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  1. Book ; Online: Advances in 3D Printing

    Sharma, Ashutosh

    2023  

    Keywords Manufacturing industries ; additive manufacturing ; radiotherapy ; cancer ; sustainability ; biomarkers ; nanoparticles
    Language English
    Size 1 electronic resource (446 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030380796
    ISBN 9781803558455 ; 1803558458
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Nanocomposite Materials for Biomedical and Energy Storage Applications

    Sharma, Ashutosh

    2022  

    Keywords Materials science ; Mechanical engineering & materials
    Language English
    Size 1 electronic resource (340 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030378322
    ISBN 9781803556208 ; 180355620X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Engineering Steels and High Entropy-Alloys

    Sharma, Ashutosh / Duriagina, Zoia / Kumar, Sanjeev

    2020  

    Keywords Materials science
    Size 1 electronic resource (286 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021045087
    ISBN 9781838805562 ; 1838805567
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Special section on Recent Trends in Information and Communication Technologies

    Sharma Ashutosh

    Journal of Intelligent Systems, Vol 30, Iss 1, Pp 1070-

    2021  Volume 1074

    Keywords Science ; Q ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Projected decline in the strength of vegetation carbon sequestration under climate change in India.

    Bejagam, Vijaykumar / Sharma, Ashutosh / Wei, Xiaohua

    The Science of the total environment

    2024  Volume 916, Page(s) 170166

    Abstract: Tropical vegetation plays a critical role in terrestrial carbon budget and supply many ecological functions such as carbon sequestration. In recent decades, India has witnessed an increase in net primary productivity (NPP), an important measure of carbon ...

    Abstract Tropical vegetation plays a critical role in terrestrial carbon budget and supply many ecological functions such as carbon sequestration. In recent decades, India has witnessed an increase in net primary productivity (NPP), an important measure of carbon sequestration. However, uncertainties persist regarding the sustainability of these land carbon sinks in the face of climate change. The enhanced NPP is driven by the strong CO
    Language English
    Publishing date 2024-01-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Assessment of antimicrobial, antidiabetic, and anti-inflammatory properties of acetone extract of Aerva lanata (L.) by in-vitro approach and bioactive compounds characterization.

    Shanmuganathan, Rajasree / Devanesan, Sandhanasamy / Oza, Goldie / Sharma, Ashutosh

    Environmental research

    2024  Volume 248, Page(s) 118348

    Abstract: The antimicrobial, antidiabetic, and anti-inflammatory activities efficiency of Aerva lanata plant extracts (aqueous (Aqu-E), acetone (Ace-E), and ethanol (Eth-E)) were investigated in this study. Furthermore, the active molecules exist in the crude ... ...

    Abstract The antimicrobial, antidiabetic, and anti-inflammatory activities efficiency of Aerva lanata plant extracts (aqueous (Aqu-E), acetone (Ace-E), and ethanol (Eth-E)) were investigated in this study. Furthermore, the active molecules exist in the crude extract were characterized by UV-Visible spectrophotometer, Fourier transform infrared (FTIR), High-performance liquid chromatography (HPLC), and Gas Chromatography-Mass Spectrometry (GC-MS) analyses. The preliminary phytochemical study revealed that the Ace-E restrain more phytochemicals like alkaloids, saponins, anthraquinone, tannins, phenolics, flavonoids, glycosides, terpenoids, amino acid, steroids, protein, coumarin, as well as quinine than Aqu-E and Eth-E. Accordingly to this Ace-E showed considerable antimicrobial activity as the follows: for bacteria S. aureus > E. coli > K. pneumoniae > P. aeruginosa > B. subtilis and for fungi T. viride > A.flavus > C. albicans > A.niger at 30 mg ml concentration. Similarly, Ace-E showed considerable antidiabetic (α-amylase: 71.7 % and α-glucosidase: 70.1 %) and moderate anti-inflammatory (59 % and 49.8 %) activities. The spectral and chromatogram studies confirmed that the Ace-E have pharmaceutically valuable bioactive molecules such as (Nbutyl)-octadecane, propynoic acid, neophytadiene, and 5,14-di (N-butyl)-octadecane. These findings suggest that Ace-E from A. lanata can be used to purify additional bioactive substances and conduct individual compound-based biomedical application research.
    MeSH term(s) Acetone ; Hypoglycemic Agents ; Escherichia coli ; Staphylococcus aureus ; Anti-Infective Agents ; Amaranthaceae/chemistry ; Antioxidants ; Anti-Bacterial Agents ; Alkanes
    Chemical Substances octadecane (N102P6HAIU) ; Acetone (1364PS73AF) ; Hypoglycemic Agents ; Anti-Infective Agents ; Antioxidants ; Anti-Bacterial Agents ; Alkanes
    Language English
    Publishing date 2024-01-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: High Energy electron and proton acceleration by circularly polarized laser pulse from near critical density hydrogen gas target.

