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  1. Article ; Online: Our Arduous Research Journey from Preeclampsia to Alzheimer's Disease - Report from the Center of Biomedical Research Excellence (COBRE) for Reproductive Health.

    Sharma, Surendra

    Rhode Island medical journal (2013)

    2021  Volume 104, Issue 2, Page(s) 46–49

    Abstract: This article is contributed by the COBRE for Reproductive Health. The programmatic and scientific goals of this COBRE support a multidisciplinary, translational, and innovative program in women's reproductive health. The research projects focus on using ... ...

    Abstract This article is contributed by the COBRE for Reproductive Health. The programmatic and scientific goals of this COBRE support a multidisciplinary, translational, and innovative program in women's reproductive health. The research projects focus on using pre-clinical and human models to understand mechanisms of preeclampsia, gestational diabetes, preterm birth, IVF pregnancies, and the application of contemporary computational approaches to identify the networks and pathways underlying these devastating pregnancy complications. We discuss how novel observations emanating from the preeclampsia project can be leveraged to understand chronic diseases such as Alzheimer's disease (AD). Proteinopathy is a hallmark feature of neurodegenerative disorders such as AD. We recently reported that preeclampsia (PE), a severe pregnancy complication, is another prevalent proteinopathy disorder in a younger population. This review provides a comprehensive discussion on shared etiology between PE and AD, establishing a novel blood test for their prediction and diagnosis, and a novel therapeutic option for these disorders.
    MeSH term(s) Alzheimer Disease/diagnosis ; Biomedical Research ; Female ; Humans ; Infant, Newborn ; Pre-Eclampsia ; Pregnancy ; Premature Birth ; Reproductive Health
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 419430-5
    ISSN 2327-2228 ; 0363-7913
    ISSN (online) 2327-2228
    ISSN 0363-7913
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 222: Show issues Location:
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  2. Article ; Online: Trend Analysis of Nitrogen dioxide (NO2) in Northern Part of India During Paddy Residue Burning Using a Contextual Approach

    Maithani, Sandeep / Sharma, Surendra Kumar

    J Indian Soc Remote Sens. 2023 Jan., v. 51, no. 1 p.61-73

    2023  

    Abstract: Mann–Kendall (MK) test is a non-parametric technique widely used for trend analysis in time series datasets. However, the datasets tend to be noisy which increases data variance and often results in false rejection of null hypothesis. The present study ... ...

    Abstract Mann–Kendall (MK) test is a non-parametric technique widely used for trend analysis in time series datasets. However, the datasets tend to be noisy which increases data variance and often results in false rejection of null hypothesis. The present study investigates use of spatial autocorrelation (i.e., contextual information) to address influence of noise in the MK test. By incorporating spatial autocorrelation, the false trend can be identified, while at the same time spatial autocorrelation provides support for strengthening the results. The contextual MK test (CMK) was used for analysing NO₂ trend in the Northern Indian states of Punjab, Haryana, Delhi, Uttar Pradesh, Madhya Pradesh, and Rajasthan during paddy stubble burning, using TROPOspheric Monitoring Instrument total vertical column density data. The serial correlation in the datasets was removed using pre-whitening before running the CMK and conventional MK test. In year 2021, MK test identified 12.9% of the grid cells with monotonous increasing trend of NO₂, which increased to 14.1% when CMK test was used. Similarly, cells with monotonous increasing NO₂ trend in year 2020, were 8.7% and 9.5% using MK and CMK tests respectively. Thus, CMK test was able to identify more cells having a monotonous increasing trend of NO₂ compared to the MK test, while at the same time the spurious trend could also be efficiently handled. Subsequently, using CMK test state-wise analysis of NO₂ trend was also carried out.
    Keywords autocorrelation ; data collection ; nitrogen dioxide ; paddies ; stubble ; time series analysis ; troposphere ; variance ; India
    Language English
    Dates of publication 2023-01
    Size p. 61-73.
    Publishing place Springer India
    Document type Article ; Online
    ZDB-ID 2439566-3
    ISSN 0974-3006 ; 0255-660X
    ISSN (online) 0974-3006
    ISSN 0255-660X
    DOI 10.1007/s12524-022-01623-7
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  3. Article ; Online: Autophagy-Based Diagnosis of Pregnancy Hypertension and Pre-Eclampsia.

