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Article ; Online: Determination of pentoxifylline efficacy on microalbuminuria in patients with type-2 diabetes.

Shayanpour, Shokouh / Mehri, Aslan / Hayati, Fatemeh / Zakerkish, Mehrnoosh / Beladi Mousavi, Seyed Seifollah / Hoseinynejad, Khojasteh

Recenti progressi in medicina

2024 Volume 115, Issue 1, Page(s) 15–20

Abstract: Background: Diabetic nephropathy is a clinical syndrome characterized by persistent albuminuria and progressive impairment in renal function. Pentoxifylline is a non-specific inhibitor of phosphodiesterase with anti-inflammatory properties which may ... ...

Abstract	Background: Diabetic nephropathy is a clinical syndrome characterized by persistent albuminuria and progressive impairment in renal function. Pentoxifylline is a non-specific inhibitor of phosphodiesterase with anti-inflammatory properties which may have therapeutic potency in patients with diabetic kidney disease. Objective: The present study is aimed at evaluating the efficacy of pentoxifylline as a treatment strategy for alleviating the microalbuminuria in type-2 diabetic patients with nephropathy. Methods: This double-blind randomized clinical trial was performed on outpatients with type 2 diabetic nephropathy who presented urine albumin excretion of 30-300 mg per 24 hours on at least three consecutive occasions. A total of 58 patients were randomly assigned to the treatment and control groups. The treatment group (n=29) received pentoxifylline (400 mg/day) for 3 months in addition to the standard drugs for diabetic nephropathy (Raas blockers), while the control group (n=29) received placebo as add-on therapy. Finally, urine albumin test was measured before and after 3 months of treatment and compared between the two groups. Results: Before the intervention, no significant difference in the levels of albuminuria was observed between the two groups (153.21±130.80 mg/day vs. 159.93 ±130.45; p=0.845); but after 12 weeks of treatment, albuminuria in the treatment group was significantly reduced compared to the placebo group (29.59 ±27.88 mg/day vs. 160.48±129.53 mg/day; p<0.0001). At the end of the study, the response rate to treatment (more than 50% reduction in albuminuria) was 89.7% in the pentoxifylline group, while no response to treatment was observed in the placebo group (p<0.0001). Conclusions: Pentoxifylline as add-on therapy to the conventional treatment (Raas blockers) may reduce the microalbuminuria in patients with diabetic nephropathy without any side effects.
MeSH term(s)	Humans ; Albuminuria/drug therapy ; Albuminuria/etiology ; Albuminuria/urine ; Pentoxifylline/therapeutic use ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/urine ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Albumins/therapeutic use ; Double-Blind Method
Chemical Substances	Pentoxifylline (SD6QCT3TSU) ; Albumins
Language	English
Publishing date	2024-01-03
Publishing country	Italy
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	138266-4
ISSN	2038-1840 ; 0034-1193
ISSN (online)	2038-1840
ISSN	0034-1193
DOI	10.1701/4169.41640
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hepatitis E Virus Infection Among Chronic Hemodialysis.

Shayanpour, Shokouh / Hayati, Fatemeh

Jundishapur journal of microbiology

2016 Volume 9, Issue 3, Page(s) e26645

Language	English
Publishing date	2016-03-17
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2815501-4
ISSN	2008-4161 ; 2008-3645
ISSN (online)	2008-4161
ISSN	2008-3645
DOI	10.5812/jjm.26645
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Article: The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial.

Haghighat, Neda / Mohammadshahi, Majid / Shayanpour, Shokouh / Haghighizadeh, Mohammad Hossein / Rahmdel, Samaneh / Rajaei, Majdadin

Indian journal of nephrology

2021 Volume 31, Issue 2, Page(s) 149–156

Abstract: Introduction: The purpose of this double-blind clinical trial, was to examine the effect of supplementation with the synbiotic and probiotic on the mental health, quality of life, and anemia in HD patients.: Methods: Seventy-five HD patients were ... ...

Abstract	Introduction: The purpose of this double-blind clinical trial, was to examine the effect of supplementation with the synbiotic and probiotic on the mental health, quality of life, and anemia in HD patients. Methods: Seventy-five HD patients were randomly assigned to receive the synbiotic ( Results: From baseline to 12 weeks, synbiotic and probiotic supplementation resulted in a significant decrease in BDI and BAI score in comparison to the placebo ( Conclusion: Overall, 12 weeks of synbiotic and probiotic supplementation resulted in an improvement in mental health and anemia compared with the placebo, whereas they failed to enhance the quality of life in HD patients.
Language	English
Publishing date	2021-01-27
Publishing country	India
Document type	Journal Article
ZDB-ID	2134388-3
ISSN	1998-3662 ; 0971-4065
ISSN (online)	1998-3662
ISSN	0971-4065
DOI	10.4103/ijn.IJN_341_19
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Article: Effects of Synbiotics and Probiotics Supplementation on Serum Levels of Endotoxin, Heat Shock Protein 70 Antibodies and Inflammatory Markers in Hemodialysis Patients: a Randomized Double-Blinded Controlled Trial

Haghighat, Neda / Mohammadshahi, Majid / Shayanpour, Shokouh / Haghighizadeh, Mohammad Hossein

Probiotics and antimicrobial proteins. 2020 Mar., v. 12, no. 1

2020

Abstract: The aim of this study was to investigate the effects of probiotic and synbiotic supplementation on serum inflammatory markers, endotoxin, and anti-HSP70 in hemodialysis (HD) patients. This study was a randomized, double-blind, placebo-controlled trial. ... ...

Abstract	The aim of this study was to investigate the effects of probiotic and synbiotic supplementation on serum inflammatory markers, endotoxin, and anti-HSP70 in hemodialysis (HD) patients. This study was a randomized, double-blind, placebo-controlled trial. Seventy-five hemodialysis patients who met the inclusion and exclusion criteria were randomly assigned for 12 weeks to one of the three arms: synbiotics [n = 23; 15 g of prebiotics, 5 g of probiotic powder containing Lactobacillus acidophilus T16, Bifidobacterium bifidum BIA-6, Bifidobacterium lactis BIA-6, and Bifidobacterium longum LAF-5 (2.7 × 107 CFU/g each)], probiotics [n = 23; 5 g probiotics as in synbiotic group with 15 g of maltodextrin in the sachet as placebo], and placebo [n = 19; 20 g of maltodextrin in the sachet]. Blood and feces were collected at baseline and after intervention. Serum high sensitive C-reactive protein (hs-CRP), interleukin-6, endotoxin, and anti-heat shock protein 70 antibodies (anti-HSP70) were measured. The number of fecal colonies was determined using the plate-counting method. The mean serum level of hs-CRP, anti-HSP70, and endotoxin decreased significantly between groups (p = 0.007, p = 0.037, and p = 0.036, respectively). For the synbiotic group, the mean changes in hs-CRP and IL-6 were significantly lower than for the placebo (p < 0.001 and p < 0.001, respectively) and probiotic group (p = 0.011 and p = 0.008, respectively). Anti-HSP70 mean changes in the synbiotic and probiotic groups differed from the placebo group (p = 0.002 and p = 0.013, respectively). Administration of synbiotics was more effective than probiotics for improvement of inflammatory markers, endotoxin and anti-HSP70 serum levels. Trial registration number: IRCT2017041233393N1
Keywords	Bifidobacterium animalis subsp. lactis ; Bifidobacterium bifidum ; Bifidobacterium longum ; C-reactive protein ; Lactobacillus acidophilus ; antibodies ; blood serum ; endotoxins ; feces ; heat-shock protein 70 ; hemodialysis ; interleukin-6 ; maltodextrins ; patients ; plate count ; prebiotics ; probiotics ; randomized clinical trials
Language	English
Dates of publication	2020-03
Size	p. 144-151.
Publishing place	Springer US
Document type	Article
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-018-9509-5
Database	NAL-Catalogue (AGRICOLA)

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Article: Arteriovenous Fistula Recirculation in Hemodialysis.

Shayanpour, Shokouh / Faramarzi, Mohammad

Nephro-urology monthly

2015 Volume 7, Issue 4, Page(s) e27474

Language	English
Publishing date	2015-07-22
Publishing country	Iran
Document type	Journal Article
ISSN	2251-7006
ISSN	2251-7006
DOI	10.5812/numonthly.27474
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Article ; Online: Effects of Synbiotics and Probiotics Supplementation on Serum Levels of Endotoxin, Heat Shock Protein 70 Antibodies and Inflammatory Markers in Hemodialysis Patients: a Randomized Double-Blinded Controlled Trial.

Haghighat, Neda / Mohammadshahi, Majid / Shayanpour, Shokouh / Haghighizadeh, Mohammad Hossein

