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Article: Drought stress in

Saini, Sakshi / Sharma, Priyanka / Sharma, Jyoti / Pooja, Pooja / Sharma, Asha

Physiology and molecular biology of plants : an international journal of functional plant biology

2024 Volume 30, Issue 2, Page(s) 227–247

Language	English
Publishing date	2024-02-27
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2487126-6
ISSN	0974-0430 ; 0971-5894
ISSN (online)	0974-0430
ISSN	0971-5894
DOI	10.1007/s12298-024-01417-w
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Article ; Online: Current trends in the development of electrochemical biosensor for detecting analytes from sweat.

Singh, Anoop / Sharma, Asha / Dubey, Aman / Arya, Sandeep

Current medicinal chemistry

2023

Abstract: The need for wearable bioelectronics continues to grow, and this technology might significantly alter the medical field. In order to diagnose and treat a patient, conventional medicine takes a "reactive" approach and waits for symptoms to appear first. ... ...

Abstract	The need for wearable bioelectronics continues to grow, and this technology might significantly alter the medical field. In order to diagnose and treat a patient, conventional medicine takes a "reactive" approach and waits for symptoms to appear first. Therefore, it is preferable to progress toward continuous non-invasive wearable biomonitoring, a preventative strategy that may assist individuals in diagnosing or treating illnesses at the earliest stages, sometimes before any outward symptoms have appeared. Wearable physiological sensors, such as the Apple Watch and FitBit, have arrived on the market as a result of technology advances and have quickly become commonplace. However, few devices currently exist that can report directly on these biomarkers of relevance. This is mostly due to the challenges involved in real-time fluid sampling and generating correct readouts utilising extremely selective and sensitive sensors. Sweat is an excretory fluid that is only allowed to be used in order to reduce invasiveness, but this restriction places additional strain on sensors owing to the diluted concentration of the relevant biomarkers and the changes in pH, salinity, and other biophysical parameters that directly influence the read-out of real-time biosensors. Sweat is favoured amid slightly invasive biofluids due to its low concentration of interfering chemicals and the fact that it may be collected without touching the mucosal layers. This review offers a concise outline of the latest advances in sweat-based wearable sensors, their promise in healthcare monitoring, and the problems faced in analysis based on sweat.
Language	English
Publishing date	2023-08-07
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867331666230807143639
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Zs.A 4432: Show issues

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Article ; Online: Emerging role of osmoprotectant glycine betaine to mitigate heavy metals toxicity in plants: a systematic review.

Sharma, Jyoti / Kumar, Sandeep / Singh, Pooja / Kumar, Vikram / Verma, Shivani / Khyalia, Pradeep / Sharma, Asha

Biologia futura

2024

Abstract: Heavy metals (HMs) toxicity has become one of the major global issues and poses a serious threat to the environment in recent years. HM pollution in agricultural soil is caused by metal mining, smelting, volcanic activity, industrial discharges, and ... ...

Abstract	Heavy metals (HMs) toxicity has become one of the major global issues and poses a serious threat to the environment in recent years. HM pollution in agricultural soil is caused by metal mining, smelting, volcanic activity, industrial discharges, and excessive use of phosphate fertilizers. HMs above a threshold level adversely affect the cellular metabolism of plants by producing reactive oxygen species (ROS), which attack cellular proteins. There are different mechanisms (physiological and morphological) adopted by plants to survive in the era of abiotic stress. Various osmoprotectants or compatible solutes, including amino acids, sugar, and betaines, enable the plants to counteract the HM stress. Glycine betaine (GB) is an effective osmolyte against HM stress among compatible solutes. GB has been shown to improve plant growth, photosynthesis, uptake of nutrients, and minimize oxidative stress in plants under HM stress. Additionally, GB increases the activity of antioxidant enzymes such as CAT (catalase), SOD (superoxide dismutase), and POD (peroxidase), which are effective in scavenging unwarranted ROS. Since not all species of plants can naturally produce or accumulate GB in response to stress, various approaches have been explored for introducing them. Plant hormones like salicylic acid, ABA (abscisic acid), and JA (jasmonic acid) co-ordinately stimulate the accumulation of GB inside the cell under HM stress. Apart from the exogenous application, the introduction of GB pathway genes in GB deficient species via genetic engineering also seems to be efficient in mediating HM stress. This review complied the beneficial effects of GB in mitigating HM stress and its role as a plant growth regulator. Additionally, the review explores the potential for engineering GB biosynthesis in plants as a strategy to bolster their resilience to HMs.
Language	English
Publishing date	2024-01-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2987596-1
ISSN	2676-8607 ; 2676-8615
ISSN (online)	2676-8607
ISSN	2676-8615
DOI	10.1007/s42977-023-00198-9
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Article ; Online: Despite treatment, HbA1c ≥ 37 mmol/mol in the first trimester is associated with premature delivery among South Asian women with gestational diabetes mellitus: a retrospective cohort study.

