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  1. Article ; Online: Investigating the dynamic nature of landslide susceptibility in the Indian Himalayan region.

    Sharma, Ankur / Sandhu, Har Amrit Singh

    Environmental monitoring and assessment

    2024  Volume 196, Issue 3, Page(s) 257

    Abstract: Landslide susceptibility zonation (LSZ) mapping is used to delineate areas prone to landslides and is critical for effective landslide hazard management. The existing methodologies for generating such maps tend to neglect the influence of dynamic ... ...

    Abstract Landslide susceptibility zonation (LSZ) mapping is used to delineate areas prone to landslides and is critical for effective landslide hazard management. The existing methodologies for generating such maps tend to neglect the influence of dynamic environmental variables on landslide occurrences, which may lead to obsolete and erroneous estimates of landslide susceptibility (LS) for a concerned area. Although recent studies have started to report the effects of Land Use/ Land Cover (LULC) variation on LSZ mapping, variations in other dynamic variables like rainfall, soil moisture, and evapotranspiration apart from LULC may also influence slope stability in mountainous regions. The present study investigates the impact of variations in these four variables on the LS distribution, of a selected Indian Himalayan region between 2017 and 2021. Random Forest (RF) susceptibility models are utilized for evaluating the LS for the selected years and geospatial technologies are employed for LS change detection. The results indicate up to 19% variations in the spatial extent for some of the zones of the generated LSZ maps. The research findings of this study are crucial since they reveal the impact of dynamic behavior on LS, which has not been previously documented in the literature.
    MeSH term(s) Landslides ; Environmental Monitoring ; Safety Management ; Soil
    Chemical Substances Soil
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-024-12440-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5186: Show issues

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  2. Article ; Online: Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor Evolution.

    Sharma, Ankur

    Epigenetics insights

    2019  Volume 12, Page(s) 2516865719870760

    Abstract: Cancer is a heterogeneous disease with key differences at the cellular and molecular levels. Acquisition of these differences during the course of tumor development manifests into functional and phenotypic heterogeneity leading to tumor diversity, also ... ...

    Abstract Cancer is a heterogeneous disease with key differences at the cellular and molecular levels. Acquisition of these differences during the course of tumor development manifests into functional and phenotypic heterogeneity leading to tumor diversity, also referred to as intra-tumor heterogeneity (ITH). Within a tumor, there are subpopulations of cells capable of tumor initiation and maintenance. These cells often exhibit resistance to standard-of-care anti-cancer drugs. However, the role of various subpopulations (clones) in drug resistance remains to be investigated. Moreover, the jury is still out about whether drug resistance is a result of clonal selection of preexisting cells, or the cells acquire resistance by dynamic re-wiring of their epigenome. Therefore, we investigated the drug-induced tumor evolution in patient-derived primary cells of head and neck squamous cell carcinoma. Our data demonstrated the role of a preexisting poised epigenetic state in drug-induced adaptive evolution of tumor cells. Importantly, the combination of chemotherapy and epigenetic inhibitors can prevent/delay drug-induced tumor evolution.
    Language English
    Publishing date 2019-08-14
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2516-8657
    ISSN (online) 2516-8657
    DOI 10.1177/2516865719870760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring promising natural compounds for breast cancer treatment:

    Nagar, Amka / Dubey, Amit / Sharma, Ankur / Singh, Mohini

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–15

    Abstract: Cancer is an aberrant differentiation of normal cells, characterized by uncontrolled growth and the potential to acquire invasive and aggressive properties that ultimately lead to metastasis. In the realm of scientific exploration, a multitude of ... ...

    Abstract Cancer is an aberrant differentiation of normal cells, characterized by uncontrolled growth and the potential to acquire invasive and aggressive properties that ultimately lead to metastasis. In the realm of scientific exploration, a multitude of pathways has been investigated and targeted by researchers, among which one specific pathway is recognized as WDR5-MYC. Continuous investigations and research show that WDR5-MYC is a therapeutic target protein. Hence, the discovery of naturally occurring compounds with anticancer properties has been suggested as a rapid and efficient alternative for the development of anticancerous therapeutics. A virtual screening approach was used to identify the most potent compounds from the NP-lib database at the MTiOpenScreen webserver against WDR5-MYC. This process yielded a total of 304 identified compounds. Subsequently, after screening, four potent compounds, namely Estrone (ZINC000003869899), Ethyl-1,2-benzanthracene (ZINC000003157052), Strychnine (ZINC000000119434) and 7H-DIBENZO [C, G] CARBAZOLE (ZINC000001562130), along with a cocrystallized 5-[4-(trifluoromethyl) phenyl]-1H-tetrazole inhibitor (QBP) as a reference ligand, were considered for stringent molecular docking. Thus, each compound exhibited significant docking energy between -8.2 and -7.7 kcal/mol and molecular contacts with essential residue Asn
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2317975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: A rare case of huge frontoethmoidal encephalocele projecting through mouth, with cleft palate.

