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  1. AU="Sheila V. Kusnoor"
  2. AU="Aydoğdu, İsmet"
  3. AU=Fried Jonathan E
  4. AU="April C. Roslani"
  5. AU="Scott, Jeffrey F"
  6. AU=Piscaglia Anna Chiara AU=Piscaglia Anna Chiara
  7. AU="Ziya Bozkurt"
  8. AU="Morris, Michael A."
  9. AU="Low, Keat"
  10. AU="Zick, G."
  11. AU=Miles Alexander
  12. AU="Orzan, Fulvio"
  13. AU="Shruti A. Anant"
  14. AU="Jin, Hong-Wei"
  15. AU="Gonzalez, Louis"
  16. AU=Torres Victor J.
  17. AU="Manning, Nyla"
  18. AU="Sindkar, Anushka"
  19. AU=Rodieux Frdrique
  20. AU="Tote, Sachin"

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  1. Artikel ; Online: Design and implementation of a massive open online course on enhancing the recruitment of minorities in clinical trials – Faster Together

    Sheila V. Kusnoor / Victoria Villalta-Gil / Margo Michaels / Yvonne Joosten / Tiffany L. Israel / Marcia I. Epelbaum / Patricia Lee / Elizabeth T. Frakes / Jennifer Cunningham-Erves / Stephanie A. Mayers / Sarah C. Stallings / Nunzia B. Giuse / Paul A. Harris / Consuelo H. Wilkins

    BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-

    2021  Band 11

    Abstract: Abstract Background Racial and ethnic minorities are often underrepresented in clinical trials, threatening the generalizability of trial results. Several factors may contribute to underrepresentation of minorities in clinical trials, including lack of ... ...

    Abstract Abstract Background Racial and ethnic minorities are often underrepresented in clinical trials, threatening the generalizability of trial results. Several factors may contribute to underrepresentation of minorities in clinical trials, including lack of training for researchers and staff on the importance of diversity in clinical trials and effective strategies for recruiting and retaining minority populations. Methods Applying community engaged research principles, we developed a massive open online course (MOOC) to help research team members develop knowledge and skills to enhance the recruitment of minorities in clinical trials. A transdisciplinary working group, consisting of clinical researchers, community engagement specialists, minority clinical trial recruitment and retention educators and specialists, and knowledge management information scientists, was formed to develop an evidence-based curriculum. Feedback from the Recruitment Innovation Center Community Advisory Board was incorporated to help finalize the curriculum. The course was implemented in Coursera, an online learning platform offering MOOCs. A bootstrap paired sample t-test was used to compare pre- and post-assessments of knowledge, attitudes, and intentions as it relates to minority recruitment. Results The final course, entitled Faster Together, was divided into eight 1-h modules. Each module included video presentations, reading assignments, and quizzes. After 10 months, 382 individuals enrolled in the course, 105 participants completed the pre-test, and 14 participants completed the post-test. Participants’ knowledge scores were higher with an increase in the mean number of correct answers from 15.4 (95% CI:12.1–18.7) on the pre-test to 18.7 (95% CI:17.42–20.2) on the post-test. All post-test respondents (n = 14) indicated that the course improved their professional knowledge, and 71.4% of respondents indicated that they were very likely to make changes to their recruitment practices. Conclusions Faster Together, a massive open online course, is an acceptable, accessible approach to educating research teams on minority recruitment in clinical trials. Preliminary evidence indicates the course increased knowledge on how to recruit minorities into clinical trials and could promote change in their recruitment practices.
    Schlagwörter Clinical trials ; Education ; Race ; Ethnicity ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Systematic review of international studies evaluating MDRD and CKD-EPI estimated glomerular filtration rate (eGFR) equations in Black adults.

    Ebele M Umeukeje / Taneya Y Koonce / Sheila V Kusnoor / Ifeoma I Ulasi / Sophia Kostelanetz / Annette M Williams / Mallory N Blasingame / Marcia I Epelbaum / Dario A Giuse / Annie N Apple / Karampreet Kaur / Tavia González Peña / Danika Barry / Leo G Eisenstein / Cameron T Nutt / Nunzia B Giuse

    PLoS ONE, Vol 17, Iss 10, p e

    2022  Band 0276252

    Abstract: Use of race adjustment in estimating glomerular filtration rate (eGFR) has been challenged given concerns that it may negatively impact the clinical care of Black patients, as it results in Black patients being systematically assigned higher eGFR values ... ...

