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Artikel: Colorectal Cancer: An Emphasis on Factors Influencing Racial/Ethnic Disparities.

Sharma, Ishna / Kim, Suhhyun / Sridhar, Swathi / Basha, Riyaz

2021 Band 25, Heft 2, Seite(n) 151–160

Abstract: Current statistics related to cancer incidence and cancer-related death rates clearly show that specific racial/ethnic minorities are more likely to be diagnosed and/or die with cancer. Colorectal cancer (CRC) is one of the leading causes of cancer ... ...

Abstract	Current statistics related to cancer incidence and cancer-related death rates clearly show that specific racial/ethnic minorities are more likely to be diagnosed and/or die with cancer. Colorectal cancer (CRC) is one of the leading causes of cancer deaths in the United States and it disproportionately affects the non-Hispanic Black or African American (AA) population. When compared to the non-Hispanic White (nHW) population, incidence and death rates in AAs are 28% and 60% higher, respectively. Hispanics have an overall lower CRC incidence rate than nHWs (Hispanics: 35.5 per 100,000 population; nHWs: 40.2 per 100,000 population), but their incidence continues to rise, unlike nHWs, who are experiencing a decline. This disparity between Hispanics and nHWs is further highlighted in the younger Hispanic population. While the cause of the disparities is associated with CRC-related genetic and environmental factors, the role of specific genes/mutations in each population are still not fully unraveled. However, because CRC is a slowly progressing disease, routine screening and/or early intervention are key to achieving better outcomes in CRC patients and ultimately in closing the disparity gap among different populations. This review discusses the major factors influencing the disparities in CRC and also focuses on factors such as treatment response, family history, and screening that potentially contribute to the racial/ethnic disparities in CRC.
Mesh-Begriff(e)	Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/ethnology ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/mortality ; Early Detection of Cancer ; Health Status Disparities ; Hispanic Americans ; Humans ; Incidence ; Prognosis
Sprache	Englisch
Erscheinungsdatum	2021-01-03
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1036388-9
ISSN	0893-9675
ISSN	0893-9675
DOI	10.1615/CritRevOncog.2020035174
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Multimodal Management With Immunotherapy, Radiation, and Surgery of Histiocytic Sarcoma Following Acute Lymphoblastic Leukemia: An Unusual Presentation of a Rare Disease.

Ahmad, Hufsa / Vallance, Kelly / Sharma, Ishna / Berry, Stacey / Orr, Kaci / Ray, Anish

Journal of pediatric hematology/oncology

2023 Band 45, Heft 8, Seite(n) 463–466

Abstract: Histiocytic sarcoma (HS) is a rare neoplasm with no known cause. This sarcoma is characterized by morphology similar to that demonstrated by mature tissue histiocytes and mostly afflicts adults. HSs typically have a poor prognosis due to a rapidly ... ...

Abstract	Histiocytic sarcoma (HS) is a rare neoplasm with no known cause. This sarcoma is characterized by morphology similar to that demonstrated by mature tissue histiocytes and mostly afflicts adults. HSs typically have a poor prognosis due to a rapidly progressive clinical course. Our patient's case was unique due to its presentation four years after completion of treatment for B-cell acute lymphoblastic leukemia. The patient experienced progression with initial therapy for HS. With dual immunotherapy and radiation, however, the patient has remained clinically stable without detectable disease. Immunotherapy may be a successful and tolerable therapeutic option for histiocytic disease.
Mesh-Begriff(e)	Adult ; Humans ; Histiocytic Sarcoma/therapy ; Rare Diseases ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma ; Immunotherapy
Sprache	Englisch
Erscheinungsdatum	2023-09-09
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002751
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Concussion of the colon: paediatric patient with traumatic cecal haematoma.

Sharma, Ishna / Moote, Douglas / Campbell, Brendan T

BMJ case reports

2020 Band 13, Heft 12

Abstract: A 14-year-old boy was injured from playing football, and subsequently developed worsening abdominal pain. CT of the abdomen and pelvis was concerning for a mass of ascending colon, with free fluid in the pelvis. The patient was emergently taken to the ... ...

