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  1. Article: Wnt signaling and contact-mediated repulsion shape sensory dendritic fields.

    Tzeng, Christopher P / Shen, Kang

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The complete and non-redundant coverage of sensory tissues by neighboring neurons enables effective detection of stimuli in the environment. How the neurites of adjacent neurons establish their boundaries to achieve this completeness in coverage remains ... ...

    Abstract The complete and non-redundant coverage of sensory tissues by neighboring neurons enables effective detection of stimuli in the environment. How the neurites of adjacent neurons establish their boundaries to achieve this completeness in coverage remains incompletely understood. Here, we use distinct fluorescent reporters to study two neighboring sensory neurons with complex dendritic arbors, FLP and PVD, in
    Highlights: ▫ Secreted Wnt CWN-2 and cell-autonomous activity of neuronal LIN-17/Frizzled receptors restrict FLP dendritic field sizes▫ Endogenously tagged CWN-2/Wnt is punctate and visible in the same plane of growing FLP dendrites▫ Growth of developing FLP dendrites is inhibited upon contact with extracellular CWN-2/Wnt and with PVD dendrites.
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.14.557812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The function of the axon initial segment in neuronal polarity.

    Eichel, Kelsie / Shen, Kang

    Developmental biology

    2022  Volume 489, Page(s) 47–54

    Abstract: Neurons are highly polarized cells with extensive axonal and dendritic projections that send and receive signals over long distances. Neuronal polarity requires sorting and maintaining a unique set of proteins to the neuron's distinct axonal and ... ...

    Abstract Neurons are highly polarized cells with extensive axonal and dendritic projections that send and receive signals over long distances. Neuronal polarity requires sorting and maintaining a unique set of proteins to the neuron's distinct axonal and somatodendritic domains. The axon initial segment (AIS) is a specialized subcellular region located between these two domains and is critical for neuronal polarity. The AIS has a complex and elaborately organized molecular structure that enables its functions in neuronal polarity. Disruption of the AIS is associated with neurodevelopmental and neuropsychiatric disease pathologies, thus highlighting the importance of the AIS in neuronal physiology. This review discusses recent progress toward understanding the molecular architecture of the AIS and its importance in neuronal polarity through regulating protein diffusion and vesicular trafficking.
    MeSH term(s) Axon Initial Segment/metabolism ; Axon Initial Segment/pathology ; Axons/metabolism ; Cell Polarity/physiology ; Neurons/metabolism ; Protein Transport/physiology
    Language English
    Publishing date 2022-05-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2022.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The function of the axon initial segment in neuronal polarity

    Eichel, Kelsie / Shen, Kang

    Developmental biology. 2022 May 23,

    2022  

    Abstract: Neurons are highly polarized cells with extensive axonal and dendritic projections that send and receive signals over long distances. Neuronal polarity requires sorting and maintaining a unique set of proteins to the neuron's distinct axonal and ... ...

    Abstract Neurons are highly polarized cells with extensive axonal and dendritic projections that send and receive signals over long distances. Neuronal polarity requires sorting and maintaining a unique set of proteins to the neuron's distinct axonal and somatodendritic domains. The axon initial segment (AIS) is a specialized subcellular region located between the two domains and is critical for neuronal polarity. The AIS has a complex and elaborately organized molecular structure that enables its functions in neuronal polarity. Disruption of the AIS is associated with neurodevelopmental and neuropsychiatric disease pathologies, thus highlighting the importance of the AIS in neuronal physiology. This review discusses recent progress toward understanding the molecular architecture of the AIS and its importance in neuronal polarity through regulating protein diffusion and vesicular trafficking.
    Keywords axons ; chemical structure ; neurophysiology
    Language English
    Dates of publication 2022-0523
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2022.05.016
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Theoretical Studies on the Reaction Kinetic of 2-Acetylfuran with Hydroxyl Radicals.

    He, Wei / Chen, Kaixuan / Zhu, Liucun / Shen, Kang

    ACS omega

    2023  Volume 8, Issue 23, Page(s) 21277–21284

    Abstract: With the development of synthetic methods, 2-acetylfuran (AF2) has become a potential biomass fuel. The potential energy surfaces of AF2 and OH including OH-addition reactions and H-abstraction reactions were constructed by theoretical calculations at ... ...

    Abstract With the development of synthetic methods, 2-acetylfuran (AF2) has become a potential biomass fuel. The potential energy surfaces of AF2 and OH including OH-addition reactions and H-abstraction reactions were constructed by theoretical calculations at the CCSDT/CBS/M06-2x/cc-pVTZ level. The temperature- and pressure-dependent rate constants of the relevant reaction pathways were solved based on transition state theory and Rice-Ramsperger-Kassel-Marcus theory, as well as Eckart tunneling effect correction. The results showed that the H-abstraction reaction on CH
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c02636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dephasing-assisted preparation of asymmetric steering in coupled quantum wells.

    Luo, Shunlin / Shen, Kang / Wang, Fei

    Optics express

    2023  Volume 31, Issue 19, Page(s) 30767–30782

    Abstract: It is shown that the dephasing rates are usually harmful for quantum correlations in various systems. Nevertheless, we explore that the dephasing rates in the coupled quantum wells (QWs), as a major contribution of the decay processes, can assist to ... ...

