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Article ; Online: Two cases of diquat poisoning in adolescent children.

Duan, Mengtao / Yang, Baowang / Cheng, Xiaohang / Shen, Fuhui / Lu, Xia / Wang, Fan

2024 Volume 50, Issue 1, Page(s) 80

Abstract: Diquat (DQ) is among the most widely used herbicides, and its intake can cause severe systemic toxicity that manifests rapidly. The resultant symptoms can cause the dysfunction of a range of tissues and organs,. As there is no specific antidote for ... ...

Abstract	Diquat (DQ) is among the most widely used herbicides, and its intake can cause severe systemic toxicity that manifests rapidly. The resultant symptoms can cause the dysfunction of a range of tissues and organs,. As there is no specific antidote for diquat poisoning and the efficacy of extant treatments is suboptimal, physicians must acquire a more comprehensive understanding of the most effective approaches to managing affected patients. Relative few studies have been published to date focused on diquat poisoning in pediatric patients. In this report, we compare two similar cases of juvenile diquat poisoning with dynamic changes in clinical manifestations, laboratory values, and imaging results. For the first time, the difference in whether to perform blood flow perfusion and the time difference of initiation of hemoperfusion had a clear clinical difference in the subsequent effects of diquat poisoning in children with diquat poisoning. Limited evidence is available regarding the efficacy of early hemoperfusion for diquat poisoning; however, the differences in clinical outcomes articulated here highlight the benefits of early and timely hemoperfusion therapy in the treatment of DQ toxicity in children, in conjunction with primary supportive care in the management of DQ poisoning in children.
MeSH term(s)	Humans ; Diquat/poisoning ; Adolescent ; Male ; Herbicides/poisoning ; Female ; Hemoperfusion ; Child
Chemical Substances	Diquat (A9A615U4MP) ; Herbicides
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-024-01640-x
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Article: miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating β-catenin.

He, Zhenhua / Shen, Fuhui / Qi, Ping / Zhai, Zhenxing / Wang, Zhiping

Cell death discovery

2021 Volume 7, Issue 1, Page(s) 18

Abstract: Heat shock protein 27 (HSP27), a regulator of cell survival, can enhance the resistance of cancer cells to radiotherapy. As microRNA-541-3p (miR-541-3p) was recently predicted to be a putative upstream modulator of HSP27, the present study was designed ... ...

Abstract	Heat shock protein 27 (HSP27), a regulator of cell survival, can enhance the resistance of cancer cells to radiotherapy. As microRNA-541-3p (miR-541-3p) was recently predicted to be a putative upstream modulator of HSP27, the present study was designed to investigate the function and mechanism underlying how miR-541-3p modulates the radiosensitivity of prostate cancer (PCa) cells by regulating HSP27. Through quantitative PCR, miR-541-3p was determined to be poorly expressed in PCa tissues relative to normal controls, whereas its expression was enhanced after radiotherapy. Consistently, miR-541-3p expression levels in PCa cells were elevated after radiation. Cell viability and proliferation and apoptosis under radiation were subsequently evaluated in response to loss-of-function of miR-541-3p. It was found that inhibition of miR-541-3p facilitated the viability and proliferation of PCa cells and promoted their apoptosis post radiation, hence reducing the radiosensitivity of LNCaP cells. Dual-luciferase reporter assay identified that miR-541-3p negatively regulated the HSP27 mRNA expression by targeting its 3'-UTR. Meanwhile, miR-541-3p overexpression inhibited the β-catenin expression by targeting HSP27. Furthermore, HSP27 or β-catenin overexpression was noted to significantly reverse the miR-541-3p-mediated changes in the biological functions of PCa cells post radiation, suggesting that HSP27-dependent activation of β-catenin might be the mechanism responsible for the promotive effect of miR-541-3p on radiosensitivity. Collectively, this study suggests that miR-541-3p specifically inhibits the HSP27 expression and downregulates β-catenin, thereby enhancing the radiosensitivity of PCa cells. Our findings highlight the underlying mechanism of the miR-541-3p/HSP27/Wnt/β-catenin axis regarding radiotherapy for PCa.
Language	English
Publishing date	2021-01-18
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-020-00387-8
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Article: DRAGen - A deep learning supported RVE generator framework for complex microstructure models.