Abstract	A 14-year-old boy was injured from playing football, and subsequently developed worsening abdominal pain. CT of the abdomen and pelvis was concerning for a mass of ascending colon, with free fluid in the pelvis. The patient was emergently taken to the operating room where he was found to have a cecal haematoma. The patient underwent a right hemicolectomy and ileocolostomy and was discharged home just days later without any acute complications. As cecal haematomas are a rare entity, the best approach to management is not well defined. When the diagnosis is uncertain, or if the possibility of full-thickness injury exists, exploratory laparoscopy or laparotomy is the safest approach.
Mesh-Begriff(e)	Abdominal Pain/surgery ; Adolescent ; Cecal Diseases/diagnostic imaging ; Cecal Diseases/etiology ; Cecal Diseases/surgery ; Colectomy ; Football/injuries ; Hematoma/diagnostic imaging ; Hematoma/etiology ; Hematoma/surgery ; Humans ; Ileostomy ; Male ; Tomography, X-Ray Computed ; Treatment Outcome
Sprache	Englisch
Erscheinungsdatum	2020-12-12
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-236066
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Utilization of Genomic Tumor Profiling in Pediatric Liquid Tumors: A Clinical Series.

Sharma, Ishna / Son, Min Ji / Motamedi, Shoaleh / Hoeft, Alice / Teller, Christa / Hamby, Tyler / Ray, Anish

Hematology reports

2023 Band 15, Heft 2, Seite(n) 256–265

Abstract: Hematologic tumors are mostly treated with chemotherapies that have poor toxicity profiles. While molecular tumor profiling can expand therapeutic options, our understanding of potential targetable drivers comes from studies of adult liquid tumors, which ...

Abstract	Hematologic tumors are mostly treated with chemotherapies that have poor toxicity profiles. While molecular tumor profiling can expand therapeutic options, our understanding of potential targetable drivers comes from studies of adult liquid tumors, which does not necessarily translate to efficacious treatment in pediatric liquid tumors. There is also no consensus on when profiling should be performed and its use in guiding therapies. We describe a single institution's experience in integrating profiling for liquid tumors. Pediatric patients diagnosed with leukemia or lymphoma and who underwent tumor profiling were retrospectively reviewed. Ten (83.3%) patients had relapsed disease prior to tumor profiling. Eleven (91.7%) patients had targetable alterations identified on profiling, and three (25%) received targeted therapy based on these variants. Of the three patients that received targeted therapy, two (66.7%) were living, and one (33.3%) decreased. For a portion of our relapsing and/or treatment-refractory patients, genetic profiling was feasible and useful in tailoring therapy to obtain stable or remission states. Practitioners may hesitate to deviate from the 'standard of therapy', resulting in the underutilization of profiling results. Prospective studies should identify actionable genetic variants found more frequently in pediatric liquid tumors and explore the benefits of proactive tumor profiling prior to the first relapse.
Sprache	Englisch
Erscheinungsdatum	2023-04-19
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2586645-X
ISSN	2038-8330 ; 2038-8322
ISSN (online)	2038-8330
ISSN	2038-8322
DOI	10.3390/hematolrep15020026
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Molecular Tumor Boards: The Next Step towards Precision Therapy in Cancer Care.

Liu, Angela / Vicenzi, Paige / Sharma, Ishna / Orr, Kaci / Teller, Christa / Koentz, Micha / Trinkman, Heidi / Vallance, Kelly / Ray, Anish

Hematology reports

2023 Band 15, Heft 2, Seite(n) 244–255

Abstract: The application of molecular tumor profiles in clinical decision making remains a challenge. To aid in the interpretation of complex biomarkers, molecular tumor boards (MTBs) have been established worldwide. In the present study, we show that a ... ...

Abstract	The application of molecular tumor profiles in clinical decision making remains a challenge. To aid in the interpretation of complex biomarkers, molecular tumor boards (MTBs) have been established worldwide. In the present study, we show that a multidisciplinary approach is essential to the success of MTBs. Our MTB, consisting of pediatric oncologists, pathologists, and pharmacists, evaluated 115 cases diagnosed between March 2016 and September 2021. If targetable mutations were identified, pharmacists aided in the evaluation of treatment options based on drug accessibility. Treatable genetic alterations detected through molecular testing most frequently involved the cell cycle. For 85% of the cases evaluated, our MTB provided treatment recommendations based on the patient's history and results of molecular tumor testing. Only three patients, however, received MTB-recommended targeted therapy, and only one of these patients demonstrated an improved clinical outcome. For the remaining patients, MTB-recommended treatment often was not administered because molecular tumor profiling was not performed until late in the disease course. For the three patients who did receive MTB-recommended therapy, such treatment was not administered until months after diagnosis due to physician preference. Thus, the education of healthcare providers regarding the benefits of targeted therapy may increase acceptance of these novel agents and subsequently improve patient survival.
Sprache	Englisch
Erscheinungsdatum	2023-04-04
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2586645-X
ISSN	2038-8330 ; 2038-8322
ISSN (online)	2038-8330
ISSN	2038-8322
DOI	10.3390/hematolrep15020025
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Factors Affecting Presentation and Treatment of Pediatric/Adolescent Cancer Patients Diagnosed With SARS-CoV-2.

Sharma, Ishna / Hamby, Tyler / Noorani, Sahil / Liu, Angela / Omar, Salma / Ahmad, Hufsa / Watts, Shelley / Hoeft, Alice / Whitworth, Suzanne / Ray, Anish

Journal of pediatric hematology/oncology

2023 Band 45, Heft 3, Seite(n) e304–e308

Abstract: Background: It is thought that the clinical course of actively treated pediatric/adolescent cancer patients diagnosed with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is more severe than experienced by the general pediatric population. ... ...

Abstract	Background: It is thought that the clinical course of actively treated pediatric/adolescent cancer patients diagnosed with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is more severe than experienced by the general pediatric population. We describe the clinical course, risk factors affecting presentation, and management of coronavirus disease 2019 (COVID-19) infection for these patients. Methods: Patients at a single institution receiving cancer therapy while diagnosed with SARS-CoV-2 between January 2020 and June 2021 were retrospectively reviewed. Data collected included age at SARS-CoV-2 diagnosis, sex, ethno-race, adjusted body mass index, and active therapies. Results: Twenty-nine patients met inclusion criteria, with 16 (55.2%) experiencing symptoms. Twenty-three (79.3%) patients required no institutional support; 10 (34.4%) required hospitalization, of which 80.0% required oxygen, 30.0% required intensive care, and 10.0% required intubation. Three (10.3%) patients developed MIS-C. Obesity increased odds of hospitalization (odds ratio=25.5; P =0.002) and oxygenation (odds ratio=14.88; P =0.012). Conclusions: Hospitalization and MIS-C rates were significantly higher than, whereas mortality rates and symptom presentations were consistent with, rates in the general pediatric population. Obesity was the only risk factor predictive of clinical severity. Cancer treatment modifications and pre-emptive administration of COVID-19 treatment did not modify clinical course.
Mesh-Begriff(e)	Humans ; Child ; Adolescent ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19 Testing ; Retrospective Studies ; COVID-19 Drug Treatment ; Obesity/complications ; Obesity/epidemiology ; Disease Progression ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/therapy
Sprache	Englisch
Erscheinungsdatum	2023-02-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002628
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: When do leaks occur? An analysis of the metabolic and bariatric surgery accreditation and quality improvement program.

Clapp, Benjamin / Corbett, John / Ahmad, Maria / Vivar, Andres / Sharma, Ishna / Hage, Karl / Ghanem, Omar M

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

2023 Band 19, Heft 10, Seite(n) 1128–1133

Abstract: Background: Leak is a feared complication of bariatric surgeries. Time to presentation is important in their management. We used the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) to evaluate the rate and timing ... ...

Abstract	Background: Leak is a feared complication of bariatric surgeries. Time to presentation is important in their management. We used the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) to evaluate the rate and timing of leaks. Objectives: To determine when leaks present after bariatric surgery. Setting: MBSAQIP database. Methods: The MBSAQIP Participant Use Files (PUF) for the years 2015-2020 were evaluated. Outcomes of interest were "organ space infection" and "leak." We evaluated the time to presentation for these variables as well as patient characteristics, operative time, complication rates and 30-day outcomes. Results: There were 370,369 sleeve gastrectomies (SG) and 159,280 Roux-en-Y gastric bypasses (RYGB). We identified 598 (.16%) SG leaks with an average time to presentation of 13.2 ± 7.8 days. For RYGB, there were 520 leaks (.32%) with an average time to presentation of 9.5 ± 7.4 days. Both procedures had longer operative times for the patients with leak; RYGB was 115 minutes versus 131 minutes and SG was 67 minutes versus 77 minutes (both P < .01). SG and RYGB patients with a leak had a higher relative risk (RR) of grade 4 and 5 Clavien-Dindo complication rates. RR of mortality rates in SG patients with leak was 35.2 (confidence interval (CI): 20-61) and in RYGB with leak was 31.4 (CI: 19-50). Conclusions: The length of time for SG leak presentation was more delayed than RYGB leak presentation. Surgeons should be vigilant for leaks for at least 3 weeks after surgery. Leaks increase the mortality rate and overall serious complications.
Mesh-Begriff(e)	Humans ; Obesity, Morbid/surgery ; Quality Improvement ; Treatment Outcome ; Retrospective Studies ; Bariatric Surgery ; Gastric Bypass ; Gastrectomy ; Accreditation
Sprache	Englisch
Erscheinungsdatum	2023-05-04
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2274243-8
ISSN	1878-7533 ; 1550-7289
ISSN (online)	1878-7533
ISSN	1550-7289
DOI	10.1016/j.soard.2023.04.334
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Traumatic complications of inpatient massage therapy: Case report and literature review.

