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Article: Editorial: Retinal Changes in Neurological Diseases.

Sharma, Samridhi / You, Yuyi

2022 Volume 15, Page(s) 813044

Language	English
Publishing date	2022-01-14
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.813044
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Article: A Case of “Telogen Effluvium” Cured by Individualized Medicine

Gupta, Yogeshwari / Chahar, Anshul / Sharma, Samridhi

Homœopathic Links

2024 Volume 37, Issue 02, Page(s) 119–120

Language	English
Publishing date	2024-03-26
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1199312-1
ISSN	1860-3149 ; 1019-2050
ISSN (online)	1860-3149
ISSN	1019-2050
DOI	10.1055/s-0044-1785233
Database	Thieme publisher's database

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Article ; Online: Antibiotic procurement and ABC analysis for a comprehensive primary health care clinic in the Eastern Cape province, South Africa.

Sharma, Samridhi / Tandlich, Roman / Docrat, Mohamed / Srinivas, Sunitha

Southern African journal of infectious diseases

2020 Volume 35, Issue 1, Page(s) 134

Abstract: Background: Antimicrobial resistance (AMR), a major threat to global public health, can be addressed using a managed care approach. This includes timely analysis of antibiotic consumption and procurement data to drive evidence-based policies and ... ...

Abstract	Background: Antimicrobial resistance (AMR), a major threat to global public health, can be addressed using a managed care approach. This includes timely analysis of antibiotic consumption and procurement data to drive evidence-based policies and practices in healthcare facilities. 'ABC analysis' presents an opportunity for this. Methods: ABC analysis data for a comprehensive Primary Health Care (PHC) clinic in the Eastern Cape province of South Africa was obtained from the Provincial Department of Health for 01 April 2015 to 31 March 2018. Procured antibiotics were analysed on the quantities purchased, total cost, route of administration and spectrum of activity. Antibiotic categorization was also carried out according to the Results: Antibiotics made up approximately 7% of the total annual pharmaceutical expenditure. A total of 31, 35 and 34 antibiotics were procured in the first, second and third years, respectively. The most procured antibiotics were: (1) isoniazid, (2) flucloxacillin, (3) azithromycin, (4) a combination of rifampicin, isoniazid, pyrazinamide, and ethambutol and (5) amoxicillin. Overall, 55%, 2% and 15% of antibiotics accounted for the 'Access', 'Watch' and 'Access and Watch' categories, respectively, of the WHO EML. No 'Reserve' antibiotics were procured. The remaining 28% were antituberculosis medicines. Altogether, 89%, 8% and 3% of the antibiotics were respectively administered orally, systemically, and topically. A total of 58% were broad-spectrum and 42% were narrow-spectrum antibiotics. Conclusion: Oral antibiotics in the 'Access' category presented favourable usage of antibiotics. Decreasing the use of broad-spectrum antibiotics requires consideration.
Language	English
Publishing date	2020-11-25
Publishing country	South Africa
Document type	Journal Article
ZDB-ID	3046282-4
ISSN	2313-1810 ; 2312-0053
ISSN (online)	2313-1810
ISSN	2312-0053
DOI	10.4102/sajid.v35i1.134
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Article: Effective use of telemedicine in Mumbai with a cohort of extensively drug-resistant "XDR" tuberculosis patients on bedaquiline during COVID-19 pandemic.

Udwadia, Zarir F / Sharma, Samridhi / Mullerpattan, Jai B / Gajjar, Ishita / Pinto, Lancelot

Lung India : official organ of Indian Chest Society

2021 Volume 38, Issue 1, Page(s) 98–99

Language	English
Publishing date	2021-01-05
Publishing country	India
Document type	Journal Article
ZDB-ID	2410801-7
ISSN	0974-598X ; 0970-2113
ISSN (online)	0974-598X
ISSN	0970-2113
DOI	10.4103/lungindia.lungindia_464_20
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Article ; Online: Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions.

