location of stenosis can be determined using fluid mechanics and parameters such as pressure, effective wall shear ... ...

    Abstract Atherosclerosis is a vascular disease in which some parts of the artery undergo stenosis due to the aggregation of fat. The causes and location of stenosis can be determined using fluid mechanics and parameters such as pressure, effective wall shear stress, and oscillatory shear index (OSI). The present study, for the first time, numerically investigates the pulsatile blood flow inside arteries with elastic and rigid walls in simple and double stenosis (80% stenosis) by using
    Language English
    Publishing date 2022-04-05
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2179924-6
    ISSN 1754-2103 ; 1176-2322
    ISSN (online) 1754-2103
    ISSN 1176-2322
    DOI 10.1155/2022/3446166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Computer modeling of pulsatile blood flow in elastic artery using a software program for application in biomedical engineering.

    Sharifzadeh, Bahador / Kalbasi, Rasool / Jahangiri, Mehdi / Toghraie, Davood / Karimipour, Arash

    Computer methods and programs in biomedicine

    2020  Volume 192, Page(s) 105442

    Abstract: Background and objective: Atherosclerosis-a condition in which an artery is constricted-alters blood flow in the artery, that can exacerbate the condition. Focusing on previous studies, it can be seen that the k-ε model has been used in the simulation. ... ...

    Abstract Background and objective: Atherosclerosis-a condition in which an artery is constricted-alters blood flow in the artery, that can exacerbate the condition. Focusing on previous studies, it can be seen that the k-ε model has been used in the simulation. Therefore, the reverse flow on the back of stenosis is not well represented. In this study, the simulated results are much closer to clinical results, relying on the use of physiological pulses, and considering elasticity of the vessel wall, and the applying k-ω model. It can therefore be claimed that a much more accurate prediction will be made regarding the formation, development and progression of the disease.
    Methods: Modeling biological systems usually contain many parameters, which cannot be calculated experimentally, or are too costly and time consuming. In addition, it is occasionally required to examine the influence of different physical variables, which, given the complexity of the governing equations, make analytical methods feasible (or very limited). The present study is an attempt to investigate the turbulent pulsatile blood flow in an elastic artery with single and double stenoses using a finite element software program, ADINA 8.8.
    Results: According to the results, the k - ω turbulence model predicted a larger reverse flow in the post-stenotic region and between the two stenoses in comparison with the k - ε model. In other words, the k - ω model results suggest that a larger region is prone to atherosclerosis. In addition, that the k - ε model predicted a greater maximum shear stress at the throat and a shorter reverse flow region (Mean WSS < 0) in both stenosis scenarios. In other words, relative to the k - ε model, the k - ω model underestimated the damage to the plaque and the risk of its rupture though it predicted new stenosis developing behind the previous one. It was observed that the presence of a double stenosis causes the upstream pressure to reach the critical value in less time. Velocity profiles revealed that in the stenosis throat, the maximum velocity exceeds the normal biological state, which may cause disorders in the blood circulation.
    Conclusions: The artery wall displacement results are suggestive of the greater difference between the two turbulence models in the case with double stenosis compared with single stenosis. Moreover, the difference between the two turbulence models in double stenosis is minimized in both post-stenotic and pre-stenotic regions.
    MeSH term(s) Algorithms ; Arteries/physiology ; Biomedical Engineering ; Computer Simulation ; Constriction, Pathologic/physiopathology ; Elasticity ; Humans ; Nonlinear Dynamics ; Pulsatile Flow/physiology ; Software
    Language English
    Publishing date 2020-03-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2020.105442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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