Sharma, Ishna / Joseph, D'Andrea / Kirton, Orlando

Trauma case reports

2018 Band 18, Seite(n) 1–4

Sprache	Englisch
Erscheinungsdatum	2018-11-16
Erscheinungsland	Netherlands
Dokumenttyp	Case Reports
ZDB-ID	2835433-3
ISSN	2352-6440 ; 2352-6440
ISSN (online)	2352-6440
ISSN	2352-6440
DOI	10.1016/j.tcr.2018.11.003
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Artikel ; Online: Aspirin Use as a Risk Factor for Marginal Ulceration in Roux-en-Y Gastric Bypass Patients: A Meta-Analysis of 24,770 Patients.

Portela, Ray C / Sharma, Ishna / Vahibe, Ahmet / Hassan, Omer / Spaniolas, Konstantinos / Dayyeh, Barham Abu / Clapp, Benjamin / Ghanem, Omar M

The American surgeon

2022 Band 89, Heft 6, Seite(n) 2537–2544

Abstract: Background: Roux-en-Y gastric bypass (RYGB) is a recognized, safe bariatric procedure with minimal complications. Marginal ulceration, however, remains a challenging problem with an incidence of 8-12%. While chronic NSAID use is an established risk ... ...

Abstract	Background: Roux-en-Y gastric bypass (RYGB) is a recognized, safe bariatric procedure with minimal complications. Marginal ulceration, however, remains a challenging problem with an incidence of 8-12%. While chronic NSAID use is an established risk factor for ulcer formation, aspirin use itself as a cause for marginal ulceration is still unclear. We aim to compare the rates of marginal ulceration in RYGB with and without aspirin use. Methods: PubMed, ScienceDirect, Cochrane, Web of Science, and Google Scholar were searched for articles between 2008 and 2021 by two independent reviewers using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). The risk of bias was assessed using Newcastle-Ottawa Scale. Meta-analysis was conducted using a fixed-effect model. Results: From 5324 studies screened, we included 3 studies. Two studies had a low risk of bias, and the other one presented a high risk of bias on the Newcastle-Ottawa Scale. We included 24,770 patients, 1911 with aspirin use and 22,859 without aspirin use. After the meta-analysis, patients who used aspirin had a significantly higher marginal ulceration rate than those who did not (OR = 1.33 [95% CI 1.08 to 1.63], Conclusions: Aspirin use is associated with increased rates of marginal ulceration after RYGB.
Mesh-Begriff(e)	Humans ; Gastric Bypass/adverse effects ; Gastric Bypass/methods ; Ulcer ; Obesity, Morbid/surgery ; Aspirin/adverse effects ; Risk Factors ; Retrospective Studies
Chemische Substanzen	Aspirin (R16CO5Y76E)
Sprache	Englisch
Erscheinungsdatum	2022-05-18
Erscheinungsland	United States
Dokumenttyp	Meta-Analysis ; Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348221103647
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Pediatric Patient With Concurrent Eosinophilic Esophagitis, Erosive Reflux Esophagitis, and Barrett's Esophagus.

Sharma, Ishna / Foster, Chris / Jensen, Todd / Balarezo, Fabiola / Finck, Christine / Sayej, Wael

ACG case reports journal

2020 Band 7, Heft 6, Seite(n) e00399

Abstract: Eosinophilic esophagitis and Barrett's esophagus are believed to be separate disease processes, with erosive esophagitis leading to Barrett's esophagus. We report a rare case of concurrent diagnoses in a pediatric patient and examine the relevant genetic ...

Abstract	Eosinophilic esophagitis and Barrett's esophagus are believed to be separate disease processes, with erosive esophagitis leading to Barrett's esophagus. We report a rare case of concurrent diagnoses in a pediatric patient and examine the relevant genetic profiles in the esophagus.
Sprache	Englisch
Erscheinungsdatum	2020-06-24
Erscheinungsland	United States
Dokumenttyp	Case Reports
ZDB-ID	2814825-3
ISSN	2326-3253
ISSN	2326-3253
DOI	10.14309/crj.0000000000000399
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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