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  1. Article ; Online: Effect of lead exposure on histone modifications: A review.

    Kumar, Kanishka / Anjali, Sudha / Sharma, Shailja

    Journal of biochemical and molecular toxicology

    2023  Volume 38, Issue 1, Page(s) e23547

    Abstract: Lead at any levels can result in detrimental health effects affecting various organ systems. These systematic manifestations under Pb exposure and the underlying probable pathophysiological mechanisms have not been elucidated completely. With ... ...

    Abstract Lead at any levels can result in detrimental health effects affecting various organ systems. These systematic manifestations under Pb exposure and the underlying probable pathophysiological mechanisms have not been elucidated completely. With advancements in molecular research under Pb exposure, epigenetics is one of the emerging field that has opened many possibilities for appreciating the role of Pb exposure in modulating gene expression profiles. In terms of epigenetic alterations reported in Pb toxicity, DNA methylation, and microRNA alterations are extensively explored in both experimental and epidemiological studies, however, the understanding of histone modifications under Pb exposure is still in its infant stage limited to experimental models. In this review, we aim to present a synoptic view of histone modifications explored in relation to Pb exposure attempting to bring out this potential lacunae in research. The scarcity of studies associating histone modifications with Pb toxicity, and the paucity of their validation in human cohort further emphasizes the strong research potential of this field. We summarize the review by presenting our hypotheses regarding the involvement of these histone modification in various diseases modalities associated with Pb toxicity.
    MeSH term(s) Humans ; Histone Code ; Lead/toxicity ; Epigenesis, Genetic ; DNA Methylation ; Protein Processing, Post-Translational
    Chemical Substances Lead (2P299V784P)
    Language English
    Publishing date 2023-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23547
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  2. Article ; Online: The efficacy of mindfulness-based intervention in ameliorating externalizing behaviors and attentional concerns among college students.

    Sharma, Shailja / Palomares-Fernandez, Ronald

    Journal of American college health : J of ACH

    2021  Volume 71, Issue 3, Page(s) 862–870

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Child ; Humans ; Mindfulness/methods ; Students ; Universities ; Attention ; Stress, Psychological/therapy
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604907-2
    ISSN 1940-3208 ; 0744-8481
    ISSN (online) 1940-3208
    ISSN 0744-8481
    DOI 10.1080/07448481.2021.1909038
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    Zs.A 427: Show issues Location:
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  3. Article ; Online: Systematic mapping on the importance of vultures in the Indian public health discourse.

    Jalihal, Smriti / Rana, Shweta / Sharma, Shailja

    Environmental sustainability (Singapore)

    2022  Volume 5, Issue 2, Page(s) 135–143

    Abstract: Vultures are of immense ecological significance to forest and urban ecosystems. These birds play a major role in curbing environmental contamination through scavenging on carcasses. Prevention of spread of diseases is pivotal for public health and is an ... ...

    Abstract Vultures are of immense ecological significance to forest and urban ecosystems. These birds play a major role in curbing environmental contamination through scavenging on carcasses. Prevention of spread of diseases is pivotal for public health and is an inexorable economic burden for any country. We present the crucial role vultures can play in disease mitigation and public health by regulating or decreasing the spread of zoonotic diseases. We elaborate examples from three zoonotic diseases; rabies, brucellosis and tuberculosis, which spread among dogs and cattle as well as human population. We establish the viable links in the transmission of these diseases from the infected dead and alive animals to humans and their possible exacerbation in the absence of vultures. These indirect links help formulate the case for increased interventions for disease spread and control along with conservation of these scavengers. Their role as natural and effective cleaners of the environment in the Indian health discourse is of importance because they can reduce the expenses of the government in waste management and maintenance of public health.
    Language English
    Publishing date 2022-04-12
    Publishing country Singapore
    Document type Journal Article ; Review
    ISSN 2523-8922
    ISSN (online) 2523-8922
    DOI 10.1007/s42398-022-00224-x
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  4. Article ; Online: Experimental setup for the Seebeck and Nernst coefficient measurements.

    Sharma, Shailja / Yadav, C S

    The Review of scientific instruments

    2020  Volume 91, Issue 12, Page(s) 123907

    Abstract: A new experimental setup is designed for the measurement of Seebeck and Nernst coefficients on the single crystal flakes and polycrystalline samples. The setup utilizes the multifunctional probe assembly of the physical property measurement system by ... ...

    Abstract A new experimental setup is designed for the measurement of Seebeck and Nernst coefficients on the single crystal flakes and polycrystalline samples. The setup utilizes the multifunctional probe assembly of the physical property measurement system by Quantum Design, Inc. and can measure in the temperature range of 1.8 K-380 K up to 8 T magnetic fields. The experimental measurement was fully automated through a computer using the code written in LabVIEW software. The setup is capable of measurements on samples as small as 2 × 1 mm
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0031544
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  5. Article: Concerns of Frontline Doctors in India during COVID-19: A Cross-Sectional Survey.

