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Article ; Online: KN-93 promotes HDAC4 nucleus translocation to promote fatty acid oxidation in myocardial infarction.

Zhao, Jianqiao / Li, Luona / Wang, Xindong / Shen, Jianping

2024 Volume 438, Issue 2, Page(s) 114050

Abstract: Myocardial infarction (MI) is a potentially fatal disease that causes a significant number of deaths worldwide. The strategy of increasing fatty acid oxidation in myocytes is considered a therapeutic avenue to accelerate metabolism to meet energy demands. ...

Abstract	Myocardial infarction (MI) is a potentially fatal disease that causes a significant number of deaths worldwide. The strategy of increasing fatty acid oxidation in myocytes is considered a therapeutic avenue to accelerate metabolism to meet energy demands. We conducted the study aiming to investigate the effect of KN-93, which induces histone deacetylase (HDAC)4 shuttling to the nucleus, on fatty acid oxidation and the expression of related genes. A mouse model of myocardial infarction was induced by isoprenaline administration. Heart damage was assessed by the detection of cardiac injury markers. The level of fatty acid oxidation level was evaluated by testing the expression of related genes. Both immunofluorescence and immunoblotting in the cytosol or nucleus were utilized to observe the distribution of HDAC4. The interaction between HDAC4 and specificity protein (SP)1 was confirmed by co-immunoprecipitation. The acetylation level of SP1 was tested after KN-93 treatment and HDAC4 inhibitor. Oxygen consumption rate and immunoblotting experiments were used to determine whether the effect of KN-93 on increasing fatty acid oxidation is through HDAC4 and SP1. Administration of KN-93 significantly reduced cardiac injury in myocardial infarction and promoted fatty acid oxidation both in vitro and in vivo. KN-93 was shown to mediate nuclear translocation of HDAC4. HDAC4 was found to interact with SP1 and reduce SP1 acetylation. HDAC4 or SP1 inhibitors attenuated the effect of KN-93 on fatty acid oxidation. In conclusion, KN-93 promotes HDAC4 translocation to the nucleus, thereby potentially enhancing fatty acid oxidation by SP1.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2024.114050
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Article ; Online: Measuring integrity and fidelity of program implementation: Validating an instrument designed for school renewal.

Ma, Xin / Shen, Jianping / Reeves, Patricia

Evaluation and program planning

2023 Volume 100, Page(s) 102341

Abstract: In this study, we attempted to explore with instrumentation that could provide a good means to measure integrity and fidelity of program implementation. The instrument, High Integrity and Fidelity Implementation for School Renewal, was created using a ... ...

Abstract	In this study, we attempted to explore with instrumentation that could provide a good means to measure integrity and fidelity of program implementation. The instrument, High Integrity and Fidelity Implementation for School Renewal, was created using a comprehensive review of the literature to provide insights into the implementation integrity and fidelity when principals renew a school. Data from 1097 teachers were used to examine the instrument for construct validity by means of factorial validity and convergent validity. We used confirmatory factor analysis to compared five factorial structures of the instrument, resulting in the identification of a four-factor structure (coming from the comprehensive review of the literature) as the best fitting structure to the data. Strong convergent validity of the instrument was confirmed by correlating the instrument with a psychometrically established instrument measuring a similar construct. Finally, McDonald's Omega indicated strong internal consistency of the instrument in our reliability analysis.
MeSH term(s)	Humans ; Reproducibility of Results ; Psychometrics ; Program Evaluation ; Factor Analysis, Statistical ; Surveys and Questionnaires
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2013444-7
ISSN	1873-7870 ; 0149-7189
ISSN (online)	1873-7870
ISSN	0149-7189
DOI	10.1016/j.evalprogplan.2023.102341
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Article: Salvianolate injection for hypertensive nephropathy patients who were using valsartan: A systematic review and meta-analysis.

