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  1. Book ; Online: Immunosuppression and Immunomodulation

    Tyagi, Rajeev K / Sharma, Prakriti / Sharma, Praveen

    2023  

    Keywords Immunology ; immune system ; cancer ; immunotherapy ; pregnancy ; exosomes ; oxidation
    Language English
    Size 1 electronic resource (206 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030381171
    ISBN 9781837680733 ; 1837680736
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Molecular diagnostics in cancer patients

    Shukla, Kamla Kant / Sharma, Praveen / Misra, Sanjeev

    2019  

    Author's details Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra editors
    Keywords Oncology
    Language English
    Size 1 Online-Ressource (viii, 341 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020029705
    ISBN 978-981-135-877-7 ; 9789811358760 ; 981-135-877-X ; 9811358761
    DOI 10.1007/978-981-13-5877-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Over 30 Years of Omeprazole.

    Sharma, Praveen

    The Journal of the Association of Physicians of India

    2023  Volume 71, Issue 8, Page(s) 11–12

    Abstract: Background: In the last 3 decades, omeprazole has proved its mettle in managing acid peptic diseases (APDs). It has established itself as the first line of therapy for duodenal and gastric ulcers, gastroesophageal reflux disease (GERD), ulcers due to ... ...

    Abstract Background: In the last 3 decades, omeprazole has proved its mettle in managing acid peptic diseases (APDs). It has established itself as the first line of therapy for duodenal and gastric ulcers, gastroesophageal reflux disease (GERD), ulcers due to nonsteroidal anti-inflammatory drugs (NSAID), and Zollinger-Ellison syndrome (ZES).
    Objectives: The purpose of this literature review is to assess the effectiveness of omeprazole as compared to the other proton pump inhibitors (PPIs) currently in use and its safety and efficacy in special populations, including the pediatric and geriatric populations.
    Results: Omeprazole was found to be the most effective PPI in the management of APDs due to its rapid action, good antioxidant effects, and effectiveness against nocturnal acid breakthroughs. Its safety and tolerance have been proved in various randomized controlled trials.
    Conclusion: Omeprazole is the prototypical drug in the management of APDs and has withstood the test of time. After 3 decades, omeprazole remains the drug of choice in managing APD.
    MeSH term(s) Humans ; Child ; Aged ; Omeprazole/therapeutic use ; Proton Pump Inhibitors/therapeutic use ; Gastroesophageal Reflux/drug therapy ; Stomach Ulcer ; Anti-Inflammatory Agents, Non-Steroidal
    Chemical Substances Omeprazole (KG60484QX9) ; Proton Pump Inhibitors ; Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2023-08-31
    Publishing country India
    Document type Review ; Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    DOI 10.59556/japi.71.0322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Review on Microencapsulation as Method of Drug Delivery

    Chaturvedi Priyanka / Sharma Praveen

    BIO Web of Conferences, Vol 86, p

    2024  Volume 01033

    Abstract: Microencapsulation can be described as heavy, fluid or gaseous substance packaging engineering with thin polymeric coatings, creating small particles called microcapsules. Microencapsulation is very helpful to increase the solubility of drugs. For the ... ...

    Abstract Microencapsulation can be described as heavy, fluid or gaseous substance packaging engineering with thin polymeric coatings, creating small particles called microcapsules. Microencapsulation is very helpful to increase the solubility of drugs. For the drugs of BCS Class-II we use this technique which enables us to get more solubility and increase dissolution profile. This is a novel method of drug delivery. In future aspect we can use this technique in the foodindustry, beverages. A microencapsulation approach for the preparation of an intrauterine contraceptionsystem was alsosuggested. This technique is helpful to overcome poor solubility, low Bioavaibility and less stability.This method also gives more control over the drawback of conventional dosages form.
    Keywords microencapsulation ; bioavailability ; solubility ; novel drug delivery ; Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Value of Liver Function Tests in Cirrhosis.

    Sharma, Praveen

    Journal of clinical and experimental hepatology

    2021  Volume 12, Issue 3, Page(s) 948–964

    Abstract: The liver comprises both parenchymal and non-parenchymal cells with varying functions. Cirrhosis is often complicated by the development of portal hypertension and its associated complications. Hence, assessment of liver in cirrhosis should include ... ...