Probiotics and antimicrobial proteins

2019 Volume 12, Issue 1, Page(s) 144–151

Abstract	The aim of this study was to investigate the effects of probiotic and synbiotic supplementation on serum inflammatory markers, endotoxin, and anti-HSP70 in hemodialysis (HD) patients. This study was a randomized, double-blind, placebo-controlled trial. Seventy-five hemodialysis patients who met the inclusion and exclusion criteria were randomly assigned for 12 weeks to one of the three arms: synbiotics [n = 23; 15 g of prebiotics, 5 g of probiotic powder containing Lactobacillus acidophilus T16, Bifidobacterium bifidum BIA-6, Bifidobacterium lactis BIA-6, and Bifidobacterium longum LAF-5 (2.7 × 10
MeSH term(s)	Adult ; Aged ; Antibodies/blood ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Double-Blind Method ; Endotoxins/blood ; Female ; HSP70 Heat-Shock Proteins/immunology ; Humans ; Interleukin-6/blood ; Male ; Middle Aged ; Probiotics/administration & dosage ; Renal Dialysis ; Synbiotics/administration & dosage
Chemical Substances	Antibodies ; Biomarkers ; Endotoxins ; HSP70 Heat-Shock Proteins ; IL6 protein, human ; Interleukin-6 ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2019-01-08
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-018-9509-5
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Article: Effect of Synbiotic and Probiotic Supplementation on Serum Levels of Endothelial Cell Adhesion Molecules in Hemodialysis Patients: a Randomized Control Study

Haghighat, Neda / Mohammadshahi, Majid / Shayanpour, Shokouh / Haghighizadeh, Mohammad Hossein

Probiotics and antimicrobial proteins. 2019 Dec., v. 11, no. 4

2019

Abstract: The aim of this study was to investigate the effect of synbiotic and probiotic supplementation on serum vascular dysfunction and necrosis markers in hemodialysis (HD) patients. In this randomized, double-blind, placebo-controlled trial, 75 HD patients ... ...

Abstract	The aim of this study was to investigate the effect of synbiotic and probiotic supplementation on serum vascular dysfunction and necrosis markers in hemodialysis (HD) patients. In this randomized, double-blind, placebo-controlled trial, 75 HD patients were randomly assigned to either the synbiotic or probiotic or placebo group. The patients in the synbiotic group received 15 g of prebiotics and 5 g probiotic powder containing Lactobacillus acidophilus strain T16 (IBRC-M10785), Bifidobacterium bifidum strain BIA-6, Bifidobacterium lactis strain BIA-6, Bifidobacterium longum strain LAF-5 (2.7 × 10⁷ CFU/g each) in sachets (n = 25), whereas the probiotic group received 5 g probiotics same to the first group with 15 g of maltodextrin powder in sachets (n = 25) and the placebo group received 20 g of maltodextrin powder in sachets (n = 25) for 12 weeks. At baseline and the end of the study, serum concentrations of soluble intercellular adhesion molecule type 1 (sICAM-1), soluble vascular cell adhesion molecule type 1 (sVCAM-1), cytokeratin 18 (CK-18) as the necrosis marker, uric acid, and phosphate levels were measured. Feces also were collected for microbiota colony counting. Serum ICAM-1 level reduced significantly in the synbiotic group after the intervention period (P = 0.02), and this reduction was significantly different in the synbiotic group in comparison to the placebo group (P = 0.03). Serum levels of VCAM-1 and CK-18 were not significantly different between the groups. However, the reduction in serum levels of VCAM-1 in the synbiotic group was significantly higher in comparison to the placebo group (P = 0.01). Multivariate linear regression analysis revealed that ∆ phosphate was the sole independent determinant of ∆ICAM-1 (P = 0 < 001). The study indicated that synbiotic supplementation reduced serum ICAM-1 level, which is a risk factor for cardiovascular diseases in HD patients, but has no effect on the necrosis marker. Trial registration: www.irct.ir (IRCT2017041233393N1).
Keywords	Bifidobacterium animalis subsp. lactis ; Bifidobacterium bifidum ; Bifidobacterium longum ; Lactobacillus acidophilus ; blood serum ; cardiovascular diseases ; endothelial cells ; feces ; hemodialysis ; intercellular adhesion molecule-1 ; maltodextrins ; necrosis ; patients ; phosphates ; placebos ; prebiotics ; probiotics ; randomized clinical trials ; regression analysis ; risk factors ; uric acid ; vascular cell adhesion molecules
Language	English
Dates of publication	2019-12
Size	p. 1210-1218.
Publishing place	Springer US
Document type	Article
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-018-9477-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Synbiotic and Probiotic Supplementation on Serum Levels of Endothelial Cell Adhesion Molecules in Hemodialysis Patients: a Randomized Control Study.