Palanivel, Viswanthram / Gupta, Vivek / Mirshahvaladi, Seyed Shahab Oddin / Sharma, Samridhi / Gupta, Veer / Chitranshi, Nitin / Mirzaei, Mehdi / Graham, Stuart L / Basavarajappa, Devaraj

Cells

2022 Volume 11, Issue 22

Abstract: Neuropeptide Y (NPY), a sympathetic neurotransmitter, is involved in various physiological functions, and its dysregulation is implicated in several neurodegenerative diseases. Glutamate excitotoxicity, endoplasmic reticulum (ER) stress, and oxidative ... ...

Abstract	Neuropeptide Y (NPY), a sympathetic neurotransmitter, is involved in various physiological functions, and its dysregulation is implicated in several neurodegenerative diseases. Glutamate excitotoxicity, endoplasmic reticulum (ER) stress, and oxidative stress are the common mechanisms associated with numerous neurodegenerative illnesses. The present study aimed to elucidate the protective effects of NPY against glutamate toxicity and tunicamycin-induced ER stress in the human neuroblastoma SH-SY5Y cell line. We exposed the SH-SY5Y cells to glutamate and tunicamycin for two different time points and analyzed the protective effects of NPY at different concentrations. The protective effects of NPY treatments were assessed by cell viability assay, and the signalling pathway changes were evaluated by biochemical techniques such as Western blotting and immunofluorescence assays. Our results showed that treatment of SH-SY5Y cells with NPY significantly increased the viability of the cells in both glutamate toxicity and ER stress conditions. NPY treatments significantly attenuated the glutamate-induced pro-apoptotic activation of ERK1/2 and JNK/BAD pathways. The protective effects of NPY were further evident against tunicamycin-induced ER stress. NPY treatments significantly suppressed the ER stress activation by downregulating BiP, phospho-eIF2α, and CHOP expression. In addition, NPY alleviated the Akt/FoxO3a pathway in acute oxidative conditions caused by glutamate and tunicamycin in SH-SY5Y cells. Our results demonstrated that NPY is neuroprotective against glutamate-induced cell toxicity and tunicamycin-induced ER stress through anti-apoptotic actions.
MeSH term(s)	Humans ; Neuroprotective Agents/pharmacology ; Neuropeptide Y/pharmacology ; Neuroblastoma ; Glutamic Acid/toxicity ; Tunicamycin/pharmacology ; Cell Line, Tumor
Chemical Substances	Neuroprotective Agents ; Neuropeptide Y ; Glutamic Acid (3KX376GY7L) ; Tunicamycin (11089-65-9)
Language	English
Publishing date	2022-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11223665
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Article ; Online: Revisiting the therapeutic potential of gingerols against different pharmacological activities.

Sharma, Samridhi / Shukla, Monu Kumar / Sharma, Krishan Chander / Tirath / Kumar, Lokender / Anal, Jasha Momo H / Upadhyay, Santosh Kumar / Bhattacharyya, Sanjib / Kumar, Deepak

Naunyn-Schmiedeberg's archives of pharmacology

2022 Volume 396, Issue 4, Page(s) 633–647

Abstract: The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic ... ...

Abstract	The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer's disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases.
MeSH term(s)	Catechols/pharmacology ; Catechols/therapeutic use ; Fatty Alcohols/pharmacology ; Fatty Alcohols/therapeutic use ; Fatty Alcohols/chemistry ; Plant Extracts/chemistry ; Zingiber officinale/chemistry ; Zingiber officinale/metabolism
Chemical Substances	gingerol (925QK2Z900) ; ginger extract (C5529G5JPQ) ; Catechols ; Fatty Alcohols ; Plant Extracts
Language	English
Publishing date	2022-12-31
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-022-02372-7
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Article: Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell–cell interactions in the pathophysiology of neurological disease

Godinez, Angela / Rajput, Rashi / Chitranshi, Nitin / Gupta, Veer / Basavarajappa, Devaraj / Sharma, Samridhi / You, Yuyi / Pushpitha, Kanishka / Dhiman, Kunal / Mirzaei, Mehdi / Graham, Stuart / Gupta, Vivek

Cellular and molecular life sciences. 2022 Mar., v. 79, no. 3

2022

Abstract: Neuroserpin is an axonally secreted serpin that is involved in regulating plasminogen and its enzyme activators, such as tissue plasminogen activator (tPA). The protein has been increasingly shown to play key roles in neuronal development, plasticity, ... ...

