LIVIVO - Search results -

Search results

Result 1 - 10 of total 19

Search options

Article ; Online: Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression.

Pan, Rumeng / Wang, Rongli / Cheng, Feiyan / Wang, Lihui / Cui, Zhiwei / She, Jing / Yang, Xinyuan

Reproductive biology and endocrinology : RB&E

2024 Volume 22, Issue 1, Page(s) 41

Abstract: Background: Premature ovarian failure (POF) caused by cisplatin is a severe and intractable sequela for young women with cancer who received chemotherapy. Cisplatin causes the dysfunction of granulosa cells and mainly leads to but is not limited to its ... ...

Abstract	Background: Premature ovarian failure (POF) caused by cisplatin is a severe and intractable sequela for young women with cancer who received chemotherapy. Cisplatin causes the dysfunction of granulosa cells and mainly leads to but is not limited to its apoptosis and autophagy. Ferroptosis has been also reported to participate, while little is known about it. Our previous experiment has demonstrated that endometrial stem cells (EnSCs) can repair cisplatin-injured granulosa cells. However, it is still unclear whether EnSCs can play a repair role by acting on ferroptosis. Methods: Western blotting and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) were applied to detect the expression levels of ferroptosis-related genes. CCK-8 and 5-Ethynyl-2'-deoxyuridine (EdU) assays were used to evaluate cell viability. Transmission electron microscopy (TEM) was performed to detect ferroptosis in morphology. And the extent of ferroptosis was assessed by ROS, GPx, GSSG and MDA indicators. In vivo, ovarian morphology was presented by HE staining and the protein expression in ovarian tissue was detected by immunohistochemistry. Results: Our results showed that ferroptosis could occur in cisplatin-injured granulosa cells. Ferroptosis inhibitor ferrostatin-1 (Fer-1) and EnSCs partly restored cell viability and mitigated the damage of cisplatin to granulosa cells by inhibiting ferroptosis. Moreover, the repair potential of EnSCs can be markedly blocked by ML385. Conclusion: Our study demonstrated that cisplatin could induce ferroptosis in granulosa cells, while EnSCs could inhibit ferroptosis and thus exert repair effects on the cisplatin-induced injury model both in vivo and in vitro. Meanwhile, Nrf2 was validated to participate in this regulatory process and played an essential role.
MeSH term(s)	Female ; Humans ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Ferroptosis ; Granulosa Cells/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Stem Cells/metabolism
Chemical Substances	Cisplatin (Q20Q21Q62J) ; NF-E2-Related Factor 2
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2119215-7
ISSN	1477-7827 ; 1477-7827
ISSN (online)	1477-7827
ISSN	1477-7827
DOI	10.1186/s12958-024-01208-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors.

She, Jing / Sheng, Rui / Qin, Zheng-Hong

Aging and disease

2021 Volume 12, Issue 8, Page(s) 1879–1897

Abstract: Coenzyme I (nicotinamide adenine dinucleotide, ... ...

Abstract	Coenzyme I (nicotinamide adenine dinucleotide, NAD
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2021.0523
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway.

Wang, Lihui / Cheng, Feiyan / Pan, Rumeng / Cui, Zhiwei / She, Jing / Zhang, Yidan / Yang, Xinyuan

International journal of molecular sciences

2023 Volume 24, Issue 18

Abstract: Premature ovarian failure (POF) is a complicated disorder related to the apoptosis of granulosa cells. The incidence of chemotherapy-associated POF is rising dramatically owing to the increasing proportion of cancer in adolescents. According to previous ... ...