Haghighat, Neda / Mohammadshahi, Majid / Shayanpour, Shokouh / Haghighizadeh, Mohammad Hossein

Probiotics and antimicrobial proteins

2018 Volume 11, Issue 4, Page(s) 1210–1218

Abstract	The aim of this study was to investigate the effect of synbiotic and probiotic supplementation on serum vascular dysfunction and necrosis markers in hemodialysis (HD) patients. In this randomized, double-blind, placebo-controlled trial, 75 HD patients were randomly assigned to either the synbiotic or probiotic or placebo group. The patients in the synbiotic group received 15 g of prebiotics and 5 g probiotic powder containing Lactobacillus acidophilus strain T16 (IBRC-M10785), Bifidobacterium bifidum strain BIA-6, Bifidobacterium lactis strain BIA-6, Bifidobacterium longum strain LAF-5 (2.7 × 10
MeSH term(s)	Adult ; Aged ; Bifidobacterium bifidum/physiology ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism ; Dietary Supplements/analysis ; Double-Blind Method ; Feces/microbiology ; Female ; Humans ; Keratin-18/genetics ; Keratin-18/metabolism ; Kidney Failure, Chronic/drug therapy ; Kidney Failure, Chronic/metabolism ; Kidney Failure, Chronic/microbiology ; Kidney Failure, Chronic/therapy ; Lactobacillus acidophilus/physiology ; Lactobacillus casei/physiology ; Male ; Middle Aged ; Probiotics/administration & dosage ; Renal Dialysis ; Synbiotics/administration & dosage
Chemical Substances	Cell Adhesion Molecules ; Keratin-18
Language	English
Publishing date	2018-10-02
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-018-9477-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of administration of oral N-acetylcysteine to reduce oxidative stress in chronic hemodialysis patients: A double-blind, randomized, controlled clinical trial.

Shahbazian, Heshmatollah / Shayanpour, Shokouh / Ghorbani, Ali

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2016 Volume 27, Issue 1, Page(s) 88–93

Abstract: This study was designed to assess the efficacy of N-acetylcysteine (NAC) on the reduction of oxidative stress in chronic hemodialysis (HD) patients through measurement of total serum anti-oxidant capacity. In this randomized, double-blind, controlled ... ...

Abstract	This study was designed to assess the efficacy of N-acetylcysteine (NAC) on the reduction of oxidative stress in chronic hemodialysis (HD) patients through measurement of total serum anti-oxidant capacity. In this randomized, double-blind, controlled clinical trial, the efficacy and safety of NAC in reduction of oxidative stress was evaluated in 40 chronic HD patients. The study was conducted at the HD Department of the Golestan Hospital, Ahvaz, Iran. Data were analyzed using SPSS version 19. Paired samples test showed that the mean score of the serum level of total anti-oxidant capacity (TAC) increased from 26.39±17.03 to 33.26±18.8 (Pvalue=0.01) and from 24.02±16.47 to 25.38±17.04 (P=0.1) in the NAC and placebo groups, respectively. Difference in the mean TAC changes between groups was statistically significant (P=0.042). In our study, NAC administration could reduce oxidative stress in chronic HD patients. No major side-effects were observed.
MeSH term(s)	Acetylcysteine/administration & dosage ; Adult ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Free Radical Scavengers/administration & dosage ; Humans ; Kidney Failure, Chronic/metabolism ; Kidney Failure, Chronic/therapy ; Male ; Oxidative Stress/drug effects ; Prospective Studies ; Renal Dialysis ; Time Factors ; Treatment Outcome
Chemical Substances	Free Radical Scavengers ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2016-01
Publishing country	Saudi Arabia
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.174084
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Diabetes and end-stage renal disease; a review article on new concepts.

Ghaderian, Seyed Bahman / Hayati, Fatemeh / Shayanpour, Shokouh / Beladi Mousavi, Seyed Seifollah

Journal of renal injury prevention

2015 Volume 4, Issue 2, Page(s) 28–33

Abstract: It is well established that diabetic nephropathy is the most common cause or in combination with hypertensive nephropathy are the most common causes of end-stage renal disease (ESRD) in developed and developing countries. For this review, we used a ... ...

Abstract	It is well established that diabetic nephropathy is the most common cause or in combination with hypertensive nephropathy are the most common causes of end-stage renal disease (ESRD) in developed and developing countries. For this review, we used a variety of sources by searching through PubMed, Embase, Scopus, Current Content and Iran Medex from January 1990 up to December 2014. Manuscripts published in English and Persian languages, as full-text articles, and or as abstract were included in the study. Patient survival in diabetics on maintenance renal replacement therapy including hemodialysis (HD), peritoneal dialysis (PD) and kidney transplantation is significantly lower than that seen in nondiabetics with ESRD. The poor prognosis of diabetic patients with ESRD is partly due to presence of significant cardiovascular disease, problems with vascular access, more susceptible to infections, foot ulcer, and hemodynamic instability during HD. Although, many complications related to kidney transplantation may occur in diabetic ESRD patients, multiple studies have found that the kidney transplantation is the preferred renal replacement therapy for diabetic patients with ESRD and it is associated with a much better survival and quality of life than dialysis among these patients.
Language	English
Publishing date	2015-06-01
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2747305-3
ISSN	2345-2781
ISSN	2345-2781
DOI	10.12861/jrip.2015.07
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