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Article ; Online: Genome sequence, antibiotic resistance genes, and plasmids in a monophasic variant of

Ghorbani Tajani, Anahita / Sharma, Aniket / Blouin, Nicolas / Bisha, Bledar

Microbiology resource announcements

2024 , Page(s) e0075423

Abstract: ... ...

Abstract	A
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.00754-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Decentralized Aerial Transportation and Manipulation of a Cable-Slung Payload With Swarm of Agents

Sharma, Aniket / Sinha, Nandan K

2023

Abstract: With the advent of Unmanned Aerial Vehicles (UAV) and Micro Aerial Vehicles (MAV) in commercial sectors, their application for transporting and manipulating payloads has attracted many research work. A swarm of agents, cooperatively working to transport ... ...

Abstract	With the advent of Unmanned Aerial Vehicles (UAV) and Micro Aerial Vehicles (MAV) in commercial sectors, their application for transporting and manipulating payloads has attracted many research work. A swarm of agents, cooperatively working to transport and manipulate a payload can overcome the physical limitations of a single agent, adding redundancy and tolerance against failures. In this paper, the dynamics of a swarm connected to a payload via flexible cables are modeled, and a decentralized control is designed using Artificial Potential Field (APF). The swarm is able to transport the payload through an unknown environment to a goal position while avoiding obstacles from the local information received from the onboard sensors. The key contributions are (a) the cables are modelled more accurately using lumped mass model instead of geometric constraints, (b) a decentralized swarm control is designed using potential field approach to ensure hover stability of system without payload state information, (c) the manipulation of payload elevation and azimuth angles are controlled by APF, and (d) the trajectory of the payload for transportation is governed by potential fields generated by goal point and obstacles. The efficacy of the method proposed in this work are evaluated through numerical simulations under the influence of external disturbances and failure of agents.
Keywords	Computer Science - Multiagent Systems ; Computer Science - Robotics
Subject code	629
Publishing date	2023-06-21
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mortality of in-hospital cardiac arrest among patients with and without preceding sepsis: A national inpatient sample analysis.

Hasegawa, Daisuke / Sharma, Aniket / Dugar, Siddharth / Lee, Young Im / Sato, Ryota

Journal of critical care

2023 Volume 78, Page(s) 154404

Abstract: Introduction: The impact of preceding sepsis on in-hospital cardiac arrest (IHCA)-related mortality has not been established. This study aimed to determine the association between IHCA-related mortality and sepsis.: Methods: This retrospective study ... ...

Abstract	Introduction: The impact of preceding sepsis on in-hospital cardiac arrest (IHCA)-related mortality has not been established. This study aimed to determine the association between IHCA-related mortality and sepsis. Methods: This retrospective study used the National Inpatient Sample data from 01/2017 to 12/2019. The study included adults (≥18 years) who suffered from IHCA. The study classified cardiac arrest rhythms as ventricular tachycardia/ventricular fibrillation or pulseless electronic activity/asystole. We compared the IHCA-related in-hospital mortality between sepsis and non-sepsis groups in all patients and subgroups divided by cardiac arrest rhythm and age. Multivariable logistic regression analysis was performed to assess the independent association between sepsis and in-hospital mortality. Results: A total of 357,850 hospitalizations who suffered from IHCA were identified, with sepsis present in 17.6% of patients. IHCA-related in-hospital mortality was 84.8% in sepsis and 68.4% in non-sepsis-related hospitalizations (p < 0.001). IHCA-related in-hospital mortality was higher in sepsis than in non-sepsis groups, regardless of age or cardiac arrest rhythms. In multivariable logistic regression analysis, sepsis was significantly associated with higher mortality with an odds ratio of 2.27 (95% confidence interval: 2.07-2.50, p < 0.001). Conclusion: Sepsis was associated with higher in-hospital cardiac arrest mortality compared to non-sepsis cases, regardless of age and cardiac rhythm.
MeSH term(s)	Adult ; Humans ; Inpatients ; Retrospective Studies ; Heart Arrest ; Hospital Mortality ; Sepsis/complications ; Ventricular Fibrillation ; Hospitals
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2023.154404
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Article: Triple Tick Attack.