Abstract	Neuroserpin is an axonally secreted serpin that is involved in regulating plasminogen and its enzyme activators, such as tissue plasminogen activator (tPA). The protein has been increasingly shown to play key roles in neuronal development, plasticity, maturation and synaptic refinement. The proteinase inhibitor may function both independently and through tPA-dependent mechanisms. Herein, we discuss the recent evidence regarding the role of neuroserpin in healthy and diseased conditions and highlight the participation of the serpin in various cellular signalling pathways. Several polymorphisms and mutations have also been identified in the protein that may affect the serpin conformation, leading to polymer formation and its intracellular accumulation. The current understanding of the involvement of neuroserpin in Alzheimer’s disease, cancer, glaucoma, stroke, neuropsychiatric disorders and familial encephalopathy with neuroserpin inclusion bodies (FENIB) is presented. To truly understand the detrimental consequences of neuroserpin dysfunction and the effective therapeutic targeting of this molecule in pathological conditions, a cross-disciplinary understanding of neuroserpin alterations and its cellular signaling networks is essential.
Keywords	encephalopathy ; glaucoma ; neurons ; pathophysiology ; plasminogen ; plasticity ; polymers ; proteinase inhibitors ; stroke ; t-plasminogen activator ; therapeutics
Language	English
Dates of publication	2022-03
Size	p. 172.
Publishing place	Springer International Publishing
Document type	Article
Note	Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-022-04185-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In Silico Peptide Repertoire of Human Olfactory Receptor Proteomes on High-Stringency Mass Spectrometry.

Adhikari, Subash / Sharma, Samridhi / Ahn, Seong Beom / Baker, Mark S

Journal of proteome research

2019 Volume 18, Issue 12, Page(s) 4117–4123

Abstract: Human olfactory receptors (ORs) are seven-pass transmembrane G-protein coupled receptors (GPCR) involved in smell perception and many other signaling pathways. They are primarily expressed in the olfactory epithelium and ectopically expressed in several ... ...

Abstract	Human olfactory receptors (ORs) are seven-pass transmembrane G-protein coupled receptors (GPCR) involved in smell perception and many other signaling pathways. They are primarily expressed in the olfactory epithelium and ectopically expressed in several other organs and tissues. neXtProt contains 4 PE1 (protein existence 1, evidenced at the protein level) ORs, determined on the basis of either protein interaction data (i.e., OR1D4 and OR2AG1) or convincing genetic, haplotype, or biochemical data (i.e., OR1D2 and OR2J3). Not a single OR currently qualifies for neXtProt PE1 status based on mass spectrometry (MS) evidence. Many reasons for this absence of MS-based identification have been proposed, including (i) confined or spatiotemporal or developmental expression, (ii) low copy number, (iii) OR repertoire gene silencing, and (iv) limited tissue availability. OR transmembrane domains (TMDs) inherently limit MS identification because the hydrophobic nature restricts the access of trypsin to potential cleavage sites. Equally, the extremely low frequency or lack of accessible arginine and lysine residues in TMDs renders trypsin cleavage ineffective. Here, we demonstrate an analytical approach specifically focused on the hydrophilic (trypsin-accessible) domains of ORs [i.e., with all transmembrane segments and anchored peptides excluded). We predicted the ability of OR soluble (hydrophilic) domains to yield 2 or more >9 amino acids (aa) length unique mapping (unique to a protein only), non-nested (peptides with varying length at the N or C terminal but containing the same core sequence), leucine/isoleucine (I/L) switch examined (I and L have same mass and cannot be distinguished by MS) tryptic peptides. Our analysis showed that ∼58% of the human OR proteome could potentially generate tryptic peptides that satisfy current the Human Proteome Project data interpretation guidelines (version 2.1) when no missed cleavages are allowed and increases to ∼78% when one missed cleavage is allowed. The utilization of current biological data (adjuvant genomics, expression profile, transcriptomics, epigenome silencing data, etc.) and the adoption of a non-conventional proteomics approach (e.g., Confetti multiprotease digestion, CNBr cleavage of TMDs, and more-extreme chromatographic and MS methods) could aid in the detection of the remaining ORs.
MeSH term(s)	Computer Simulation ; Databases, Protein ; Humans ; Hydrophobic and Hydrophilic Interactions ; Mass Spectrometry/methods ; Peptides ; Protein Domains ; Proteome ; Proteomics/methods ; Receptors, Odorant/chemistry ; Receptors, Odorant/metabolism ; Trypsin/chemistry ; Trypsin/metabolism
Chemical Substances	Peptides ; Proteome ; Receptors, Odorant ; Trypsin (EC 3.4.21.4)
Language	English
Publishing date	2019-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.8b00494
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Article ; Online: Neuroserpin gene therapy inhibits retinal ganglion cell apoptosis and promotes functional preservation in glaucoma.

Chitranshi, Nitin / Rajput, Rashi / Godinez, Angela / Pushpitha, Kanishka / Mirzaei, Mehdi / Basavarajappa, Devaraj / Gupta, Veer / Sharma, Samridhi / You, Yuyi / Galliciotti, Giovanna / Salekdeh, Ghasem H / Baker, Mark S / Graham, Stuart L / Gupta, Vivek K

Molecular therapy : the journal of the American Society of Gene Therapy

2023 Volume 31, Issue 7, Page(s) 2056–2076

Abstract: Our research has proven that the inhibitory activity of the serine protease inhibitor neuroserpin (NS) is impaired because of its oxidation deactivation in glaucoma. Using genetic NS knockout ( ... ...

Abstract	Our research has proven that the inhibitory activity of the serine protease inhibitor neuroserpin (NS) is impaired because of its oxidation deactivation in glaucoma. Using genetic NS knockout (NS
MeSH term(s)	Mice ; Animals ; Retinal Ganglion Cells/metabolism ; Beclin-1/metabolism ; Disease Models, Animal ; Glaucoma/genetics ; Glaucoma/therapy ; Glaucoma/metabolism ; Apoptosis/genetics ; Intraocular Pressure ; Neuroserpin
Chemical Substances	Beclin-1
Language	English
Publishing date	2023-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2023.03.008
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Article ; Online: Computational refinement identifies functional destructive single nucleotide polymorphisms associated with human retinoid X receptor gene.

Sarkar, Soumalya / Gupta, Vivek K / Sharma, Samridhi / Shen, Ting / Gupta, Veer / Mirzaei, Mehdi / Graham, Stuart L / Chitranshi, Nitin

Journal of biomolecular structure & dynamics

2021 Volume 41, Issue 4, Page(s) 1458–1478

Abstract: Alterations in the nuclear retinoid X receptor (RXRs) signalling have been implicated in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis and glaucoma. Single nucleotide polymorphisms (SNPs) are the ...

Abstract	Alterations in the nuclear retinoid X receptor (RXRs) signalling have been implicated in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis and glaucoma. Single nucleotide polymorphisms (SNPs) are the main cause underlying single nucleic acid variations which in turn determine heterogeneity within various populations. These genetic polymorphisms have been suggested to associate with various degenerative disorders in population-wide analysis. This bioinformatics study was designed to investigate, search, retrieve and identify deleterious SNPs which may affect the structure and function of various RXR isoforms through a computational and molecular modelling approach. Amongst the 1,813 retrieved SNPs several were found to be deleterious with rs140464195_G139R, rs368400425_R358W and rs368586400_L383F
MeSH term(s)	Humans ; Polymorphism, Single Nucleotide/genetics ; Retinoid X Receptors/genetics ; Models, Molecular ; Mutation ; Mutation, Missense ; Computational Biology/methods
Chemical Substances	Retinoid X Receptors
Language	English
Publishing date	2021-12-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2021.2021991
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