    Singh, Harshvardhan / Sharma, Shailja

    Indian journal of public health

    2020  Volume 64, Issue Supplement, Page(s) S237–S239

    Abstract: A rapid cross-sectional survey was conducted across India among frontline allopathic doctors to know their prime concerns. Four hundred and five responses were received from 16 states and 3 union territories. Among doctors working in COVID-dedicated ... ...

    Abstract A rapid cross-sectional survey was conducted across India among frontline allopathic doctors to know their prime concerns. Four hundred and five responses were received from 16 states and 3 union territories. Among doctors working in COVID-dedicated hospitals, 56.18% are formally trained for the same, and 40.5% of these are satisfied with the training. 47.3% of these have personal protective equipment (PPE) kits, 35.1% have no PPE kits, and 17.6% are not aware of their availability. 31.1% of doctors reported attending to COVID suspects without PPE. 58.1% of institutions have a dedicated task force, 20.3% do not, whereas 21.6% of doctors are not aware of such a task force. Only 21.6% of the participants consider their institution to be fully prepared for COVID. After performing COVID duties, 45.9% are being provided with an alternative place of stay, whereas only 16.2% have been quarantined. In non-COVID institutions, 82.4% of doctors are using protective gear, of these 35.2% procured them on their own.
    MeSH term(s) Attitude of Health Personnel ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Cross-Sectional Studies ; Disaster Planning ; Humans ; India ; Inservice Training ; Pandemics ; Personal Protective Equipment/supply & distribution ; Physicians/psychology ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.IJPH_472_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 760: Show issues Location:
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  6. Article: Tobacco use and uncontrolled hypertension among Indian men: Insights from the National Family He alth Survey (NFHS-4), 2015-2016.

    Singh, Harshvardhan / Sharma, Shailja / Kathiresan, Jeyashree / Bhatt, Garima / Goel, Sonu

    Journal of family medicine and primary care

    2022  Volume 11, Issue 9, Page(s) 5792–5798

    Abstract: Background: Tobacco use is a modifiable risk factor for developing cardiovascular diseases, of which hypertension is a major killer. Uncontrolled hypertension (UHT) is a major public health concern that exerts a financial and service burden on the ... ...

    Abstract Background: Tobacco use is a modifiable risk factor for developing cardiovascular diseases, of which hypertension is a major killer. Uncontrolled hypertension (UHT) is a major public health concern that exerts a financial and service burden on the health system.
    Aim: The current analysis aimed to determine the association between tobacco use and UHT among Indian males.
    Material and methods: Data from the 4
    Results: The prevalence of UHT was the lowest (41.02%) among those who did not consume tobacco in any form. Among tobacco users, those smoking tobacco had the highest prevalence (53.53%) of UHT followed by those using both smoked and smokeless forms of tobacco (43.84%) and those using only smokeless forms of tobacco (42.26%). Factors significantly associated with UHT were alcohol consumption (aPR: 1.30; 95% CI: 1.19-1.43), belonging to the richer wealth quintile (richest quintile- aPR: 1.27; 95% CI: 1.05-1.38), being overweight (aPR: 3.14, 95% CI: 2.35-4.21), and being obese (aPR: 2.89, 95% CI: 2.12-.94). Higher educational status was significantly protective against UHT (aPR: 0.75; 95% CI: 0.63-0.88).
    Conclusions: Tobacco use is significantly associated with hypertension in Indian men. Addressing tobacco control and prevention of UHT remain the cornerstones for achieving the SDG target 3.4 by 2030, which aims to reduce premature mortality from NCDs by a third by 2030 relative to 2015 levels.
    Language English
    Publishing date 2022-10-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_163_22
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  7. Article: Hypertension and its association with body mass index among the Indian population. Findings from a nationwide survey (NFHS-4), 2015-16.

    Sharma, Shailja / Singh, Harshvardhan / Mehta, Kedar / Verma, Madhur / Goel, Sonu

    Journal of family medicine and primary care

    2022  Volume 11, Issue 9, Page(s) 5826–5833

    Abstract: Background: Globally, hypertension (HTN) and obesity are two cardinal causes of morbidity and mortality. The Asian population shows comorbidities associated with obesity at a much lower body mass index (BMI) than the western population.: Aim: The ... ...