    Sharma, Ashutosh

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 2191

    Abstract: Relativistic electron rings hold the possibility of very high accelerating rates, and hopefully a relatively cheap and compact accelerator/collimator for ultrahigh energy proton source. In this work, we investigate the generation of helical shaped quasi- ... ...

    Abstract Relativistic electron rings hold the possibility of very high accelerating rates, and hopefully a relatively cheap and compact accelerator/collimator for ultrahigh energy proton source. In this work, we investigate the generation of helical shaped quasi-monoenergetic relativistic electron beam and high-energy proton beam from near critical density plasmas driven by petawatt-circularly polarized-short laser pulses. We numerically observe the efficient proton acceleration from magnetic vortex acceleration mechanism by using the three dimensional particle-in-cell simulations; proton beam with peak energy 350 MeV, charge ~10nC and conversion efficiency more than 6% (which implies 2.4 J proton beam out of the 40 J incident laser energy) is reported. We detailed the microphysics involved in the ion acceleration mechanism, which requires investigating the role of self-generated plasma electric and magnetic fields. The concept of efficient generation of quasi-monoenergetic electron and proton beam from near critical density gas targets may be verified experimentally at advanced high power - high repetition rate laser facilities e.g. ELI-ALPS. Such study should be an important step towards the development of high quality electron and proton beam.
    Language English
    Publishing date 2018-02-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-20506-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Phloridzin's Diabetic Wound Healing Potential through DPP-4 Enzyme Inhibition: A Review Article.

    Sharma, Khushi / Ramachandran, Vadivelan / Sharma, Ashutosh / Mohanasundaram, Tharani / Mageshkumar, Harshini

    Current diabetes reviews

    2024  

    Abstract: Diabetic wound healing is a dynamic medical process that takes place in an environment within the body that is complex and contains elevated sugar levels, oxygen deprivation, and cellular oxidative stress. Phloridzin (Phlorizin) is one of the most well- ... ...

    Abstract Diabetic wound healing is a dynamic medical process that takes place in an environment within the body that is complex and contains elevated sugar levels, oxygen deprivation, and cellular oxidative stress. Phloridzin (Phlorizin) is one of the most well-known polyphenols found in apples because of its anti-inflammatory, antioxidant, antibacterial, antidiabetic, and antiseptic properties; it can also play a significant part in the healing of diabetic wounds. The study aimed to investigate the role of phloridzin as an efficient DPP-4 inhibitor with additional therapeutic effects in diabetic wound healing, as Dipeptidyl Peptidase-4 (DPP-4) expression increases in response to increases in glucose, Reactive Oxygen Species (ROS), and inflammation. Phloridzin inhibiting DPP-4 preserves Stromal cell-derived Factor-1α (SDF-1α), Insulin-like Growth Factor (IGF), and Glucagon-like Peptide-1 (GLP-1), which are possible DPP-4 substrates involved in wound healing. The accessible material from systemic searches in PubMed, Scopus, and published articles was reviewed with no period of limitation. The in silico study showed strong binding of phloridzin with DPP-4 protein (2P8S); also, in vitro DPP-4 inhibition assay has shown better inhibition by phloridzin. This study offers new research directions for examining phloridzin's capacity to withstand oxidative stress, as well as for redefining its tactical function as a powerful DPP-4 inhibitor to regulate the process involved in the healing of diabetic wounds.
    Language English
    Publishing date 2024-04-26
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6417
    ISSN (online) 1875-6417
    DOI 10.2174/0115733998291941240416053855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Impact of climatic changes and anthropogenic activities on ecosystem net primary productivity in India during 2001–2019

    Bejagam, Vijaykumar / Sharma, Ashutosh

    Ecological informatics. 2022 June 21,

    2022  

    Abstract: Climate change and anthropogenic activities have altered the terrestrial ecosystem dynamics around the globe. Due to the complex ecosystem-atmosphere interactions at different scales, these impacts are difficult to quantify and are poorly understood, ... ...

