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  1. Article: Renal involvement in idiopathic hypereosinophic syndrome.

    Shehwaro, Nathalie / Langlois, Anne Lyse / Gueutin, Victor / Izzedine, Hassane

    Clinical kidney journal

    2015  Volume 6, Issue 3, Page(s) 272–276

    Abstract: The hypereosinophilic syndromes (HESs) are a group of disorders marked by the sustained overproduction of eosinophils, in which eosinophilic infiltration and mediator release cause damage to multiple organs. In idiopathic HES, the underlying cause of ... ...

    Abstract The hypereosinophilic syndromes (HESs) are a group of disorders marked by the sustained overproduction of eosinophils, in which eosinophilic infiltration and mediator release cause damage to multiple organs. In idiopathic HES, the underlying cause of hypereosinophilia (HE) remains unknown despite thorough aetiological work-up. Kidney disease is thought to be rare in HES. Renal manifestations described include eosinophilic interstitial nephritis, various types of glomerulopathies, thrombotic microangiopathy (TMA) and electrolyte disturbances. The diagnosis must be made in time, because a recovery of renal function can be obtained if treatment is initiated promptly.
    Language English
    Publishing date 2015-05-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sft046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6587: Show issues Location:
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  2. Article: La doxycycline ou comment faire du neuf avec du vieux ?

    Shehwaro, Nathalie / Langlois, Anne-Lyse / Gueutin, Victor / Gauthier, Marion / Casenave, Maud / Izzedine, Hassane

    Therapie

    2014  Volume 69, Issue 2, Page(s) 129–141

    Abstract: Tetracyclines are broad-spectrum antibiotics that interfere with protein synthesis. They were first widely prescribed by dermatologists in the early 1950s in the treatment of acne. More recently, their biological actions on inflammation, proteolysis, ... ...

    Title translation Doxycycline or how to create new with the old?.
    Abstract Tetracyclines are broad-spectrum antibiotics that interfere with protein synthesis. They were first widely prescribed by dermatologists in the early 1950s in the treatment of acne. More recently, their biological actions on inflammation, proteolysis, angiogenesis, apoptosis, metal chelation, ionophoresis, and bone metabolism were studied. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade components of the extracellular matrix (ECM). MMPs have direct or indirect effects on the vascular endothelium and the vascular relaxation/contraction system. The therapeutic effects of tetracyclines and analogues were studied in rosacea, bullous dermatoses, neutrophilic diseases, pyoderma gangrenosum, sarcoidosis, aortic aneurysms, cancer metastasis, periodontitis and autoimmune diseases autoimmune diseases such as rheumatoid arthritis and scleroderma. In addition, downregulation of MMP using doxycycline could be beneficial in reducing vascular dysfunction mediated by MMPs and progressive damage of the vascular wall. We review the nonantibiotic properties of doxycycline and its potential clinical applications.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Doxycycline/pharmacology ; Doxycycline/therapeutic use ; Drug Repositioning ; Humans ; Matrix Metalloproteinase Inhibitors/pharmacology ; Matrix Metalloproteinase Inhibitors/therapeutic use ; Matrix Metalloproteinases/metabolism ; Neoplasms/drug therapy ; Neoplasms/pathology ; Periodontal Diseases/drug therapy ; Rheumatic Diseases/drug therapy ; Skin Diseases/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Matrix Metalloproteinase Inhibitors ; Matrix Metalloproteinases (EC 3.4.24.-) ; Doxycycline (N12000U13O)
    Language French
    Publishing date 2014-03
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.2515/therapie/2013069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nephrotic Syndrome Associated with Lung Cancer: A Rare Case of Malignancy Associated with AA Amyloidosis.

    Gueutin, Victor / Langlois, Anne-Lyse / Shehwaro, Nathalie / Elharraqui, Ryme / Rouvier, Philippe / Izzedine, Hassane

    Case reports in nephrology

    2013  Volume 2013, Page(s) 831903

    Abstract: Nonhematologic malignancies are rarely reported to be associated with AA amyloidosis. Although the association between renal cell carcinoma and systemic AA amyloidosis has been established, the evidence linking pulmonary cancer to AA amyloidosis is ... ...

    Abstract Nonhematologic malignancies are rarely reported to be associated with AA amyloidosis. Although the association between renal cell carcinoma and systemic AA amyloidosis has been established, the evidence linking pulmonary cancer to AA amyloidosis is scarce. Here, a case of biopsy-proven renal AA amyloidosis complicated with nephrotic syndrome associated with lung carcinoma is reported.
    Language English
    Publishing date 2013-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627652-5
    ISSN 2090-665X ; 2090-6641
    ISSN (online) 2090-665X
    ISSN 2090-6641
    DOI 10.1155/2013/831903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Le syndrome hépatorénal : mise au point.

    Gueutin, Victor / Meftah, Aimele / Desbuissons, Geoffroy / Debchi, Lamis / Langlois, Anne-Lyse / Shehwaro, Nathalie / Izzedine, Hassane

    Nephrologie & therapeutique

    2013  Volume 9, Issue 7, Page(s) 471–480

    Abstract: Hepatorenal syndrome (HRS) is a severe complication of cirrhosis. It develops as a result of abnormal hemodynamics, leading to systemic vasodilatation and renal vasoconstriction. Increased bacterial translocation, various cytokines and systemic ... ...

    Title translation Hepatorenal syndrome: focus.
    Abstract Hepatorenal syndrome (HRS) is a severe complication of cirrhosis. It develops as a result of abnormal hemodynamics, leading to systemic vasodilatation and renal vasoconstriction. Increased bacterial translocation, various cytokines and systemic inflammatory response system contribute to splanchnic vasodilatation, and altered renal autoregulation. An inadequate cardiac output with systolic incompetence increases the risk of renal failure. Type 1 HRS is usually initiated by a precipitating event associated with an exaggerated systemic inflammatory response, resulting in multiorgan failure. Vasoconstrictors are the basic treatment in patients with type 1 HRS; terlipressin is the superior agent. Norepinephrine can be used as an alternative. Transjugular intrahepatic portosystemic stent shunt may be applicable in a small number of patients with type 1 HRS and in most patients with type 2 HRS. Liver transplantation is the definitive treatment for HRS. The decision to do simultaneous or sequential liver and kidney transplant remains controversial. In general, patients who need more than 8 to 12 weeks of pretransplant dialysis should be considered for combined liver-kidney transplantation.
    MeSH term(s) Hepatorenal Syndrome/diagnosis ; Hepatorenal Syndrome/physiopathology ; Hepatorenal Syndrome/therapy ; Humans
    Language French
    Publishing date 2013-12
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2013.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6298: Show issues Location:
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  5. Article: Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome.

    Langlois, Anne Lyse / Shehwaro, Nathalie / Rondet, Claire / Benbrik, Youssef / Maloum, Karim / Gueutin, Victor / Rouvier, Philippe / Izzedine, Hassane

    Clinical kidney journal

    2013  Volume 6, Issue 4, Page(s) 418–420

    Abstract: We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA ... ...

    Abstract We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA in HES, suggesting that the pathogenesis of thrombosis is at least in part related to damage from activated eosinophils.
    Language English
    Publishing date 2013-06-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sft067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6587: Show issues Location:
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