    Rathod, Darshana / Goyal, Neha / Sharma, Ankur / Kumari, Kamlesh / Meshram, Tanvi

    Saudi journal of anaesthesia

    2024  Volume 18, Issue 2, Page(s) 283–285

    Abstract: Frontoethmoidal encephalocele represents protrusion of meninges and brain in a sac through a defect in the anterior skull base, mostly as swelling over the nose. Rarely it is associated with facial dysmorphism and palatal cleft. There are various ... ...

    Abstract Frontoethmoidal encephalocele represents protrusion of meninges and brain in a sac through a defect in the anterior skull base, mostly as swelling over the nose. Rarely it is associated with facial dysmorphism and palatal cleft. There are various perioperative concerns like airway difficulties, leaking from the swelling causing fluid and electrolyte disturbances, risk of infection, compression of the swelling causing a rise in intracranial pressure, bleeding, hypothermia, etc., In neonates, these challenges rise exponentially because of the inherent difficulties in dealing with this group of patients. Frontoethmoidal encephaloceles are common in low socioeconomic strata and are often missed in the antenatal period. We are reporting a rare case of frontoethmoidal encephalocele, with a huge swelling protruding through the cleft palate and occupying more than 50% of the face and oral cavity, making mask ventilation impossible.
    Language English
    Publishing date 2024-03-14
    Publishing country India
    Document type Case Reports
    ZDB-ID 2562174-9
    ISSN 0975-3125 ; 1658-354X
    ISSN (online) 0975-3125
    ISSN 1658-354X
    DOI 10.4103/sja.sja_748_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of SiC and MgO addition on mechanical and ablation characteristics of spark plasma sintered ZrB2-based composites

    Sharma, Ankur / Karunakar, Dagarapu Benny

    J Mater Sci. 2022 Aug., v. 57, no. 32, p. 15354-15373

    2022  , Page(s) 15354–15373

    Abstract: The effects of SiC (20–30 vol. %) and MgO (1–3 vol. %) on sinterability, phase evolution, microstructures, mechanical and ablation characteristics of spark plasma sintered ZrB₂-based composites were investigated in the present study. The analytically ... ...

    Abstract The effects of SiC (20–30 vol. %) and MgO (1–3 vol. %) on sinterability, phase evolution, microstructures, mechanical and ablation characteristics of spark plasma sintered ZrB₂-based composites were investigated in the present study. The analytically estimated residual stresses decreased with SiC and MgO addition. The highest relative density of 98.29 ± 0.36% and microhardness of 16.13 ± 2.91 GPa were observed for the composite containing 2 vol. % MgO owing to uniform dispersion of SiC and MgO in the ZrB₂ matrix. The highest fracture toughness and critical energy release rate of 6.15 ± 0.41 MPa.m⁰.⁵ and 88.53 ± 11.73 J/m² were observed for the composite containing 3 vol. % MgO due to the invigoration of toughening mechanisms (SiC particle pull-out, crack deflection and bridging). The ablation resistance was enhanced with MgO addition and the highest ablation resistance was observed for the composite containing 2 vol. % MgO. The composites retained maximum hardness and fracture toughness of 14.17 ± 3.03 GPa and 5.91 ± 0.4 MPa.m⁰.⁵ after ablation test, which were 87.85% and 96.09% of maximum hardness and fracture toughness before ablation test.
    Keywords clothing ; composite materials ; cracking ; dispersions ; energy ; hardness ; mechanical properties ; microstructure ; particles ; testing
    Language English
    Dates of publication 2022-08
    Size p. 15354-15373
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 2015305-3
    ISSN 1573-4803 ; 0022-2461
    ISSN (online) 1573-4803
    ISSN 0022-2461
    DOI 10.1007/s10853-022-07587-w
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Daisley Barton syndrome.

    Sharma, Ankur / Jalandra, Ram N / Bohra, Gopal K

    Saudi journal of anaesthesia

    2023  Volume 17, Issue 2, Page(s) 290–291

    Language English
    Publishing date 2023-03-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2562174-9
    ISSN 0975-3125 ; 1658-354X
    ISSN (online) 0975-3125
    ISSN 1658-354X
    DOI 10.4103/sja.sja_567_22
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  7. Article ; Online: Low Interfacial Resistance and Superior Suppression to Li-Dendrite Penetration Facilitated by Air-Stable and Mechanically Robust Al/Mg-Co-Doped Li-La-Zirconate as Electrolyte for Li-Based Solid-State Cells.

    Kobi, Sushobhan / Sharma, Ankur / Mukhopadhyay, Amartya

    ACS applied materials & interfaces

    2023  Volume 15, Issue 33, Page(s) 39276–39290

    Abstract: In the context of usage as a solid electrolyte (SE) for Li-based solid-state cells, the interfacial characteristics of Li-La-zirconate (LLZO) with the electrodes and the mechanical properties of LLZO influence the overall impedance and stability. In this ...

    Abstract In the context of usage as a solid electrolyte (SE) for Li-based solid-state cells, the interfacial characteristics of Li-La-zirconate (LLZO) with the electrodes and the mechanical properties of LLZO influence the overall impedance and stability. In this regard, the newly developed air-stable Al/Mg-co-doped LLZO has been found to possess greater resistance to crack propagation (by ∼31%) and fracture stress (by ∼52%), along with elevated hardness and stiffness, as compared to simply Al-doped LLZO. Furthermore, as directly visualized via cross-section electron microscopy at the Li/LLZO interfaces, the air-stability, along with mechanical robustness of Al/Mg-co-doped LLZO, facilitates the complete absence of impurity phase and cracks at the Li/LLZO interface, unlike for the simply Al-doped LLZO. These result in a very low area specific resistance for the Li/"Al/Mg-co-doped LLZO" interface of ∼9 Ω cm
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c05954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MAFLD: an optimal framework for understanding liver cancer phenotypes.

    Crane, Harry / Gofton, Cameron / Sharma, Ankur / George, Jacob

    Journal of gastroenterology

    2023  Volume 58, Issue 10, Page(s) 947–964

    Abstract: Hepatocellular carcinoma has a substantial global mortality burden which is rising despite advancements in tackling the traditional viral risk factors. Metabolic (dysfunction) associated fatty liver disease (MAFLD) is the most prevalent liver disease, ... ...

    Abstract Hepatocellular carcinoma has a substantial global mortality burden which is rising despite advancements in tackling the traditional viral risk factors. Metabolic (dysfunction) associated fatty liver disease (MAFLD) is the most prevalent liver disease, increasing in parallel with the epidemics of obesity, diabetes and systemic metabolic dysregulation. MAFLD is a major factor behind this sustained rise in HCC incidence, both as a single disease entity and often via synergistic interactions with other liver diseases. Mechanisms behind MAFLD-related HCC are complex but is crucially underpinned by systemic metabolic dysregulation with variable contributions from interacting disease modifiers related to environment, genetics, dysbiosis and immune dysregulation. MAFLD-related HCC has a distinct clinical presentation, most notably its common occurrence in non-cirrhotic liver disease. This is just one of several major challenges to effective surveillance programmes. The response of MAFLD-related HCC to immune-checkpoint therapy is currently controversial, and is further complicated by the high prevalence of MAFLD in individuals with HCC from viral aetiologies. In this review, we highlight the current data on epidemiology, clinical characteristics, outcomes and screening controversies. In addition, concepts that have arisen because of the MAFLD paradigm such as HCC in MAFLD/NAFLD non-overlapping groups, dual aetiology tumours and MAFLD sub-phenotypes is reviewed.
    MeSH term(s) Humans ; Liver Neoplasms/epidemiology ; Liver Neoplasms/etiology ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/therapy ; Dysbiosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Phenotype
    Language English
    Publishing date 2023-07-20
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-023-02021-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 620: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Author Reply: Comparison of Norepinephrine and Terlipressin vs Norepinephrine Alone for Management of Septic Shock: A Randomized Control Study.

    Sahoo, Pallavi / Kothari, Nikhil / Sharma, Ankur / Goyal, Shilpa

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2023  Volume 27, Issue 8, Page(s) 603–604

    Abstract: How to cite this article: ...

    Abstract How to cite this article:
    Language English
    Publishing date 2023-07-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-24514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Anaesthetic considerations in a child with ROHHADNET syndrome - A case study.

    Chhabra, Deepak / Goyal, Shilpa / Rathod, Darshana / Sharma, Ankur

    Indian journal of anaesthesia

    2023  Volume 67, Issue 6, Page(s) 571–572

    Language English
    Publishing date 2023-06-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 412570-8
    ISSN 0019-5049
    ISSN 0019-5049
    DOI 10.4103/ija.ija_670_21
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    Zs.B 1841: Show issues Location:
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