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  1. Article ; Online: Top tips for endoscopic diverticulotomy for Zenker's diverticula (with video).

    Sharma, Neil R

    Gastrointestinal endoscopy

    2022  Volume 97, Issue 2, Page(s) 365–368

    MeSH term(s) Humans ; Zenker Diverticulum/surgery ; Esophagoscopy
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Video-Audio Media ; Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2022.09.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 283: Show issues Location:
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  2. Article: Comparison of scissor-type knife to non-scissor-type knife for endoscopic submucosal dissection: a systematic review and meta-analysis.

    Gopakumar, Harishankar / Vohra, Ishaan / Reddy Puli, Srinivas / R Sharma, Neil

    Clinical endoscopy

    2024  Volume 57, Issue 1, Page(s) 36–47

    Abstract: Background/aims: Scissor-type endoscopic submucosal dissection (ST-ESD) knives can reduce the adverse events associated with ESDs. This study aimed to compare ST-ESD and non-scissor-type (NST)-ESD knives.: Methods: We identified ten studies that ... ...

    Abstract Background/aims: Scissor-type endoscopic submucosal dissection (ST-ESD) knives can reduce the adverse events associated with ESDs. This study aimed to compare ST-ESD and non-scissor-type (NST)-ESD knives.
    Methods: We identified ten studies that compared the performance characteristics and safety profiles of ST-ESD and NST-ESD knives. Fixed- and random-effects models were used to calculate the pooled proportions. Heterogeneity was assessed using the I2 test.
    Results: On comparing ST-ESD knives to NST-ESD knives, the weighted odds of en bloc resection was 1.61 (95% confidence interval [CI], 0.90-2.90; p=0.14), R0 resection was 1.10 (95% CI, 0.71-1.71; p=0.73), delayed bleeding was 0.40 (95% CI, 0.17-0.90; p=0.03), perforation was 0.35 (95% CI, 0.18-0.70; p<0.01) and ESD self-completion by non-experts was 1.89 (95% CI, 1.20-2.95; p<0.01). There was no heterogeneity, with an I2 score of 0% (95% CI, 0%-54.40%).
    Conclusion: The findings of reduced odds of perforation, a trend toward reduced delayed bleeding, and an improvement in the rates of en bloc and R0 resection with ST-ESD knives compared to NST-ESD knives support the use of ST-ESD knives when non-experts perform ESDs or as an adjunct tool for challenging ESD procedures.
    Language English
    Publishing date 2024-01-05
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2643507-X
    ISSN 2234-2443 ; 2234-2400
    ISSN (online) 2234-2443
    ISSN 2234-2400
    DOI 10.5946/ce.2023.122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Endoscopic spray cryotherapy for dysphagia palliation in esophageal cancer: Systematic review and meta-analysis.

    Gopakumar, Harishankar / Khan, Hamza / Sharma, Neil / Puli, Srinivas Reddy

    Endoscopy international open

    2024  Volume 12, Issue 2, Page(s) E211–E217

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2024-02-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-2231-7328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Diagnosis and Management of Pancreatic Cysts: A Comprehensive Review of the Literature.

    Singh, Ritu R / Gopakumar, Harishankar / Sharma, Neil R

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 3

    Abstract: The prevalence of pancreatic cysts has been rising due to the widespread use of cross-sectional imaging (CT scan and MRI) of the abdomen. While most pancreatic cysts are benign and do not require treatment or surveillance, a significant minority are ... ...