    Abstract Use of race adjustment in estimating glomerular filtration rate (eGFR) has been challenged given concerns that it may negatively impact the clinical care of Black patients, as it results in Black patients being systematically assigned higher eGFR values than non-Black patients. We conducted a systematic review to assess how well eGFR, with and without race adjustment, estimates measured GFR (mGFR) in Black adults globally. A search across multiple databases for articles published from 1999 to May 2021 that compared eGFR to mGFR and reported outcomes by Black race was performed. We included studies that assessed eGFR using the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPICr) creatinine equations. Risk of study bias and applicability were assessed with the QUality Assessment of Diagnostic Accuracy Studies-2. Of 13,167 citations identified, 12 met the data synthesis criteria (unique patient cohorts in which eGFR was compared to mGFR with and without race adjustment). The studies included patients with and without kidney disease from Africa (n = 6), the United States (n = 3), Europe (n = 2), and Brazil (n = 1). Of 11 CKD-EPI equation studies, all assessed bias, 8 assessed accuracy, 6 assessed precision, and 5 assessed correlation/concordance. Of 7 MDRD equation studies, all assessed bias, 6 assessed accuracy, 5 assessed precision, and 3 assessed correlation/concordance. The majority of studies found that removal of race adjustment improved bias, accuracy, and precision of eGFR equations for Black adults. Risk of study bias was often unclear, but applicability concerns were low. Our systematic review supports the need for future studies to be conducted in diverse populations to assess the possibility of alternative approaches for estimating GFR. This study additionally provides systematic-level evidence for the American Society of Nephrology-National Kidney Foundation Task Force efforts to pursue other options for GFR estimation.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: The Recruitment Innovation Center

    Consuelo H. Wilkins / Terri L. Edwards / Mary Stroud / Nan Kennedy / Rebecca N. Jerome / Colleen E. Lawrence / Sheila V. Kusnoor / Sarah Nelson / Loretta M. Byrne / Leslie R. Boone / Julia Dunagan / Tiffany Israel / Casey Rodweller / Bethany Drury / Rhonda G. Kost / Jill M. Pulley / Gordon R. Bernard / Paul A. Harris

    Journal of Clinical and Translational Science, Vol

    Developing novel, person-centered strategies for clinical trial recruitment and retention

    2021  Band 5

    Abstract: Clinical trials continue to face significant challenges in participant recruitment and retention. The Recruitment Innovation Center (RIC), part of the Trial Innovation Network (TIN), has been funded by the National Center for Advancing Translational ... ...

    Abstract Clinical trials continue to face significant challenges in participant recruitment and retention. The Recruitment Innovation Center (RIC), part of the Trial Innovation Network (TIN), has been funded by the National Center for Advancing Translational Sciences of the National Institutes of Health to develop innovative strategies and technologies to enhance participant engagement in all stages of multicenter clinical trials. In collaboration with investigator teams and liaisons at Clinical and Translational Science Award institutions, the RIC is charged with the mission to design, field-test, and refine novel resources in the context of individual clinical trials. These innovations are disseminated via newsletters, publications, a virtual toolbox on the TIN website, and RIC-hosted collaboration webinars. The RIC has designed, implemented, and promised customized recruitment support for 173 studies across many diverse disease areas. This support has incorporated site feasibility assessments, community input sessions, recruitment materials recommendations, social media campaigns, and an array of study-specific suggestions. The RIC’s goal is to evaluate the efficacy of these resources and provide access to all investigating teams, so that more trials can be completed on time, within budget, with diverse participation, and with enough accrual to power statistical analyses and make substantive contributions to the advancement of healthcare.
    Schlagwörter Translational research ; multicenter clinical trials ; participant recruitment ; participant retention ; CTSA program ; Medicine ; R
    Thema/Rubrik (Code) 020
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Cambridge University Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Collection of social determinants of health in the community clinic setting

    Sheila V. Kusnoor / Taneya Y. Koonce / Suzanne T. Hurley / Kalonji M. McClellan / Mallory N. Blasingame / Elizabeth T. Frakes / Li-Ching Huang / Marcia I. Epelbaum / Nunzia B. Giuse

    BMC Public Health, Vol 18, Iss 1, Pp 1-

    a cross-sectional study

    2018  Band 9

    Abstract: Abstract Background Addressing social and behavioral determinants of health (SBDs) may help improve health outcomes of community clinic patients. This cross-sectional study explored how assessing SBDs can be used to complement health data collection ... ...

    Abstract Abstract Background Addressing social and behavioral determinants of health (SBDs) may help improve health outcomes of community clinic patients. This cross-sectional study explored how assessing SBDs can be used to complement health data collection strategies and provide clinicians with a more in-depth understanding of their patients. Methods Adult patients, ages 18 and older, at an urban community health care clinic in Tennessee, U.S.A., were asked to complete a questionnaire regarding health status, health history and SBDs while waiting for their clinic appointment. The SBD component included items from the National Academy of Medicine, the Protocol for Responding to and Assessing Patient Assets, Risks, and Experiences instrument, and the Survey of Household Economics and Decisionmaking. Data collection and analysis occurred in 2017. Results One hundred participants completed the study. The questionnaire took approximately 11 min to complete, and the response rate was 90% or higher for all items except annual household income (unanswered by 40 participants). The median number of negative SBDs was 4 (IQR 2.75–7.0), 96 participants had at least one unmet need, and the most common negative SBD was physical activity (75%; 75/100). Conclusions The hybrid questionnaire provided insight into a community clinic population’s SBDs and allowed for a more complete understanding than a single questionnaire alone. The brief questionnaire administration time and low non-response rate support the questionnaire’s feasibility in the community clinic setting, and results can be used by clinicians to further the personalization goals of precision medicine. Next steps include evaluating how to connect patients with appropriate resources for addressing their SBDs.
    Schlagwörter Social determinants of health ; PRAPARE ; Community health clinic ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 300
    Sprache Englisch
    Erscheinungsdatum 2018-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Why equating all evidence searches to systematic reviews defies their role in information seeking

    Zachary E. Fox / Annette M. Williams / Mallory N. Blasingame / Taneya Y. Koonce / Sheila V. Kusnoor / Jing Su / Patricia Lee / Marcia I. Epelbaum / Helen M. Naylor / Spencer J. DesAutels / Elizabeth T. Frakes / Nunzia Bettinsoli Giuse

    Journal of the Medical Library Association, Vol 107, Iss

    2019  Band 4

    Abstract: All too often the quality and rigor of topic investigations is inaccurately conveyed to information professionals, resulting in a mischaracterization of the research, which, if left unchecked and published, may in turn mislead potential readers. ... ...

    Abstract All too often the quality and rigor of topic investigations is inaccurately conveyed to information professionals, resulting in a mischaracterization of the research, which, if left unchecked and published, may in turn mislead potential readers. Accurately understanding and categorizing the types of topic investigation searches that are requested of information professionals is critical to both meeting requestors’ needs and reflecting their intended methodological approaches. Information professionals’ expertise can be an invaluable resource to guide users through the investigative and publication process.
    Schlagwörter systematic reviews ; evidence ; information needs ; Bibliography. Library science. Information resources ; Z ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2019-10-01T00:00:00Z
    Verlag University Library System, University of Pittsburgh
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Diversity and inclusion for the All of Us research program

    Brandy M Mapes / Christopher S Foster / Sheila V Kusnoor / Marcia I Epelbaum / Mona AuYoung / Gwynne Jenkins / Maria Lopez-Class / Dara Richardson-Heron / Ahmed Elmi / Karl Surkan / Robert M Cronin / Consuelo H Wilkins / Eliseo J Pérez-Stable / Eric Dishman / Joshua C Denny / Joni L Rutter / All of Us Research Program

    PLoS ONE, Vol 15, Iss 7, p e

    A scoping review.

    2020  Band 0234962

    Abstract: The All of Us Research Program (All of Us) is a national effort to accelerate health research by exploring the relationship between lifestyle, environment, and genetics. It is set to become one of the largest research efforts in U.S. history, aiming to ... ...

    Abstract The All of Us Research Program (All of Us) is a national effort to accelerate health research by exploring the relationship between lifestyle, environment, and genetics. It is set to become one of the largest research efforts in U.S. history, aiming to build a national resource of data from at least one million participants. All of Us aims to address the need for more diversity in research and set the stage for that diversity to be leveraged in precision medicine research to come. This paper describes how the program assessed demographic characteristics of participants who have enrolled in other U.S. biomedical research cohorts to better understand which groups are traditionally represented or underrepresented in biomedical research. We 1) reviewed the enrollment characteristics of national cohort studies like All of Us, and 2) surveyed the literature, focusing on key diversity categories essential to the program's enrollment aims. Based on these efforts, All of Us emphasizes enrollment of racial and ethnic minorities, and has formally designated the following additional groups as historically underrepresented: individuals-with inadequate access to medical care; under the age of 18 or over 65; with an annual household income at or below 200% of the federal poverty level; who have a cognitive or physical disability; have less than a high school education or equivalent; are intersex; identify as a sexual or gender minority; or live in rural or non-metropolitan areas. Research accounting for wider demographic variability is critical. Only by ensuring diversity and by addressing the very barriers that limit it, can we position All of Us to better understand and tackle health disparities.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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