Punnose, John / Malhotra, Rajeev Kumar / Sukhija, Komal / Rijhwani, Rashika M / Choudhary, Naimaa / Sharma, Asha

Archives of gynecology and obstetrics

2024

Abstract: Purpose: To examine the effects of first-trimester HbA1c (HbA1c-FT) ≥ 37 mmol/mol on preterm birth (PTB) and large-for-gestational-age (LGA) babies in a retrospective cohort of South Asian pregnant women with gestational diabetes (GDM).: Methods: The ...

Abstract	Purpose: To examine the effects of first-trimester HbA1c (HbA1c-FT) ≥ 37 mmol/mol on preterm birth (PTB) and large-for-gestational-age (LGA) babies in a retrospective cohort of South Asian pregnant women with gestational diabetes (GDM). Methods: The cohort (n = 686) was separated into two groups based on HbA1c-FT values: Group A (n = 97) and Group B (n = 589), with values of 37-46 mmol/mol (5.5-6.4%) and < 37 mmol/mol (5.5%), respectively. HbA1c-FT's independent influence on PTB and LGA babies was examined using multivariable logistic regression in groups A and B women. The reference group (Group C) included 2031 non-GDM women with HbA1c-FT < 37 mmol/mol (< 5.5%). The effects of HbA1c-FT on PTB and LGA babies in obese women in Groups A, B, and C (designated as A-ob, B-ob, and C-ob, respectively) were re-analyzed using multivariable logistic regression. Results: Group A GDM women with greater HbA1c-FT had a higher risk for PTB (aOR:1.86, 95% CI:1.10-3.14) but not LGA babies (aOR:1.13, 95%: 0.70-1.83). The risk of PTB was higher for obese women in Group A-ob: aOR 3.28 [95% CI 1.68-6.39]. However, GDM women with normal HbA1c-FT exhibited no elevated risk for PTB: Groups B and B-ob had aORs of 1.30 (95% CI 0.86-1.98) and 1.28 (95% CI 0.88-1.85) respectively. Conclusions: South Asian GDM women with prediabetic HbA1c FT; 37-46 mmol/mol (5.5-6.4%) are more likely to deliver preterm babies despite treatment, while the risk for LGA babies was the same as non-GDM women.
Language	English
Publishing date	2024-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-024-07422-4
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Article ; Online: Graphene and Its Derivatives: Synthesis and Application in the Electrochemical Detection of Analytes in Sweat.

Singh, Anoop / Ahmed, Aamir / Sharma, Asha / Arya, Sandeep

Biosensors

2022 Volume 12, Issue 10

Abstract: Wearable sensors and invasive devices have been studied extensively in recent years as the demand for real-time human healthcare applications and seamless human-machine interaction has risen exponentially. An explosion in sensor research throughout the ... ...

Abstract	Wearable sensors and invasive devices have been studied extensively in recent years as the demand for real-time human healthcare applications and seamless human-machine interaction has risen exponentially. An explosion in sensor research throughout the globe has been ignited by the unique features such as thermal, electrical, and mechanical properties of graphene. This includes wearable sensors and implants, which can detect a wide range of data, including body temperature, pulse oxygenation, blood pressure, glucose, and the other analytes present in sweat. Graphene-based sensors for real-time human health monitoring are also being developed. This review is a comprehensive discussion about the properties of graphene, routes to its synthesis, derivatives of graphene, etc. Moreover, the basic features of a biosensor along with the chemistry of sweat are also discussed in detail. The review mainly focusses on the graphene and its derivative-based wearable sensors for the detection of analytes in sweat. Graphene-based sensors for health monitoring will be examined and explained in this study as an overview of the most current innovations in sensor designs, sensing processes, technological advancements, sensor system components, and potential hurdles. The future holds great opportunities for the development of efficient and advanced graphene-based sensors for the detection of analytes in sweat.
MeSH term(s)	Humans ; Sweat/chemistry ; Graphite/chemistry ; Wearable Electronic Devices ; Monitoring, Physiologic ; Biosensing Techniques ; Glucose/analysis
Chemical Substances	Graphite (7782-42-5) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios12100910
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Article ; Online: Involvement of metal organic frameworks in wearable electrochemical sensor for efficient performance

Sharma, Asha / Singh, Anoop / Gupta, Vinay / Sundramoorthy, Ashok K. / Arya, Sandeep

Trends in Environmental Analytical Chemistry. 2023 June, v. 38 p.e00200-

2023

Abstract: Research into wearable electrochemical sensors based on two- and three-dimensional nanomaterials is urgently needed for clinical monitoring and analysis in health care. Among various materials available, Metal-organic frameworks (MOFs) have a huge ... ...