Kumar, Manish / Sharma, Aniket / Grover, Prashant

Cureus

2019 Volume 11, Issue 2, Page(s) e4064

Abstract: Tick-borne diseases are frequently seen in tick-inhabited areas. Lyme disease is the most common tick-borne illness. However, patients with co-infections can present with nonspecific symptoms, which can make the diagnosis far more challenging. We present ...

Abstract	Tick-borne diseases are frequently seen in tick-inhabited areas. Lyme disease is the most common tick-borne illness. However, patients with co-infections can present with nonspecific symptoms, which can make the diagnosis far more challenging. We present a case of triple infection with babesiosis, Lyme disease, and anaplasmosis treated with antibiotics and red blood cell (RBC) exchange (erythrocytapheresis). A 74-year-old, avid female gardener presented with one week of progressive dyspnea, cough with mucoid expectoration, and fatigue. On presentation, she was afebrile, hypotensive, and tachycardic. General examination was significant for altered mental status, dyspnea, pallor, and peripheral edema. Lung examination was remarkable for bibasilar crackles. Pertinent laboratory findings were significant for hemolytic anemia and thrombocytopenia. A peripheral blood smear revealed the presence of intracytoplasmic parasites consistent with Babesia. The patient was started on azithromycin and atovaquone. Doxycycline was added empirically for Lyme disease, which was later confirmed by serology. In addition, Anaplasma titers were also positive. Further investigation revealed that the parasitic load was 9.04%, and RBC exchange (erythrocytapheresis) was performed for severe babesiosis. Repeat laboratory tests demonstrated an inadequate reduction in parasitic load (6.54%), requiring a second round of RBC exchange. Antimicrobials were changed to clindamycin, quinine, and doxycycline for a total of 14 days. There was an improvement in the patient's anemia and thrombocytopenia along with clinical improvement.
Language	English
Publishing date	2019-02-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.4064
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Article: Metastatic cholangiocarcinoma in a patient with undiagnosed Wilson disease.

Mavilia, Marianna G / Sharma, Aniket / Forouhar, Faripour

Annals of hepatology

2019 Volume 18, Issue 6, Page(s) 929–931

Abstract: Cholangiocarcinoma (CC) is the second most common primary hepatic malignancy. Although the frequency of malignancy is generally increased in chronic liver disease, CC rarely presents in Wilson disease (WD). The incidence of hepatic malignancy in WD is ... ...

Abstract	Cholangiocarcinoma (CC) is the second most common primary hepatic malignancy. Although the frequency of malignancy is generally increased in chronic liver disease, CC rarely presents in Wilson disease (WD). The incidence of hepatic malignancy in WD is only 1.2%, with CC accounting for 0.5%. A 66 year old male with history of hypertension, diabetes, and compensated cryptogenic cirrhosis presented with acute onset dyspnea and pleuritic chest pain. He was incidentally found to have a sizeable mass in the right hepatic lobe. Ultimately, a liver biopsy revealed dense demoplasia and increased mucin production, consistent with diagnosis of CC. Biopsy also demonstrated increased copper deposition consistent with WD, explaining the patient's underlying cirrhosis. Unlike other forms of chronic liver disease where incidence of liver cancer is increased, the lower rate of malignancy seen in WD may be explained by a protective effect of copper in WD. Copper acts to both directly stabilize DNA and inhibit angiogenesis. In this case, it is possible that the degree of copper deposition in his liver was mild, causing cirrhosis and the chronic liver inflammation that caused his CC. However, it may not have been sufficient to "protect" against development of CC.
MeSH term(s)	Aged ; Bile Duct Neoplasms/complications ; Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/metabolism ; Bile Duct Neoplasms/pathology ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/secondary ; Cholangiocarcinoma/complications ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/metabolism ; Cholangiocarcinoma/secondary ; Copper/metabolism ; Hepatolenticular Degeneration/complications ; Hepatolenticular Degeneration/diagnosis ; Hepatolenticular Degeneration/pathology ; Humans ; Incidental Findings ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/secondary ; Male
Chemical Substances	Copper (789U1901C5)
Language	English
Publishing date	2019-05-30
Publishing country	Mexico
Document type	Case Reports ; Journal Article
ZDB-ID	2188733-0
ISSN	1665-2681
ISSN	1665-2681
DOI	10.1016/j.aohep.2019.04.016
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Article ; Online: A natural small molecule-mediated inhibition of alpha-synuclein aggregation leads to neuroprotection in Caenorhabditis elegans.