Xu, Qiyao / Shen, Yuehong / Zhao, Jianqiao / Shen, Jianping

Frontiers in pharmacology

2023 Volume 14, Page(s) 1119150

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1119150
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Article ; Online: Impact of rubber-based land use changes on soil properties and carbon pools: A meta-analysis

Liu, Yong / Shen, Jianping / Zhang, Changhui / Chen, Zhe

Catena. 2023 June, v. 227 p.107121-

2023

Abstract: The rapid expansion of rubber plantations may have greatly influenced the carbon stocks of the ecosystem, with potential impacts on mitigating climate change and future carbon fluxes. Therefore, soil carbon pools and other properties must be reliably ... ...

Abstract	The rapid expansion of rubber plantations may have greatly influenced the carbon stocks of the ecosystem, with potential impacts on mitigating climate change and future carbon fluxes. Therefore, soil carbon pools and other properties must be reliably estimated after rubber-based land cover transitions. The aim of this meta-analysis is to understand how various land use changes based on rubber plantations affect soil physicochemical properties, especially soil organic carbon (SOC) pools. This study focuses on three land use changes: (1) forest-to-rubber conversion; (2) rubber monoculture vs. intercropping; and (3) the age and altitude of the rubber stand over a chronosequence in rubber plots. Results showed that the conversion of forest to rubber plantation significantly reduced the SOC, microbial carbon (MBC), total nitrogen (TN) and total magnesium pools by 24%, 35%, 13% and 94% respectively, whereas rubber intercropping with different crops profoundly increased the SOC and MBC pools by 6% and 24% on average, respectively. The improvement of rubber intercropping on SOC and properties mainly occurred in the surface soil at 0–20 cm and at altitudes of 500–800 m, but these effects were diminished in the subsurface soil at 20–60 cm and at altitudes higher than 800 m. Rubber intercropping plantations can significantly alleviate soil acidification. Changes in the response ratio of SOC were closely related to the variations in soil clay, bulk density, and C/N ratio. These results suggest that rubber-based land use management policies should promote intercropping plantations, especially those with woody plants, and the altitude of rubber planting should be manipulated to minimize the loss of soil C, N, and other nutrients.
Keywords	altitude ; bulk density ; catenas ; chronosequences ; clay ; climate change ; ecosystems ; forests ; land cover ; land use planning ; magnesium ; meta-analysis ; microbial carbon ; rubber ; soil acidification ; soil organic carbon ; subsurface soil layers ; total nitrogen ; Rubber plantations ; Land use change ; SOC ; Stand age ; Soil texture ; C/N ratio
Language	English
Dates of publication	2023-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	519608-5
ISSN	1872-6887 ; 0008-7769 ; 0341-8162
ISSN (online)	1872-6887 ; 0008-7769
ISSN	0341-8162
DOI	10.1016/j.catena.2023.107121
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Article ; Online: A rare case of daratumumab-associated encephalopathy in multiple myeloma.

Xiang, Jingjing / Hong, Zirui / Zhang, Yu / Chen, Junfa / Shen, Jianping / Zhu, Ni

Immunotherapy

2024 Volume 16, Issue 7, Page(s) 447–452

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Male ; Humans ; Middle Aged ; Multiple Myeloma/diagnosis ; Multiple Myeloma/drug therapy ; Antibodies, Monoclonal/adverse effects ; Brain Diseases/etiology ; Brain Diseases/chemically induced ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Chemical Substances	daratumumab (4Z63YK6E0E) ; Antibodies, Monoclonal
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2023-0321
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Article ; Online: Assessing the pollution level of a subtropical lake by using a novel hydrogen sulfide fluorescence technology.

Hao, Yu / Shen, Jianping / Zhang, Yue / Xie, Ping / Liu, Yong

Environmental research

2023 Volume 229, Page(s) 115916

Abstract: Hydrogen sulfide ( ... ...

Abstract	Hydrogen sulfide (H
MeSH term(s)	Hydrogen Sulfide ; Lakes/chemistry ; Reproducibility of Results ; Metals, Heavy/analysis ; Technology
Chemical Substances	Hydrogen Sulfide (YY9FVM7NSN) ; Metals, Heavy
Language	English
Publishing date	2023-04-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.115916
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Article ; Online: Assessing the pollution level of a subtropical lake by using a novel hydrogen sulfide fluorescence technology

Hao, Yu / Shen, Jianping / Zhang, Yue / Xie, Ping / Liu, Yong

Environmental Research. 2023, p.115916-

2023 , Page(s) 115916–

Abstract: Hydrogen sulfide (H₂S) is an important environmental toxin with bi-directional biological effects on organisms. In natural waters, H₂S complexes with heavy metal ions in an anaerobic environment influence heavy metals' bioavailability and induce ... ...

Abstract	Hydrogen sulfide (H₂S) is an important environmental toxin with bi-directional biological effects on organisms. In natural waters, H₂S complexes with heavy metal ions in an anaerobic environment influence heavy metals' bioavailability and induce phosphorus release and eutrophication in water columns. Traditional detection techniques, such as colorimetric, electrochemical, and chromatographic, cannot simultaneously detect H₂S and pollution assessment of subtropical lakes. To address these technical defects, we developed small-molecule fluorescent probes to evaluate the pollution level in natural water bodies. This method relies on the combination of the probes' response signals to raw water and the water quality index, thereby enhancing the accuracy and reliability of water quality assessments. Furthermore, this novel material has a large Stokes shift. It can detect complex levels of H₂S concentrations in natural water bodies by correlating the degree of contamination and fluorescence signals. The development of this visual research tool for detecting environmental H₂S levels in natural water bodies is expected to have meaningful, practical applications.
Keywords	bioavailability ; chromatography ; colorimetry ; electrochemistry ; eutrophication ; fluorescence ; heavy metals ; hydrogen sulfide ; lakes ; phosphorus ; pollution ; research ; toxins ; water quality ; Fluorescence detection ; Subtropical lake ; Pollution assessment ; Water sample
Language	English
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.115916
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Article ; Online: Icariin protects bone marrow mesenchymal stem cells in aplastic anemia by targeting MAPK pathway.

Deng, Shu / Zeng, Yuqing / Xiang, Jingjing / Lin, Shengyun / Shen, Jianping

Molecular biology reports

2022 Volume 49, Issue 9, Page(s) 8317–8324

Abstract: Background: Icariin, the main pharmacological active flavonoid extracted from Epimedi herba, can regulate cellular processes in diverse diseases. The aim of this study was to explore the effects and mechanisms of icariin on proliferation and ... ...

Abstract	Background: Icariin, the main pharmacological active flavonoid extracted from Epimedi herba, can regulate cellular processes in diverse diseases. The aim of this study was to explore the effects and mechanisms of icariin on proliferation and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) in aplastic anemia (AA). Methods and results: Bone marrow mesenchymal stem cells were isolated from posterior tibias and femurs of AA rats that were induced by benzene and cyclophosphamide and gavaged with icariin. The isolated BMSCs were characterized morphologically and immunologically by positive markers (CD29 and CD90) and negative markers (CD34 and CD45). CCK-8 assay was performed to examine the BMSCs proliferation. Cell apoptosis and cell cycle were detected by flow cytometry. Oil red O staining was carried out to evaluate the adipogenesis of BMSCs. The mRNA expression of PPARγ, C/EBP-α, and FABP4 was measured by qRT-PCR. The protein levels of p-p38/p38, p-JNK/JNK, p-ERK/ERK, PPARγ, C/EBP-α, and FABP4 were detected using Western blotting. Icariin promoted the proliferation of BMSCs from AA rats in a dose-dependent manner. The protein levels of p-p38/p38, p-JNK/JNK, and p-ERK/ERK were downregulated in BMSCs from AA rats after icariin treatment. Icariin inhibited the apoptosis and arrested cell cycle at G/S phase of BMSCs from AA rats. The adipogenesis of BMSCs from AA rats was also suppressed after icariin treatment. However, the effects of icariin on BMSCs were weakened by p38 agonist addition. Conclusions: Icariin promoted the proliferation and inhibited the apoptosis and adipogenesis of BMSCs in AA by suppressing MAPK pathway.
MeSH term(s)	Anemia, Aplastic/drug therapy ; Anemia, Aplastic/metabolism ; Animals ; Bone Marrow Cells ; Cell Differentiation ; Cells, Cultured ; Flavonoids/metabolism ; Flavonoids/pharmacology ; Mesenchymal Stem Cells/metabolism ; PPAR gamma/metabolism ; Rats
Chemical Substances	Flavonoids ; PPAR gamma ; icariin (VNM47R2QSQ)
Language	English
Publishing date	2022-06-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07645-1
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Article ; Online: Visualization of microcystin-LR and sulfides in plateau lakes.