    Abstract It is shown that the dephasing rates are usually harmful for quantum correlations in various systems. Nevertheless, we explore that the dephasing rates in the coupled quantum wells (QWs), as a major contribution of the decay processes, can assist to generate one-way Einstein-Podolsky-Rosen (EPR) steering. By applying two strong fields to drive two dipole-allowed transitions while the other transitions are coupled with two quantized modes, the asymmetric EPR steering is possible to obtain at steady state through a single-pathway dissipation in the three-well system. According to dressed-state and Bogoliubov mode transformation, we find that the dephasing rates play a role in modifying the dressed-state populations and the dissipation rate through multiple quantum interference mechanisms. The positive effect of the dephasing rates from a nanostructure on quantum correlation is expected to find potential applications in quantum information processing.
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.499410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The complete mitogenome of the Greytail angelfish

    Shen, Kang-Ning / Chang, Chih-Wei

    Mitochondrial DNA. Part B, Resources

    2021  Volume 6, Issue 12, Page(s) 3333–3335

    Abstract: The mitogenome of the Greytail ... ...

    Abstract The mitogenome of the Greytail angelfish
    Language English
    Publishing date 2021-11-03
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2021.1933632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Phenylboronic acid modification-based novel dumbbell-shaped Au-Ag nanorod SERS substrates for ultrasensitive detection of SO

    Shen, Kang / Bi, Caili / Yang, Haifan / Xu, Miaowen / Huang, Lili / Wang, Youwei

    Analytical methods : advancing methods and applications

    2024  Volume 16, Issue 15, Page(s) 2311–2321

    Abstract: Based on the coordination principle of Lewis acids, a 4-mercaptophenylboronic acid (4-MPBA)-modified novel dumbbell-shaped Au-Ag nanorod (4-MPBA@DS Au-AgNR) substrate was developed, which could be combined with the surface-enhanced Raman scattering (SERS) ...

    Abstract Based on the coordination principle of Lewis acids, a 4-mercaptophenylboronic acid (4-MPBA)-modified novel dumbbell-shaped Au-Ag nanorod (4-MPBA@DS Au-AgNR) substrate was developed, which could be combined with the surface-enhanced Raman scattering (SERS) technique to detect SO
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay01831h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Theoretical Study of the Decomposition Reactions of 2-Vinylfuran.

    He, Wei / Zhang, Qichun / Chen, Kaixuan / Nie, Yusen / Li, Yan / Zhu, Liucun / Shen, Kang

    ACS omega

    2024  Volume 9, Issue 17, Page(s) 19063–19070

    Abstract: With the development of new synthetic methods, 2-vinylfuran (V2F) has become a potential renewable biofuel. In this work, the potential energy surfaces for the V2F unimolecular dissociation reaction, the H-addition reaction, and the H-abstraction ... ...

    Abstract With the development of new synthetic methods, 2-vinylfuran (V2F) has become a potential renewable biofuel. In this work, the potential energy surfaces for the V2F unimolecular dissociation reaction, the H-addition reaction, and the H-abstraction reaction were constructed at the G4 level. The temperature- and pressure-dependent rate constants for the relevant reactions on the potential energy surfaces were calculated by solving the master equation based on the transition state theory and Rice-Ramsperger-Kassel-Marcus theory. The results show that the rate constant for the intramolecular H-transfer reaction of V2F with H atoms from the C(5) site to the C(4) site to form 2-vinylfuran-3(2
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c09818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Streak artifact suppressed back projection for sparse-view photoacoustic computed tomography.

    Wang, Tong / Chen, Chenyang / Shen, Kang / Liu, Wen / Tian, Chao

    Applied optics

    2023  Volume 62, Issue 15, Page(s) 3917–3925

    Abstract: The development of fast and accurate image reconstruction algorithms under constrained data acquisition conditions is important for photoacoustic computed tomography (PACT). Sparse-view measurements have been used to accelerate data acquisition and ... ...

    Abstract The development of fast and accurate image reconstruction algorithms under constrained data acquisition conditions is important for photoacoustic computed tomography (PACT). Sparse-view measurements have been used to accelerate data acquisition and reduce system complexity; however, reconstructed images suffer from sparsity-induced streak artifacts. In this paper, a modified back-projection (BP) method termed anti-streak BP is proposed to suppress streak artifacts in sparse-view PACT reconstruction. During the reconstruction process, the anti-streak BP finds the back-projection terms contaminated by high-intensity sources with an outlier detection method. Then, the weights of the contaminated back-projection terms are adaptively adjusted to eliminate the effects of high-intensity sources. The proposed anti-streak BP method is compared with the conventional BP method on both simulation and in vivo data. The anti-streak BP method shows substantially fewer artifacts in the reconstructed images, and the streak index is 54% and 20% lower than that of the conventional BP method on simulation and in vivo data, when the transducer number
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.487957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition.

    McDonald, Nathan A / Tao, Li / Dong, Meng-Qiu / Shen, Kang

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Neuronal development orchestrates the formation of an enormous number of synapses that connect the nervous system. In developing presynapses, the core active zone structure has been found to assemble through a liquid-liquid phase separation. Here, we ... ...

    Abstract Neuronal development orchestrates the formation of an enormous number of synapses that connect the nervous system. In developing presynapses, the core active zone structure has been found to assemble through a liquid-liquid phase separation. Here, we find that the phase separation of SYD-2/Liprin-α, a key active zone scaffold, is controlled by phosphorylation. Using phosphoproteomics, we identify the SAD-1 kinase to phosphorylate SYD-2 and a number of other substrates. Presynaptic assembly is impaired in
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.12.544643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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