LIVIVO - Search results -

Search results

Result 1 - 9 of total 9

Search options

Article: Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review.

Panda, Biswajit / Sharma, Yashvi / Gupta, Suchi / Mohanty, Sujata

2021 Volume 11, Issue 8

Abstract: Mesenchymal Stem Cells are potent therapeutic candidates in the field of regenerative medicine, owing to their immunomodulatory and differentiation potential. However, several complications come with their translational application like viability, ... ...

Abstract	Mesenchymal Stem Cells are potent therapeutic candidates in the field of regenerative medicine, owing to their immunomodulatory and differentiation potential. However, several complications come with their translational application like viability, duration, and degree of expansion, long-term storage, and high maintenance cost. Therefore, drawbacks of cell-based therapy can be overcome by a novel therapeutic modality emerging in translational research and application, i.e., exosomes. These small vesicles derived from mesenchymal stem cells are emerging as new avenues in the field of nano-medicine. These nano-vesicles have caught the attention of researchers with their potency as regenerative medicine both in nanotherapeutics and drug delivery systems. In this review, we discuss the current knowledge in the biology and handling of exosomes, with their limitations and future applications. Additionally, we highlight current perspectives that primarily focus on their effect on various diseases and their potential as a drug delivery vehicle.
Language	English
Publishing date	2021-08-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life11080784
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Mesenchymal Stem Cell Derived Exosomes: a Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19.

Pinky / Gupta, Suchi / Krishnakumar, Vishnu / Sharma, Yashvi / Dinda, Amit Kumar / Mohanty, Sujata

Stem cell reviews and reports

2020 Volume 17, Issue 1, Page(s) 33–43

Abstract: The recent pandemic situation transpired due to coronavirus novel strain SARS-CoV-2 has become a global concern. This human coronavirus (HCov-19) has put the world on high alert as the numbers of confirmed cases are continuously increasing. The world is ... ...

Abstract	The recent pandemic situation transpired due to coronavirus novel strain SARS-CoV-2 has become a global concern. This human coronavirus (HCov-19) has put the world on high alert as the numbers of confirmed cases are continuously increasing. The world is now fighting against this deadly virus and is leaving no stone unturned to find effective treatments through testing of various available drugs, including those effective against flu, malaria, etc. With an urgent need for the development of potential strategies, two recent studies from China using Mesenchymal Stem Cells (MSCs) to treat COVID-19 pneumonia have shed some light on a potential cure for the COVID-19 infected patients. However, MSCs, despite being used in various other clinical trials have always been questioned for their tendency to aggregate or form clumps in the injured or disease microenvironment. It has also been reported in various studies that exosomes secreted by these MSCs, contribute towards the cell's biological and therapeutic efficacy. There have been reports evaluating the safety and feasibility of these exosomes in various lung diseases, thereby proposing them as a cell-free therapeutic agent. Also, attractive features like cell targeting, low-immunogenicity, safety, and high biocompatibility distinguish these exosomes from other synthetic nano-vesicles and thus potentiate their role as a drug delivery nano-platform. Building upon these observations, herein, efforts are made to give an overview of stem cell-derived exosomes as an appealing therapeutic agent and drug delivery nano-carrier. In this review, we briefly recapitulate the recent evidence and developments in understanding exosomes as a promising candidate for novel nano-intervention in the current pandemic scenario. Furthermore, this review will highlight and discuss mechanistic role of exosomes to combat severe lung pathological conditions. We have also attempted to dwell into the nano-formulation of exosomes for its better applicability, storage, and stability thereby conferring them as off the shelf therapeutic.
MeSH term(s)	COVID-19/therapy ; COVID-19/virology ; Cytokines/genetics ; Exosomes/chemistry ; Exosomes/transplantation ; Humans ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/chemistry ; Mesenchymal Stem Cells/metabolism ; Pandemics ; SARS-CoV-2/pathogenicity
Chemical Substances	Cytokines
Keywords	covid19
Language	English
Publishing date	2020-07-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-020-10002-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Mesenchymal Stem Cell Derived Exosomes: a Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19

Gupta, Suchi / Krishnakumar, Vishnu / Sharma, Yashvi / Dinda, Amit Kumar / Mohanty, Sujata

