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Article ; Online: Retraction Note: Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.

Afridi, Ruqayya / Khan, Ashraf Ullah / Khalid, Sidra / Shal, Bushra / Rasheed, Hina / Ullah, Muhammad Zia / Shehzad, Omer / Kim, Yeong Shik / Khan, Salman

BMC pharmacology & toxicology

2023 Volume 24, Issue 1, Page(s) 39

Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	2680259-4
ISSN	2050-6511 ; 2050-6511
ISSN (online)	2050-6511
ISSN	2050-6511
DOI	10.1186/s40360-023-00679-6
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Article: Anti-allergic activities of Umbelliferone against histamine- and Picryl chloride-induced ear edema by targeting Nrf2/iNOS signaling in mice

Younas / Khan, Ashrafullah / Shehzad, Omer / Seo, Eun Kyoung / Onder, Alev / Khan, Salman

BMC complementary medicine and therapies. 2021 Dec., v. 21, no. 1

2021

Abstract: BACKGROUND: The current study was aimed to investigate the anti-allergic activities of the Umbelliferone (UMB) against the acute Histamine and chronic Picryl chloride (PiCl)-induced allergy in mice. UMB is a coumarin derivative (isolated from Angelica ... ...

Abstract	BACKGROUND: The current study was aimed to investigate the anti-allergic activities of the Umbelliferone (UMB) against the acute Histamine and chronic Picryl chloride (PiCl)-induced allergy in mice. UMB is a coumarin derivative (isolated from Angelica decursiva) found in various parts of the plants such as flowers, roots and, stems isolated from the plants of Umbelliferae family. METHODS: The UMB (1, 10, 50 mg/kg) was administered intraperitoneally (i.p) half an h before or 2 h after the induction of allergic ear edema. The acute ear edema was induced by histamine (intradermally, i.d), while the chronic ear edema was induced by painting the PiCl (sensitized with the toluene) on the ear. The antioxidants and oxidative stress markers were assessed. The histological changes were assessed using Hematoxylin and eosin (H and E) and giemsa staining. The immunohistochemistry studies were performed to assess the expression of the nuclear factor erythroid 2-related factor 2 (Nrf2) and inducible nitric oxide synthase (iNOS). The data was analyzed using one-way ANOVA tests followed by Tukey’s test with p < 0.05 was chosen as criteria for statistical significance. RESULTS: UMB treatment markedly reduced the allergic ear edema and ear weight compared to the negative control. Furthermore, the UMB attenuated the oxidative stress markers, while induced the antioxidants enzymes. Similarly, the UMB treatment significantly attenuated the serum immunoglobulin E (IgE) level. The UMB treatment markedly improved the histological parameters using H and E staining and Giemsa staining. The UMB administration induced the Nrf2 expression, while attenuated the iNOS expression. Furthermore, the computational analysis was performed to assess the interaction of the UMB with the various protein targets and to determine the mechanism of interaction with the target proteins. CONCLUSION: In conclusion, the UMB treatment significantly alleviated the allergic symptoms, attenuating the oxidative stress, improved the histological features using in vivo and computational approaches.
Keywords	Angelica ; alternative medicine ; anti-allergic agents ; blood serum ; chlorides ; coumarin ; ears ; edema ; eosin ; histamine ; hypersensitivity ; immunoglobulin E ; immunohistochemistry ; inducible nitric oxide synthase ; oxidative stress ; toluene ; umbelliferones
Language	English
Dates of publication	2021-12
Size	p. 215.
Publishing place	BioMed Central
Document type	Article
ISSN	2662-7671
DOI	10.1186/s12906-021-03384-1
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Article ; Online: Anti-allergic activities of Umbelliferone against histamine- and Picryl chloride-induced ear edema by targeting Nrf2/iNOS signaling in mice.

Younas / Khan, Ashrafullah / Shehzad, Omer / Seo, Eun Kyoung / Onder, Alev / Khan, Salman

BMC complementary medicine and therapies

2021 Volume 21, Issue 1, Page(s) 215

Abstract: Background: The current study was aimed to investigate the anti-allergic activities of the Umbelliferone (UMB) against the acute Histamine and chronic Picryl chloride (PiCl)-induced allergy in mice. UMB is a coumarin derivative (isolated from Angelica ... ...

Abstract	Background: The current study was aimed to investigate the anti-allergic activities of the Umbelliferone (UMB) against the acute Histamine and chronic Picryl chloride (PiCl)-induced allergy in mice. UMB is a coumarin derivative (isolated from Angelica decursiva) found in various parts of the plants such as flowers, roots and, stems isolated from the plants of Umbelliferae family. Methods: The UMB (1, 10, 50 mg/kg) was administered intraperitoneally (i.p) half an h before or 2 h after the induction of allergic ear edema. The acute ear edema was induced by histamine (intradermally, i.d), while the chronic ear edema was induced by painting the PiCl (sensitized with the toluene) on the ear. The antioxidants and oxidative stress markers were assessed. The histological changes were assessed using Hematoxylin and eosin (H and E) and giemsa staining. The immunohistochemistry studies were performed to assess the expression of the nuclear factor erythroid 2-related factor 2 (Nrf2) and inducible nitric oxide synthase (iNOS). The data was analyzed using one-way ANOVA tests followed by Tukey's test with p < 0.05 was chosen as criteria for statistical significance. Results: UMB treatment markedly reduced the allergic ear edema and ear weight compared to the negative control. Furthermore, the UMB attenuated the oxidative stress markers, while induced the antioxidants enzymes. Similarly, the UMB treatment significantly attenuated the serum immunoglobulin E (IgE) level. The UMB treatment markedly improved the histological parameters using H and E staining and Giemsa staining. The UMB administration induced the Nrf2 expression, while attenuated the iNOS expression. Furthermore, the computational analysis was performed to assess the interaction of the UMB with the various protein targets and to determine the mechanism of interaction with the target proteins. Conclusion: In conclusion, the UMB treatment significantly alleviated the allergic symptoms, attenuating the oxidative stress, improved the histological features using in vivo and computational approaches.
MeSH term(s)	Animals ; Anti-Allergic Agents/pharmacology ; Antioxidants/pharmacology ; Dose-Response Relationship, Drug ; Ear Auricle/drug effects ; Edema/chemically induced ; Edema/drug therapy ; Mice ; Oxidative Stress/drug effects ; Plant Extracts/pharmacology ; Umbelliferones/pharmacology
Chemical Substances	Anti-Allergic Agents ; Antioxidants ; Plant Extracts ; Umbelliferones
Language	English
Publishing date	2021-08-27
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-021-03384-1
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Article ; Online: Comprehensive in vivo and in silico approaches to explore the hepatoprotective activity of poncirin against paracetamol toxicity.

Ullah, Hadayat / Khan, Ashrafullah / Bibi, Tehmina / Ahmad, Sajjad / Shehzad, Omer / Ali, Hussain / Seo, Eun Kyoung / Khan, Salman

Naunyn-Schmiedeberg's archives of pharmacology

2022 Volume 395, Issue 2, Page(s) 195–215

Abstract: In the present study, poncirin was evaluated against paracetamol-induced liver injury using in vivo and computational approaches. Paracetamol was administered intraperitoneally (i.p,) to establish liver injury in mice and, subsequently, to investigate ... ...

Abstract	In the present study, poncirin was evaluated against paracetamol-induced liver injury using in vivo and computational approaches. Paracetamol was administered intraperitoneally (i.p,) to establish liver injury in mice and, subsequently, to investigate the hepatoprotective effect of poncirin (administered intraperitoneally) on liver injury. The effect of poncirin was evaluated against the liver injury markers and inflammatory cytokines. Similarly, in the present study, the antioxidants and oxidative stress parameters were also assessed following paracetamol-induced liver injury. The histological studies following liver injury were also assessed using H and E staining, Masson's trichrome staining, and periodic acid-Schiff staining. Similarly, the computational approach was used to assess the pharmacokinetic parameters of poncirin and its interaction with various protein targets. Poncirin markedly improved the antioxidant enzymes while attenuated the oxidative stress markers and inflammatory cytokines. Poncirin also markedly improved hematological parameters. Furthermore, poncirin treatment significantly improved the histological parameters using H and E staining, Masson's trichrome, and PAS staining compared to the control. Poncirin treatment also improved the liver function tests and liver synthetic activity compared to paracetamol treated group. The immunohistochemistry analysis revealed significant decrease in the inflammatory signaling protein such as nuclear factor kappa light chain enhancer of activated B cells (NF-κB), Jun N-terminal kinase (JNK), and cyclooxygenase-2 (COX-2) expression level compared to the paracetamol treated group. Computational analysis (molecular docking and molecular dynamic simulation) showed significant binding affinity of poncirin with the NF-κB, JNK, COX-2, IL-1β, IL-6, and TNF-α via multiple hydrophilic and hydrophobic binds. Similarly, the SwissADME software revealed that poncirin follows various drug-likeness rules and exhibited better pharmacokinetic parameters. Poncirin improved the sign and symptoms associated with liver injury using both in vivo and computational approaches.
MeSH term(s)	Acetaminophen/toxicity ; Analgesics, Non-Narcotic/toxicity ; Animals ; Antioxidants/metabolism ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/prevention & control ; Cytokines/metabolism ; Flavonoids/pharmacokinetics ; Flavonoids/pharmacology ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Oxidative Stress/drug effects
Chemical Substances	Analgesics, Non-Narcotic ; Antioxidants ; Cytokines ; Flavonoids ; Acetaminophen (362O9ITL9D) ; poncirin (8MUY4P95B4)
Language	English
Publishing date	2022-01-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-021-02192-1
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Article ; Online: Antidiarrheal and antispasmodic activities of Trillium govanianum rhizomes extract: involvement of calcium channel blockade

Naveed, Muhammad / Ur Rahman, Shafiq / Uddin, Hilal / Shehzad, Omer / Ismail, Muhammad / Ali, Niaz / Khan, Aslam / Shāhid, Muḥammad / Ullah, Abid / Ahmad, Shujaat / Hussain, Haya / ul Haq, Ikram / Vitalini, Sara / Iriti, Marcello

Natural Product Research. 2022 July 29, v. 36, no. 16 p.4238-4242

2022

Abstract: The antidiarrheal effect of methanolic extract of Trillium govanianum Wall. ex D. Don (Melanthiaceae alt. Trilliaceae) was studied at doses of 12.5, 25, and 50 mg/kg in different animal models of diarrhea including castor oil (6 mL/kg), magnesium sulfate ...

Abstract	The antidiarrheal effect of methanolic extract of Trillium govanianum Wall. ex D. Don (Melanthiaceae alt. Trilliaceae) was studied at doses of 12.5, 25, and 50 mg/kg in different animal models of diarrhea including castor oil (6 mL/kg), magnesium sulfate (2 gm/kg), sodium picosulfate (2 mL/kg) and lactitol (0.25 mL/kg). The antispasmodic effect of T. govanianum was studied on isolated rabbit’s jejunum, using acetylcholine as tissue stabiliser and verapamil as calcium channel blocker. T. govanianum attenuated the diarrhea by producing a significant decrease in the number and weight of stool, and an increase in stool latency time. T. govanianum completely inhibited both spontaneous as well as high potassium induced contractions of isolated rabbit’s jejunum, which was analogous to verapamil. Moreover, T. govanianum produced a right shift in calcium concentration response curve, confirming its calcium channel blocking activity. These findings provide scientific ground to its medicinal use in diarrhea and gut spasms.
Keywords	Trillium ; acetylcholine ; antidiarrheal effect ; calcium ; calcium channels ; castor oil ; diarrhea ; jejunum ; lactitol ; magnesium sulfate ; parasympatholytics ; potassium ; rabbits ; research ; sodium ; verapamil ; Medicinal plants ; traditional medicine ; diarrheal disease ; natural products
Language	English
Dates of publication	2022-0729
Size	p. 4238-4242.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.1973463
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Article ; Online: Therapeutic potential of curcumin for multiple sclerosis.

Qureshi, Munibah / Al-Suhaimi, Ebtesam A / Wahid, Fazli / Shehzad, Omer / Shehzad, Adeeb

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2018 Volume 39, Issue 2, Page(s) 207–214

Abstract: Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS), characterized by demyelination, neuronal injury, and breaching of the blood-brain barrier (BBB). Epidemiological studies have shown that ... ...

Abstract	Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS), characterized by demyelination, neuronal injury, and breaching of the blood-brain barrier (BBB). Epidemiological studies have shown that immunological, genetic, and environmental factors contribute to the progression and development of MS. T helper 17 (Th17) cells are crucial immunological participant in the pathophysiology of MS. The aberrant production of IL-17 and IL-22 by Th17 cells crosses BBB promotes its disruption and interferes with transmission of nerve signals through activation of neuroinflammation in the CNS. These inflammatory responses promote demyelination through transcriptional activation of signal transducers and activators of transcription-1 (STAT-1), nuclear factor kappa-B (NF-κB), matrix metalloproteinases (MMPs), interferon ϒ (IFNϒ), and Src homology region 2 domain-containing phosphatase-1 (SHP-1). B cells also contribute to disease progression through abnormal regulation of antibodies, cytokines, and antigen presentation. Additionally, oxidative stress has been known as a causative agent for the MS. Curcumin is a hydrophobic yellowish diphenolic component of turmeric, which can interact and modulate multiple cell signaling pathways and prevent the development of various autoimmune neurological diseases including MS. Studies have reported curcumin as a potent anti-inflammatory, antioxidant agent that could modulate cell cycle regulatory proteins, enzymes, cytokines, and transcription factors in CNS-related disorders including MS. The current study summarizes the reported knowledge on therapeutic potential of curcumin against MS, with future indication as neuroprotective and neuropharmacological drug.
MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Curcumin/therapeutic use ; Humans ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/physiopathology
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2018-02
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-017-3149-5
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Article: The pharmacological basis of Cuscuta reflexa whole plant as an antiemetic agent in pigeons

Muhammad, Naveed / Ullah, Sana / Abu-Izneid, Tareq / Rauf, Abdur / Shehzad, Omer / Atif, Muhammad / Khan, Haroon / Naz, Humira / Herrera-Calderon, Oscar / Khalil, Anees Ahmed / Uddin, Md. Sahab

Toxicology reports. 2020, v. 7

2020

Abstract: Cuscuta reflexa has been traditionally used as an antiemetic. Additionally, it has been used in various herbal formulations for the treatment of emesis. So far, there is no scientific evidence of the plant extract as antiemetic. Therefore, this study was ...

Abstract	Cuscuta reflexa has been traditionally used as an antiemetic. Additionally, it has been used in various herbal formulations for the treatment of emesis. So far, there is no scientific evidence of the plant extract as antiemetic. Therefore, this study was intended to assess the antiemetic activity of Juice (JCR), aqueous (CRAE) and methanolic extract (CRME) of C. reflexa in pigeons. Emesis was induced through GIT irritants like ampicillin (300 mg/kg, IM), copper sulphate (100 mg/kg, PO), conc. sodium chloride solution (1600 mg/kg, PO) and cisplatin (5-HT₃ receptor stimulator) (6 mg/kg, IM). Dimenhydrinate acted as a positive control (2 mg/kg; IM). JCR [(1 ml/kg (1 %) and 1 ml/kg (2 %)], CRAE, and CRME were administered intramuscularly at different doses (50, 100 and 200 mg/kg) to each pigeon (n = 6). In each group, calculation of total number of jerks & vomiting episodes, and vomiting-weight was carried out to evaluate its antiemetic activity. The JCR exhibited a significant (p < 0.05) antiemetic impact on both the frequency and onset of emesis at 1 ml/kg (2 %) against various emesis mediator, except sodium chloride. Similarly, CRAE and CRME elicited marked dose dependent inhibition both on onset and frequency of emesis with highly significant (p < 0.001) effect at 200 mg/kg. The study reflects that juice, aqueous and methanolic extract of C. reflexa have significant antiemetic potential and possess pharmacological active constituent(s) that interfered with the emetic mediators by acting through GIT irritation and 5-HT₃ receptor stimulations. Results of this study provide a scientific background to its traditional antiemetic uses.
Keywords	Cuscuta reflexa ; ampicillin ; antiemetics ; cisplatin ; copper sulfate ; dose response ; emetics ; juices ; pigeons ; plant extracts ; sodium chloride ; toxicology ; vomiting
Language	English
Size	p. 1305-1310.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2805786-7
ISSN	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2020.09.009
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Article ; Online: Anomalin attenuates LPS-induced acute lungs injury through inhibition of AP-1 signaling.

Khan, Ashrafullah / Khan, Salman / Ali, Hassan / Shah, Kifayat Ullah / Ali, Hussain / Shehzad, Omer / Onder, Alev / Kim, Yeong Shik

International immunopharmacology

2019 Volume 73, Page(s) 451–460

Abstract: In the present study, the anomalin was investigated to determine the protective effects and underlying mechanism against LPS-induced acute lung injury in mice. Anomalin administration 30 min after the LPS injection, significantly attenuated the ... ...

Abstract	In the present study, the anomalin was investigated to determine the protective effects and underlying mechanism against LPS-induced acute lung injury in mice. Anomalin administration 30 min after the LPS injection, significantly attenuated the mechanical allodynia, decrease body temperature, and improved the histological changes and inhibited the infiltration of leukocytes. The anomalin treatment markedly inhibited the production of pro-inflammatory mediators such as cytokines (IL-1β, IL-6 and TNF-α) and NO in contrast to the LPS treated groups. Similarly, the anomalin also enhanced the level of anti-oxidant enzymes such as GST, GSH, Catalase and inhibited oxidative stress marker such as MDA. In order to explore the molecular mechanism the effect of anomalin was evaluated for mitogen activated protein kinases (MAPK) in LPS-stimulated RAW264.7 cells. The anomalin treatment significantly attenuated the MAPK proteins such as ERK1/2, JNK and p38 (which is downstream signaling proteins to the MAPKKKs and MAPKKs protein) in the RAW264.7 macrophages using western blot analysis. Furthermore, the western blot analysis showed that anomalin treatment significantly inhibited the activation of the Akt proteins in the RAW264.7 macrophages. The AP-1 served as downstream target for the MAPK pathways and the blocking MAPK pathways is responsible for the inhibition of the AP-1 protein. The AP-1/DNA binding was assessed in the RAW264.7 cells using EMSA. The anomalin treatment significantly restricted the AP-1/DNA binding activity and the decrease in the AP-1/DNA binding activity might be contributed due to the upstream inhibition of the MAPKs signaling.
MeSH term(s)	Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/metabolism ; Animals ; Coumarins/pharmacology ; Coumarins/therapeutic use ; Cytokines/metabolism ; DNA/metabolism ; Lipopolysaccharides ; Male ; Mice ; Mice, Inbred BALB C ; Mitogen-Activated Protein Kinases/metabolism ; Nitric Oxide/metabolism ; RAW 264.7 Cells ; Signal Transduction/drug effects ; Transcription Factor AP-1/antagonists & inhibitors ; Transcription Factor AP-1/metabolism
Chemical Substances	Coumarins ; Cytokines ; Lipopolysaccharides ; Transcription Factor AP-1 ; Nitric Oxide (31C4KY9ESH) ; anomalin (81740-07-0) ; DNA (9007-49-2) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2019-05-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2019.05.032
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Article ; Online: Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.

Afridi, Ruqayya / Khan, Ashraf Ullah / Khalid, Sidra / Shal, Bushra / Rasheed, Hina / Ullah, Muhammad Zia / Shehzad, Omer / Kim, Yeong Shik / Khan, Salman

publication RETRACTED

BMC pharmacology & toxicology

2019 Volume 20, Issue 1, Page(s) 57

Abstract: Background: Poncirin is flavanone derivative (isolated from Poncirus trifoliata) with known pharmacological activities such as anti-tumor, anti-osteoporotic, anti-inflammatory and anti-colitic. The present study aimed to explore the anti-allodynic and ... ...