Abstract	Research into wearable electrochemical sensors based on two- and three-dimensional nanomaterials is urgently needed for clinical monitoring and analysis in health care. Among various materials available, Metal-organic frameworks (MOFs) have a huge surface vicinity, a managed variable porous structure, enhanced capability, and a wonderful catalytic property; accordingly, they may be feasible contenders to be effectively utilised as electrochemical sensors to detect analytes. They, in particular, offer up new possibilities for enhancing the functionality of wearable electrochemical sensors. This article reviews the synthesis and analysis of metal-organic frameworks (MOFs), as well as their use as electrochemical sensors in the medical field. It concludes with a viewpoint and constraints that are expected to arise in this field.
Keywords	analytical chemistry ; chemical species ; electrochemistry ; health services ; nanomaterials ; sensors (equipment) ; Metal organic Framework ; Porous structure ; Wearable sensors ; Electrochemical biosensors
Language	English
Dates of publication	2023-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ISSN	2214-1588
DOI	10.1016/j.teac.2023.e00200
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nitric oxide: An emerging warrior of plant physiology under abiotic stress.

Saini, Sakshi / Sharma, Priyanka / Singh, Pooja / Kumar, Vikram / Yadav, Priya / Sharma, Asha

Nitric oxide : biology and chemistry

2023 Volume 140-141, Page(s) 58–76

Abstract: The natural environment of plants comprises a complex set of various abiotic stresses and their capability to react and survive under this anticipated changing climate is highly flexible and involves a series of balanced interactions between signaling ... ...

Abstract	The natural environment of plants comprises a complex set of various abiotic stresses and their capability to react and survive under this anticipated changing climate is highly flexible and involves a series of balanced interactions between signaling molecules where nitric oxide becomes a crucial component. In this article, we focussed on the role of nitric oxide (NO) in various signal transduction pathways of plants and its positive impact on maintaining cellular homeostasis under various abiotic stresses. Besides this, the recent data on interactions of NO with various phytohormones to control physiological and biochemical processes to attain abiotic stress tolerance have also been considered. These crosstalks modulate the plant's defense mechanism and help in alleviating the negative impact of stress. While focusing on the diverse functions of NO, an effort has been made to explore the functions of NO-mediated post-translational modifications, such as the N-end rule pathway, tyrosine nitration, and S-nitrosylation which revealed the exact mechanism and characterization of proteins that modify various metabolic processes in stressed conditions. Considering all of these factors, the present review emphasizes the role of NO and its interlinking with various phytohormones in maintaining developmental processes in plants, specifically under unfavorable environments.
MeSH term(s)	Nitric Oxide/metabolism ; Plant Growth Regulators/metabolism ; Plant Physiological Phenomena ; Plants/metabolism ; Stress, Physiological
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; Plant Growth Regulators
Language	English
Publishing date	2023-10-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1362794-6
ISSN	1089-8611 ; 1089-8603
ISSN (online)	1089-8611
ISSN	1089-8603
DOI	10.1016/j.niox.2023.10.001
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Zs.A 4677: Show issues

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Article: Nano to rescue: repository of nanocarriers for targeted drug delivery to curb breast cancer

Banthia, Poonam / Gambhir, Lokesh / Sharma, Asha / Daga, Dhiraj / Kapoor, Neha / Chaudhary, Rishabh / Sharma, Gaurav

3 Biotech. 2022 Mar., v. 12, no. 3

2022

Abstract: Breast cancer is a heterogeneous disease with different intrinsic subtypes. The conventional treatment of surgical resection, chemotherapy, immunotherapy and radiotherapy has not shown significant improvement in the survival rate of breast cancer ... ...

Abstract	Breast cancer is a heterogeneous disease with different intrinsic subtypes. The conventional treatment of surgical resection, chemotherapy, immunotherapy and radiotherapy has not shown significant improvement in the survival rate of breast cancer patients. The therapeutics used cause bystander toxicities deteriorating healthy tissues. The breakthroughs of nanotechnology have been a promising feat in selective targeting of tumor site thus increasing the therapeutic gain. By the application of nanoenabled carriers, nanomedicines ensure targeted delivery, stability, enhanced cellular uptake, biocompatibility and higher apoptotic efficacy. The present review focuses on breakthrough of nanoscale intervention in targeted drug delivery as novel class of therapeutics. Nanoenabled carriers like polymeric and metallic nanoparticles, dendrimers, quantum dots, liposomes, solid lipid nanoparticles, carbon nanotubes, drug-antibody conjugates and exosomes revolutionized the targeted therapeutic delivery approach. These nanoassemblies have shown additional effect of improving the solubility of drugs such as paclitaxel, reducing the dose and toxicity. The present review provides an insight on the different drug conjugates employed/investigated to curb breast cancer using nanocarrier mediated targeted drug delivery. However, identification of appropriate biomarkers to target, clearer insight of the biological processes, batch uniformity, reproducibility, nanomaterial toxicity and stabilities are the hurdles faced by nanodrugs. The potential of nano-therapeutics delivery necessitates the agglomerated efforts of research community to bridge the route of nanodrugs for scale-up, commercialization and clinical applications.
Keywords	apoptosis ; biocompatibility ; biomarkers ; breast neoplasms ; carbon nanotubes ; commercialization ; dendrimers ; drug therapy ; drugs ; exosomes ; immunotherapy ; lipids ; nanocarriers ; nanomedicine ; paclitaxel ; radiotherapy ; resection ; solubility ; survival rate ; toxicity
Language	English
Dates of publication	2022-03
Size	p. 70.
Publishing place	Springer International Publishing
Document type	Article
Note	Review
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-022-03121-6
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Article: A randomised controlled trial to study Bispectral guided induction of general anaesthesia using propofol and etomidate infusion.