Henrich, Manuel / Fehlemann, Niklas / Bexter, Felix / Neite, Maximilian / Kong, Linghao / Shen, Fuhui / Könemann, Markus / Dölz, Michael / Münstermann, Sebastian

Heliyon

2023 Volume 9, Issue 8, Page(s) e19003

Abstract: In this study an improved version of the Discrete RVE Automation and Generation Framework, also called DRAGen, is presented. The Framework incorporates a generator for Representative Volume Elements (RVEs). Several complex microstructure features, ... ...

Abstract	In this study an improved version of the Discrete RVE Automation and Generation Framework, also called DRAGen, is presented. The Framework incorporates a generator for Representative Volume Elements (RVEs). Several complex microstructure features, extracted from real microstructures, have been added to the generator, to enable it to generate RVEs with realistic microstructures. DRAGen is now capable of reading trained neural networks as well as .csv-files as input data for the microstructure generation. Furthermore, features such as pores and inclusions, martensite bands, hierarchical substructures, and crystallographic textures can be reconstructed in the RVEs. Besides the features, the functionality for different solvers was introduced. Therefore, the code was extended by modules for the generation of Finite Element (FE) and spectral solver input files. DRAGen now has the ability to create models for three powerful multiphysics frameworks used in the community: DAMASK, Abaqus and MOOSE. The evaluation of the features, as well as the simulations performed on sample models, show that the new version of DRAGen is a very powerful tool with flexible applicability for scientists in the ICME community. Also, due to the modular architecture of the project, the code can easily be expanded with features of interest. Therefore, it delivers a variety of functions and possible outputs, which offers researchers a broad spectrum of microstructures that can be used in microstructure studies or microstructure design developments.
Language	English
Publishing date	2023-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e19003
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Article ; Online: Atorvastatin Enhances Inhibitory Effects of Irradiation on Tumor Growth by Reducing MSH2 Expression Both in Prostate Cancer Cells and Xenograft Tumor Models.

He, Zhenhua / Xu, Dingkai / Shen, Fuhui / Zeng, Fangang / Qi, Ping / Zhai, Zhenxing / Wang, Zhiping

Anti-cancer agents in medicinal chemistry

2021 Volume 22, Issue 7, Page(s) 1328–1339

Abstract: Background: Prostate cancer (PCa) is the fourth most common tumor in males.: Objective: This study aimed to investigate effects of atorvastatin (AS) on PCa cells proliferation and clarify the associated mechanisms.: Methods: PCa cell lines were ... ...

Abstract	Background: Prostate cancer (PCa) is the fourth most common tumor in males. Objective: This study aimed to investigate effects of atorvastatin (AS) on PCa cells proliferation and clarify the associated mechanisms. Methods: PCa cell lines were cultured and treated with irradiation (IR) (4 Gy), AS (6 μg/ml), transfected with Bcl-2 siRNA, and then divided into different groups. Xenograft tumor mouse model was established. Bcl-2 and MSH2 gene transcription and protein expression were evaluated using RT-PCR assay and western blot assay. Plate clone formation assay was employed to examine colony formation. MTT assay was used to detect cell viabilities. Flow cytometry analysis was utilized to verify apoptosis. Co-immunoprecipitation and immuno-fluorescence assay were used to identify interaction between Bcl-2 and MSH2. Results: IR significantly reduced colony formation, enhanced Bcl-2 and reduced MSH2 gene transcription in PCa cells compared to un-treated cells (p<0.05). AS significantly strengthened radio-therapeutic effects of IR on colony formation, decreased cell apoptosis and increased Bcl-2 gene transcription/protein expression in PCa cells compared to single IR treatment cells (p<0.05). AS combining IR down-regulated MSH2 gene transcription/protein expression in PCa cells compared to single IR treatment cells (p<0.05). Bcl-2 interacted with MSH2 both in PCa cells and tumor tissues administrating with AS. AS enhanced reductive effects of IR on tumor size of Xenograft tumor mice. Conclusion: Atorvastatin administration enhanced inhibitory effects of IR either on PCa cells or tumor size of Xenograft tumor mice. The inhibitory effects of atorvastatin were mediated by reducing MSH2 expression and triggering interaction between Bcl-2 and MSH2, both in vitro and in vivo levels.
MeSH term(s)	Animals ; Apoptosis ; Atorvastatin/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Disease Models, Animal ; Heterografts ; Humans ; Male ; Mice ; Mice, Nude ; MutS Homolog 2 Protein ; Prostatic Neoplasms/pathology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Xenograft Model Antitumor Assays
Chemical Substances	Proto-Oncogene Proteins c-bcl-2 ; Atorvastatin (A0JWA85V8F) ; MSH2 protein, human (EC 3.6.1.3) ; MutS Homolog 2 Protein (EC 3.6.1.3)
Language	English
Publishing date	2021-06-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/1871520621666210602133005
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Book ; Online: The differences of damage initiation and accumulation of DP steels