Abstract	Background: Poncirin is flavanone derivative (isolated from Poncirus trifoliata) with known pharmacological activities such as anti-tumor, anti-osteoporotic, anti-inflammatory and anti-colitic. The present study aimed to explore the anti-allodynic and anti-hyperalgesic potentials of poncirin in murine models of inflammatory pain. Methods: The analgesic potential of poncirin was evaluated in formalin-, acetic acid-, carrageenan- and Complete Freund's Adjuvant (CFA)-induced inflammatory pain models in mice. Anti-allodynic and anti-hyperalgesic activities were measured using Von Frey filaments, Randall Selitto, hotplate and cold acetone tests. The serum nitrite levels were determined using Griess reagent. The Quantitative Real-time PCR (qRT-PCR) was performed to assess the effect of poncirin on mRNA expression levels of inflammatory cytokines and anti-oxidant enzymes. Results: Intraperitoneal administration of poncirin (30 mg/kg) markedly reduced the pain behavior in both acetic acid-induced visceral pain and formalin-induced tonic pain models used as preliminary screening tools. The poncirin (30 mg/kg) treatment considerably inhibited the mechanical hyperalgesia and allodynia as well as thermal hyperalgesia and cold allodynia. The qRT-PCR analysis showed noticeable inhibition of pro-inflammatory cytokines (mRNA expression levels of TNF-α, IL-1β and IL-6) (p < 0.05) in poncirin treated group. Similarly, poncirin treatment also enhanced the mRNA expressions levels of anti-oxidant enzymes such as transcription factor such as nuclear factor (erythroid-derived 2)-like 2 (Nrf2) (p < 0.05), heme oxygenase (HO-1) (p < 0.05) and superoxide dismutase (SOD2) (p < 0.05). Chronic treatment of poncirin for 6 days did not confer any significant hepatic and renal toxicity. Furthermore, poncirin treatment did not altered the motor coordination and muscle strength in CFA-induced chronic inflammatory pain model. Conclusion: The present study demonstrated that poncirin treatment significantly reduced pain behaviors in all experimental models of inflammatory pain, suggesting the promising analgesic potential of poncirin in inflammatory pain conditions.
MeSH term(s)	Acetic Acid/antagonists & inhibitors ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/toxicity ; Carrageenan/antagonists & inhibitors ; Chronic Pain/chemically induced ; Chronic Pain/drug therapy ; Disease Models, Animal ; Flavonoids/therapeutic use ; Flavonoids/toxicity ; Formaldehyde/adverse effects ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Inflammation/chemically induced ; Inflammation/drug therapy ; Male ; Mice ; Mice, Inbred BALB C ; Respiratory Hypersensitivity/drug therapy
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Flavonoids ; Formaldehyde (1HG84L3525) ; poncirin (8MUY4P95B4) ; Carrageenan (9000-07-1) ; Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2019-09-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	2680259-4
ISSN	2050-6511 ; 2050-6511
ISSN (online)	2050-6511
ISSN	2050-6511
DOI	10.1186/s40360-019-0335-5
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Article ; Online: Evaluation of the anti-diarrheal effects of the whole plant extracts of

Muhammad, Naveed / Ullah, Sana / Rauf, Abdur / Atif, Muhammad / Patel, Seema / Israr, Muhammad / Akbar, Sajid / Shehzad, Omer / Saeed, Muhammad / Bawazeer, Saud / Uddin, Md Sahab / Derkho, Marina / Shariati, Mohammad Ali / Mubarak, Mohammad S

Toxicology reports

2021 Volume 8, Page(s) 395–404

Abstract: Background: Cuscuta reflexa: Methods: The antidiarrheal effect of : Results: In addition to cisplatin-induced diarrhea, all paradigms tested gave significant results (: Conclusions: Taken all together, results from this study reveal that the ... ...

Abstract	Background: Cuscuta reflexa Methods: The antidiarrheal effect of Results: In addition to cisplatin-induced diarrhea, all paradigms tested gave significant results ( Conclusions: Taken all together, results from this study reveal that the juice, aqueous, and methanol extract of
Language	English
Publishing date	2021-02-23
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2021.02.013
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