    Sharma, Surendra

    The American journal of pathology

    2018  Volume 188, Issue 11, Page(s) 2457–2460

    Abstract: This commentary highlights the article by Aoki et al that shows that Atg7 deficiency-mediated placental autophagy imbalance may contribute towards pre-eclampsia. ...

    Abstract This commentary highlights the article by Aoki et al that shows that Atg7 deficiency-mediated placental autophagy imbalance may contribute towards pre-eclampsia.
    MeSH term(s) Animals ; Autophagy ; Autophagy-Related Protein 7 ; Female ; Humans ; Hypertension, Pregnancy-Induced ; Mice ; Mice, Knockout ; Pre-Eclampsia ; Pregnancy ; Trophoblasts
    Chemical Substances Atg7 protein, mouse ; ATG7 protein, human (EC 6.2.1.45) ; Autophagy-Related Protein 7 (EC 6.2.1.45)
    Language English
    Publishing date 2018-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2018.09.001
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  4. Article: Pathogenic Infections during Pregnancy and the Consequences for Fetal Brain Development.

    Jash, Sukanta / Sharma, Surendra

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: Pathogens comprised of viruses, bacteria, gut microbiome, and parasites are a leading cause of ever-emerging diseases in humans. Studying pathogens for their ability to cause diseases is a topic of critical discussion among scientists and pharmaceutical ... ...

    Abstract Pathogens comprised of viruses, bacteria, gut microbiome, and parasites are a leading cause of ever-emerging diseases in humans. Studying pathogens for their ability to cause diseases is a topic of critical discussion among scientists and pharmaceutical centers for effective drug development that diagnose, treat, and prevent infection-associated disorders. Pathogens impact health either directly by invading the host or by eliciting an acute inflammatory immune response. This paradigm of inflammatory immune responses is even more consequential in people who may be immunocompromised. In this regard, pregnancy offers an altered immunity scenario, which may allow the onset of severe diseases. Viruses, such as Influenza, HIV, and now SARS-CoV-2, associated with the COVID-19 pandemic, raise new concerns for maternal and fetal/neonatal health. Intrauterine bacterial and parasitic infections are also known to impact pregnancy outcomes and neonatal health. More importantly, viral and bacterial infections during pregnancy have been identified as a common contributor to fetal brain development defects. Infection-mediated inflammatory uterine immune milieu is thought to be the main trigger for causing poor fetal brain development, resulting in long-term cognitive impairments. The concept of in utero programming of childhood and adult disorders has revolutionized the field of neurodevelopment and its associated complications. Recent findings in mice and humans clearly support the idea that uterine immunity during pregnancy controls the health trajectory of the child and considerably influences the cognitive function and mental health. In this review, we focus on the in utero programming of autism spectrum disorders (ASD) and assess the effects of pathogens on the onset of ASD-like symptoms.
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020193
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  5. Article: Allergic bronchopulmonary aspergillosis misdiagnosed & incorrectly treated as pulmonary tuberculosis.

    Sharma, Surendra K / Upadhyay, Vishwanath

    The Indian journal of medical research

    2022  Volume 152, Issue Suppl 1, Page(s) S241

    MeSH term(s) Aspergillosis, Allergic Bronchopulmonary/diagnostic imaging ; Aspergillosis, Allergic Bronchopulmonary/drug therapy ; Asthma ; Diagnostic Errors ; Humans ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/drug therapy
    Language English
    Publishing date 2022-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2419_19
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  6. Article: Addison's disease due to histoplasmosis of bilateral adrenal glands in a previously treated extrapulmonary tuberculosis case.