Pütz, Felix / Shen, Fuhui / Könemann, Markus / Münstermann, Sebastian

a numerical and experimental analysis

2020

Abstract: Many studies have examined the damage behaviour of dual-phase steels already. It is a topic of high interest, since understanding the mechanisms of damage during forming processes enables the production of steels with improved properties and damage ... ...

Abstract	Many studies have examined the damage behaviour of dual-phase steels already. It is a topic of high interest, since understanding the mechanisms of damage during forming processes enables the production of steels with improved properties and damage tolerance. However, the focus was rarely on the comparison between representatives of this steel class, and the numerical simulation for the quantification of damage states was not thoroughly used. Therefore, this study compares the damage initiation and accumulation of two dual-phase steels (DP800 and DP1000), which are used in the automotive industry. Additionally, parameter sets of a phenomenological damage mechanics model with coupled damage evolution are calibrated for each material. The combined analysis reveals an earlier initiation of damage for the DP800, where the damage accumulation phase is prolonged. For DP1000 the damage nucleates only shortly before material failure. The material model is able to correctly predict the behaviour, while experimental analysis confirms the prediction via light optical and SEM metallography.
Keywords	Condensed Matter - Materials Science ; 74cxx
Subject code	621
Publishing date	2020-04-27
Publishing country	us
Document type	Book ; Online
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Article ; Online: Atorvastatin Enhances Effects of Radiotherapy on Prostate Cancer Cells and Xenograft Tumor Mice Through Triggering Interaction Between Bcl-2 and MSH2.

He, Zhenhua / Yuan, Jingmin / Shen, Fuhui / Zeng, Fangang / Qi, Ping / Wang, Zhiping / Zhai, Zhenxing

Medical science monitor : international medical journal of experimental and clinical research

2020 Volume 26, Page(s) e923560

Abstract: BACKGROUND Prostate cancer (PCa) is considered to be the 4th most common cancer in males in the world. This study aimed to explore effects of atorvastatin on colony formation of PCa cells and radio-resistance of xenograft tumor models. MATERIAL AND ... ...

Abstract	BACKGROUND Prostate cancer (PCa) is considered to be the 4th most common cancer in males in the world. This study aimed to explore effects of atorvastatin on colony formation of PCa cells and radio-resistance of xenograft tumor models. MATERIAL AND METHODS PCa cell lines, including PC3, DU145, and Lncap, were treated with irradiation (4 Gy) and/or atorvastatin (6 μg/mL). Cells were divided into tumor cell group, irradiation treatment group (IR group) and irradiation+atorvastatin treatment group (IR-AS group). Xenograft tumor mouse model was established. Plate clone formation assay (multi-target/single-hit model) was conducted to evaluate colony formation. Flow cytometry analysis was employed to detect apoptosis. Interaction between Bcl-2 and MSH2 was evaluated with immuno-fluorescence assay. RESULTS According to the plate colony formation assay and multi-target/single-hit model, IR-treatment significantly suppressed colony formation in PCa cells (including PC3, DU145, and Lncap cells) compared to no-IR treated cells (P<0.05). Atorvastatin remarkably enhanced inhibitive effects of irradiation on colony formation of PCa cells (P<0.05), however, the IR+AS group demonstrated no effects on apoptosis, comparing to IR group (P>0.05). Atorvastatin administration (IR+AS group) significantly reduced tumor size of IR-treated PCa cells-induced xenograft tumor mice (P<0.05). Bcl-2 interacted with MSH2 both in tumor tissues of xenograft tumor mice. CONCLUSIONS Atorvastatin administration inhibited colony formation in PCa cells and enhanced effects of radiotherapy on tumor growth of xenograft tumor mice, which might be associated with interaction between Bcl-2 and MSH2 molecule.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Atorvastatin/pharmacology ; Atorvastatin/therapeutic use ; Cell Line, Tumor ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Mice ; Mice, Nude ; MutS Homolog 2 Protein/metabolism ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Protein Interaction Maps ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Xenograft Model Antitumor Assays
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Proto-Oncogene Proteins c-bcl-2 ; Atorvastatin (A0JWA85V8F) ; MSH2 protein, human (EC 3.6.1.3) ; MutS Homolog 2 Protein (EC 3.6.1.3)
Language	English
Publishing date	2020-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.923560
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Article ; Online: Research progress of nucleostemin signaling pathway in tumorigenesis and development

