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  1. Article ; Online: Examining the barriers to accepting big health data from a health marketeer's perspective.

    Benn, Rebecca / Shaw, Alan

    Health marketing quarterly

    2021  Volume 40, Issue 1, Page(s) 1–18

    Abstract: Studies have shown that the sharing of big health data can improve patient management across primary and secondary care sectors. It can also reduce costs and can enhance the medical research process. Unfortunately, many big health data initiatives are ... ...

    Abstract Studies have shown that the sharing of big health data can improve patient management across primary and secondary care sectors. It can also reduce costs and can enhance the medical research process. Unfortunately, many big health data initiatives are being impeded because of a range of complex issues. This study was initiated to identify the said issues and develop a tool for health marketers to use to negate the barriers in big healthcare data projects. The study demonstrates how the Interactive Communication Technology Adoption Model can be operationalized to support qualitative researchers.
    MeSH term(s) Humans ; Delivery of Health Care ; Qualitative Research
    Language English
    Publishing date 2021-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 639428-0
    ISSN 1545-0864 ; 0735-9683
    ISSN (online) 1545-0864
    ISSN 0735-9683
    DOI 10.1080/07359683.2021.1994115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3244: Show issues Location:
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  2. Article ; Online: Solid Phase Synthesis of DNA Nanostructures in Heavy Liquid.

    Smyrlaki, Ioanna / Shaw, Alan / Yang, Yunshi / Shen, Boxuan / Högberg, Björn

    Small (Weinheim an der Bergstrasse, Germany)

    2022  Volume 19, Issue 4, Page(s) e2204513

    Abstract: Introduction of the solid phase method to synthesize biopolymers has revolutionized the field of biological research by enabling efficient production of peptides and oligonucleotides. One of the advantages of this method is the ease of removal of excess ... ...

    Abstract Introduction of the solid phase method to synthesize biopolymers has revolutionized the field of biological research by enabling efficient production of peptides and oligonucleotides. One of the advantages of this method is the ease of removal of excess production materials from the desired product, as it is immobilized on solid substrate. The DNA origami method utilizes the nature of nucleotide base-pairing to construct well-defined objects at the nanoscale, and has become a potent tool for manipulating matter in the fields of chemistry, physics, and biology. Here, the development of an approach to synthesize DNA nanostructures directly on magnetic beads, where the reaction is performed in heavy liquid to maintain the beads in suspension is reported. It is demonstrated that the method can achieve high folding yields of up to 90% for various DNA shapes, comparable to standard folding. At the same time, this establishes an easy, fast, and efficient way to further functionalize the DNA origami in one-pot, as well as providing a built-in purification method for easy removal of excess by-products such as non-integrated DNA strands and residual functionalization molecules.
    MeSH term(s) Nanotechnology/methods ; Solid-Phase Synthesis Techniques ; Nucleic Acid Conformation ; Nanostructures/chemistry ; DNA/chemistry
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-11-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202204513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: New technologies for new influenza vaccines.

    Shaw, Alan

    Vaccine

    2012  Volume 30, Issue 33, Page(s) 4927–4933

    Abstract: The currently available influenza vaccines were developed in the 1930s through the 1960s using technologies that were state-of-the art for the times. Decades of advancement in virology and immunology have provided the tools for making better vaccines ... ...

    Abstract The currently available influenza vaccines were developed in the 1930s through the 1960s using technologies that were state-of-the art for the times. Decades of advancement in virology and immunology have provided the tools for making better vaccines against influenza. We now have the means to make vaccines that address some of the shortcomings of the original products, in particular performance in the elderly.
    MeSH term(s) Animals ; Biotechnology/methods ; Humans ; Influenza Vaccines/genetics ; Influenza Vaccines/immunology ; Technology, Pharmaceutical/methods
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2012-07-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2012.04.095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 458: Show issues

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  4. Article ; Online: The rotavirus saga revisited.

    Shaw, Alan R

    Annual review of medicine

    2013  Volume 64, Page(s) 165–174

    Abstract: Two live oral rotavirus vaccines were approved by the US Food and Drug Administration in 2005 and 2008, following large studies of ∼70,000 each in order to address questions about intussusception triggered by a third earlier vaccine. Both new rotavirus ... ...

    Abstract Two live oral rotavirus vaccines were approved by the US Food and Drug Administration in 2005 and 2008, following large studies of ∼70,000 each in order to address questions about intussusception triggered by a third earlier vaccine. Both new rotavirus vaccines showed almost identical rates of intussusception in vaccine and placebo recipients. These vaccines have been used extensively in the United States with positive results. Efforts are under way to implement these vaccines in developing countries where the need is greatest.
    MeSH term(s) Global Health ; Humans ; Incidence ; Rotavirus/immunology ; Rotavirus Infections/epidemiology ; Rotavirus Infections/immunology ; Rotavirus Infections/prevention & control ; Rotavirus Vaccines/immunology ; Rotavirus Vaccines/therapeutic use
    Chemical Substances Rotavirus Vaccines
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-121511-093810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Human papillomavirus vaccines six years after approval.

    Shaw, Alan R

    Annual review of medicine

    2013  Volume 64, Page(s) 91–100

    Abstract: Human papillomavirus vaccines were developed beginning in the early 1990s. Two similar vaccines were approved in 2006 and 2009 following extensive clinical testing. Both vaccines prevent HPV infection. Implementation of these vaccines is the next ... ...

    Abstract Human papillomavirus vaccines were developed beginning in the early 1990s. Two similar vaccines were approved in 2006 and 2009 following extensive clinical testing. Both vaccines prevent HPV infection. Implementation of these vaccines is the next challenge.
    MeSH term(s) Drug Approval ; Humans ; Papillomaviridae/immunology ; Papillomavirus Infections/prevention & control ; Papillomavirus Infections/virology ; Papillomavirus Vaccines/therapeutic use ; Retrospective Studies
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-061511-125226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Stochastic modeling of antibody binding predicts programmable migration on antigen patterns.

    Hoffecker, Ian T / Shaw, Alan / Sorokina, Viktoria / Smyrlaki, Ioanna / Högberg, Björn

    Nature computational science

    2022  Volume 2, Page(s) 179–192

    Abstract: Viruses and bacteria commonly exhibit spatial repetition of surface molecules that directly interface with the host immune system. However the complex interaction of patterned surfaces with immune molecules containing multiple binding domains is poorly ... ...

    Abstract Viruses and bacteria commonly exhibit spatial repetition of surface molecules that directly interface with the host immune system. However the complex interaction of patterned surfaces with immune molecules containing multiple binding domains is poorly understood. We developed a pipeline for constructing mechanistic models of antibody interactions with patterned antigen substrates. Our framework relies on immobilized DNA origami nanostructures decorated with precisely placed antigens. The results revealed that antigen spacing is a spatial control parameter that can be tuned to influence antibody residence time and migration speed. The model predicts that gradients in antigen spacing can drive persistent, directed antibody migration in the direction of more stable spacing. These results depict antibody-antigen interactions as a computational system wherein antigen geometry constrains and potentially directs antibody movement. We propose that this form of molecular programmability could be exploited during co-evolution of pathogens and immune systems or in the design of molecular machines.
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article
    ISSN 2662-8457
    ISSN (online) 2662-8457
    DOI 10.1038/s43588-022-00218-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Universal influenza vaccine: the holy grail?

    Shaw, Alan R

    Expert review of vaccines

    2012  Volume 11, Issue 8, Page(s) 923–927

    Abstract: Influenza vaccines have been available since the 1950s and have seen increasingly wide use as public health authorities expanded recommendations. Recent events including shortages and avian influenza outbreaks have renewed interest in influenza vaccines, ...

    Abstract Influenza vaccines have been available since the 1950s and have seen increasingly wide use as public health authorities expanded recommendations. Recent events including shortages and avian influenza outbreaks have renewed interest in influenza vaccines, particularly improved vaccines.
    MeSH term(s) Adjuvants, Immunologic/chemistry ; Antibodies, Viral/immunology ; Antigens, Viral/immunology ; Biomedical Research/trends ; Clinical Trials as Topic ; Drug Industry/organization & administration ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Humans ; Influenza A virus/immunology ; Influenza A virus/pathogenicity ; Influenza Vaccines/immunology ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Technology, Pharmaceutical/trends ; Viral Matrix Proteins/immunology
    Chemical Substances Adjuvants, Immunologic ; Antibodies, Viral ; Antigens, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza Vaccines ; M2 protein, Influenza A virus ; Viral Matrix Proteins
    Language English
    Publishing date 2012-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1586/erv.12.73
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6077: Show issues Location:
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  8. Book: The evaluation and treatment of basic foot deformities

    Shaw, Alan H.

    in Washington, D.C. [1973]

    (Scientific papers presented at the ... annual meeting of the American Podiatry Association ; 61)

    1974  

    Author's details Alan H. Shaw ed
    Series title Scientific papers presented at the ... annual meeting of the American Podiatry Association ; 61
    Collection
    Language English
    Size XII, 425 S. : Ill., graph. Darst.
    Publisher Intercontinental Medical Book Corp
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT006877952
    ISBN 0-88372-023-X ; 978-0-88372-023-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1979 A 1349 order for loan Magazin

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  9. Article: New technologies for new influenza vaccines

    Shaw, Alan

    Vaccine. 2012 July 13, v. 30, no. 33

    2012  

    Abstract: The currently available influenza vaccines were developed in the 1930s through the 1960s using technologies that were state-of-the art for the times. Decades of advancement in virology and immunology have provided the tools for making better vaccines ... ...

    Abstract The currently available influenza vaccines were developed in the 1930s through the 1960s using technologies that were state-of-the art for the times. Decades of advancement in virology and immunology have provided the tools for making better vaccines against influenza. We now have the means to make vaccines that address some of the shortcomings of the original products, in particular performance in the elderly.
    Keywords elderly ; immunology ; influenza ; technology ; vaccines ; virology
    Language English
    Dates of publication 2012-0713
    Size p. 4927-4933.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2012.04.095
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Nanopore molecular trajectories of a eukaryotic reverse transcriptase reveal a long-range RNA structure sensing mechanism.

    Shaw, Alan / Craig, Jonathan M / Amiri, Hossein / Kim, Jeonghoon / Upton, Heather E / Pimentel, Sydney C / Huang, Jesse R / Marqusee, Susan / Collins, Kathleen / Gundlach, Jens H / Bustamante, Carlos J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Eukaryotic reverse transcriptases (RTs) can have essential or deleterious roles in normal human physiology and disease. Compared to well-studied helicases, it remains unclear how RTs overcome the ubiquitous RNA structural barriers during reverse ... ...

    Abstract Eukaryotic reverse transcriptases (RTs) can have essential or deleterious roles in normal human physiology and disease. Compared to well-studied helicases, it remains unclear how RTs overcome the ubiquitous RNA structural barriers during reverse transcription. Herein, we describe the development of a Mycobacterium smegmatis porin A (MspA) nanopore technique to sequence RNA to quantify the single-molecule kinetics of an RT from
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.05.535757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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