Abstract	The recent pandemic situation transpired due to coronavirus novel strain SARS-CoV-2 has become a global concern. This human coronavirus (HCov-19) has put the world on high alert as the numbers of confirmed cases are continuously increasing. The world is now fighting against this deadly virus and is leaving no stone unturned to find effective treatments through testing of various available drugs, including those effective against flu, malaria, etc. With an urgent need for the development of potential strategies, two recent studies from China using Mesenchymal Stem Cells (MSCs) to treat COVID-19 pneumonia have shed some light on a potential cure for the COVID-19 infected patients. However, MSCs, despite being used in various other clinical trials have always been questioned for their tendency to aggregate or form clumps in the injured or disease microenvironment. It has also been reported in various studies that exosomes secreted by these MSCs, contribute towards the cell's biological and therapeutic efficacy. There have been reports evaluating the safety and feasibility of these exosomes in various lung diseases, thereby proposing them as a cell-free therapeutic agent. Also, attractive features like cell targeting, low-immunogenicity, safety, and high biocompatibility distinguish these exosomes from other synthetic nano-vesicles and thus potentiate their role as a drug delivery nano-platform. Building upon these observations, herein, efforts are made to give an overview of stem cell-derived exosomes as an appealing therapeutic agent and drug delivery nano-carrier. In this review, we briefly recapitulate the recent evidence and developments in understanding exosomes as a promising candidate for novel nano-intervention in the current pandemic scenario. Furthermore, this review will highlight and discuss mechanistic role of exosomes to combat severe lung pathological conditions. We have also attempted to dwell into the nano-formulation of exosomes for its better applicability, storage, and stability thereby conferring them as off the shelf therapeutic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #641088
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Mesenchymal Stem Cell Derived Exosomes

Pinky / Gupta, Suchi / Krishnakumar, Vishnu / Sharma, Yashvi / Dinda, Amit Kumar / Mohanty, Sujata

Stem Cell Reviews and Reports ; ISSN 2629-3269 2629-3277

a Nano Platform for Therapeutics and Drug Delivery in Combating COVID-19

2020

Keywords	covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s12015-020-10002-z
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Uncovering a population of gravitational lens galaxies with magnified standard candle SN Zwicky.

Goobar, Ariel / Johansson, Joel / Schulze, Steve / Arendse, Nikki / Carracedo, Ana Sagués / Dhawan, Suhail / Mörtsell, Edvard / Fremling, Christoffer / Yan, Lin / Perley, Daniel / Sollerman, Jesper / Joseph, Rémy / Hinds, K-Ryan / Meynardie, William / Andreoni, Igor / Bellm, Eric / Bloom, Josh / Collett, Thomas E / Drake, Andrew /

Graham, Matthew / Kasliwal, Mansi / Kulkarni, Shri R / Lemon, Cameron / Miller, Adam A / Neill, James D / Nordin, Jakob / Pierel, Justin / Richard, Johan / Riddle, Reed / Rigault, Mickael / Rusholme, Ben / Sharma, Yashvi / Stein, Robert / Stewart, Gabrielle / Townsend, Alice / Vinko, Jozsef / Wheeler, J Craig / Wold, Avery

Nature astronomy

2023 Volume 7, Issue 9, Page(s) 1098–1107

Abstract: Detecting gravitationally lensed supernovae is among the biggest challenges in astronomy. It involves a combination of two very rare phenomena: catching the transient signal of a stellar explosion in a distant galaxy and observing it through a nearly ... ...

Abstract	Detecting gravitationally lensed supernovae is among the biggest challenges in astronomy. It involves a combination of two very rare phenomena: catching the transient signal of a stellar explosion in a distant galaxy and observing it through a nearly perfectly aligned foreground galaxy that deflects light towards the observer. Here we describe how high-cadence optical observations with the Zwicky Transient Facility, with its unparalleled large field of view, led to the detection of a multiply imaged type Ia supernova, SN Zwicky, also known as SN 2022qmx. Magnified nearly 25-fold, the system was found thanks to the standard candle nature of type Ia supernovae. High-spatial-resolution imaging with the Keck telescope resolved four images of the supernova with very small angular separation, corresponding to an Einstein radius of only
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article
ISSN	2397-3366
ISSN (online)	2397-3366
DOI	10.1038/s41550-023-01981-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A radio-detected type Ia supernova with helium-rich circumstellar material.

Kool, Erik C / Johansson, Joel / Sollerman, Jesper / Moldón, Javier / Moriya, Takashi J / Mattila, Seppo / Schulze, Steve / Chomiuk, Laura / Pérez-Torres, Miguel / Harris, Chelsea / Lundqvist, Peter / Graham, Matthew / Yang, Sheng / Perley, Daniel A / Strotjohann, Nora Linn / Fremling, Christoffer / Gal-Yam, Avishay / Lezmy, Jeremy / Maguire, Kate /

Omand, Conor / Smith, Mathew / Andreoni, Igor / Bellm, Eric C / Bloom, Joshua S / De, Kishalay / Groom, Steven L / Kasliwal, Mansi M / Masci, Frank J / Medford, Michael S / Park, Sungmin / Purdum, Josiah / Reynolds, Thomas M / Riddle, Reed / Robert, Estelle / Ryder, Stuart D / Sharma, Yashvi / Stern, Daniel

Nature

2023 Volume 617, Issue 7961, Page(s) 477–482

Abstract: Type Ia supernovae (SNe Ia) are thermonuclear explosions of degenerate white dwarf stars destabilized by mass accretion from a companion ... ...

Abstract	Type Ia supernovae (SNe Ia) are thermonuclear explosions of degenerate white dwarf stars destabilized by mass accretion from a companion star
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-05916-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Minutes-duration optical flares with supernova luminosities.

