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Article ; Online: Reply to: Comments on "Social inequalities in treatment receipt for childhood cancers in Ireland: A population-based analysis".

Molcho, Michal / Thomas, Audrey A / Sharp, Linda

2024 Volume 154, Issue 9, Page(s) 1675–1676

MeSH term(s)	Humans ; Child ; Ireland/epidemiology ; Neoplasms/epidemiology ; Neoplasms/therapy ; Socioeconomic Factors ; Social Class
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Letter
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34837
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Book: Cancer registration statistics Scotland 1981 - 1990

Sharp, Linda

(ISD publications)

1993

Institution	Great Britain / Scottish Cancer Intelligence Unit
Author's details	Scottish Cancer Intelligence Unit. Linda Sharp
Series title	ISD publications
Keywords	Neoplasms / epidemiology / Scotland / statistics
Language	English
Size	VI, 142 S. : zahlr. graph. Darst.
Publisher	Information & Statistics Division, Directorate of Information Services, The National Health Service in Scotland
Publishing place	Edinburgh
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT007834148
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Article ; Online: Implementation of Self-Management Interventions in Cancer Survivors: Why Are We Not There Yet?

Rimmer, Ben / Sharp, Linda

Journal of cancer education : the official journal of the American Association for Cancer Education

2021 Volume 36, Issue 6, Page(s) 1355–1358

Abstract: Despite the growing evidence base for supported self-management for the improvement of quality of life, there is a lack of widespread implementation of self-management interventions for cancer survivors. We propose five key areas that, if addressed, ... ...

Abstract	Despite the growing evidence base for supported self-management for the improvement of quality of life, there is a lack of widespread implementation of self-management interventions for cancer survivors. We propose five key areas that, if addressed, would optimise the development and evaluation of these interventions, namely: (1) improving intervention adaptability to different survivor populations; (2) establishing intervention acceptability (and feasibility); (3) ensuring systematic description of interventions, their content, and active ingredients; (4) conducting process evaluations; and (5) assessing cost-effectiveness. These areas are an essential prerequisite for translation of self-management interventions from research into routine cancer care.
MeSH term(s)	Cancer Survivors ; Humans ; Neoplasms/therapy ; Quality of Life ; Self-Management ; Survivors
Language	English
Publishing date	2021-05-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632898-2
ISSN	1543-0154 ; 0885-8195 ; 1543-1154
ISSN (online)	1543-0154
ISSN	0885-8195 ; 1543-1154
DOI	10.1007/s13187-021-02021-2
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Zs.A 2185: Show issues

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Article ; Online: Assessing quality of life in solid organ transplant recipients: A systematic review of the development, content, and quality of available condition- and transplant-specific patient-reported outcome measures.

Rimmer, Ben / Jenkins, Rebeka / Russell, Siân / Craig, Dawn / Sharp, Linda / Exley, Catherine

Transplantation reviews (Orlando, Fla.)

2024 Volume 38, Issue 2, Page(s) 100836

Abstract: Purpose: We aimed to identify the condition- and transplant-specific patient-reported outcome measures (PROMs) available to measure quality of life (QoL) in solid organ transplant (SOT) recipients, examine their development and content, and critically ... ...

Abstract	Purpose: We aimed to identify the condition- and transplant-specific patient-reported outcome measures (PROMs) available to measure quality of life (QoL) in solid organ transplant (SOT) recipients, examine their development and content, and critically appraise the quality of their measurement properties, to inform recommendations for clinical and research use. Methods: We systematically searched MEDLINE, Embase, CINAHL, PsycINFO, Cochrane CENTRAL, and Scopus from inception to 27th January 2023. Search hits were screened for eligibility by two independent reviewers; papers reporting the development and/or validation of condition- and transplant-specific PROMs measuring QoL in adult SOT recipients were considered eligible. We abstracted and synthesised data on PROM characteristics, development (item generation and/or reduction), and content (QoL dimensions). Quality appraisal and synthesis were informed by the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines, and included methodological and quality assessment of measurement properties, GRADE levels of evidence, feasibility and interpretability. Results: We identified 33 papers reporting 26 QoL PROMs validated in SOT recipients (kidney n = 10 PROMs; liver n = 6; lung n = 3; heart n = 2; pancreas n = 1; multiple organs n = 4). Patient discussions (n = 17 PROMs) and factor analysis (n = 11) were the most common item generation and reduction techniques used, respectively. All PROMs measured ≥3 of nine QoL dimensions (all measured emotional functioning); KDQoL-SF and NIDDK-QA measured all nine. Methodological quality was variable; no PROM had low evidence or better for all measurement properties. All PROMs were COSMIN recommendation category 'B', primarily because none had sufficient content validity. Conclusions: There are many condition- and transplant-specific QoL PROMs validated in SOT recipients, particularly kidney. These findings can help inform PROM selection for clinicians and researchers. However, caution is required when adopting measures, due to the substantial heterogeneity in development, content, and quality. Each PROM has potential but requires further research to be recommendable. Greater consideration of patient and professional involvement in PROM development in this setting is needed to ensure sufficient content validity.
MeSH term(s)	Adult ; Humans ; Quality of Life ; Patient Reported Outcome Measures ; Consensus ; Pancreas ; Organ Transplantation
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	639400-0
ISSN	1557-9816 ; 0955-470X
ISSN (online)	1557-9816
ISSN	0955-470X
DOI	10.1016/j.trre.2024.100836
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Article ; Online: Routes to diagnosis of hypopharyngeal cancer: A single-centre experience.

Pearce, Helen / Hamilton, David / Sharp, Linda / Deane, Jennifer / Kennedy, Matthew / O'Hara, James

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

2024

Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2205891-6
ISSN	1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
ISSN (online)	1749-4486
ISSN	1749-4478 ; 0307-7772 ; 1365-2273
DOI	10.1111/coa.14156
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Zs.A 1309: Show issues

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Article ; Online: Initiatives to increase colonoscopy capacity - is there an impact on polyp detection? A UK National Endoscopy Database analysis.

Lu, Liya / Catlow, Jamie / Rutter, Matthew D / Sharp, Linda

Endoscopy

2023 Volume 56, Issue 4, Page(s) 302–310

Abstract: Background: To address mismatch between routine endoscopy capacity and demand, centers often implement initiatives to increase capacity, such as weekend working or using locums/agency staff (insourcing). However, there are concerns that such ... ...

Abstract	Background: To address mismatch between routine endoscopy capacity and demand, centers often implement initiatives to increase capacity, such as weekend working or using locums/agency staff (insourcing). However, there are concerns that such initiatives may negatively impact quality. We investigated polyp detection for weekend vs. weekday and insourced vs. standard procedures using data from the UK National Endoscopy Database. Methods: We conducted a national, retrospective, cross-sectional study of diagnostic colonoscopies performed during 01/01-04/04/2019. The primary outcome was mean number of polyps (MNP) and the secondary outcome was polyp detection rate (PDR). Multi-level mixed-effect regression, fitting endoscopist as a random effect, was used to examine associations between procedure day (weekend/weekday) and type (insourced/standard) and these outcomes, adjusting for patient age, sex, and indication. Results: 92 879 colonoscopies (weekends: 19 977 [21.5 %]; insourced: 9909 [10.7 %]) were performed by 2496 endoscopists. For weekend colonoscopies, patients were less often male or undergoing screening-related procedures; for insourced colonoscopies, patients were younger and less often undergoing screening-related procedures (all P < 0.05). Fully adjusted MNP was significantly lower for weekend vs. weekday (incidence rate ratio [IRR] 0.86 [95 %CI 0.83-0.89]) and for insourced vs. standard procedures (IRR 0.91 [95 %CI 0.87-0.95]). MNP was highest for weekday standard procedures and lowest for weekend insourced procedures; there was no interaction between procedure day and type. Similar associations were found for PDR. Conclusions: Strategies to increase colonoscopy capacity may negatively impact polyp detection and should be monitored for quality. Reasons for this unwarranted variation require investigation.
MeSH term(s)	Humans ; Male ; Colonic Polyps/diagnostic imaging ; Retrospective Studies ; Cross-Sectional Studies ; Adenoma/diagnosis ; Colonoscopy/methods ; United Kingdom
Language	English
Publishing date	2023-11-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2214-9840
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Speaking up for the lost voices: representation and inclusion of people with communication impairment in brain tumour research.

Menger, Fiona / Cresswell, Harriet / Lewis, Joanne / Volkmer, Anna / Sharp, Linda

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2023 Volume 31, Issue 6, Page(s) 355

Abstract: Brain tumours and their associated treatments can lead to progressive impairments of communication, adversely affecting quality-of-life. This commentary explores our concerns that people with speech, language, and communication needs face barriers to ... ...

Abstract	Brain tumours and their associated treatments can lead to progressive impairments of communication, adversely affecting quality-of-life. This commentary explores our concerns that people with speech, language, and communication needs face barriers to representation and inclusion in brain tumour research; we then offer possible solutions to support their participation. Our main concerns are that there is currently poor recognition of the nature of communication difficulties following brain tumours, limited focus on the psychosocial impact, and lack of transparency on why people with speech, language, and communication needs were excluded from research or how they were supported to take part. We propose solutions focusing on working towards more accurate reporting of symptoms and the impact of impairment, using innovative qualitative methods to collect data on the lived experiences of speech, language, and communication needs, and empowering speech and language therapists to become part of research teams as experts and advocates for this population. These solutions would support the accurate representation and inclusion of people with communication needs after brain tumour in research, allowing healthcare professionals to learn more about their priorities and needs.
MeSH term(s)	Humans ; Communication ; Language ; Quality of Life
Language	English
Publishing date	2023-05-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-023-07804-5
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Zs.A 3697: Show issues

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Article ; Online: The association between marital status and treatment initiation in lung cancer: A systematic review and meta-analysis of observational studies.

Richardson, Charlotte Lucy / Saeed, Mariam / Sharp, Linda / Todd, Adam

Cancer epidemiology

2023 Volume 87, Page(s) 102494

Abstract: Lung cancer is associated with high mortality, and significant health burden. Marital status has been associated with lung cancer survival. This systematic review and meta-analysis set out to investigate the association between marital status and ... ...

Abstract	Lung cancer is associated with high mortality, and significant health burden. Marital status has been associated with lung cancer survival. This systematic review and meta-analysis set out to investigate the association between marital status and treatment receipt in lung cancer. The search was conducted across three databases: Medline (OVID), Embase and CINAHL, from inception to June 2022. Retrospective or prospective observational studies that quantified treatment receipt by marital status were eligible for inclusion. Study quality was assessed via a modified checklist for retrospective databased-based studies. Meta-analysis using a random effects model was undertaken by chemotherapy, radiotherapy, surgery, and any treatment relative to married or not married. Pooled unadjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each type of treatment. 837 papers were screened and 18 met the inclusion criteria with eight being eligible for inclusion in the meta-analysis. Studies were excluded from meta-analysis due to overlap in the data reported in papers; the mean quality score of the 18 included papers was 12/17. Being married was associated with increased odds of overall treatment OR 1.43 (95 % CI 1.14-1.79; I
MeSH term(s)	Humans ; Retrospective Studies ; Lung Neoplasms/epidemiology ; Lung Neoplasms/therapy ; Marital Status ; Cognition ; Marriage ; Observational Studies as Topic
Language	English
Publishing date	2023-11-21
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2508729-0
ISSN	1877-783X ; 1877-7821
ISSN (online)	1877-783X
ISSN	1877-7821
DOI	10.1016/j.canep.2023.102494
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Zs.A 1427: Show issues

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Article ; Online: Co-design to deliver service improvement: What does this mean and how can we do it? A qualitative study with upper gastrointestinal cancer patients and professionals.

Haste, Anna / Sharp, Linda / Thomson, Richard / Sowden, Sarah

Cancer reports (Hoboken, N.J.)

2022 Volume 6, Issue 3, Page(s) e1748

Abstract: Background: There is strategic objective to incorporate the principles and practice of co-design into routine service development and improvement.: Aim: The aim was to explore the concept and feasibility of service co-design with patients and health ... ...

Abstract	Background: There is strategic objective to incorporate the principles and practice of co-design into routine service development and improvement. Aim: The aim was to explore the concept and feasibility of service co-design with patients and health professionals with regards to the upper gastrointestinal (UGI) cancer care pathway. Methods and results: Qualitative telephone interviews and face-to-face focus groups in one region of England. Twenty patients completed interviews. Nine patients and ten professionals formed two focus groups. Patients were referred through the urgent (two week) GP referral route and were within six months of receiving their first treatment for an UGI cancer. Professionals were working as service planners and providers of the UGI cancer care pathway. Thematic analysis was undertaken. Six themes emerged: Responsibilities and expectations, Knowledge and understanding, Valuing patient input, Building relationships, Environment for co-design activities, Impact and effectiveness. Based on the themes a checklist has been created to provide practical suggestions for both professionals and patients on approaching co-design for service improvement. Conclusion: This study offers policy and practice partners a clearer understanding of co-design and factors to consider when approaching co-design in real life settings.
MeSH term(s)	Humans ; Qualitative Research ; Health Personnel ; England ; Neoplasms
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2573-8348
ISSN (online)	2573-8348
DOI	10.1002/cnr2.1748
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Article ; Online: Systematic review of caregiver burden, unmet needs and quality-of-life among informal caregivers of patients with pancreatic cancer.

Chong, Eric / Crowe, Lisa / Mentor, Keno / Pandanaboyana, Sanjay / Sharp, Linda

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2022 Volume 31, Issue 1, Page(s) 74

Abstract: Purpose: Informal caregivers play an important supportive care role for patients with cancer. This may be especially true for pancreatic cancer which is often diagnosed late, has a poor prognosis and is associated with a significant symptom burden. We ... ...

Abstract	Purpose: Informal caregivers play an important supportive care role for patients with cancer. This may be especially true for pancreatic cancer which is often diagnosed late, has a poor prognosis and is associated with a significant symptom burden. We systematically reviewed the evidence on caregiver burden, unmet needs and quality-of-life of informal caregivers to patients with pancreatic cancer. Method: PubMed, Medline, CINAHL and Embase databases were systematically searched on 31 August 2021. Qualitative and quantitative data on informal caregivers' experiences were extracted and coded into themes of burden, unmet needs or quality-of-life with narrative synthesis of the data undertaken. Results: Nine studies (five qualitative, four quantitative), including 6023 informal caregivers, were included in the review. We categorised data into three key themes: caregiver burden, unmet needs and quality-of-life. Data on caregiver burden was organised into a single subtheme relating to symptom management as a source of burden. Data on unmet needs was organised into three subthemes need for: better clinical communication; support and briefings for caregivers; and help with navigating the health care system. Data on quality-of-life indicate large proportions of informal caregivers experience clinical levels of anxiety (33%) or depression (12%-32%). All five qualitative studies were graded as good quality; three quantitative studies were poor quality, and one was fair quality. Conclusion: High-quality pancreatic cancer care should consider the impacts of informal caregiving. Prospective longitudinal studies examining multiple dimensions of caregiver burden, needs, and quality-of-life would be valuable at informing supportive care cancer delivery to pancreatic cancer informal caregivers.
MeSH term(s)	Humans ; Caregivers ; Caregiver Burden ; Prospective Studies ; Quality of Life ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms
Language	English
Publishing date	2022-12-22
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-022-07468-7
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