    Abstract Climate change and anthropogenic activities have altered the terrestrial ecosystem dynamics around the globe. Due to the complex ecosystem-atmosphere interactions at different scales, these impacts are difficult to quantify and are poorly understood, especially in developing countries with limited ground-based observations. This study analyzed the impact of climatic changes and anthropogenic activities on ecosystem net primary productivity (NPP) in India using remote sensing-based observations, correlation analysis, and Residual Trend analysis (RESTREND). Using different climate variables such as precipitation, temperature, and solar radiation, along with Land Use and Land Cover (LULC) and NPP maps, we first classified the ecosystems (ES) into two categories: natural ecosystems – influenced only by climate change (ESc), covering about 19.7% of the area, and human-influenced ecosystems – influenced by both climate change and anthropogenic activities (ESc₊ₐ), covering about 80.3% of the area. RESTREND analysis was performed on both ESc and ESc₊ₐ to analyze the relative contributions of climate change and human activities to changes in NPP. The correlation analysis between NPP and climate variables suggested that precipitation was the dominant control of NPP in about 72% area, whereas temperature and solar radiation controlled NPP in Himalayan and forest-dominated regions, respectively. The human-influenced ecosystems (ESc₊ₐ) experienced an increasing trend in NPP, whereas natural ecosystems (ESc) experienced a decreasing trend, particularly in forest-dominated regions. Overall, NPP increased in the country during the study duration. The contributions of climatic changes and anthropogenic activities varied spatially and temporally. In general, climatic factors enhanced the NPP, whereas human activities contributed to a slight decline in NPP. These findings improve our understanding of how ecosystems in India are influenced by climate change and anthropogenic activities in recent decades. The results from this study will aid in identifying ecological hotspots and key drivers for better ecosystem management strategies.
    Keywords climate change ; ecosystem management ; humans ; land use and land cover maps ; net primary productivity ; solar radiation ; temperature ; terrestrial ecosystems ; India
    Language English
    Dates of publication 2022-0621
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 2212016-6
    ISSN 1878-0512 ; 1574-9541
    ISSN (online) 1878-0512
    ISSN 1574-9541
    DOI 10.1016/j.ecoinf.2022.101732
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7643: Show issues

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  10. Article ; Online: Unravelling the Mystery inside Cells by Using Single-Molecule Fluorescence Imaging.

    Zalejski, Julian / Sun, Jiachen / Sharma, Ashutosh

    Journal of imaging

    2023  Volume 9, Issue 9

    Abstract: Live-cell imaging is a powerful technique to study the dynamics and mechanics of various biological molecules like proteins, organelles, DNA, and RNA. With the rapid evolution of optical microscopy, our understanding of how these molecules are implicated ...

    Abstract Live-cell imaging is a powerful technique to study the dynamics and mechanics of various biological molecules like proteins, organelles, DNA, and RNA. With the rapid evolution of optical microscopy, our understanding of how these molecules are implicated in the cells' most critical physiological roles deepens. In this review, we focus on how spatiotemporal nanoscale live-cell imaging at the single molecule level allows for profound contributions towards new discoveries in life science. This review will start by summarizing how single-molecule tracking has been used to analyze membrane dynamics, receptor-ligand interactions, protein-protein interactions, inner- and extra-cellular transport, gene expression/transcription, and whole organelle tracking. We then move on to how current authors are trying to improve single-molecule tracking and overcome current limitations by offering new ways of labeling proteins of interest, multi-channel/color detection, improvements in time-lapse imaging, and new methods and programs to analyze the colocalization and movement of targets. We later discuss how single-molecule tracking can be a beneficial tool used for medical diagnosis. Finally, we wrap up with the limitations and future perspectives of single-molecule tracking and total internal reflection microscopy.
    Language English
    Publishing date 2023-09-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2824270-1
    ISSN 2313-433X ; 2313-433X
    ISSN (online) 2313-433X
    ISSN 2313-433X
    DOI 10.3390/jimaging9090192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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