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Article ; Online: Spontaneous resolution of Verruca Vulgaris in a paediatric atopic dermatitis patient treated with dupilumab.

Shen, C P / Zhao, M T / Ma, L

Journal of the European Academy of Dermatology and Venereology : JEADV

2022 Volume 36, Issue 5, Page(s) e396–e398

MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Child ; Dermatitis, Atopic/drug therapy ; Humans ; Injections, Subcutaneous ; Treatment Outcome ; Warts/drug therapy
Chemical Substances	Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
Language	English
Publishing date	2022-01-27
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.17936
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 413: Show issues

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Article: [Analysis of clinical characteristics and treatment status of atopic dermatitis in a children's hospital in Beijing from 2015 to 2019].

Shen, C P / Liang, Y / Liu, Y / Jiao, L / Tian, J / Wang, Y / Wang, S / Zhao, M T / Dang, N / Ma, L

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

2023 Volume 57, Issue 11, Page(s) 1848–1854

Abstract: To analyze the clinical characteristics and treatment status of atopic dermatitis (AD) in children in the outpatient department of a children's hospital in Beijing from 2015 to 2019. This study used a cross-sectional study method to retrospectively ... ...

Abstract	To analyze the clinical characteristics and treatment status of atopic dermatitis (AD) in children in the outpatient department of a children's hospital in Beijing from 2015 to 2019. This study used a cross-sectional study method to retrospectively analyze the data of AD patients who visited the Dermatology outpatient department of Beijing Children's Hospital, Capital Medical University, from April 2015 to April 2019. A total of 1 926 AD patients aged 0-17.5 years old living in Beijing and its surrounding areas were included, and the general situation, severity and distribution of AD disease, clinical characteristics and severity of AD, relevant influencing factors of AD onset, AD disease prognosis and treatment status were recorded. SAS 9.4, SPSS19.0, and R software were used for data processing, and descriptive statistical analysis, Chi-square test, Analysis of Variance, and correspondence analysis were used for statistical analysis. The results showed that the male to female ratio of AD patients in children included in this study was 1.4∶1; 79.0% (1 522/1 926), 86.1%(1 658/1 926), 91.3%(1 758/1 926), and 97.3%(1 907/1 926) of AD onset at the age of 6 months, 1 year, 2 years, and 5 years, respectively; mild of AD patients accounted for 13.2% (255/1 926)(SCORAD score 0-24), moderate of AD patients accounted for 50.1%(965/1 926) (SCORAD score 25-50), and severe of AD patients accounted for 36.7% (706/1 926)(SCORAD score>50).The age of severe AD patients were younger than mild and moderate AD patients. The face, head, trunk, and lower limbs were common areas of onset for moderate to severe AD, while the hands, feet, and ears were common areas of onset for severe AD patients. Temperature changes, hot water factors, mental and emotional states, and spring and winter were the main aggravation factors of AD;35.2% (678/1 926) aggravated and 61.8% (1 191/1 926) persistent. The more frequent bathing, the less severity of AD disease (
MeSH term(s)	Humans ; Child ; Male ; Female ; Infant, Newborn ; Infant ; Child, Preschool ; Adolescent ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/therapy ; Dermatitis, Atopic/psychology ; Cross-Sectional Studies ; Retrospective Studies ; Severity of Illness Index ; Hospitals ; Quality of Life
Language	Chinese
Publishing date	2023-10-13
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604575-3
ISSN	0253-9624
ISSN	0253-9624
DOI	10.3760/cma.j.cn112150-20221121-01138
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Book ; Online: Evidence for a new resonance and search for the Y(4140) in $\gamma \gamma \to \phi J/\psi$

The Belle Collaboration / Shen, C. P.

2009

Abstract: The process $\gamma \gamma \to \phi \jpsi$ is measured for $\phi \jpsi$ masses between threshold and 5 GeV/${\it c}^2$, using a data sample of 825 fb$^{-1}$ collected with the Belle detector. A narrow peak of $8.8^{+4.2}_{-3.2}$ events, with a ... ...

Abstract	The process $\gamma \gamma \to \phi \jpsi$ is measured for $\phi \jpsi$ masses between threshold and 5 GeV/${\it c}^2$, using a data sample of 825 fb$^{-1}$ collected with the Belle detector. A narrow peak of $8.8^{+4.2}_{-3.2}$ events, with a significance of 3.2 standard deviations including systematic uncertainty, is observed. The mass and natural width of the structure (named X(4350)) are measured to be $(4350.6^{+4.6}_{-5.1}(\rm{stat})\pm 0.7(\rm{syst})) \hbox{MeV}/{\it c}^2$ and $(13^{+18}_{-9}(\rm{stat})\pm 4(\rm{syst})) \hbox{MeV}$, respectively. The product of its two-photon decay width and branching fraction to $\phi\jpsi$ is $(6.7^{+3.2}_{-2.4}(\rm{stat}) \pm 1.1(\rm{syst})) \hbox{eV}$ for $J^P=0^+$, or $(1.5^{+0.7}_{-0.6}(\rm{stat}) \pm 0.3(\rm{syst})) \hbox{eV}$ for $J^P=2^+$. No signal for the $Y(4140)\to \phi \jpsi$ structure reported by the CDF Collaboration in $B\to K^+ \phi \jpsi$ decays is observed, and limits of $\Gamma_{\gamma \gamma}(Y(4140)) \BR(Y(4140)\to\phi \jpsi)<41 \hbox{eV}$ for $J^P=0^+$ or $<6.0 \hbox{eV}$ for $J^P=2^+$ are determined at the 90% C.L. This disfavors the scenario in which the Y(4140) is a $D_{s}^{\ast+} {D}_{s}^{\ast-}$ molecule. Comment: 9 pages, 3 figures, publication in Phys. Rev. Lett. 104, 112004, 2010
Keywords	High Energy Physics - Experiment
Subject code	612
Publishing date	2009-12-11
Publishing country	us
Document type	Book ; Online
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Article: B-cell-specific DNA binding by an E47 homodimer.

Shen, C P / Kadesch, T

Molecular and cellular biology

1995 Volume 15, Issue 8, Page(s) 4518–4524

Abstract: B cells express a unique E-box-binding activity that contains basic helix-loop-helix (bHLH) proteins encoded by the E2A gene. E2A proteins play a central role in immunoglobulin gene transcription and are also required for the generation of the B- ... ...

Abstract	B cells express a unique E-box-binding activity that contains basic helix-loop-helix (bHLH) proteins encoded by the E2A gene. E2A proteins play a central role in immunoglobulin gene transcription and are also required for the generation of the B-lymphocyte lineage. In muscle, E2A proteins bind DNA as heterodimers with muscle-specific bHLH partners, such as MyoD and myogenin, and these heterodimers are thought to be both necessary and sufficient for muscle determination in cultured cells. Our results indicate that in B cells, the bHLH partners for E2A proteins are not B-cell-restricted proteins, but are the E2A proteins themselves. UV cross-linking, gel purification, and the analysis of "forced heterodimers" indicate that BCF1 is primarily a homodimer of the E2A protein E47. Since E47 is widely expressed, our results argue for a difference in the inherent DNA-binding properties of the E47 protein in B cells and may help explain the restricted B-lineage defect observed in E2A-deficient mice.
MeSH term(s)	Amino Acid Sequence ; B-Lymphocytes/metabolism ; Base Sequence ; Binding Sites ; Cross-Linking Reagents ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation, Developmental ; Helix-Loop-Helix Motifs ; Humans ; Molecular Sequence Data ; Protein Binding ; Protein Conformation ; RNA Splicing ; TCF Transcription Factors ; Tissue Distribution ; Transcription Factor 7-Like 1 Protein ; Transcription Factors/metabolism ; Tumor Cells, Cultured
Chemical Substances	Cross-Linking Reagents ; DNA-Binding Proteins ; TCF Transcription Factors ; TCF7L1 protein, human ; Tcf7l1 protein, mouse ; Transcription Factor 7-Like 1 Protein ; Transcription Factors
Language	English
Publishing date	1995-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.15.8.4518
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Zs.A 1666: Show issues

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Article: Synovial fibroblasts and the sphingomyelinase pathway: sphingomyelin turnover and ceramide generation are not signaling mechanisms for the actions of tumor necrosis factor-alpha.

Gerritsen, M E / Shen, C P / Perry, C A

The American journal of pathology

1998 Volume 152, Issue 2, Page(s) 505–512

Abstract: The activation of sphingomyelinase and the generation of ceramide has been proposed to mediate tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor (NF)-kappaB activation through its second messenger ceramide. Ceramide may also be an important ... ...

Abstract	The activation of sphingomyelinase and the generation of ceramide has been proposed to mediate tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor (NF)-kappaB activation through its second messenger ceramide. Ceramide may also be an important regulator of cell growth, senescence, and apoptosis. Aberrant cell proliferation and apoptosis have been implicated in the rampant fibroblast proliferation and pannus formation characteristic of rheumatoid arthritis. However, the role of TNF-alpha and the sphingomyelinase pathway in the process have not been determined. The objective of this study was to determine whether TNF-alpha activates the sphingomyelin pathway in human synovial fibroblasts (HSF) and the potential role of ceramide in HSF proliferation and apoptosis. Cultured human synovial fibroblasts were stimulated with exogenous TNF-alpha, sphingomyelinase, and ceramide. Apoptosis was assessed by cell morphology and annexin V labeling. NF-kappaB and stress kinase pathway activation were determined by immunoblotting techniques. Sphingomyelinase activation was determined by quantitation of sphingomyelin and ceramide radioactivity in [14C]serine-prelabeled HSF cells. The addition of TNF-alpha (50 ng/ml) to HSF did not elicit detectable sphingomyelinase activation. TNF-alpha was shown to activate NF-kappaB (p65 translocation and degradation of IkappaBalpha) and the stress kinase pathway (phosphorylation of ATF-2, p38, and c-jun). In contrast, exogenous ceramide had no effect on these signaling pathways nor did ceramide stimulate the generation of interleukin-6 or interleukin-8. High concentrations of ceramide (> or =25 micromol/L) were cytotoxic, whereas lower concentrations of ceramide inhibited cell cycle progression. Thus, although TNF-alpha stimulates the NF-kappaB and stress kinase pathways in HSF, these effects of TNF-alpha are not associated with sphingomyelinase turnover or induction of apoptosis.
MeSH term(s)	Apoptosis/physiology ; Cell Division/drug effects ; Ceramides/biosynthesis ; Ceramides/pharmacology ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/physiology ; Humans ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Sphingomyelin Phosphodiesterase/metabolism ; Sphingomyelin Phosphodiesterase/pharmacology ; Sphingomyelins/metabolism ; Synovial Membrane/cytology ; Synovial Membrane/physiology ; Tumor Necrosis Factor-alpha/pharmacology ; Tumor Necrosis Factor-alpha/physiology
Chemical Substances	Ceramides ; Sphingomyelins ; Tumor Necrosis Factor-alpha ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
Language	English
Publishing date	1998-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
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Ud II Zs.76: Show issues

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Article: Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila.

Shen, C P / Jan, L Y / Jan, Y N

Cell

1997 Volume 90, Issue 3, Page(s) 449–458

Abstract: Asymmetric division of Drosophila neuroblasts, sensory organ precursor cells, and cells in the procephalic neurogenic region involves the segregation of Numb and Prospero proteins into one of the two daughter cells. We have isolated a novel gene, miranda, ...

Abstract	Asymmetric division of Drosophila neuroblasts, sensory organ precursor cells, and cells in the procephalic neurogenic region involves the segregation of Numb and Prospero proteins into one of the two daughter cells. We have isolated a novel gene, miranda, based on the ability of its gene product to interact with the Prospero asymmetric localization domain. miranda expression coincides spatially and temporally with asymmetric cell divisions and asymmetric localization of Prospero. Miranda protein is localized asymmetrically, along with Prospero, to the basal cell membrane during mitosis. Loss of miranda gene function abolishes asymmetric Prospero localization during mitosis. The asymmetric localization of Miranda protein requires inscuteable. Our results suggest that miranda functions downstream of inscuteable and works as an adapter that connects Prospero to the basal cell membrane during asymmetric cell division.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Cell Cycle Proteins/biosynthesis ; Cell Cycle Proteins/chemistry ; Cell Division ; Cell Membrane/physiology ; Cell Polarity ; Cloning, Molecular ; Drosophila/embryology ; Drosophila/genetics ; Drosophila Proteins ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/physiology ; Gene Expression Regulation, Developmental ; Genes, Insect ; Mitosis ; Models, Biological ; Molecular Sequence Data ; Nerve Tissue Proteins/biosynthesis ; Nervous System/cytology ; Nervous System/embryology ; Neurons/cytology ; Neurons/physiology ; Nuclear Proteins/biosynthesis ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/chemistry ; Saccharomyces cerevisiae ; Transcription Factors/biosynthesis
Chemical Substances	Cell Cycle Proteins ; Drosophila Proteins ; Mira protein, Drosophila ; Nerve Tissue Proteins ; Nuclear Proteins ; Recombinant Fusion Proteins ; Transcription Factors ; pros protein, Drosophila
Language	English
Publishing date	1997-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/s0092-8674(00)80505-x
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article: Genetic variability in copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with Alzheimer's disease in a Chinese population.

Liu, H P / Lin, W Y / Wang, W F / Tsai, C H / Wu, W C / Chiou, M T / Shen, C P / Wu, B T / Tsai, F J

Journal of biological regulators and homeostatic agents

2013 Volume 27, Issue 2, Page(s) 319–327

Abstract: Previous experiments demonstrated that transgenic mice carrying both amyloid precursor protein and mutant ATP7B transgenes reduce amyloid plaques and diminish plasma Abeta levels. These experiments showed that a structural change of ATP7B may affect ... ...

Abstract	Previous experiments demonstrated that transgenic mice carrying both amyloid precursor protein and mutant ATP7B transgenes reduce amyloid plaques and diminish plasma Abeta levels. These experiments showed that a structural change of ATP7B may affect Alzheimers disease (AD) susceptibility. In this study three missense SNPs in ATP7B gene (rs1801243, rs1801244, and rs1801249) were chosen to test whether they were associated with AD. We tested this hypothesis using a case control design. The experimental data showed that there was a significant deviation from Hardy-Weinberg equilibrium (HWE) for SNP rs1801249 (c.3419 T greater than C, Val1140Ala) in the case group (p = 0.014) but not in the control group and that there was an association between SNP rs1801249 and AD under a recessive model (p = 0.003). The data also showed that the genotype frequency distribution of the ATP7B c.1366 G greater than C polymorphism (rs1801244, Val456Leu) differed significantly between the AD patients and the normal subjects (p = 0.012). In addition, the frequency of the TGC haplotype of SNPs rs1801243, rs1801244, and rs1801249 was significantly higher in the AD patients compared with the normal subjects (p = 8.49×10-7). These observations suggested that genetic variations in the copper transporter gene ATP7B might contribute to AD pathogenesis in the Taiwanese population.
MeSH term(s)	Adenosine Triphosphatases/genetics ; Alzheimer Disease/etiology ; Alzheimer Disease/genetics ; Asian Continental Ancestry Group/genetics ; Cation Transport Proteins/genetics ; Copper-transporting ATPases ; Genetic Variation ; Genotype ; Humans ; Polymorphism, Single Nucleotide
Chemical Substances	Cation Transport Proteins ; Adenosine Triphosphatases (EC 3.6.1.-) ; Copper-transporting ATPases (EC 3.6.3.54) ; ATP7B protein, human (EC 7.2.2.8)
Language	English
Publishing date	2013-06-28
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639196-5
ISSN	1724-6083 ; 0393-974X
ISSN (online)	1724-6083
ISSN	0393-974X
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Zs.A 2270: Show issues

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Article: A list and survey of stored-product mites in China

Shen, C.P

Proceedings of the Third International Working Conference on Stored-Product Entomology : Oct 23-28, 1983, Kansas State Univ., Manhattan, Kansas / spon. Dept. of Entomology and Dept. of Grain Science and Industry, KSU.

1984

Keywords	storage pests ; mites ; China
Language	English
Size	p. 680-686.
Publisher	Kansas State University, 1984.
Publishing place	[Manhattan]
Document type	Article
Database	NAL-Catalogue (AGRICOLA)

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Article: Studies on the life history of Carpoglyphus lactis (L.) (Astigmata, Carpoglyphidae)

Shen, C.P

K'un ch'ung hsueh pao. = Acta entomologica Sinica. Nov 1979. v. 22 (4)

1979

Title variant	Studies on the life history of Carpoglyphus lactis (L.) (Astigmata, Carpoglyphidae) [Pest of stored sugar, dried fruits]
Keywords	Astigmata ; Carpoglyphidae
Language	Chinese
Dates of publication	1979-11
Size	p. 443-447., ill.
Document type	Article
Note	In Chinese; Summary in English. ; Title in original language could not be transcribed.
ISSN	0454-6396
Database	NAL-Catalogue (AGRICOLA)

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Article: Role of deep-ploughing on the balance of soil moisture

Shen, C.P

Chung-kuo nung yeh k'o hsueh Nov 1978. (4)

1978

Keywords	soil science ; soil resources ; soil resource management ; soil management
Language	Chinese
Dates of publication	1978-11
Size	p. 46-50., ill.
Document type	Article
Note	In Chinese. ; Title in original language could not be transcribed.
Database	NAL-Catalogue (AGRICOLA)

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