Ho, Anna Y Q / Perley, Daniel A / Chen, Ping / Schulze, Steve / Dhillon, Vik / Kumar, Harsh / Suresh, Aswin / Swain, Vishwajeet / Bremer, Michael / Smartt, Stephen J / Anderson, Joseph P / Anupama, G C / Awiphan, Supachai / Barway, Sudhanshu / Bellm, Eric C / Ben-Ami, Sagi / Bhalerao, Varun / de Boer, Thomas / Brink, Thomas G /

Burruss, Rick / Chandra, Poonam / Chen, Ting-Wan / Chen, Wen-Ping / Cooke, Jeff / Coughlin, Michael W / Das, Kaustav K / Drake, Andrew J / Filippenko, Alexei V / Freeburn, James / Fremling, Christoffer / Fulton, Michael D / Gal-Yam, Avishay / Galbany, Lluís / Gao, Hua / Graham, Matthew J / Gromadzki, Mariusz / Gutiérrez, Claudia P / Hinds, K-Ryan / Inserra, Cosimo / A J, Nayana / Karambelkar, Viraj / Kasliwal, Mansi M / Kulkarni, Shri / Müller-Bravo, Tomás E / Magnier, Eugene A / Mahabal, Ashish A / Moore, Thomas / Ngeow, Chow-Choong / Nicholl, Matt / Ofek, Eran O / Omand, Conor M B / Onori, Francesca / Pan, Yen-Chen / Pessi, Priscila J / Petitpas, Glen / Polishook, David / Poshyachinda, Saran / Pursiainen, Miika / Riddle, Reed / Rodriguez, Antonio C / Rusholme, Ben / Segre, Enrico / Sharma, Yashvi / Smith, Ken W / Sollerman, Jesper / Srivastav, Shubham / Strotjohann, Nora Linn / Suhr, Mark / Svinkin, Dmitry / Wang, Yanan / Wiseman, Philip / Wold, Avery / Yang, Sheng / Yang, Yi / Yao, Yuhan / Young, David R / Zheng, WeiKang

Nature

2023 Volume 623, Issue 7989, Page(s) 927–931

Abstract: In recent years, certain luminous extragalactic optical transients have been observed to last only a few ... ...

Abstract	In recent years, certain luminous extragalactic optical transients have been observed to last only a few days
Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06673-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Publisher Correction: A very luminous jet from the disruption of a star by a massive black hole.

Andreoni, Igor / Coughlin, Michael W / Perley, Daniel A / Yao, Yuhan / Lu, Wenbin / Cenko, S Bradley / Kumar, Harsh / Anand, Shreya / Ho, Anna Y Q / Kasliwal, Mansi M / de Ugarte Postigo, Antonio / Sagués-Carracedo, Ana / Schulze, Steve / Kann, D Alexander / Kulkarni, S R / Sollerman, Jesper / Tanvir, Nial / Rest, Armin / Izzo, Luca /

Somalwar, Jean J / Kaplan, David L / Ahumada, Tomás / Anupama, G C / Auchettl, Katie / Barway, Sudhanshu / Bellm, Eric C / Bhalerao, Varun / Bloom, Joshua S / Bremer, Michael / Bulla, Mattia / Burns, Eric / Campana, Sergio / Chandra, Poonam / Charalampopoulos, Panos / Cooke, Jeff / D'Elia, Valerio / Das, Kaustav Kashyap / Dobie, Dougal / Fernández, José Feliciano Agüí / Freeburn, James / Fremling, Cristoffer / Gezari, Suvi / Goode, Simon / Graham, Matthew J / Hammerstein, Erica / Karambelkar, Viraj R / Kilpatrick, Charles D / Kool, Erik C / Krips, Melanie / Laher, Russ R / Leloudas, Giorgos / Levan, Andrew / Lundquist, Michael J / Mahabal, Ashish A / Medford, Michael S / Miller, M Coleman / Möller, Anais / Mooley, Kunal P / Nayana, A J / Nir, Guy / Pang, Peter T H / Paraskeva, Emmy / Perley, Richard A / Petitpas, Glen / Pursiainen, Miika / Ravi, Vikram / Ridden-Harper, Ryan / Riddle, Reed / Rigault, Mickael / Rodriguez, Antonio C / Rusholme, Ben / Sharma, Yashvi / Smith, I A / Stein, Robert D / Thöne, Christina / Tohuvavohu, Aaron / Valdes, Frank / van Roestel, Jan / Vergani, Susanna D / Wang, Qinan / Zhang, Jielai

Nature

2023 Volume 613, Issue 7945, Page(s) E6

Language	English
Publishing date	2023-01-09
Publishing country	England
Document type	Published Erratum
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-05699-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A very luminous jet from the disruption of a star by a massive black hole.

Nature

2022 Volume 612, Issue 7940, Page(s) 430–434

Abstract: Tidal disruption events (TDEs) are bursts of electromagnetic energy that are released when supermassive black holes at the centres of galaxies violently disrupt a star that passes too ... ...

Abstract	Tidal disruption events (TDEs) are bursts of electromagnetic energy that are released when supermassive black holes at the centres of galaxies violently disrupt a star that passes too close
Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05465-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito