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  1. Article: Editorial: Novel regulatory mechanisms behind thermogenesis of brown and beige adipocytes.

    Shaw, Abhirup / Kristóf, Endre / Cereijo, Rubén

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1268299

    MeSH term(s) Adipocytes, Beige ; Thermogenesis
    Language English
    Publishing date 2023-08-18
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1268299
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  2. Article ; Online: Role of the nucleotide excision repair pathway proteins (UvrB and UvrD2) in recycling UdgB, a base excision repair enzyme in Mycobacterium smegmatis.

    Kapoor, Indu / Shaw, Abhirup / Naha, Arindam / Emam, Elhassan Ali Fathi / Varshney, Umesh

    DNA repair

    2022  Volume 113, Page(s) 103316

    Abstract: Cross-talks between DNA repair pathways are emerging as a crucial strategy in the maintenance of the genomic integrity. A double-stranded (ds) DNA specific DNA glycosylase, UdgB is known to excise uracil, hypoxanthine and ethenocytosine. We earlier ... ...

    Abstract Cross-talks between DNA repair pathways are emerging as a crucial strategy in the maintenance of the genomic integrity. A double-stranded (ds) DNA specific DNA glycosylase, UdgB is known to excise uracil, hypoxanthine and ethenocytosine. We earlier showed that Mycobacterium smegmatis (Msm) UdgB stays back on the AP-sites it generates in the DNA upon excision of the damaged bases. Here, we show that in an Msm strain deleted for a nucleotide excision repair (NER) protein, UvrB (uvrB
    Language English
    Publishing date 2022-03-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2022.103316
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5555: Show issues Location:
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  3. Article ; Online: Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.

    Rahbani, Janane F / Bunk, Jakub / Lagarde, Damien / Samborska, Bozena / Roesler, Anna / Xiao, Haopeng / Shaw, Abhirup / Kaiser, Zafir / Braun, Jessica L / Geromella, Mia S / Fajardo, Val A / Koza, Robert A / Kazak, Lawrence

    Cell metabolism

    2024  Volume 36, Issue 3, Page(s) 526–540.e7

    Abstract: That uncoupling protein 1 (UCP1) is the sole mediator of adipocyte thermogenesis is a conventional viewpoint that has primarily been inferred from the attenuation of the thermogenic output of mice genetically lacking Ucp1 from birth (germline ... ...

    Abstract That uncoupling protein 1 (UCP1) is the sole mediator of adipocyte thermogenesis is a conventional viewpoint that has primarily been inferred from the attenuation of the thermogenic output of mice genetically lacking Ucp1 from birth (germline Ucp1
    MeSH term(s) Animals ; Mice ; Adipocytes, Brown/metabolism ; Adipose Tissue, Brown/metabolism ; Thermogenesis ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism ; Creatine Kinase, BB Form/metabolism
    Chemical Substances Uncoupling Protein 1 ; Creatine Kinase, BB Form (EC 2.7.3.2) ; Ucp1 protein, mouse
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2024.01.001
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  4. Article ; Online: Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli.

    Kapoor, Indu / Emam, Elhassan Ali Fathi / Shaw, Abhirup / Varshney, Umesh

    Journal of bacteriology

    2019  Volume 202, Issue 1

    Abstract: The chemical integrity of the nucleotide pool and its homeostasis are crucial for genome stability. Nucleoside diphosphate kinase (NDK) is a crucial enzyme that carries out reversible conversions from nucleoside diphosphate (NDP) to nucleoside ... ...

    Abstract The chemical integrity of the nucleotide pool and its homeostasis are crucial for genome stability. Nucleoside diphosphate kinase (NDK) is a crucial enzyme that carries out reversible conversions from nucleoside diphosphate (NDP) to nucleoside triphosphate (NTP) and deoxynucleoside diphosphate (dNDP) to deoxynucleoside triphosphate (dNTP). Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP. MutT proteins in cells hydrolyze 8-O-GTP to 8-O-GMP or 8-O-dGTP to 8-O-dGMP to avoid its incorporation in nucleic acids. In
    MeSH term(s) Deoxyguanine Nucleotides/metabolism ; Escherichia coli/genetics ; Escherichia coli Proteins/physiology ; Genomic Instability ; Mutation ; Nucleoside-Diphosphate Kinase/genetics ; Nucleoside-Diphosphate Kinase/physiology ; Pyrophosphatases/physiology
    Chemical Substances Deoxyguanine Nucleotides ; Escherichia coli Proteins ; deoxyguanosine triphosphate (8C2O37Y44Q) ; Nucleoside-Diphosphate Kinase (EC 2.7.4.6) ; Pyrophosphatases (EC 3.6.1.-) ; mutT protein, E coli (EC 3.6.1.-)
    Language English
    Publishing date 2019-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00567-19
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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Corrigendum: Human abdominal subcutaneous-derived active beige adipocytes carrying

    Vámos, Attila / Arianti, Rini / Vinnai, Boglárka Ágnes / Alrifai, Rahaf / Shaw, Abhirup / Póliska, Szilárd / Guba, Andrea / Csősz, Éva / Csomós, István / Mocsár, Gábor / Lányi, Cecilia / Balajthy, Zoltán / Fésüs, László / Kristóf, Endre

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1249909

    Abstract: This corrects the article DOI: 10.3389/fcell.2023.1155673.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcell.2023.1155673.].
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1249909
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  6. Article: Human abdominal subcutaneous-derived active beige adipocytes carrying

    Vámos, Attila / Arianti, Rini / Vinnai, Boglárka Ágnes / Alrifai, Rahaf / Shaw, Abhirup / Póliska, Szilárd / Guba, Andrea / Csősz, Éva / Csomós, István / Mocsár, Gábor / Lányi, Cecilia / Balajthy, Zoltán / Fésüs, László / Kristóf, Endre

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1155673

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1155673
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  7. Article: ASC‐1 transporter‐dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation

    Arianti, Rini / Vinnai, Boglárka Ágnes / Tóth, Beáta B. / Shaw, Abhirup / Csősz, Éva / Vámos, Attila / Győry, Ferenc / Fischer‐Posovszky, Pamela / Wabitsch, Martin / Kristóf, Endre / Fésüs, László

    FEBS letters. 2021 Aug., v. 595, no. 16

    2021  

    Abstract: Brown and beige adipocytes dissipate energy by uncoupling protein 1 (UCP1)‐dependent and UCP1‐independent thermogenesis, which may be utilized to develop treatments against obesity. We have found that mRNA and protein expression of the alanine/serine/ ... ...

    Abstract Brown and beige adipocytes dissipate energy by uncoupling protein 1 (UCP1)‐dependent and UCP1‐independent thermogenesis, which may be utilized to develop treatments against obesity. We have found that mRNA and protein expression of the alanine/serine/cysteine transporter‐1 (ASC‐1) was induced during adipocyte differentiation of human brown‐prone deep neck and beige‐competent subcutaneous neck progenitors, and SGBS preadipocytes. cAMP stimulation of differentiated adipocytes led to elevated uptake of serine, cysteine, and glycine, in parallel with increased oxygen consumption, augmented UCP1‐dependent proton leak, increased creatine‐driven substrate cycle‐coupled respiration, and upregulation of thermogenesis marker genes and several respiratory complex subunits; these outcomes were impeded in the presence of the specific ASC‐1 inhibitor, BMS‐466442. Our data suggest that ASC‐1‐dependent consumption of serine, cysteine, and glycine is required for efficient thermogenic stimulation of human adipocytes.
    Keywords adipocytes ; alanine ; cysteine ; energy ; heat production ; humans ; neck ; obesity ; oxygen consumption ; protein synthesis ; serine
    Language English
    Dates of publication 2021-08
    Size p. 2085-2098.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14155
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  8. Article: Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo.

    Vámos, Attila / Shaw, Abhirup / Varga, Klára / Csomós, István / Mocsár, Gábor / Balajthy, Zoltán / Lányi, Cecília / Bacso, Zsolt / Szatmári-Tóth, Mária / Kristóf, Endre

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 3

    Abstract: Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes ... ...

    Abstract Brown and beige adipocytes have multilocular lipid droplets, express uncoupling protein (UCP) 1, and promote energy expenditure. In rodents, when the stimulus of browning subsides, parkin-dependent mitophagy is activated and dormant beige adipocytes persist. In humans, however, the molecular events during the beige to white transition have not been studied in detail. In this study, human primary subcutaneous abdominal preadipocytes were differentiated to beige for 14 days, then either the beige culture conditions were applied for an additional 14 days or it was replaced by a white medium. Control white adipocytes were differentiated by their specific cocktail for 28 days. Peroxisome proliferator-activated receptor γ-driven beige differentiation resulted in increased mitochondrial biogenesis, UCP1 expression, fragmentation, and respiration as compared to white. Morphology, UCP1 content, mitochondrial fragmentation, and basal respiration of the adipocytes that underwent transition, along with the induction of mitophagy, were similar to control white adipocytes. However, white converted beige adipocytes had a stronger responsiveness to dibutyril-cAMP, which mimics adrenergic stimulus, than the control white ones. Gene expression patterns showed that the removal of mitochondria in transitioning adipocytes may involve both parkin-dependent and -independent pathways. Preventing the entry of beige adipocytes into white transition can be a feasible way to maintain elevated thermogenesis and energy expenditure.
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15030363
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  9. Article: Irisin Stimulates the Release of CXCL1 From Differentiating Human Subcutaneous and Deep-Neck Derived Adipocytes

    Shaw, Abhirup / Tóth, Beáta B / Király, Róbert / Arianti, Rini / Csomós, István / Póliska, Szilárd / Vámos, Attila / Korponay-Szabó, Ilma R / Bacso, Zsolt / Győry, Ferenc / Fésüs, László / Kristóf, Endre

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 737872

    Abstract: Thermogenic brown and beige adipocytes might open up new strategies in combating obesity. Recent studies in rodents and humans have indicated that these adipocytes release cytokines, termed "batokines". Irisin was discovered as a polypeptide regulator of ...

    Abstract Thermogenic brown and beige adipocytes might open up new strategies in combating obesity. Recent studies in rodents and humans have indicated that these adipocytes release cytokines, termed "batokines". Irisin was discovered as a polypeptide regulator of beige adipocytes released by myocytes, primarily during exercise. We performed global RNA sequencing on adipocytes derived from human subcutaneous and deep-neck precursors, which were differentiated in the presence or absence of irisin. Irisin did not exert an effect on the expression of characteristic thermogenic genes, while upregulated genes belonging to various cytokine signaling pathways. Out of the several upregulated cytokines,
    Language English
    Publishing date 2021-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.737872
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  10. Article: BMP7 Increases UCP1-Dependent and Independent Thermogenesis with a Unique Gene Expression Program in Human Neck Area Derived Adipocytes.

    Shaw, Abhirup / Tóth, Beáta B / Arianti, Rini / Csomós, István / Póliska, Szilárd / Vámos, Attila / Bacso, Zsolt / Győry, Ferenc / Fésüs, László / Kristóf, Endre

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 11

    Abstract: White adipocytes contribute to energy storage, accumulating lipid droplets, whereas brown and beige adipocytes mainly function in dissipating energy as heat primarily via the action of uncoupling protein 1 (UCP1). Bone morphogenic protein 7 (BMP7) was ... ...

    Abstract White adipocytes contribute to energy storage, accumulating lipid droplets, whereas brown and beige adipocytes mainly function in dissipating energy as heat primarily via the action of uncoupling protein 1 (UCP1). Bone morphogenic protein 7 (BMP7) was shown to drive brown adipocyte differentiation in murine interscapular adipose tissue. Here, we performed global RNA-sequencing and functional assays on adipocytes obtained from subcutaneous (SC) and deep-neck (DN) depots of human neck and differentiated with or without BMP7. We found that BMP7 did not influence differentiation but upregulated browning markers, including UCP1 mRNA and protein in SC and DN derived adipocytes. BMP7 also enhanced mitochondrial DNA content, levels of oxidative phosphorylation complex subunits, along with PGC1α and p-CREB upregulation, and fragmentation of mitochondria. Furthermore, both UCP1-dependent proton leak and UCP1-independent, creatine-driven substrate cycle coupled thermogenesis were augmented upon BMP7 addition. The gene expression analysis also shed light on the possible role of genes unrelated to thermogenesis thus far, including ACAN, CRYAB, and ID1, which were among the highest upregulated ones by BMP7 treatment in both types of adipocytes. Together, our study shows that BMP7 strongly upregulates thermogenesis in human neck area derived adipocytes, along with genes, which might have a supporting role in energy expenditure.
    Language English
    Publishing date 2021-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14111078
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