LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas.

    Liu, Shiqin / Chai, Timothy / Garcia-Marques, Fernando / Yin, Qingqing / Hsu, En-Chi / Shen, Michelle / Shaw Toland, Angus Martin / Bermudez, Abel / Hartono, Alifiani B / Massey, Christopher F / Lee, Chung S / Zheng, Liwei / Baron, Maya / Denning, Caden J / Aslan, Merve / Nguyen, Holly M / Nolley, Rosalie / Zoubeidi, Amina / Das, Millie /
    Kunder, Christian A / Howitt, Brooke E / Soh, H Tom / Weissman, Irving L / Liss, Michael A / Chin, Arnold I / Brooks, James D / Corey, Eva / Pitteri, Sharon J / Huang, Jiaoti / Stoyanova, Tanya

    Cell reports. Medicine

    2024  Volume 5, Issue 2, Page(s) 101381

    Abstract: Neuroendocrine carcinomas, such as neuroendocrine prostate cancer and small-cell lung cancer, commonly have a poor prognosis and limited therapeutic options. We report that ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is ... ...

    Abstract Neuroendocrine carcinomas, such as neuroendocrine prostate cancer and small-cell lung cancer, commonly have a poor prognosis and limited therapeutic options. We report that ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is elevated in tissues and plasma from patients with neuroendocrine carcinomas. Loss of UCHL1 decreases tumor growth and inhibits metastasis of these malignancies. UCHL1 maintains neuroendocrine differentiation and promotes cancer progression by regulating nucleoporin, POM121, and p53. UCHL1 binds, deubiquitinates, and stabilizes POM121 to regulate POM121-associated nuclear transport of E2F1 and c-MYC. Treatment with the UCHL1 inhibitor LDN-57444 slows tumor growth and metastasis across neuroendocrine carcinomas. The combination of UCHL1 inhibitors with cisplatin, the standard of care used for neuroendocrine carcinomas, significantly delays tumor growth in pre-clinical settings. Our study reveals mechanisms of UCHL1 function in regulating the progression of neuroendocrine carcinomas and identifies UCHL1 as a therapeutic target and potential molecular indicator for diagnosing and monitoring treatment responses in these malignancies.
    MeSH term(s) Male ; Humans ; Ubiquitin Thiolesterase/genetics ; Ubiquitin Thiolesterase/metabolism ; Carcinoma, Neuroendocrine/drug therapy ; Carcinoma, Neuroendocrine/genetics ; Small Cell Lung Carcinoma ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Membrane Glycoproteins
    Chemical Substances Ubiquitin Thiolesterase (EC 3.4.19.12) ; POM121 protein, human ; Membrane Glycoproteins ; UCHL1 protein, human
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101381
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

    Fernández-Castañeda, Anthony / Lu, Peiwen / Geraghty, Anna C. / Song, Eric / Lee, Myoung-Hwa / Wood, Jamie / O’Dea, Michael R. / Dutton, Selena / Shamardani, Kiarash / Nwangwu, Kamsi / Mancusi, Rebecca / Yalçın, Belgin / Taylor, Kathryn R. / Acosta-Alvarez, Lehi / Malacon, Karen / Keough, Michael B. / Ni, Lijun / Woo, Pamelyn J. / Contreras-Esquivel, Daniel /
    Shaw Toland, Angus Martin / Gehlhausen, Jeff R. / Klein, Jon / Takahashi, Takehiro / Silva, Julio / Israelow, Benjamin / Lucas, Carolina / Mao, Tianyang / Peña-Hernández, Mario A. / Tabachnikova, Alexandra / Homer, Robert J. / Tabacof, Laura / Tosto-Mancuso, Jenna / Breyman, Erica / Kontorovich, Amy / McCarthy, Dayna / Quezado, Martha / Vogel, Hannes / Hefti, Marco M. / Perl, Daniel P. / Liddelow, Shane / Folkerth, Rebecca / Putrino, David / Nath, Avindra / Iwasaki, Akiko / Monje, Michelle

    Cell. 2022 June 07,

    2022  

    Abstract: COVID survivors frequently experience lingering neurological symptoms that resemble cancer therapy-related cognitive impairment, a syndrome for which white-matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the ...

    Abstract COVID survivors frequently experience lingering neurological symptoms that resemble cancer therapy-related cognitive impairment, a syndrome for which white-matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans. Following mild respiratory COVID in mice, persistently impaired hippocampal neurogenesis, decreased oligodendrocytes and myelin loss were evident together with elevated CSF cytokines/chemokines including CCL11. Systemic CCL11 administration specifically caused hippocampal microglial reactivity and impaired neurogenesis. Concordantly, humans with lasting cognitive symptoms post-COVID exhibit elevated CCL11 levels. Compared to SARS-CoV-2, mild respiratory influenza in mice caused similar patterns of white matter-selective microglial reactivity, oligodendrocyte loss, impaired neurogenesis and elevated CCL11 at early timepoints, but after influenza only elevated CCL11 and hippocampal pathology persisted. These findings illustrate similar neuropathophysiology after cancer therapy and respiratory SARS-CoV-2 infection which may contribute to cognitive impairment following even mild COVID.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; cancer therapy ; cognition ; cognitive disorders ; influenza ; myelin sheath ; neurogenesis ; oligodendroglia
    Language English
    Dates of publication 2022-0607
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.06.008
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 75/702: Show issues
    Z 93: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top