    Abstract Background: Globally, hypertension (HTN) and obesity are two cardinal causes of morbidity and mortality. The Asian population shows comorbidities associated with obesity at a much lower body mass index (BMI) than the western population.
    Aim: The primary objective of the present study was to evaluate the association between BMI and HTN among the adult population.
    Material and methods: We did a cross-sectional secondary data analysis of the NFHS-4 datasets, conducted during 2015-16. We included the adult population, that is, ≥19 years of age (93,040 men and 5,46,066 women), and excluded adolescents and pregnant women from our analysis. HTN was the primary dependent variable, while BMI was the primary predictor variable. Other covariates included age, education, place of residence, wealth index, use of alcohol and tobacco, and diabetes. Weighted analysis was done to depict our results.
    Results: Around 18.7% of men and 13.5% of women were hypertensive, of which 53.86% of males and 38.7% females were either overweight or obese. The odds of living with HTN among obese men and women increased with age, wealth, use of alcohol and tobacco, and comorbidities such as diabetes. The prevalence of HTN was higher even among the underweight adults living with diabetes and those consuming alcohol and tobacco.
    Conclusion: We reaffirm the significant association between BMI and HTN among adults. The use of the Asian classification of BMI for India and its neighboring countries to assess the burden of obesity would help in planning better interventions. A community-based targeted approach would help in controlling and reducing the prevalence of HTN.
    Language English
    Publishing date 2022-10-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_168_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Infrared rainbow trapping via optical Tamm modes in an one-dimensional dielectric chirped photonic crystals.

    Sharma, Shailja / Mondal, Abhishek / Das, Ritwick

    Optics letters

    2021  Volume 46, Issue 18, Page(s) 4566–4569

    Abstract: The phenomenon of trapping a broad spectrum of light is known as "rainbow trapping" and is achieved by using all-dielectric, hybrid metallo-dielectric, or all-metallic configurations. The latter architectures allow strong confinement but exhibit very ... ...

    Abstract The phenomenon of trapping a broad spectrum of light is known as "rainbow trapping" and is achieved by using all-dielectric, hybrid metallo-dielectric, or all-metallic configurations. The latter architectures allow strong confinement but exhibit very high ohmic losses. This results in practical lifetimes of trapped modes to less than 1 ps. Therefore, novel strategies are required to be devised for trapping and, subsequently, releasing broadband electromagnetic field with lifetime >1
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.437958
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  9. Article: Selenium Levels in Occupationally Lead Exposed Workers of Rajasthan.

    Saikiran, Gangam / Mitra, Prasenjit / Sharma, Praveen / Sharma, Shailja

    Indian journal of clinical biochemistry : IJCB

    2021  Volume 37, Issue 2, Page(s) 218–223

    Abstract: Occupational and environmental exposure to Lead (Pb) has profound detrimental effects on human health. The underlying mechanism of lead toxicity is not fully understood but antioxidant imbalance is suggested to be a key player in its pathogenesis. ... ...

    Abstract Occupational and environmental exposure to Lead (Pb) has profound detrimental effects on human health. The underlying mechanism of lead toxicity is not fully understood but antioxidant imbalance is suggested to be a key player in its pathogenesis. Selenium (Se) being a vital component of antioxidant system in the body, has been linked to many health benefits in humans. Selenium levels in occupationally Pb exposed individuals has not been explored in Indian setup. The aim of the present study is to find out the association of Se with blood lead levels (BLL) in occupationally Pb exposed individuals. In the present study 91 occupationally Pb exposed workers employed in handicraft and paint industries were recruited after taking informed consent. The demographic details were noted on self-generated questionnaire. The BLL and Se were measured using GFAAS (Thermofisher Scientific, Waltham, USA). Samples were run in duplicate after ensuring quality control. The mean Pb and Se levels in the study population were 5.5 ± 5.6 µg/dl (0.42-31.76 µg/dl) and 105.5 ± 23.8 µg/dl (46.4-189.6 µg/dl) respectively. BLL was significantly higher in tobacco chewers and those occupationally exposed to Pb for more than 5 years. Significantly low Se levels were observed in individuals with high BLL. Statistically significant negative linear relationship was noted between BLL and Se. The negative correlation of Se with BLL indicates the antagonistic relationship between these metals.
    Language English
    Publishing date 2021-05-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-021-00980-3
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    Zs.A 2949: Show issues Location:
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  10. Article: Correlation and Path Analysis Studies for Various Yield and Component Traits in the Segregating Generations of Blackgram [Vigna mungo (L.) Hepper]

    Sood, Rhitisha / Mittal, R.K. / Sood, V.K. / Sharma, Shailja

    Legume research

    2023  Volume 46, Issue 9, Page(s) 1141

    Document type Article
    ZDB-ID 407856-1
    ISSN 0250-5371
    Database Current Contents Nutrition, Environment, Agriculture

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    Z 3393: Show issues

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