Saini, Savita / Bhardwaj, Mamta / Sharma, Asha / Taxak, Susheela

Indian journal of anaesthesia

2020 Volume 64, Issue Suppl 3, Page(s) S180–S185

Abstract: Background and aims: The present prospective, randomised study was done to evaluate induction characteristics with bispectral (BIS) index guided infusion of propofol and etomidate.: Materials and methods: After institutional ethical committee ... ...

Abstract	Background and aims: The present prospective, randomised study was done to evaluate induction characteristics with bispectral (BIS) index guided infusion of propofol and etomidate. Materials and methods: After institutional ethical committee approval, 70 patients, aged 18-60 years, American Society of Anaesthesiologists (ASA) I and II scheduled for elective surgery were included. Patients were randomly allocated into one of the two groups. In Group E, patients received etomidate infusion at a rate of 0.07 mg kg Results: T Conclusion: BIS-guided titration of propofol and etomidate infusion for induction did not result in reduction of the dose, haemodynamic variations and other effects.
Language	English
Publishing date	2020-08-15
Publishing country	India
Document type	Journal Article
ZDB-ID	412570-8
ISSN	0019-5049
ISSN	0019-5049
DOI	10.4103/ija.IJA_221_20
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Article ; Online: Assessment of heavy metals in faecal pellets of blue rock pigeon from rural and industrial environment in India.

Bala, Manju / Sharma, Asha / Sharma, Gaurav

Environmental science and pollution research international

2020 Volume 27, Issue 35, Page(s) 43646–43655

Abstract: The study was conducted to monitor concentration of six toxic metals in faecal pellets of blue rock pigeon from six industrial areas of Jaipur, i.e. Jhotwara, Malviya, Mansarover, Sitapura, Vishwakarma industrial areas and Sanganer industries, by using ... ...

Abstract	The study was conducted to monitor concentration of six toxic metals in faecal pellets of blue rock pigeon from six industrial areas of Jaipur, i.e. Jhotwara, Malviya, Mansarover, Sitapura, Vishwakarma industrial areas and Sanganer industries, by using atomic absorption spectrophotometer. At the same time, trace metals were also analysed for a reference area so that a comparative impact of the metal pollution from the industries could be figured out. From the data obtained, the highest Cd, Cu, Ni, Pb and Zn concentrations were found in the faecal pellets from Sitapura industrial area (1.12 ± 0.60 μg/g; 128.9 ± 11.10 μg/g; 17 ± 2.87 μg/g; 79.6 ± 42.69 μg/g; 2250 ± 1390.16 μg/g) and the highest Cr (18.6 ± 3.65 μg/g) from Jhotwara industrial area. However, industrial environment has high deposition of studied trace metals (except Ni for Sanganer industries) as compared with reference area. The concentration of Cd was below the detectable level in faecal pellets from reference area. The trend of trace metals from Malviya, Sitapura, Jhotwara and reference areas was noticed as Zn > Cu > Pb > Cr > Ni > Cd and almost same for Sanganer industries and Mansarover industrial area as Zn > Cu > Cr > Pb > Ni > Cd. The excretion of heavy metals in fa1ecal pellets from Vishwakarma industrial area was noticed as Zn > Cr > Cu > Pb > Ni > Cd. Further levels of metals were varied significantly among different industrial areas, P ≤ 0.05, as well as between industrial areas and reference area. The observed high concentration of different heavy metals in faecal pellets of bird species shows their exposure to metal contamination which is warning to spiked environmental pollution.
MeSH term(s)	Animals ; Columbidae ; Environmental Monitoring ; India ; Metals, Heavy/analysis ; Risk Assessment ; Soil
Chemical Substances	Metals, Heavy ; Soil
Language	English
Publishing date	2020-07-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-020-09409-5
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