Wang, Zhaomin / Hao, Yu / Shen, Jianping / Li, Bingyan / Chuan, Huiyan / Xie, Ping / Liu, Yong

Journal of hazardous materials

2023 Volume 462, Page(s) 132771

Abstract: In eutrophic water bodies, sulfides are closely related to the growth of cyanobacteria and the production of microcystin-LR (MC-LR). To date, the underlying interaction mechanism between a sulfides and MC-LR remains controversial. Thus, visually ... ...

Abstract	In eutrophic water bodies, sulfides are closely related to the growth of cyanobacteria and the production of microcystin-LR (MC-LR). To date, the underlying interaction mechanism between a sulfides and MC-LR remains controversial. Thus, visually presenting the distribution characteristics of sulfides and MC-LR in contaminated water is crucial. Here, we propose a novel and expeditious practical approach, utilizing fluorescence probe technology, to assess the distribution characteristics of MC-LR and sulfur in natural lakes. We have developed novel probes, pib2, to detect HSO
MeSH term(s)	Lakes/microbiology ; Sulfides/analysis ; Microcystins ; Fluorescent Dyes/analysis ; Water/analysis ; Sulfur
Chemical Substances	cyanoginosin LR (EQ8332842Y) ; Sulfides ; Microcystins ; Fluorescent Dyes ; Water (059QF0KO0R) ; Sulfur (70FD1KFU70)
Language	English
Publishing date	2023-10-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.132771
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Article ; Online: A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for Bruton's tyrosine kinase inhibitors (BTKis) single and its combination therapy.

Xiang, Sichun / Shen, Rongbin / Xiang, Jingjing / Zhu, Ni / Gu, Jianyou / Shen, Jianping / Zhang, Yu / Ge, Hangping

Expert opinion on drug safety

2024 , Page(s) 1–10

Abstract: Background: Bruton's tyrosine kinase inhibitors (BTKis) are targeted treatments for B-cell tumors but have significant side effects. This study assesses and contrasts the side effects of BTKis alone and its four combination therapies.: Research design ...

Abstract	Background: Bruton's tyrosine kinase inhibitors (BTKis) are targeted treatments for B-cell tumors but have significant side effects. This study assesses and contrasts the side effects of BTKis alone and its four combination therapies. Research design and methods: The reporting odds ratio (ROR) was used to analyze the data on three BTKis monotherapies and combinations of ibrutinib with rituximab, obinutuzumab, venetoclax, and lenalidomide in the FDA Adverse Event Reporting System (FAERS) database up to December 2022. Results: We analyzed the top 20 PTs for each treatment regimen. In monotherapies, atrial fibrillation (ROR (95% CI): 9.88 (9.47-10.32)) in zanubrutinib and rash (6.97 (5.42-8.98)) in acalabrutinib had higher associations. In combinations, infection (6.86 (6.11-7.70)), atrial fibrillation (27.96 (22.61-34.58)) and myelosuppression (10.09 (8.89-11.46)) were vital signals when ibrutinib was combined with obinutuzumab, and pyrexia (4.22 (2.57-6.93)) had a high signal value when combined with lenalidomide. Hemorrhage had a lower signal value when combined with venetoclax compared to ibrutinib alone (2.50 (2.18-2.87) vs 3.60 (3.52-3.68)). Conclusions: The ibrutinib-obinutuzumab combo has the highest risk of infection, atrial fibrillation, and myelosuppression, and the ibrutinib-lenalidomide combo has the highest risk of pyrexia. However, the ibrutinib-venetoclax combo has a lower risk of hemorrhage than monotherapy.
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2088728-0
ISSN	1744-764X ; 1474-0338
ISSN (online)	1744-764X
ISSN	1474-0338
DOI	10.1080/14740338.2024.2327507
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