HE Zhen-hua / SHEN Fu-hui / ZENG Fan-gang / LIU Qian-lin / YUAN Jing-min

Jichu yixue yu linchuang, Vol 40, Iss 4, Pp 547-

2020 Volume 551

Abstract: Silencing nucleostemin (NS) can activate the p53 pathway and p53 inhibit proliferation of the tumor cell through the phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (PKB or AKT)/ mammalian target of rapamycin (mTOR) signal pathway. Low expression ... ...

Abstract	Silencing nucleostemin (NS) can activate the p53 pathway and p53 inhibit proliferation of the tumor cell through the phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (PKB or AKT)/ mammalian target of rapamycin (mTOR) signal pathway. Low expression of NS also inhibits the PI3K/AKT/mTOR signal pathway through a non-p53 pathway. Inhibition of p53 activates the Wnt/β-catenin signal pathway. High expression of NS also activates the Wnt/β-catenin signal pathway. Over-expression of c-Myc increases NS expression and inhibits p53 expression,which may promote cell proliferation.
Keywords	nucleostemin(ns)\|gene\|protein\|signal pathway ; Medicine ; R
Language	Chinese
Publishing date	2020-04-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
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Article ; Online: Combined hyperactive dysfunction syndrome of the cranial nerves complicated by essential hypertension: A case report.

Yuan, Jingmin / Wu, Haiyang / Chen, Niandong / Shen, Fuhui / Jiao, Pengfei / Lan, Zhengbo / Yang, Wenzhen / Zhang, Xinding / Li, Qiang / He, Zhenhua

Medicine

2019 Volume 98, Issue 33, Page(s) e16849

Abstract: Rationale: Combined hyperactive dysfunction syndrome (HDS) refers to a special type of HDS characterized by a combination of trigeminal neuralgia (TN), hemi facial spasm (HFS), and/or gloss pharyngeal neuralgia (GPN). Rostra ventrolateral medulla (RVLM) ...

Abstract	Rationale: Combined hyperactive dysfunction syndrome (HDS) refers to a special type of HDS characterized by a combination of trigeminal neuralgia (TN), hemi facial spasm (HFS), and/or gloss pharyngeal neuralgia (GPN). Rostra ventrolateral medulla (RVLM) plays a crucial role in central cardiovascular regulation, and neurovascular compression of the RVLM has been identified as a contributor to essential hypertension. Patient concerns: A 65-year-old female with a facial tic and pain located in the root of the tongue and throat on the same side; the systolic and diastolic blood pressure was approximately 170 and 100 mmHg. Diagnosis: The patient was diagnosed with combined HDS (HFS-GPN) and essential hypertension. Brain magnetic resonance 3-dimensional time-of-flight imaging and digital subtraction angiography revealed vertebrobasilar artery compressed the left RVLM and contacted with the root entry zones of multiple cranial nerves. Interventions: The patient was treated with microvascular decompression surgery OUTCOMES:: The symptoms were completely relieved, and blood pressure was well-controlled. Lessons: The pathological association of hypertension and HDS should be highlighted, and microvascular decompression is an effective approach for relieving the hypertension.
MeSH term(s)	Aged ; Cranial Nerves/diagnostic imaging ; Cranial Nerves/surgery ; Essential Hypertension/complications ; Female ; Hemifacial Spasm/complications ; Hemifacial Spasm/diagnostic imaging ; Hemifacial Spasm/surgery ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Microvascular Decompression Surgery/methods ; Syndrome ; Trigeminal Neuralgia/complications ; Trigeminal Neuralgia/diagnostic imaging ; Trigeminal Neuralgia/surgery
Language	English
Publishing date	2019-08-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000016849
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Article ; Online: Analysis of ESAFORM 2021 cup drawing benchmark of an Al alloy, critical factors for accuracy and efficiency of FE simulations.

Habraken, Anne Marie / Aksen, Toros Arda / Alves, José L / Amaral, Rui L / Betaieb, Ehssen / Chandola, Nitin / Corallo, Luca / Cruz, Daniel J / Duchêne, Laurent / Engel, Bernd / Esener, Emre / Firat, Mehmet / Frohn-Sörensen, Peter / Galán-López, Jesús / Ghiabakloo, Hadi / Kestens, Leo A I / Lian, Junhe / Lingam, Rakesh / Liu, Wencheng /

International journal of material forming

2022 Volume 15, Issue 5, Page(s) 61

Abstract: This article details the ESAFORM Benchmark 2021. The deep drawing cup of a 1 mm thick, AA 6016-T4 sheet with a strong cube texture was simulated by 11 teams relying on phenomenological or crystal plasticity approaches, using commercial or self-developed ... ...

Abstract	This article details the ESAFORM Benchmark 2021. The deep drawing cup of a 1 mm thick, AA 6016-T4 sheet with a strong cube texture was simulated by 11 teams relying on phenomenological or crystal plasticity approaches, using commercial or self-developed Finite Element (FE) codes, with solid, continuum or classical shell elements and different contact models. The material characterization (tensile tests, biaxial tensile tests, monotonic and reverse shear tests, EBSD measurements) and the cup forming steps were performed with care (redundancy of measurements). The Benchmark organizers identified some constitutive laws but each team could perform its own identification. The methodology to reach material data is systematically described as well as the final data set. The ability of the constitutive law and of the FE model to predict Lankford and yield stress in different directions is verified. Then, the simulation results such as the earing (number and average height and amplitude), the punch force evolution and thickness in the cup wall are evaluated and analysed. The CPU time, the manpower for each step as well as the required tests versus the final prediction accuracy of more than 20 FE simulations are commented. The article aims to guide students and engineers in their choice of a constitutive law (yield locus, hardening law or plasticity approach) and data set used in the identification, without neglecting the other FE features, such as software, explicit or implicit strategy, element type and contact model.
Language	English
Publishing date	2022-07-15
Publishing country	France
Document type	Journal Article
ZDB-ID	2423930-6
ISSN	1960-6214 ; 1960-6206
ISSN (online)	1960-6214
ISSN	1960-6206
DOI	10.1007/s12289-022-01672-w
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Article ; Online: Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects.

Wu, Chang-Fu / Shen, Fu-Hui / Li, Ya-Ru / Tsao, Tsung-Ming / Tsai, Ming-Jer / Chen, Chu-Chih / Hwang, Jing-Shiang / Hsu, Sandy Huey-Jen / Chao, Hsing / Chuang, Kai-Jen / Chou, Charles C K / Wang, Ya-Nan / Ho, Chi-Chang / Su, Ta-Chen

The Science of the total environment

2016 Volume 569-570, Page(s) 300–305

Abstract: This study evaluated whether exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) is associated with cardiovascular effects by examining a panel of 89 healthy subjects in Taipei, Taiwan. The subjects received two health examinations ... ...

Abstract	This study evaluated whether exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) is associated with cardiovascular effects by examining a panel of 89 healthy subjects in Taipei, Taiwan. The subjects received two health examinations approximately 8months apart in 2013. Brachial-ankle pulse wave velocity (baPWV), a physiological indicator of arterial stiffness, and high-sensitivity C-reactive protein (hsCRP), a biomarker of vascular inflammations, were measured during each examination. Two exposure assessment methods were used for estimating the subjects' exposure to PM2.5 and NO2. The first method involved constructing daily land use regression (LUR) models according to measurements collected at ambient air quality monitoring stations. The second method required combining the LUR estimates with indoor monitoring data at the workplace of the subjects. Linear mixed models were used to examine the association between the exposure estimates and health outcomes. The results showed that a 10-μg/m(3) increase in PM2.5 concentration at a 1-day lag was associated with 2.1% (95% confidence interval: 0.7%-3.6%) and 2.4% (0.8%-4.0%) increases in baPWV based on the two exposure assessment methods, whereas no significant association was observed for NO2. The significant effects of PM2.5 remained in the two-pollutant models. By contrast, NO2, but not PM2.5, was significantly associated with increased hsCRP levels (16.0%-37.3% in single-pollutant models and 26.4%-44.6% in two-pollutant models, per 10-ppb increase in NO2). In conclusion, arterial stiffness might be more sensitive to short-term PM2.5 exposure than is inflammation.
Language	English
Publishing date	2016-11-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2016.06.084
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