    Abstract The liver comprises both parenchymal and non-parenchymal cells with varying functions. Cirrhosis is often complicated by the development of portal hypertension and its associated complications. Hence, assessment of liver in cirrhosis should include assessment of its structural, function of both hepatic and non-hepatic tissue and haemodynamic assessment of portal hypertension. There is no single test that can evaluate all functions of liver and assess prevalence and severity of portal hypertension. Commonly available tests like serum bilirubin, liver enzymes (alanine [ALT] and aspartate aminotransferase [AST], serum alkaline phosphatase [ALP], gamma glutamyl transpeptidase [GGT]), serum albumin and prothrombin time for assessment of liver functions partly assess liver functions. quantitative liver functions like indocyanine clearance tests [ICG-K], methacetin breath test [MBT] were developed to assess dynamic status of liver but has its own limitation and availability. Imaging based assessment of liver by transient elastography, MRI based 99 mTc-coupled asialoglycoprotein mebrofenin scan help the clinician to assess liver function, functional volume of liver left after surgery and portal hypertension [PH]. Hepatic venous pressure gradient still remains the gold standard for the assessment of portal hypertension but is invasive and not available in all centres. Combinations of blood parameters in form of various indices like fibrosis score of 4 [FIB-4], Lok index, scores like model for end stage liver disease (MELD) and Child-Turcotte Pugh score are commonly used for assessing liver function in clinical practice.
    Language English
    Publishing date 2021-11-14
    Publishing country India
    Document type Journal Article ; Review
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2021.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: An Update on the Links Between Periodontal Health and General Health.

    Sharma, Praveen

    Primary dental journal

    2020  Volume 8, Issue 4, Page(s) 22–27

    Abstract: It should come as no surprise to the reader that the oral cavity, including the periodontal tissues, are not somehow disjointed from the rest of the body. In this paper, we will explore the links between the periodontal and general health of our patients ...

    Abstract It should come as no surprise to the reader that the oral cavity, including the periodontal tissues, are not somehow disjointed from the rest of the body. In this paper, we will explore the links between the periodontal and general health of our patients in both directions. That is to say we will explore how someone's general or systemic health conditions/habits are likely to affect their periodontal health, and how someone's periodontal health is likely to affect their systemic health.<br/> Before exploring these links, we will discuss the distinction between an association and a causal relationship, which is a subtle but vital distinction to make. We will then discuss the role of systemic conditions/habits such as diabetes, smoking, diet and stress on the periodontal health of individuals. Following from this, we will discuss the potential influence of the periodontal health of our patients on their systemic health, focussing on the more established links with diabetes and cardiovascular diseases as well as exploring the mechanisms by which these links may exist.<br/> We will conclude with some tips on the holistic care of our patients, incorporating changes that will benefit their oral and systemic health.
    MeSH term(s) Cardiovascular Diseases ; Humans ; Periodontal Diseases ; Smoking
    Language English
    Publishing date 2020-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2685942-7
    ISSN 2050-1684
    ISSN 2050-1684
    DOI 10.1308/205016820828463799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6971: Show issues Location:
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  7. Article: Basic Understanding of Liver Transplant Immunology.

    Sharma, Praveen / Arora, Anil

    Journal of clinical and experimental hepatology

    2023  Volume 13, Issue 6, Page(s) 1091–1102

    Abstract: The liver is a specialized organ and plays an important role in our immune system. The liver constitutes parenchymal cells which are hepatocytes and cholangiocytes (60-80%) and non-parenchymal cells like liver sinusoidal endothelial cells (LSECs), ... ...

