Article: Wnt signaling and contact-mediated repulsion shape sensory dendritic fields.
bioRxiv : the preprint server for biology
2023
Abstract: The complete and non-redundant coverage of sensory tissues by neighboring neurons enables effective detection of stimuli in the environment. How the neurites of adjacent neurons establish their boundaries to achieve this completeness in coverage remains ... ...
Abstract | The complete and non-redundant coverage of sensory tissues by neighboring neurons enables effective detection of stimuli in the environment. How the neurites of adjacent neurons establish their boundaries to achieve this completeness in coverage remains incompletely understood. Here, we use distinct fluorescent reporters to study two neighboring sensory neurons with complex dendritic arbors, FLP and PVD, in Highlights: ▫ Secreted Wnt CWN-2 and cell-autonomous activity of neuronal LIN-17/Frizzled receptors restrict FLP dendritic field sizes▫ Endogenously tagged CWN-2/Wnt is punctate and visible in the same plane of growing FLP dendrites▫ Growth of developing FLP dendrites is inhibited upon contact with extracellular CWN-2/Wnt and with PVD dendrites. |
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Language | English |
Publishing date | 2023-09-15 |
Publishing country | United States |
Document type | Preprint |
DOI | 10.1101/2023.09.14.557812 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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