    Abstract The prevalence of pancreatic cysts has been rising due to the widespread use of cross-sectional imaging (CT scan and MRI) of the abdomen. While most pancreatic cysts are benign and do not require treatment or surveillance, a significant minority are premalignant and rarely malignant. The risk stratification of these lesions is not straightforward, and individual risk assessment, cyst size, distribution, and alarming morphologic features (when present) can guide the next steps in management. Neoplastic pancreatic cysts are mucinous or non-mucinous. Endoscopic ultrasound with fine-needle aspiration is often required to classify pancreatic cysts into mucinous and non-mucinous cysts and to assess the malignant potential. Advances in endoscopic techniques (confocal laser endomicroscopy, microforceps biopsy) can provide a definitive diagnosis of pancreatic cysts in some cases; however, the use of these techniques involves a higher risk of adverse events.
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13030550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Efficacy of self-assembling peptide in mitigating delayed bleeding after advanced endoscopic resection of gastrointestinal lesions: A meta-analysis.

    Gopakumar, Harishankar / Vohra, Ishaan / Sharma, Neil R / Puli, Srinivas R

    Endoscopy international open

    2023  Volume 11, Issue 5, Page(s) E553–E560

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2023-05-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-2057-4505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bilateral optic disc swelling in a man aged 32 years.

    Chew, Gem Rui Ping / Ouyang, Catherine Ming Hong / Nevin, Hunter / Sharma, Neil

    Australian journal of general practice

    2023  Volume 52, Issue 11, Page(s) 793–795

    MeSH term(s) Male ; Humans ; Optic Disk/diagnostic imaging ; Papilledema/diagnosis ; Papilledema/etiology ; Visual Acuity
    Language English
    Publishing date 2023-08-18
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2924889-9
    ISSN 2208-7958 ; 2208-794X
    ISSN (online) 2208-7958
    ISSN 2208-794X
    DOI 10.31128/AJGP-02-23-6735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2235: Show issues Location:
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  7. Article: Efficacy of scissor-type knife for endoscopic submucosal dissection: a systematic review and meta-analysis.

    Gopakumar, Harishankar / Vohra, Ishaan / Sharma, Neil R / Puli, Srinivas R

    Annals of gastroenterology

    2023  Volume 36, Issue 6, Page(s) 615–623

    Abstract: Background: Endoscopic submucosal dissection (ESD) is an effective resection technique for early cancers and large gastrointestinal luminal lesions. However, ESD is technically challenging, with the potential for severe adverse events. Scissor-type ESD ( ...

    Abstract Background: Endoscopic submucosal dissection (ESD) is an effective resection technique for early cancers and large gastrointestinal luminal lesions. However, ESD is technically challenging, with the potential for severe adverse events. Scissor-type ESD (ST-ESD) knives with an inner cutting edge and an electrically insulated external coating could mitigate some of these risks. This study aimed to evaluate the performance of ST electrosurgical knives when used for ESDs.
    Methods: Electronic databases were queried for studies from January 2005 through December 2022 evaluating the performance of ST-ESD knives. Fixed- and random-effects models were used to calculate pooled proportions. Heterogeneity was assessed using the I
    Results: Final analysis included data from 17 studies comprising 1652 ESD procedures. The pooled en bloc resection rate and R0 resection rate were 97.94% (95% confidence interval [CI] 97.20-98.57) and 94.32% (95%CI 93.11-95.43), respectively. The main adverse events were perforation and delayed post-procedural bleeding, with pooled rates of 1.07% (95%CI 0.63-1.62) and 1.86% (95%CI 1.26-2.56), respectively. There was no heterogeneity, as indicated by an I
    Conclusions: Our analysis shows that ST-ESD knives deliver consistently good performance across various locations in the gastrointestinal lumen and lesion sizes, with a good safety profile. This could be particularly appealing to newer adopters of ESD.
    Language English
    Publishing date 2023-10-30
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2023.0838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2455: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Clinical safety and outcomes of glucagon use during endoscopic retrograde cholangiopancreatography (ERCP).

    Perisetti, Abhilash / Goyal, Hemant / Sharma, Neil

    Endoscopy international open

    2022  Volume 10, Issue 4, Page(s) E558–E561

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2022-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-1747-3242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A systematic review on the efficacy of tranexamic acid in head and neck surgery.

    Jamshaid, Warda / Jamshaid, Maryam / Coulson, Chris / Sharma, Neil / Muzaffar, Jameel / Nieto, Hannah

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2023  Volume 48, Issue 4, Page(s) 527–539

    Abstract: Background: Intraoperative and postoperative blood loss is a major risk in head and neck (H&N) surgery. Recently the use of tranexamic acid (TXA) has been investigated by multiple studies for reducing intraoperative and postoperative bleeding, however ... ...

    Abstract Background: Intraoperative and postoperative blood loss is a major risk in head and neck (H&N) surgery. Recently the use of tranexamic acid (TXA) has been investigated by multiple studies for reducing intraoperative and postoperative bleeding, however reported results are variable.
    Objectives: To determine the safety and efficacy of TXA use in H&N surgery.
    Methods: Systematic review of MEDLINE, EMBASE, CINAHL, Cochrane Library, PubMed, ClinicalKey, and Clinicaltrials.gov according to the PRISMA guidelines. Studies were included if they reported on intraoperative bleeding, volume or duration of postoperative drain or return to theatre rate for postoperative haemorrhage in adult populations following use of TXA. Risk of bias assessment with Cochrane Risk of Bias (RoB2) tool for randomised controlled trials and Newcastle-Ottawa Scale tool for non-randomised studies.
    Results: Sixteen studies were identified (114 407 patients). Eight studies evaluated TXA in major H&N surgery and eight studies in tonsillectomy. Primary outcomes were reduction in intraoperative or postoperative bleeding. Secondary outcomes included the duration of postoperative drain placement and return to theatre rate. No adverse events were reported in any patients. TXA is effective in reducing intraoperative blood loss in tonsillectomy. However, the effect on posttonsillectomy haemorrhage was unclear. Insufficient evidence exists of benefit of TXA on intraoperative bleeding in major H&N procedures. Postoperative drainage volumes were significantly reduced in most major H&N studies. The duration of drain placement and risk of blood transfusion was unchanged in most cases.
    Conclusion: TXA use is safe in H&N patients. Whilst sufficient evidence exists to support the use of TXA in tonsillectomy, insufficient evidence exists to recommend use in major H&N surgery.
    MeSH term(s) Adult ; Humans ; Tranexamic Acid ; Antifibrinolytic Agents ; Postoperative Hemorrhage ; Blood Loss, Surgical ; Tonsillectomy
    Chemical Substances Tranexamic Acid (6T84R30KC1) ; Antifibrinolytic Agents
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.14059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1309: Show issues Location:
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  10. Article: Percutaneous Transhepatic Embolization of Ectopic Varices in a Patient With Portal Hypertension Presenting With Hemorrhagic Shock.

    Ohs, Zachary / Jones, Matthew / Sharma, Neil / Loveridge, Kristian

    Cureus

    2021  Volume 13, Issue 9, Page(s) e18209

    Abstract: Varices secondary to portal hypertension in the setting of liver cirrhosis typically occur in the gastroesophageal region. Management guidelines for bleeding gastroesophageal varices are well established in the literature. Ectopic varices that occur ... ...

    Abstract Varices secondary to portal hypertension in the setting of liver cirrhosis typically occur in the gastroesophageal region. Management guidelines for bleeding gastroesophageal varices are well established in the literature. Ectopic varices that occur outside of this typical location are an uncommon complication of portal hypertension. Rarely, these varices can result in life-threatening hemorrhage. Management guidelines of ectopic variceal bleeds are not yet standardized as cases are rare and treatment approach in the literature has historically varied. We present an interesting case of a 37-year-old patient with alcoholic liver disease and cirrhosis who developed spontaneous hemorrhage and shock from bleeding ectopic varices. This report exemplifies how coil embolization via a percutaneous transhepatic approach can be used to manage ectopic variceal bleeds in the setting of hemorrhagic shock.
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.18209
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