    Sharma, Surendra K / Tripathi, Madhavi

    The Indian journal of medical research

    2022  Volume 152, Issue Suppl 1, Page(s) S1–S3

    MeSH term(s) Addison Disease ; Adrenal Glands/diagnostic imaging ; Histoplasmosis/diagnostic imaging ; Histoplasmosis/drug therapy ; Humans ; Tuberculosis/diagnostic imaging ; Tuberculosis/drug therapy
    Language English
    Publishing date 2022-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2424_19
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.143: Show issues Location:
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  7. Article: Pathogenic Infections during Pregnancy and the Consequences for Fetal Brain Development

    Jash, Sukanta / Sharma, Surendra

    Pathogens. 2022 Jan. 31, v. 11, no. 2

    2022  

    Abstract: Pathogens comprised of viruses, bacteria, gut microbiome, and parasites are a leading cause of ever-emerging diseases in humans. Studying pathogens for their ability to cause diseases is a topic of critical discussion among scientists and pharmaceutical ... ...

    Abstract Pathogens comprised of viruses, bacteria, gut microbiome, and parasites are a leading cause of ever-emerging diseases in humans. Studying pathogens for their ability to cause diseases is a topic of critical discussion among scientists and pharmaceutical centers for effective drug development that diagnose, treat, and prevent infection-associated disorders. Pathogens impact health either directly by invading the host or by eliciting an acute inflammatory immune response. This paradigm of inflammatory immune responses is even more consequential in people who may be immunocompromised. In this regard, pregnancy offers an altered immunity scenario, which may allow the onset of severe diseases. Viruses, such as Influenza, HIV, and now SARS-CoV-2, associated with the COVID-19 pandemic, raise new concerns for maternal and fetal/neonatal health. Intrauterine bacterial and parasitic infections are also known to impact pregnancy outcomes and neonatal health. More importantly, viral and bacterial infections during pregnancy have been identified as a common contributor to fetal brain development defects. Infection-mediated inflammatory uterine immune milieu is thought to be the main trigger for causing poor fetal brain development, resulting in long-term cognitive impairments. The concept of in utero programming of childhood and adult disorders has revolutionized the field of neurodevelopment and its associated complications. Recent findings in mice and humans clearly support the idea that uterine immunity during pregnancy controls the health trajectory of the child and considerably influences the cognitive function and mental health. In this review, we focus on the in utero programming of autism spectrum disorders (ASD) and assess the effects of pathogens on the onset of ASD-like symptoms.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; adults ; autism ; brain ; childhood ; children ; cognition ; drug development ; immune response ; influenza ; intestinal microorganisms ; mental health ; neurodevelopment
    Language English
    Dates of publication 2022-0131
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020193
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  8. Article: Gestational Age-Dependent Regulation of Transthyretin in Mice during Pregnancy.

    Cheng, Shibin / Huang, Zheping / Nakashima, Akitoshi / Sharma, Surendra

    Biology

    2023  Volume 12, Issue 8

    Abstract: Our prior studies have shown that protein misfolding and aggregation in the placenta are linked to the development of preeclampsia, a severe pregnancy complication. We identified transthyretin (TTR) as a key component of the aggregated protein complex. ... ...

    Abstract Our prior studies have shown that protein misfolding and aggregation in the placenta are linked to the development of preeclampsia, a severe pregnancy complication. We identified transthyretin (TTR) as a key component of the aggregated protein complex. However, the regulation of native TTR in normal pregnancy remains unclear. In this study, we found that pregnant mice exhibited a remarkable and progressive decline in serum TTR levels through gestational day (gd) 12-14, followed by an increase in late pregnancy and postpartum. Meanwhile, serum albumin levels showed a modest but statistically significant increase throughout gestation. TTR protein and mRNA levels in the liver, a primary source of circulating TTR, mirrored the changes observed in serum TTR levels during gestation. Intriguingly, a similar pattern of TTR alteration was also observed in the serum of pregnant women and pregnant interleukin-10-knockout (IL-10
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12081048
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  9. Article ; Online: Plasmonic nanoparticle's anti-aggregation application in sensor development for water and wastewater analysis.

    Pandey, Shailja / Gupta, Shipra Mital / Sharma, Surendra Kumar

    Environmental monitoring and assessment

    2023  Volume 195, Issue 7, Page(s) 874

    Abstract: Colorimetric sensors have emerged as a powerful tool in the detection of water pollutants. Plasmonic nanoparticles use localized surface plasmon resonance (LSPR)-based colorimetric sensing. LSPR-based sensing can be accomplished through different ... ...

    Abstract Colorimetric sensors have emerged as a powerful tool in the detection of water pollutants. Plasmonic nanoparticles use localized surface plasmon resonance (LSPR)-based colorimetric sensing. LSPR-based sensing can be accomplished through different strategies such as etching, growth, aggregation, and anti-aggregation. Based on these strategies, various sensors have been developed. This review focuses on the newly developed anti-aggregation-based strategy of plasmonic nanoparticles. Sensors based on this strategy have attracted increasing interest because of their exciting properties of high sensitivity, selectivity, and applicability. This review highlights LSPR-based anti-aggregation sensors, their classification, and role of plasmonic nanoparticles in these sensors for the detection of water pollutants. The anti-aggregation based sensing of major water pollutants such as heavy metal ions, anions, and small organic molecules has been summarized herein. This review also provides some personal insights into current challenges associated with anti-aggregation strategy of LSPR-based colorimetric sensors and proposes future research directions.
    MeSH term(s) Water ; Wastewater ; Metal Nanoparticles ; Environmental Monitoring ; Surface Plasmon Resonance ; Water Pollutants
    Chemical Substances Water (059QF0KO0R) ; Wastewater ; Water Pollutants
    Language English
    Publishing date 2023-06-23
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-023-11355-x
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  10. Article ; Online: Gestational Age-Dependent Regulation of Transthyretin in Mice during Pregnancy

    Cheng, Shibin / Huang, Zheping / Nakashima, Akitoshi / Sharma, Surendra

    Biology (Basel). 2023 July 26, v. 12, no. 8

    2023  

    Abstract: Our prior studies have shown that protein misfolding and aggregation in the placenta are linked to the development of preeclampsia, a severe pregnancy complication. We identified transthyretin (TTR) as a key component of the aggregated protein complex. ... ...

    Abstract Our prior studies have shown that protein misfolding and aggregation in the placenta are linked to the development of preeclampsia, a severe pregnancy complication. We identified transthyretin (TTR) as a key component of the aggregated protein complex. However, the regulation of native TTR in normal pregnancy remains unclear. In this study, we found that pregnant mice exhibited a remarkable and progressive decline in serum TTR levels through gestational day (gd) 12–14, followed by an increase in late pregnancy and postpartum. Meanwhile, serum albumin levels showed a modest but statistically significant increase throughout gestation. TTR protein and mRNA levels in the liver, a primary source of circulating TTR, mirrored the changes observed in serum TTR levels during gestation. Intriguingly, a similar pattern of TTR alteration was also observed in the serum of pregnant women and pregnant interleukin-10-knockout (IL-10⁻/⁻) mice with high inflammation background. In non-pregnant IL-10⁻/⁻ mice, serum TTR levels were significantly lower than those in age-matched wild-type mice. Administration of IL-10 to non-pregnant IL-10⁻/⁻ mice restored their serum TTR levels. Notably, dysregulation of TTR resulted in fewer implantation units, lower fetal weight, and smaller litter sizes in human TTR-overexpressing transgenic mice. Thus, TTR may play a pivotal role as a crucial regulator in normal pregnancy, and inflammation during pregnancy may contribute to the downregulation of serum TTR presence.
    Keywords blood serum ; genetically modified organisms ; humans ; inflammation ; interleukin-10 ; liver ; placenta ; pre-eclampsia ; prealbumin ; pregnancy ; protein folding
    Language English
    Dates of publication 2023-0726
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12081048
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