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  1. Article ; Online: A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4.

    Chou, Wen-Cheng / Chen, Wei-Ting / Shen, Chen-Yang

    NPJ genomic medicine

    2022  Volume 7, Issue 1, Page(s) 4

    Abstract: Large-scale genome-wide associations comprising multiple studies have identified hundreds of genetic loci commonly associated with hyperlipidemia-related phenotypes. However, single large cohort remains necessary in aiming to investigate ethnicity- ... ...

    Abstract Large-scale genome-wide associations comprising multiple studies have identified hundreds of genetic loci commonly associated with hyperlipidemia-related phenotypes. However, single large cohort remains necessary in aiming to investigate ethnicity-specific genetic risks and mechanical insights. A community-based cohort comprising 23,988 samples that included both genotype and biochemical information was assembled for the genome-wide association analysis (GWAS) of hyperlipidemia. The analysis identified fifty genetic variants (P < 5 × 10
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2813848-X
    ISSN 2056-7944 ; 2056-7944
    ISSN (online) 2056-7944
    ISSN 2056-7944
    DOI 10.1038/s41525-021-00279-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Iatrogenic arteriovenous fistula after lumbar discectomy surgery: a case report.

    Tang, Kai / Zhang, Yong-Bao / Fang, Jie / Shi, Tao / Shen, Chen-Yang

    Journal of surgical case reports

    2023  Volume 2023, Issue 2, Page(s) rjac576

    Abstract: Iatrogenic arteriovenous fistula (IAVF) is an unusual and potentially fatal complication of lumbar spinal surgery. A 62-year-old patient presented with a history of dyspnea, left lower limb edema and coughing. A physical exam showed bilateral basal rales ...

    Abstract Iatrogenic arteriovenous fistula (IAVF) is an unusual and potentially fatal complication of lumbar spinal surgery. A 62-year-old patient presented with a history of dyspnea, left lower limb edema and coughing. A physical exam showed bilateral basal rales in the lungs, abdominal bruit and bilateral lower limb pitting edema. A computed tomography angiograph revealed an arteriovenous communication between the right internal iliac artery and the left common iliac vein. The patient was diagnosed with an IAVF, which developed post-lumbar disc surgery. The patient underwent a successful endovascular treatment by using covered stent at the common iliac artery with embolism of lumbar artery. The patient's symptoms were relieved 2 months after surgery.
    Language English
    Publishing date 2023-02-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjac576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Midterm Outcomes of Kissing Covered Self-Expanding Stents for Reconstruction of Complex Aortoiliac Occlusive Disease.

    Shen, Chen-Yang / Qu, Cheng-Jia / Zhang, Yong-Bao / Fang, Jie / Teng, Le-Qun / Li, Jia-Liang

    Annals of vascular surgery

    2023  Volume 94, Page(s) 239–245

    Abstract: Background: We sought to investigate the midterm results of kissing self-expanding covered stents (SECSs) for the reconstruction of aortic bifurcation in complex aortoiliac occlusive disease.: Methods: Data of consecutive patients who had undergone ... ...

    Abstract Background: We sought to investigate the midterm results of kissing self-expanding covered stents (SECSs) for the reconstruction of aortic bifurcation in complex aortoiliac occlusive disease.
    Methods: Data of consecutive patients who had undergone endovascular treatment for aortoiliac occlusive disease were screened. Only patients with TransAtlantic Inter-Society Consensus (TASC) class C and D lesions treated by bilateral iliac kissing stents (KSs) were included. Midterm primary patency, risk factors, and limb salvage rates were analyzed. Follow-up results were analyzed using the Kaplan-Meier curves. Cox proportional hazards models were used to identify the predictors of primary patency.
    Results: A total of 48 patients (95.8% men; mean age, 65.3 ± 10.2 years) were treated with kissing SECSs. Of them, 17 patients had TASC-II class C lesions and 31 had class D lesions. There were 38 total occlusive lesions, with a mean occlusive lesion length of 108.2 ± 57.3 mm. The overall mean lesion length was 140.3 ± 60.5 mm, and the mean length of implanted stents in the aortoiliac arteries was 141.9 ± 59.9 mm. The mean diameter of the deployed SECSs was 7.8 ± 0.5 mm. The mean follow-up time was 36.5 ± 15.8 months, and the follow-up rate was 95.8%. At 36 months, the overall primary patency, assisted primary patency, secondary patency, and limb salvage rates were 92.2%, 95.7%, 97.8%, and 100%, respectively. Univariate Cox regression analysis revealed that stent diameter ≤7 mm (hazard ratio [HR]: 9.53; 95% confidence interval [CI] 1.56-57.94, P = 0.014) and severe calcification (HR: 12.66; 95% CI 2.04-78.45, P = 0.006) were significantly associated with restenosis. Multivariate analysis showed severe calcification to be the only significant determinant of restenosis (HR: 12.66; 95% CI 2.04-78.45, P = 0.006).
    Conclusions: Kissing SECSs provide good midterm results for the treatment of aortoiliac occlusive disease. A stent diameter >7 mm is a potent protective factor against restenosis. Because severe calcification appears to be the only significant determinant of restenosis, patients with severe calcification require close follow-up.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Female ; Arterial Occlusive Diseases/diagnostic imaging ; Arterial Occlusive Diseases/surgery ; Treatment Outcome ; Aortic Diseases/diagnostic imaging ; Aortic Diseases/surgery ; Iliac Artery/diagnostic imaging ; Iliac Artery/surgery ; Time Factors ; Leriche Syndrome ; Risk Factors ; Atherosclerosis ; Stents ; Calcinosis ; Vascular Patency ; Aorta, Abdominal ; Retrospective Studies
    Language English
    Publishing date 2023-03-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2023.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer.

    Chou, Wen-Cheng / Chen, Wei-Ting / Kuo, Chun-Tse / Chang, Yao-Ming / Lu, Yen-Shen / Li, Chia-Wei / Hung, Mien-Chie / Shen, Chen-Yang

    Cell reports

    2023  Volume 43, Issue 1, Page(s) 113641

    Abstract: Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its effectiveness depends on biomarkers that are not precise. Here, we utilized genome-wide association study to investigate the association between genetic variants and tumor ... ...

    Abstract Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its effectiveness depends on biomarkers that are not precise. Here, we utilized genome-wide association study to investigate the association between genetic variants and tumor mutation burden to interpret ICB response. We identified 16 variants (p < 5 × 10
    MeSH term(s) Mice ; Animals ; Carbohydrate Sulfotransferases ; Genome-Wide Association Study ; Neoplasms/pathology ; Immunotherapy/methods ; Tumor Microenvironment ; B7-H1 Antigen/genetics
    Chemical Substances Carbohydrate Sulfotransferases (EC 2.8.2.-) ; B7-H1 Antigen
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: miR-622 Increases miR-30a Expression through Inhibition of Hypoxia-Inducible Factor 1α to Improve Metastasis and Chemoresistance in Human Invasive Breast Cancer Cells.

    Cheng, Chun-Wen / Liu, Yu-Fan / Liao, Wen-Ling / Chen, Po-Ming / Hung, Yueh-Tzu / Lee, Huei-Jane / Cheng, Yu-Chun / Wu, Pei-Ei / Lu, Yen-Shen / Shen, Chen-Yang

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Hypoxia-inducible factor 1α (HIF-1α) plays a pivotal role in the survival, metastasis, and response to treatment of solid tumors. Autophagy serves as a mechanism for tumor cells to eliminate misfolded proteins and damaged organelles, thus promoting ... ...

    Abstract Hypoxia-inducible factor 1α (HIF-1α) plays a pivotal role in the survival, metastasis, and response to treatment of solid tumors. Autophagy serves as a mechanism for tumor cells to eliminate misfolded proteins and damaged organelles, thus promoting invasiveness, metastasis, and resistance to treatment under hypoxic conditions. MicroRNA (miRNA) research underscores the significance of these non-coding molecules in regulating cancer-related protein synthesis across diverse contexts. However, there is limited reporting on miRNA-mediated gene expression studies, especially with respect to epithelial-mesenchymal transition (EMT) and autophagy in the context of hypoxic breast cancer. Our study reveals decreased levels of miRNA-622 (miR-622) and miRNA-30a (miR-30a) in invasive breast cancer cells compared to their non-invasive counterparts. Inducing miR-622 suppresses HIF-1α protein expression, subsequently activating miR-30a transcription. This cascade results in reduced invasiveness and migration of breast cancer cells by inhibiting EMT markers, such as Snail, Slug, and vimentin. Furthermore, miR-30a negatively regulates beclin 1, ATG5, and LC3-II and inhibits Akt protein phosphorylation. Consequently, this improves the sensitivity of invasive MDA-MB-231 cells to docetaxel treatment. In conclusion, our study highlights the therapeutic potential of inducing miR-622 to promote miR-30a expression and thus disrupt HIF-1α-associated EMT and autophagy pathways. This innovative strategy presents a promising approach to the treatment of aggressive breast cancer.
    Language English
    Publishing date 2024-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030657
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  6. Article: Tumorigenic and Metastatic Role of CD44

    Vikram, Rajeev / Chou, Wen Cheng / Hung, Shih-Chieh / Shen, Chen-Yang

    Cancers

    2020  Volume 12, Issue 5

    Abstract: Cells with high CD44 but low CD24 expression ( ... ...

    Abstract Cells with high CD44 but low CD24 expression (CD44
    Language English
    Publishing date 2020-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12051239
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  7. Article ; Online: The Genetic Diversity and the Divergence Time in Extant Primitive Mayfly,

    Tong, Yao / Shen, Chen-Yang / Zhao, Yu-Yang / Lin, Yi-Jie / Wu, Lian / Storey, Kenneth B / Yu, Dan-Na / Zhang, Jia-Yong

    Genes

    2022  Volume 13, Issue 10

    Abstract: In this study, the mitochondrial (mt) genomes ... ...

    Abstract In this study, the mitochondrial (mt) genomes of
    MeSH term(s) Animals ; Genome, Mitochondrial/genetics ; Ephemeroptera ; Phylogeny ; Bayes Theorem ; Genetic Variation/genetics
    Language English
    Publishing date 2022-10-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13101780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2.

    Liao, Wen-Ling / Liu, Yu-Fan / Ying, Tsung-Ho / Shieh, Jia-Ching / Hung, Yueh-Tzu / Lee, Huei-Jane / Shen, Chen-Yang / Cheng, Chun-Wen

    International journal of molecular sciences

    2022  Volume 24, Issue 1

    Abstract: The stemness and metastasis of cancer cells are crucial features in determining cancer progression. Argonaute-2 (AGO2) overexpression was reported to be associated with microRNA (miRNA) biogenesis, supporting the self-renewal and differentiation ... ...

    Abstract The stemness and metastasis of cancer cells are crucial features in determining cancer progression. Argonaute-2 (AGO2) overexpression was reported to be associated with microRNA (miRNA) biogenesis, supporting the self-renewal and differentiation characteristics of cancer stem cells (CSCs). Ursolic acid (UA), a triterpene compound, has multiple biological functions, including anticancer activity. In this study, we find that UA inhibits the proliferation of MDA-MB-231 and MCF-7 breast cancer cell lines using the CCK-8 assay. UA induced a significant decrease in the fraction of CSC in which it was examined by changes in the expression of stemness biomarkers, including the
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Line, Tumor ; MicroRNAs/metabolism ; Triterpenes/pharmacology ; Triterpenes/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Neoplastic Stem Cells/metabolism ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Ursolic Acid
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MicroRNAs ; Triterpenes
    Language English
    Publishing date 2022-12-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24010366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Dose-Response Relationship Between Physical Activity and the Incidence of Peripheral Artery Disease in General Population: Insights From the National Health and Nutrition Examination Survey 1999-2004.

    Qu, Cheng-Jia / Teng, Le-Qun / Liu, Xin-Nong / Zhang, Yong-Bao / Fang, Jie / Shen, Chen-Yang

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 730508

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.730508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Novel Sirolimus-eluting Biodegradable Magnesium-based Alloy Scaffold: Six-month Results In Porcine Peripheral Arteries.

    Liu, Xin-Nong / Qu, Cheng-Jia / Zhang, Yong-Bao / Fang, Jie / Teng, Le-Qun / Zhang, Xiang-Yu / Shen, Chen-Yang

    Clinical and investigative medicine. Medecine clinique et experimentale

    2021  Volume 44, Issue 1, Page(s) E28–37

    Abstract: Purpose: Magnesium-based alloy scaffold is a promising biodegradable stent due to its intrinsic mechanical performance and biocompatibility. Based on our preliminary experiments, we designed a novel sirolimus-eluting magnesium-based alloy scaffold. This ...

    Abstract Purpose: Magnesium-based alloy scaffold is a promising biodegradable stent due to its intrinsic mechanical performance and biocompatibility. Based on our preliminary experiments, we designed a novel sirolimus-eluting magnesium-based alloy scaffold. This work aimed to assess its safety and degradation performance in vivo.
    Methods: The scaffolds were implanted in the lower limb arteries of Bama mini-pigs. Safety was defined as no immediate thrombosis or >30% residual stenosis, which was assessed with optical coherence tomography and digital subtraction angiography. Blood biochemical analyses were performed to evaluate hepatorenal toxicity. The degradation process of the scaffolds, the endothelialization, and lumen loss of the stented-vessels were detected with scanning electron microscopy, immunohistochemical, hematoxylin-eosin staining and optical coherence tomography.
    Results: Twenty-four scaffolds were successfully implanted in six pigs with no signs of immediate thrombosis or >30% residual stenosis. The scaffolds were covered by endothelium at one month and absolutely resorbed at six months post implantation. Blood analysis showed that the hepatorenal function except for alanine aminotransferase and γ-glutamyl transpeptidase was normal. Obvious intimal hyperplasia and lumen loss were found in the stented vessels at three months, while the diameters and inner lumen areas of stented segments had increased significantly at six months (p.
    MeSH term(s) Absorbable Implants ; Alloys ; Animals ; Arteries ; Coronary Angiography ; Coronary Vessels ; Magnesium ; Sirolimus ; Swine ; Swine, Miniature
    Chemical Substances Alloys ; Magnesium (I38ZP9992A) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2021-03-21
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 434004-8
    ISSN 1488-2353 ; 0147-958X
    ISSN (online) 1488-2353
    ISSN 0147-958X
    DOI 10.25011/cim.v44i1.35292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1389: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 345: Show issues

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