    Abstract The liver is a specialized organ and plays an important role in our immune system. The liver constitutes parenchymal cells which are hepatocytes and cholangiocytes (60-80%) and non-parenchymal cells like liver sinusoidal endothelial cells (LSECs), hepatic satellite/Ito cells, Kupffer cells, neutrophils, mononuclear cells, T and B lymphocytes (conventional and non-conventional), natural killer cells, and natural killer T (NKT) cells. The liver mounts a rapid and strong immune response, under unfavorable conditions and acts as an immune tolerance to a variety of non-pathogenic antigens. This delicate and dynamic interaction between different kinds of immune cells in the liver maintains a balance between immune screening and immune tolerance. The liver allografts are privileged immunologically; however, allograft rejection is not uncommon and is classified as cell or antibody-mediated. Advancements in transplant immunology help in the prevention of allografts rejection by immune reactions of the host thus leading to better graft and host survival. Fewer patients may not require immunosuppression due to systemic donor-specific T-cell tolerance. The liver tolerance mechanism is poorly studied, and LSEC and unconventional lymphocytes play an important role that dampens T cell response either by inducing apoptosis of cells or inhibiting co-stimulatory pathways. Newer cell-based therapy based on Treg, dendritic cells, and mesenchymal stromal cells will probably change the future of immunosuppression. Various invasive and non-invasive biomarkers and artificial intelligence have also been investigated to predict graft survival, post-transplant complications, and immunotolerance in the future.
    Language English
    Publishing date 2023-05-26
    Publishing country India
    Document type Journal Article ; Review
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2023.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Evaluation of Polydimethylsiloxane (PDMS) as a Substrate for the Realization of Flexible/Wearable Antennas and Sensors.

    Sharma, Praveen Kumar / Chung, Jae-Young

    Micromachines

    2023  Volume 14, Issue 4

    Abstract: To demonstrate that the silicone-based polymer polydimethylsiloxane (PDMS) is suitable as a substrate for flexible/wearable antennae and sensors, an investigation of its various properties was carried out. The substrate was first developed in compliance ... ...

    Abstract To demonstrate that the silicone-based polymer polydimethylsiloxane (PDMS) is suitable as a substrate for flexible/wearable antennae and sensors, an investigation of its various properties was carried out. The substrate was first developed in compliance with the requirements, and then its anisotropy was investigated using an experimental bi-resonator approach. This material exhibited modest but discernible anisotropy, with values of ~6.2/25 % for the dielectric constant and loss tangent, respectively. Its anisotropic behavior was confirmed by a parallel dielectric constant (
    Language English
    Publishing date 2023-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14040735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Cancer Stem Cells: Future Possibilities for Cancer Therapy.

    Dwivedi, Shailendra / Sharma, Praveen

    Indian journal of clinical biochemistry : IJCB

    2023  Volume 38, Issue 2, Page(s) 149–150

    Language English
    Publishing date 2023-03-21
    Publishing country India
    Document type Editorial
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-023-01133-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Reliving 25 years of Experience with Omeprazole in Acid-peptic Diseases.

    Sharma, Praveen

    The Journal of the Association of Physicians of India

    2019  Volume 66, Issue 8, Page(s) 72–78

    Abstract: Background: Acid-peptic diseases (APDs) are commonly encountered in clinical practice. The identification of proton pump and the subsequent introduction of proton pump inhibitors (PPIs) can be heralded as a milestone in the treatment of APDs. They have ... ...

    Abstract Background: Acid-peptic diseases (APDs) are commonly encountered in clinical practice. The identification of proton pump and the subsequent introduction of proton pump inhibitors (PPIs) can be heralded as a milestone in the treatment of APDs. They have been used for the past 25 years with a good track record of safety. Omeprazole is a well-established and most studied drug in the PPI class.
    Objectives and methods: This review is an objective overview of the efficacy and safety of PPIs in APDs, with special focus on omeprazole.
    Results: The efficacy of omeprazole in gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD), including those caused by non-steroidal antiinflammatory drugs (NSAIDs) is well documented. In clinical studies, the newer, more potent PPIs, used at comparable doses, have not shown greater efficacy than omeprazole. The PPIs are in general well-tolerated. Most of the concerns regarding their long-term safety have been unfounded.
    Conclusion: Twenty five years after the introduction of omeprazole, the first of the PPIs, omeprazole has still remained a valuable drug in the armamentarium of clinicians.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal ; Anti-Ulcer Agents ; Gastroesophageal Reflux ; Humans ; Omeprazole ; Peptic Ulcer ; Proton Pump Inhibitors
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Anti-Ulcer Agents ; Proton Pump Inhibitors ; Omeprazole (KG60484QX9)
    Language English
    Publishing date 2019-07-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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