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  1. AU="Sheleg, Dmitriy"
  2. AU="Panzirer, David"

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  1. Artikel: Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules.

    Primak, Alexandra / Bozov, Kirill / Rubina, Kseniya / Dzhauari, Stalik / Neyfeld, Elena / Illarionova, Maria / Semina, Ekaterina / Sheleg, Dmitriy / Tkachuk, Vsevolod / Karagyaur, Maxim

    Frontiers in molecular neuroscience

    2024  Band 17, Seite(n) 1361764

    Abstract: Mental illness and cognitive disorders represent a serious problem for the modern society. Many studies indicate that mental disorders are polygenic and that impaired brain development may lay the ground for their manifestation. Neural tissue development ...

    Abstract Mental illness and cognitive disorders represent a serious problem for the modern society. Many studies indicate that mental disorders are polygenic and that impaired brain development may lay the ground for their manifestation. Neural tissue development is a complex and multistage process that involves a large number of distant and contact molecules. In this review, we have considered the key steps of brain morphogenesis, and the major molecule families involved in these process. The review provides many indications of the important contribution of the brain development process and correct functioning of certain genes to human mental health. To our knowledge, this comprehensive review is one of the first in this field. We suppose that this review may be useful to novice researchers and clinicians wishing to navigate the field.
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2024.1361764
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Novel missense variants in brain morphogenic genes associated with depression and schizophrenia.

    Karagyaur, Maxim / Primak, Alexandra / Bozov, Kirill / Sheleg, Dmitriy / Arbatsky, Mikhail / Dzhauari, Stalik / Illarionova, Maria / Semina, Ekaterina / Samokhodskaya, Larisa / Klimovich, Polina / Velichko, Arkadiy / Drach, Mikhail / Sotskaya, Ekaterina / Popov, Vladimir / Rubina, Kseniya / Parfenenko, Mariia / Makus, Julia / Tsygankov, Boris / Tkachuk, Vsevolod /
    Neyfeld, Elena

    Frontiers in psychiatry

    2024  Band 15, Seite(n) 1338168

    Abstract: Introduction: Impaired function of brain morphogenic genes is considered one of the predisposing factors for the manifestation of psychiatric and cognitive disorders, such as paranoid schizophrenia (SCZ) and major depressive disorder (MDD). ... ...

    Abstract Introduction: Impaired function of brain morphogenic genes is considered one of the predisposing factors for the manifestation of psychiatric and cognitive disorders, such as paranoid schizophrenia (SCZ) and major depressive disorder (MDD). Identification of such genes (genes of neurotrophic factors and guidance molecules among them) and their deleterious genetic variants serves as a key to diagnosis, prevention, and possibly treatment of such disorders. In this study, we have examined the prevalence of genomic variants in brain morphogenic genes in individuals with SCZ and MDD within a Russian population.
    Methods: We have performed whole-exome sequencing of 21 DNA samples: 11 from individuals with SCZ and 10 with MDD, followed by ARMS (Amplification-Refractory Mutation System) based screening of detected single nucleotide variants (SNVs) in larger groups: 102 for individuals with SCZ, 79 for those with MDD and 103 for healthy donors.
    Results: Whole-exome sequencing has revealed 226 missense mutations in 79 genes (out of 140 studied), some of which occur in patients with psychiatric disorders significantly more frequently than in healthy donors. We have identified previously undescribed genomic variants in brain morphogenic genes:
    Discussion: However, the functional significance of the SNVs identified has still to be confirmed in cellular and animal models. Once it is fulfilled, these SNVs have the potential to complement the diagnostic toolbox for assessing susceptibility to mental disorders. The data obtained indirectly confirm the importance of adequate brain structure formation for its correct functioning and preservation of mental health.
    Sprache Englisch
    Erscheinungsdatum 2024-04-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1338168
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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