Srivastava, Tulika / Tyagi, Divya / Fatima, Siraj / Sathyan, Malur Thirumalesh Vishnu / Raj, Ritu / Sharma, Aniket / Chaturvedi, Minal / Sinha, Meetali / Shishodia, Sonia Kumari / Kumar, Dinesh / Sharma, Sandeep K / Shankar, Jata / Satish, Aruna / Priya, Smriti

Journal of neurochemistry

2023

Abstract: Small molecules are being explored intensively for their applications as therapeutic molecules in the management of metabolic and neurological disorders. The natural small molecules can inhibit protein aggregation and underlying cellular pathogenesis of ... ...

Abstract	Small molecules are being explored intensively for their applications as therapeutic molecules in the management of metabolic and neurological disorders. The natural small molecules can inhibit protein aggregation and underlying cellular pathogenesis of neurodegenerative diseases involving multi-factorial mechanisms of action. Certain natural small molecular inhibitors of pathogenic protein aggregation are highly efficient and have shown promising therapeutic potential. In the present study, Shikonin (SHK), a natural plant-based naphthoquinone has been investigated for its aggregation inhibition activity against α-synuclein (α-syn) and the neuroprotective potential in Caenorhabditis elegans (C. elegans). SHK significantly inhibited aggregation of α-syn at sub-stochiometric concentrations, delayed the linear lag phase and growth kinetics of seeded and unseeded α-syn aggregation. The binding of SHK to the C-terminus of α-syn maintained α-helical and disordered secondary structures with reduced beta-sheet content and complexity of aggregates. Further, in C. elegans transgenic PD models, SHK significantly reduced α-syn aggregation, improved locomotor activity and prevented dopaminergic (DA) neuronal degeneration, indicating the neuroprotective role of SHK. The present study highlights the potential of natural small molecules in the prevention of protein aggregation that may further be explored for their therapeutic efficacy in the management of protein aggregation and neurodegenerative diseases.
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.15907
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Article ; Online: In-silico

Sharma, Aniket / Goyal, Shubham / Yadav, Arvind Kumar / Kumar, Pawan / Gupta, Lovely

Journal of biomolecular structure & dynamics

2020 Volume 40, Issue 1, Page(s) 86–100

Abstract: Novel Coronavirus or SARS-CoV-2 outbreak has developed a pandemic condition all over the world. The virus is highly infectious and spreads by human to human local transmission mode. Till date, there is no vaccination or drugs been approved for the ... ...

Abstract	Novel Coronavirus or SARS-CoV-2 outbreak has developed a pandemic condition all over the world. The virus is highly infectious and spreads by human to human local transmission mode. Till date, there is no vaccination or drugs been approved for the treatment by the World Health Organisation. Henceforth, the discovery of the potential drugs is an urgent and utmost requirement for the medical fraternity. Since, the side effects of plant-derived compounds will be lower compared to synthetic/chemical drugs. The Main protease (3CL
MeSH term(s)	Antiviral Agents/pharmacology ; COVID-19 ; Coronavirus 3C Proteases/antagonists & inhibitors ; Endoribonucleases/antagonists & inhibitors ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Phytochemicals/pharmacology ; Protease Inhibitors/pharmacology ; SARS-CoV-2/drug effects ; Viral Nonstructural Proteins/antagonists & inhibitors
Chemical Substances	Antiviral Agents ; Phytochemicals ; Protease Inhibitors ; Viral Nonstructural Proteins ; Endoribonucleases (EC 3.1.-) ; nidoviral uridylate-specific endoribonuclease (EC 3.1.-) ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
Keywords	covid19
Language	English
Publishing date	2020-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2020.1808077
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Article ; Online: A TALE OF TWO SPECIES: FIRST REPORTED CASE OF AN EMPYEMA SECONDARY TO CO-INFECTION WITH SARS-COV-2 AND CANDIDA ALBICANS

Sharma, Aniket / Mehta, Neha / Pirrotta, Stefania / Sheldon, Drew / Juarez, Ricardo

Chest

Keywords	covid19
Publisher	Elsevier; PMC
Document type	Article ; Online
DOI	10.1016/j.chest.2020.08.673
Database	COVID19

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Book ; Online: Indian EmoSpeech Command Dataset

Banga, Subham / Upadhyay, Ujjwal / Agarwal, Piyush / Sharma, Aniket / Mukherjee, Prerana

A dataset for emotion based speech recognition in the wild

2019

Abstract: Speech emotion analysis is an important task which further enables several application use cases. The non-verbal sounds within speech utterances also play a pivotal role in emotion analysis in speech. Due to the widespread use of smartphones, it becomes ... ...

Abstract	Speech emotion analysis is an important task which further enables several application use cases. The non-verbal sounds within speech utterances also play a pivotal role in emotion analysis in speech. Due to the widespread use of smartphones, it becomes viable to analyze speech commands captured using microphones for emotion understanding by utilizing on-device machine learning models. The non-verbal information includes the environment background sounds describing the type of surroundings, current situation and activities being performed. In this work, we consider both verbal (speech commands) and non-verbal sounds (background noises) within an utterance for emotion analysis in real-life scenarios. We create an indigenous dataset for this task namely "Indian EmoSpeech Command Dataset". It contains keywords with diverse emotions and background sounds, presented to explore new challenges in audio analysis. We exhaustively compare with various baseline models for emotion analysis on speech commands on several performance metrics. We demonstrate that we achieve a significant average gain of 3.3% in top-one score over a subset of speech command dataset for keyword spotting.
Keywords	Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Multimedia ; Computer Science - Sound
Subject code	410
Publishing date	2019-10-18
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: In-silico screening of plant-derived antivirals against main protease, 3CLpro and endoribonuclease, NSP15 proteins of SARS-CoV-2

Sharma, Aniket / Goyal, Shubham / Yadav, Arvind Kumar / Kumar, Pawan / Gupta, Lovely

J Biomol Struct Dyn

Abstract	Novel Coronavirus or SARS-CoV-2 outbreak has developed a pandemic condition all over the world. The virus is highly infectious and spreads by human to human local transmission mode. Till date, there is no vaccination or drugs been approved for the treatment by the World Health Organisation. Henceforth, the discovery of the potential drugs is an urgent and utmost requirement for the medical fraternity. Since, the side effects of plant-derived compounds will be lower compared to synthetic/chemical drugs. The Main protease (3CLpro or NSP5) and endoribonuclease (NSP15) proteins are necessity for viral replication and its survival in the host cell. In the present study, in-silico approach of drug development was used to search for potential antiviral plant-derived compounds as inhibitors against SARS-CoV-2 replication proteins. Eight plant-derived compounds of which the antiviral activity was known and available, and two reported drugs against SARS-CoV-2 selected for the molecular docking analysis. The docking results suggested that bisdemethoxycurcumin, demethoxycurcumin, scutellarin, quercetin and myricetin showed least binding energy, i.e., greater than -6.5 Kcal/mol against 3CLpro and endoribonuclease of SARS-CoV-2. Further studies of ADME-Tox and bioavailability of drugs were also performed that exhibited efficient parameters of drug likeness. Molecular dynamics simulation calculations were performed for the most negative binding affinity of the compound to evaluate the dynamic behavior,and stability of protein-ligand complex. Our findings suggest that these compounds could be potential inhibitors of SARS-CoV-2 main protease and endoribonuclease. However, further in-vitro and pre-clinical experiments would validate the potential inhibitors of SARS-CoV-2 proteins.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #752354
Database	COVID19

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