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  1. Article ; Online: Fabrication of triple-crosslinked gelatin/alginate hydrogels for controlled release applications

    Shen, Ke-Han / Chiu, Ting-Hsiang / Teng, Kuang-Chih / Yu, Jiashing / Yeh, Yi-Cheun

    International Journal of Biological Macromolecules. 2023 Aug. 03, p.126133-

    2023  , Page(s) 126133–

    Abstract: Hydrogels have been demonstrated as smart drug carriers to recognize the tumor microenvironment for cancer treatment, where the dynamic crosslinks in the hydrogel network contribute to the stimuli-responsive features but also result in poor stability and ...

    Abstract Hydrogels have been demonstrated as smart drug carriers to recognize the tumor microenvironment for cancer treatment, where the dynamic crosslinks in the hydrogel network contribute to the stimuli-responsive features but also result in poor stability and weak mechanical property of the hydrogels. Here, phenylboronic acid-grafted polyethyleneimine (PBA-PEI)-modified gelatin (PPG) was synthesized to crosslink alginate dialdehyde (ADA) through imine bonds and boronate ester bonds, and then calcium ions (Ca²⁺) were added to introduce the third calcium-carboxylate crosslinking in the network to form the triple-crosslinked PPG/ADA + Ca²⁺ hydrogels. Given the three types of dynamic bonds in the network, PPG/ADA + Ca²⁺ hydrogels possessed a self-healing manner, stimuli-responsiveness, and better mechanical properties compared to single- or double-crosslinked hydrogels. The controlled release capability of PPG/ADA + Ca²⁺ hydrogels was also demonstrated, showing the encapsulated molecules can be rapidly released from the hydrogel network in the presence of hydrogen peroxide while the release rate can be slowed down at acidic pH. Furthermore, PPG/ADA + Ca²⁺ hydrogels presented selected cytotoxicity and drug delivery to cancer cells due to the regulated degradation by the cellular microenvironment. Taken together, PPG/ADA + Ca²⁺ hydrogels have been demonstrated as promising biomaterials with multiple desirable properties and dynamic features to perform controlled molecule release for biomedical applications.
    Keywords alginates ; biocompatible materials ; calcium ; cancer therapy ; cellular microenvironment ; crosslinking ; cytotoxicity ; drugs ; encapsulation ; gelatin ; hydrogels ; hydrogen peroxide ; imines ; mechanical properties ; neoplasms ; pH ; polyethyleneimine ; Alginate ; Dynamic bonds
    Language English
    Dates of publication 2023-0803
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.126133
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Fabrication of triple-crosslinked gelatin/alginate hydrogels for controlled release applications.

    Shen, Ke-Han / Chiu, Ting-Hsiang / Teng, Kuang-Chih / Yu, Jiashing / Yeh, Yi-Cheun

    International journal of biological macromolecules

    2023  Volume 250, Page(s) 126133

    Abstract: Hydrogels have been demonstrated as smart drug carriers to recognize the tumor microenvironment for cancer treatment, where the dynamic crosslinks in the hydrogel network contribute to the stimuli-responsive features but also result in poor stability and ...

    Abstract Hydrogels have been demonstrated as smart drug carriers to recognize the tumor microenvironment for cancer treatment, where the dynamic crosslinks in the hydrogel network contribute to the stimuli-responsive features but also result in poor stability and weak mechanical property of the hydrogels. Here, phenylboronic acid-grafted polyethyleneimine (PBA-PEI)-modified gelatin (PPG) was synthesized to crosslink alginate dialdehyde (ADA) through imine bonds and boronate ester bonds, and then calcium ions (Ca
    Language English
    Publishing date 2023-08-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.126133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Dual Dynamic Covalently Crosslinked Alginate Hydrogels with Tunable Properties and Multiple Stimuli-Responsiveness.

    Shen, Ke-Han / Yeh, Ying-Yu / Chiu, Ting-Hsiang / Wang, Reuben / Yeh, Yi-Cheun

    ACS biomaterials science & engineering

    2022  Volume 8, Issue 10, Page(s) 4249–4261

    Abstract: Alginate is a biopolymer that can be crosslinked with calcium ions to fabricate cytocompatible hydrogels. However, using calcium ions to crosslink alginate provides limited properties and functions to alginate hydrogels, restricting their biomedical ... ...

    Abstract Alginate is a biopolymer that can be crosslinked with calcium ions to fabricate cytocompatible hydrogels. However, using calcium ions to crosslink alginate provides limited properties and functions to alginate hydrogels, restricting their biomedical applications. Here, phenylboronic acid-functionalized polyethyleneimine (PBA-PEI) was developed to introduce two orthogonal dynamic covalent crosslinks in the alginate hydrogels, where PBA-PEI was used to crosslink alginate dialdehyde (ADA) through imine bonds and boronate ester bonds. The grafting degree of PBA in the PEI structure was applied to fine-tune the properties of PBA-PEI/ADA hydrogels, including the rheological property, mechanical strength, swelling behavior, and antibacterial activity. In particular, the highly sensitive boronate ester bonds in the network enabled PBA-PEI/ADA hydrogels to be responsive to several stimuli, such as glucose, fructose, and hydrogen peroxide. Taken together, PBA-PEI/ADA hydrogels with tunable properties and multiple stimuli-responsiveness have been demonstrated as smart biomaterials for advanced biomedical applications.
    MeSH term(s) Alginates/chemistry ; Alginates/pharmacology ; Anti-Bacterial Agents ; Biocompatible Materials/pharmacology ; Calcium/chemistry ; Esters ; Fructose ; Glucose ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Hydrogen Peroxide/pharmacology ; Polyethyleneimine/pharmacology
    Chemical Substances Alginates ; Anti-Bacterial Agents ; Biocompatible Materials ; Esters ; Hydrogels ; Fructose (30237-26-4) ; Polyethyleneimine (9002-98-6) ; Hydrogen Peroxide (BBX060AN9V) ; Glucose (IY9XDZ35W2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.2c00571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Smart near infrared-responsive nanocomposite hydrogels for therapeutics and diagnostics.

    Shen, Ke-Han / Lu, Cheng-Hsun / Kuo, Chih-Yu / Li, Bo-Yan / Yeh, Yi-Cheun

    Journal of materials chemistry. B

    2021  Volume 9, Issue 35, Page(s) 7100–7116

    Abstract: Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the ... ...

    Abstract Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the treatment process by providing controllable structural change and payload release under internal and external simulations. Among the various external stimuli, near-infrared (NIR) light has attracted considerable interest due to its minimal photo-damage, deep tissue penetration, low auto-fluorescence in living systems, facile on/off switch, easy remote and spatiotemporal control. In this study, we discuss four types of transducing nanomaterials used in NIR-responsive NC hydrogels, including metal-based nanoparticles, carbon-based nanomaterials, polydopamine nanoparticles (PDA NPs), and upconversion nanoparticles (UCNPs). This review provides an overview of the current progress in NIR-responsive NC hydrogels, focusing on their preparation, properties, applications, and future prospects.
    MeSH term(s) Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Biocompatible Materials/therapeutic use ; Hydrogels/chemical synthesis ; Hydrogels/chemistry ; Hydrogels/therapeutic use ; Infrared Rays ; Materials Testing ; Nanocomposites/chemistry ; Nanocomposites/therapeutic use
    Chemical Substances Biocompatible Materials ; Hydrogels
    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d1tb00980j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Smart near infrared-responsive nanocomposite hydrogels for therapeutics and diagnostics

    Shen, Ke-Han / Lu, Cheng-Hsun / Kuo, Chih-Yu / Li, Bo-Yan / Yeh, Yi-Cheun

    Journal of materials chemistry B. 2021 Sept. 15, v. 9, no. 35

    2021  

    Abstract: Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the ... ...

    Abstract Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the treatment process by providing controllable structural change and payload release under internal and external simulations. Among the various external stimuli, near-infrared (NIR) light has attracted considerable interest due to its minimal photo-damage, deep tissue penetration, low auto-fluorescence in living systems, facile on/off switch, easy remote and spatiotemporal control. In this study, we discuss four types of transducing nanomaterials used in NIR-responsive NC hydrogels, including metal-based nanoparticles, carbon-based nanomaterials, polydopamine nanoparticles (PDA NPs), and upconversion nanoparticles (UCNPs). This review provides an overview of the current progress in NIR-responsive NC hydrogels, focusing on their preparation, properties, applications, and future prospects.
    Keywords biocompatible materials ; diagnostic techniques ; hydrogels ; nanocomposites ; therapeutics
    Language English
    Dates of publication 2021-0915
    Size p. 7100-7116.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d1tb00980j
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: In situ formation of nanocomposite double-network hydrogels with shear-thinning and self-healing properties

    Tsai, Tsan-Yu / Shen, Ke-Han / Chang, Chun-Wei / Jovanska, Lavernchy / Wang, Reuben / Yeh, Yi-Cheun

    Biomaterials science. 2021 Feb. 9, v. 9, no. 3

    2021  

    Abstract: Nanocomposite double-network hydrogels (ncDN hydrogels) are recently introduced to address the limitations of traditional DN hydrogels, such as the lack of diversity in the network structure and the restricted functionalities. However, two challenges ... ...

    Abstract Nanocomposite double-network hydrogels (ncDN hydrogels) are recently introduced to address the limitations of traditional DN hydrogels, such as the lack of diversity in the network structure and the restricted functionalities. However, two challenges remain, including the time-consuming preparation and the lack of shear-thinning and self-healing properties. Here, our approach to developing versatile ncDN hydrogels is through the use of multiple interfacial crosslinking chemistries (i.e., noncovalent interactions of electrostatic interaction and hydrogen bonds as well as dynamic covalent interactions of imine bonds and boronate ester bonds) and surface functionalized nanomaterials (i.e. phenylboronic acid modified reduced graphene oxide (PBA-rGO)). PBA-rGO was used as a multivalent gelator to further crosslink the two polymer chains (i.e. triethylene glycol-grafted chitosan (TEG-CS) and polydextran aldehyde (PDA)) in DN hydrogels, forming the TEG-CS/PDA/PBA-rGO ncDN hydrogels in seconds. The microstructures (i.e. pore size) and properties (i.e. rheological, mechanical, and swelling properties) of the ncDN hydrogels can be simply modulated by changing the amount of PBA-rGO. The dynamic bonds in the polymeric network provided the shear-thinning and self-healing properties to the ncDN hydrogels, allowing the hydrogels to be injected and molded into varied shapes as well as self-repair the damaged structure. Besides, the designed TEG-CS/PDA/PBA-rGO ncDN hydrogels were cytocompatible and also exhibited antibacterial activity. Taken together, we hereby provide a nanomaterial approach to fabricate a new class of ncDN hydrogels with tailorable networks and favorite properties for specific applications.
    Keywords aldehydes ; antibacterial properties ; biocompatible materials ; chitosan ; crosslinking ; electrostatic interactions ; graphene oxide ; hydrogels ; hydrogen ; imines ; nanocomposites ; phenylboronic acids ; polymers ; porosity
    Language English
    Dates of publication 2021-0209
    Size p. 985-999.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm01528h
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: In situ

    Tsai, Tsan-Yu / Shen, Ke-Han / Chang, Chun-Wei / Jovanska, Lavernchy / Wang, Reuben / Yeh, Yi-Cheun

    Biomaterials science

    2020  Volume 9, Issue 3, Page(s) 985–999

    Abstract: Nanocomposite double-network hydrogels (ncDN hydrogels) are recently introduced to address the limitations of traditional DN hydrogels, such as the lack of diversity in the network structure and the restricted functionalities. However, two challenges ... ...

    Abstract Nanocomposite double-network hydrogels (ncDN hydrogels) are recently introduced to address the limitations of traditional DN hydrogels, such as the lack of diversity in the network structure and the restricted functionalities. However, two challenges remain, including the time-consuming preparation and the lack of shear-thinning and self-healing properties. Here, our approach to developing versatile ncDN hydrogels is through the use of multiple interfacial crosslinking chemistries (i.e., noncovalent interactions of electrostatic interaction and hydrogen bonds as well as dynamic covalent interactions of imine bonds and boronate ester bonds) and surface functionalized nanomaterials (i.e. phenylboronic acid modified reduced graphene oxide (PBA-rGO)). PBA-rGO was used as a multivalent gelator to further crosslink the two polymer chains (i.e. triethylene glycol-grafted chitosan (TEG-CS) and polydextran aldehyde (PDA)) in DN hydrogels, forming the TEG-CS/PDA/PBA-rGO ncDN hydrogels in seconds. The microstructures (i.e. pore size) and properties (i.e. rheological, mechanical, and swelling properties) of the ncDN hydrogels can be simply modulated by changing the amount of PBA-rGO. The dynamic bonds in the polymeric network provided the shear-thinning and self-healing properties to the ncDN hydrogels, allowing the hydrogels to be injected and molded into varied shapes as well as self-repair the damaged structure. Besides, the designed TEG-CS/PDA/PBA-rGO ncDN hydrogels were cytocompatible and also exhibited antibacterial activity. Taken together, we hereby provide a nanomaterial approach to fabricate a new class of ncDN hydrogels with tailorable networks and favorite properties for specific applications.
    MeSH term(s) Hydrogels ; Hydrogen Bonding ; Nanocomposites ; Polymers
    Chemical Substances Hydrogels ; Polymers
    Language English
    Publishing date 2020-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm01528h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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