Abstract	Premature ovarian failure (POF) is a complicated disorder related to the apoptosis of granulosa cells. The incidence of chemotherapy-associated POF is rising dramatically owing to the increasing proportion of cancer in adolescents. According to previous studies, oxidative stress caused by chemotherapeutic agents plays an important role in the development of POF. However, the exact effects of nuclear factor-erythroid 2-related factor2 (NRF2), a pivotal anti-oxidative factor, are still unknown in chemotherapy-associated POF. Firstly, we manipulated NRF2 expressions on a genetic or pharmaceutical level in cisplatin-injured granulosa cell models. The results indicate that the increasing NRF2 in cisplatin-injured cells was just compensatory and not enough to resist the accumulated stress. Upregulation of NRF2 could protect granulosa cells against cisplatin via elevating autophagic level by using an autophagic activator (rapamycin) and inhibitor (chloroquine). Additionally, exogenous FGF2 exerted a protective role by increasing NRF2 expression and promoting its nuclear translocation. Meanwhile, the results in cisplatin-POF mice models were consistent with what was found in injured cells. In conclusion, our research proved that FGF2 rescued cisplatin-injured granulosa cells through the NRF2-autophagy pathway and might provide a possible alternative treatment choice by targeting NRF2 for POF patients who are intolerant or unsuitable to FGF2.
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Apoptosis ; Autophagy ; Cisplatin/adverse effects ; Fibroblast Growth Factor 2/metabolism ; Granulosa Cells/metabolism ; Menopause, Premature ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Primary Ovarian Insufficiency/chemically induced ; Primary Ovarian Insufficiency/drug therapy ; Primary Ovarian Insufficiency/metabolism
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Fibroblast Growth Factor 2 (103107-01-3) ; NF-E2-Related Factor 2
Language	English
Publishing date	2023-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241814215
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: A pharmacovigilance study of etoposide in the FDA adverse event reporting system (FAERS) database, what does the real world say?

Cui, Zhiwei / Cheng, Feiyan / Wang, Lihui / Zou, Fan / Pan, Rumeng / Tian, Yuhan / Zhang, Xiyuan / She, Jing / Zhang, Yidan / Yang, Xinyuan

Frontiers in pharmacology

2023 Volume 14, Page(s) 1259908

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1259908
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: [Sensitivity Analysis of Ozone Formation Using Response Surface Methodology].

Zhu, Yu-Huan / Chen, Bing / Zhang, Ya-Ru / Liu, Xiao / Li, Guang-Yao / She, Jing / Chen, Qiang

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 7, Page(s) 3669–3675

Abstract: Identifying the nonlinear relationship between ... ...

Abstract	Identifying the nonlinear relationship between O
Language	Chinese
Publishing date	2023-07-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202208115
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Spontaneous rupture of an unscarred uterus during pregnancy: A rare but life-threatening emergency: Case series.

Chen, Yue / Cao, Ying / She, Jing-Yao / Chen, Si / Wang, Pei-Juan / Zeng, Zheng / Liang, Chun-Yun

Medicine

2023 Volume 102, Issue 24, Page(s) e33977

Abstract: Rationale: In most cases, uterine rupture occurs during the third trimester of pregnancy or during labor. Even fewer reports have been published about the occurrence of this condition without a gynecologic history of any surgical procedure. Due to their ...

Abstract	Rationale: In most cases, uterine rupture occurs during the third trimester of pregnancy or during labor. Even fewer reports have been published about the occurrence of this condition without a gynecologic history of any surgical procedure. Due to their scarcity and variable clinical presentation, early diagnosis of uterine rupture may be difficult, and if the diagnosis is not timely, the condition may be life-threatening. Patient concerns: Herein, 3 cases of uterine rupture from a single institution are described. Three patients are at different gestational weeks and all have no history of uterine surgery. They came to the hospital due to acute abdominal pain, which is characterized by severe and persistent pain in the abdomen, with no apparent vaginal bleeding. Diagnoses: All 3 patients were diagnosed with uterine rupture during the operation. Interventions: One patient underwent uterine repair surgery; while the other 2 underwent subtotal hysterectomy due to persistent bleeding and pathological examination after surgery confirmed placenta implantation. Outcomes: The patients recovered well after the operation, and no discomfort occurred in the follow-up. Lessons: Acute abdominal pain during pregnancy can pose both diagnostic and therapeutic challenges. It is important to consider the possibility of uterine rupture, even in cases where there is no history of prior uterine surgery. The key to the treatment of uterine rupture is to shorten the diagnosis time as much as possible, this potential complication should be carefully monitored for and promptly addressed to ensure the best possible outcomes for both the mother and the developing fetus.
MeSH term(s)	Pregnancy ; Humans ; Female ; Uterine Rupture/diagnosis ; Uterine Rupture/etiology ; Uterine Rupture/surgery ; Rupture, Spontaneous/surgery ; Rupture, Spontaneous/etiology ; Uterus/surgery ; Hysterectomy/adverse effects ; Abdominal Pain/etiology ; Abdominal Pain/surgery ; Abdomen, Acute/diagnosis ; Abdomen, Acute/etiology ; Abdomen, Acute/surgery
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033977
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.171: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Updating and evaluating the NH

Li, Guangyao / Chen, Qiang / Sun, Wei / She, Jing / Liu, Jia / Zhu, Yuhuan / Guo, Wenkai / Zhang, Ruixin / Zhu, Yufan / Liu, Mingyue

Environmental pollution (Barking, Essex : 1987)

2023 Volume 333, Page(s) 122070

Abstract: The accuracy of determining atmospheric chemical mechanisms is a key factor in air pollution prediction, pollution-cause analysis and the development of control schemes based on air quality model simulations. However, the reaction of ... ...

Abstract	The accuracy of determining atmospheric chemical mechanisms is a key factor in air pollution prediction, pollution-cause analysis and the development of control schemes based on air quality model simulations. However, the reaction of NH
MeSH term(s)	Air Pollutants/toxicity ; Air Pollutants/analysis ; Ozone/toxicity ; Ozone/analysis ; Air Pollution/analysis ; Computer Simulation ; Environmental Pollution/analysis ; Environmental Pollutants/analysis ; Environmental Monitoring/methods ; China
Chemical Substances	Air Pollutants ; Ozone (66H7ZZK23N) ; Environmental Pollutants
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.122070
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2599: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Updating and evaluating the NH3 gas-phase chemical mechanism of MOZART-4 in the WRF-Chem model

Li, Guangyao / Chen, Qiang / Sun, Wei / She, Jing / Liu, Jia / Zhu, Yuhuan / Guo, Wenkai / Zhang, Ruixin / Zhu, Yufan / Liu, Mingyue

Environmental Pollution. 2023 Sept., v. 333 p.122070-

2023

Abstract	The accuracy of determining atmospheric chemical mechanisms is a key factor in air pollution prediction, pollution-cause analysis and the development of control schemes based on air quality model simulations. However, the reaction of NH₃ and OH to generate NH₂ and its subsequent reactions are often ignored in the MOZART-4 chemical mechanism. To solve this problem, the gas-phase chemical mechanism of NH₃ was updated in this study. Response surface methodology (RSM), integrated gas-phase reaction rate (IRR) diagnosis and process analysis (PA) were used to quantify the influence of the updated NH₃ chemical mechanism on the O₃ simulated concentration, the nonlinear response relationship of O₃ and its precursors, the chemical reaction rate of O₃ generation and the meteorological transport process. The results show that the updated NH₃ chemical mechanism can reduce the error between the simulated and observed O₃ concentrations and better simulate the O₃ concentration. Compared with the Base scenario (original chemical mechanism simulated), the first-order term of NH₃ in the Updated scenario (updated NH₃ chemical mechanism simulated) in RSM passed the significance test (p < 0.05), indicating that NH₃ emissions have an influence on the O₃ simulation, and the effects of the updated NH₃ chemical mechanism on NOx-VOC-O₃ in different cities are different. In addition, the analysis of chemical reaction rate changes showed that NH₃ can affect the generation of O₃ by affecting the NOx concentration and NOx circulation with radicals of OH and HO₂ in the Updated scenario, and the change of pollutant concentration in the atmosphere leads to the change of meteorological transmission, eventually leading to the reduction of O₃ concentration in Beijing. In conclusion, this study highlights the importance of atmospheric chemistry for air quality models to model atmospheric pollutants and should attract more research focus.
Keywords	air pollution ; air quality ; atmospheric chemistry ; chemical reactions ; models ; pollutants ; prediction ; response surface methodology ; China ; WRF-Chem ; O3 ; NH3 ; Chemical mechanism ; IRR ; RSM
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.122070
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 4136: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: From genomic spectrum of NTRK genes to adverse effects of its inhibitors, a comprehensive genome-based and real-world pharmacovigilance analysis.

Cui, Zhiwei / Zhai, Zhen / Xie, De / Wang, Lihui / Cheng, Feiyan / Lou, Siyu / Zou, Fan / Pan, Rumeng / Chang, Shixue / Yao, Haoyan / She, Jing / Zhang, Yidan / Yang, Xinyuan

Frontiers in pharmacology

2024 Volume 15, Page(s) 1329409

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1329409
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Exploring flatfeet morphology in children aged 6-12 years: relationships with body mass and body height through footprints and three-dimensional measurements.

Feng, Zi-Yu / She, Jing-Yi / Hu, Xin-Yao / Liu, Hong-Sheng / Wang, Hua-Jun / Zhu, Li-Guo / Zheng, Sheng / Li, Jian-You / Zhang, Kai-Rui / Li, Yi-Kai / Chen, Chao

European journal of pediatrics

2024 Volume 183, Issue 4, Page(s) 1901–1910

Abstract: The aim of the study was to determine the relationship between flatfoot morphology and body mass and height in children aged 6-12 years. A total of 6471 Chinese children (mean age 9.0 ± 1.9 years, 41% female) were assessed for foot morphometry, body ... ...

Abstract	The aim of the study was to determine the relationship between flatfoot morphology and body mass and height in children aged 6-12 years. A total of 6471 Chinese children (mean age 9.0 ± 1.9 years, 41% female) were assessed for foot morphometry, body height, and body mass index. Foot morphology, including foot length, width, girth, arch height, hallux valgus angle, and rearfoot valgus angle, was measured using a 3D laser scanner. Flatfoot evaluations were conducted using the Sztriter-Godunov index (KY) from footprints. All measurements were analyzed by age and sex using the mean values of the left and right sides. Comparisons were performed between flatfoot groups, between body mass index (BMI) groups, and between body height groups. The study revealed a significant decrease in the incidence of bipedal flatfoot with age (p < 0.001), whereas the prevalence of obesity remained consistent (p > 0.05). Bipedal flatfoot was associated with distinct morphological changes, including lower arches, reduced instep height, diminished ankle heights and a greater rearfoot valgus angle (p < 0.05). When comparing the BMI groups, overweight children had larger and thicker feet (p < 0.05), but no differences were found in arch height and ankle height (p > 0.05). When comparing the body height groups, short-statured children had a shorter feet girth, shorter arches, and shorter ankle height (p < 0.05), but no differences were found in the rearfoot valgus angle (p > 0.05). Conclusion: The main characteristics of flat feet include lower arches and instep heights and ankle heights but higher rearfoot valgus angles. In general, overweight children's feet do not have the common features of flat feet. In contrast, short children had similar features of flatfoot except for rearfoot valgus. Assessment of posture, such as rearfoot valgus, can be critical in identifying children with flat feet. What is known: • The morphology of children's feet is associated with body growth, but the relationship between flatfeet and body mass and height remains controversial. What is new: • Three-dimensional foot measurement shows that body mass is generally not associated with flatfeet, while short children have lower arches but no rearfoot valgus.
MeSH term(s)	Child ; Humans ; Female ; Male ; Flatfoot/epidemiology ; Flatfoot/complications ; Overweight ; Body Height ; Foot/anatomy & histology ; Obesity/complications
Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-024-05471-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Um IV Zs.75: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito