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  1. Article ; Online: Mapping the roots of specialist disparities.

    Sharma, Hemant

    The Lancet regional health. Europe

    2023  Volume 36, Page(s) 100814

    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2023.100814
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  2. Article ; Online: COVID-19 and the liver: Are footprints still there?

    Gupta, Tarana / Sharma, Hemant

    World journal of gastroenterology

    2023  Volume 29, Issue 4, Page(s) 656–669

    Abstract: The coronavirus disease 2019 (COVID-19) hit the entire world as a global pandemic and soon became the most important concern for all patients with chronic diseases. An early trend in higher mortality in patients with acute respiratory distress attracted ... ...

    Abstract The coronavirus disease 2019 (COVID-19) hit the entire world as a global pandemic and soon became the most important concern for all patients with chronic diseases. An early trend in higher mortality in patients with acute respiratory distress attracted all researchers to closely monitor patients for the involvement of other systems. It soon became apparent that patients with chronic liver diseases are at increased risk of mortality given their cirrhosis-associated immune dysfunction. Additionally, liver function abnormalities were noted in patients with severe COVID-19. Profound cytokine storm, direct viral infection, drugs and reactivation of viral infections were causes of deranged liver functions. Here, we discuss the relation between COVID-19 and chronic liver disease, specifically cirrhosis, hepatitis B, hepatitis C, and non-alcoholic fatty liver disease (NAFLD), as well as the liver manifestations of COVID-19. The metabolic syndrome, obesity, diabetes mellitus and NAFLD were found to worsen outcome in different studies reported worldwide. Decompensated cirrhosis should be considered a risk factor for death and severe COVID-19. Recently, COVID-19 related cholangiopathy has also been reported with changes of secondary sclerosing cholangitis. The long-term persistence of viral antigens in gut epithelia raises concern regarding the future risk of autoimmune liver diseases.
    MeSH term(s) Humans ; COVID-19/complications ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Liver Cirrhosis/complications ; Risk Factors
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i4.656
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    Zs.A 6039: Show issues Location:
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  3. Article ; Online: Transplant Renal Artery Stenosis: Current Concepts.

    Gunawardena, Thilina / Sharma, Hemant

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2023  Volume 20, Issue 12, Page(s) 1049–1057

    Abstract: Transplant renal artery stenosis is an increasingly recognized vascular complication after renal transplant. It can result in posttransplant hypertension and graft dysfunction and eventually in graft loss. Timely diagnosis and appropriate intervention ... ...

    Abstract Transplant renal artery stenosis is an increasingly recognized vascular complication after renal transplant. It can result in posttransplant hypertension and graft dysfunction and eventually in graft loss. Timely diagnosis and appropriate intervention for clinically significant transplant renal artery stenosis can potentially halt or reverse these adverse effects, leading to better outcomes. Duplex ultrasonography is the imaging modality of choice to screen suspected cases. Some patients with transplant renal artery stenosis will require invasive treatment with endovascular intervention or surgery, whereas others can be safely treated with blood pressure control and follow-up. In this review, we aimed to discuss the epidemiology, clinical presentation, pathogenesis, diagnosis, and management of this common posttransplant complication.
    MeSH term(s) Humans ; Renal Artery Obstruction/diagnostic imaging ; Renal Artery Obstruction/etiology ; Renal Artery Obstruction/surgery ; Hypertension/etiology ; Blood Pressure
    Language English
    Publishing date 2023-01-30
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2022.0334
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  4. Article ; Online: Transport through a correlated polar side-coupled quantum dot transistor in the presence of a magnetic field and dissipation.

    Sharma, Hemant Kumar / Kalla, Manasa / Chatterjee, Ashok

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 998

    Abstract: Non-equilibrium magneto-transport properties of a quantum dot dimer transistor are studied in the presence of electron-electron and electron-phonon interactions and the interaction of the dimer phonons with the substrate phonon bath that gives rise to ... ...

    Abstract Non-equilibrium magneto-transport properties of a quantum dot dimer transistor are studied in the presence of electron-electron and electron-phonon interactions and the interaction of the dimer phonons with the substrate phonon bath that gives rise to dissipation. The entire system is modeled by the Anderson-Holstein-Caldeira-Leggett Hamiltonian where the Caldeira-Leggett term takes care of the damping. The electron-phonon interaction is dealt with the Lang-Firsov transformation and the electron-electron interaction is treated at the mean-field level. The transport problem is studied using the Keldysh non-equilibrium Green function theory and the effects of electron-electron interaction, external magnetic field, electron-phonon interaction and damping on spectral function, tunneling current and differential conductance of the dimer transistor are calculated.
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-51142-9
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  5. Article ; Online: Enhancing practice efficiency: A key organizational strategy to improve professional fulfillment in allergy and immunology.

    Sharma, Hemant P

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 126, Issue 3, Page(s) 235–239

    Abstract: Objective: To review evidence-based strategies that have been noted to improve professional fulfillment and reduce burnout by enhancing practice efficiency.: Data sources: A comprehensive literature review was conducted to evaluate the strategies to ... ...

    Abstract Objective: To review evidence-based strategies that have been noted to improve professional fulfillment and reduce burnout by enhancing practice efficiency.
    Data sources: A comprehensive literature review was conducted to evaluate the strategies to improve efficiency of practice-a key driver of burnout among physicians.
    Study selections: Studies of efficiency-enhancing practices relevant to allergy-immunology were included.
    Results: Professional burnout is prevalent among physicians and is associated with negative outcomes affecting physicians, patients, and health care organizations. Recent surveys suggest at least 35% of US allergists-immunologists experience burnout. There are multiple drivers of professional burnout, some at the individual level and others at the organizational or practice level. Strategies to improve professional fulfillment may be conceptualized using the Stanford physician wellness framework, in which efforts target the following 3 reciprocal domains: culture, personal resilience, and practice efficiency. Organizational strategies that support physician well-being by creating a more efficient practice environment hold great promise, particularly for allergists-immunologists. The reduction of administrative burden and fostering of team-based care have been found in multiple studies to be cost-effective strategies to improve physician and patient satisfaction.
    Conclusion: To ensure the well-being of the US allergy-immunology workforce and optimize patient outcomes, both private and academic allergy-immunology institutions should prioritize the adoption and iterative evaluation and refinement of these strategies to cocreate an efficient and ideal practice environment.
    MeSH term(s) Allergy and Immunology ; Burnout, Professional/prevention & control ; Efficiency, Organizational ; Humans ; Job Satisfaction ; Organizational Culture ; Physicians/psychology ; Professionalism
    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.12.001
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    Uh III Zs.136: Show issues Location:
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  6. Article ; Online: Need for functional validation of B cell trajectory in transplant tolerance.

    Sharma, Hemant / Al-Amiedy, Zaid / Mehra, Sanjay

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2023  Volume 24, Issue 2, Page(s) 308–309

    MeSH term(s) Transplantation Tolerance ; B-Lymphocytes ; Immune Tolerance ; Immunologic Memory
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Letter
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2023.09.018
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    Zs.A 5542: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Informative Artifacts in AI-Assisted Care.

    Sharma, Hemant / Baberwal, Harshita / Sharma, Abhishek

    The New England journal of medicine

    2023  Volume 389, Issue 22, Page(s) 2114

    MeSH term(s) Humans ; Artifacts ; Artificial Intelligence
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2311525
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Outcomes of operative intervention for ulcers over hemodialysis arteriovenous access.

    Gunawardena, Thilina / Sharma, Hemant / Mehra, Sanjay

    Hemodialysis international. International Symposium on Home Hemodialysis

    2023  Volume 27, Issue 2, Page(s) 112–116

    Abstract: Introduction: The native arteriovenous fistula (AVF) is the gold standard for long-term hemodialysis access. When native vein options are exhausted, arteriovenous graft (AVG) becomes the next choice. An ulcer over an AVF or AVG is a serious condition ... ...

    Abstract Introduction: The native arteriovenous fistula (AVF) is the gold standard for long-term hemodialysis access. When native vein options are exhausted, arteriovenous graft (AVG) becomes the next choice. An ulcer over an AVF or AVG is a serious condition with the potential for life-threatening hemorrhage.
    Objectives: This study aims to present our experience with surgical management of ulcers over AVFs or AVGs.
    Materials and methods: Electronic records of 26 patients who underwent 27 consecutive surgical procedures for ulcers over AVFs or AVGs from December 31, 2016 to December 31, 2021 at the Royal Liverpool University Hospital were retrospectively analyzed.
    Results: The majority were males (14/26, 53.8%) and the median age was 64.5 years. Operative repair was required for 25 ulcers over 24 AVFs and 2 ulcers over 2 AVGs. Ten patients (37%) presented with bleeding. Seventeen (63%) had impending bleeding suggested by a thin soft tissue covering or a false aneurysm at the site of the ulcer. Previous endovascular intervention for fistula outflow stenosis was a significant predictor for presenting with bleeding (p = 0.031). All ulcers (27/27, 100%) underwent excision and primary skin closure. Fistula wall defects were directly repaired in 18/27 (66.7%). Four/26 (14.8%) fistulas had to be ligated and 2 (7.4%) had end-to-end re-anastomosis after excision of damaged segments. Three/26 (11.53%) fistulas thrombosed immediately after the intervention. The overall fistula salvage rate was 73.08% (19/26). There was 1 (3.7%) patient mortality due to bleeding from wound breakdown after surgery.
    Conclusions: An acceptable fistula salvage rate can be expected following surgical repair of ulcers over AVFs and AVGs. A history of previous endovascular interventions for fistula outflow stenosis was a predictor of bleeding from these ulcers.
    MeSH term(s) Male ; Humans ; Middle Aged ; Female ; Renal Dialysis/methods ; Ulcer ; Arteriovenous Shunt, Surgical/adverse effects ; Graft Occlusion, Vascular/surgery ; Vascular Patency ; Retrospective Studies ; Constriction, Pathologic ; Treatment Outcome
    Language English
    Publishing date 2023-02-09
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2192458-2
    ISSN 1542-4758 ; 1492-7535
    ISSN (online) 1542-4758
    ISSN 1492-7535
    DOI 10.1111/hdi.13075
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    Zs.A 6091: Show issues Location:
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  9. Article ; Online: Refining proposed transplant pharmacy metrics.

    Sharma, Hemant / Devkaran, Bhavesh / Sharma, Abhishek

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2023  Volume 24, Issue 5, Page(s) 874–875

    MeSH term(s) Humans ; Organ Transplantation/standards
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2023.12.006
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  10. Article: Compensatory mechanisms for proximal & distal joint alignment & gait in varus knee osteoarthritis treated with high tibial osteotomy: A systematic review.

    Harvey, Jessica / Eltayeb, Momin / Moulder, Elizabeth H / Muir, Ross L / Sharma, Hemant K

    Journal of orthopaedics

    2024  Volume 54, Page(s) 148–157

    Abstract: Background: Varus deformity is common in medial compartment knee osteoarthritis (OA). This coronal plane malalignment is compensated for by static and dynamic adjustments in the position of the adjacent joints, principally in the hindfoot & ankle. Varus ...

    Abstract Background: Varus deformity is common in medial compartment knee osteoarthritis (OA). This coronal plane malalignment is compensated for by static and dynamic adjustments in the position of the adjacent joints, principally in the hindfoot & ankle. Varus knee OA can be treated in selected patients with high tibial osteotomy (HTO) and stabilised with a fixed angle plate or circular frame, which may reverse these compensatory adjustments. The aim of this systematic review is to determine the evidence available for static and dynamic compensations with the main objectives being to improve deformity planning and optimise patient outcomes.
    Method: A systematic review with meta-analysis was designed using the PRISMA template to meet the research aims & objectives.
    Results: A total of 1006 patients (1020 knees) with acombined mean age of 54.5 years, female:male ratio of 0.9:1 were extracted from 19 included studies. The methodologies of the majority of studies were at high risk of bias according to the Newcastle-Ottawa Scale demonstrating significant heterogeneity. The combined mean change in the HKA axis was 7.7°; MPTA 7.4°; TT, 0.21°; TI 4.56° & AJLO 4°
    Conclusions: An inverse relationship between ankle and hindfoot alignment in varus deformity of the knee forms the basis of this compensation theory. In cases with a stiff hindfoot which may not revert postoperatively, the reconstructive orthopaedic surgeon may consider angulation with translation HTO, in order to optimise joint alignment and minimise transference of symptoms to the foot and ankle.
    Language English
    Publishing date 2024-03-19
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2024.02.022
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