LIVIVO - Search results -

Search results

Result 1 - 10 of total 566

Search options

Book ; Thesis: Molecular genetics of phenylketonuria and the development of a new therapeutic approach

Shen, Nan

from phenomics to therapy

2016

Author's details	vorgelegt von Nan Shen
Language	English
Size	95 Seiten, Illustrationen, Diagramme
Publishing place	Heidelberg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Ruprecht-Karls-Universität Heidelberg, 2017
HBZ-ID	HT019311801
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2017 E 785	order for loan	Magazin

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Non-coding DNA variants for risk in lupus.

Zhang, Yutong / Hou, Guojun / Shen, Nan

Best practice & research. Clinical rheumatology

2024 , Page(s) 101937

Abstract: Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease that arises from a dynamic interplay between genetics and environmental triggers. The advent of sophisticated genomics technology has catalyzed a shift in our understanding of ... ...

Abstract	Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease that arises from a dynamic interplay between genetics and environmental triggers. The advent of sophisticated genomics technology has catalyzed a shift in our understanding of disease etiology, spotlighting the pivotal role of non-coding DNA variants in SLE pathogenesis. In this review, we present a comprehensive examination of the non-coding variants associated with SLE, shedding light on their role in influencing disease risk and progression. We discuss the latest methodological advancements that have been instrumental in the identification and functional characterization of these genomic elements, with a special focus on the transformative power of CRISPR-based gene-editing technologies. Additionally, the review probes into the therapeutic opportunities that arise from modulating non-coding regions associated with SLE. Through an exploration of the complex network of non-coding DNA, this review aspires to decode the genetic puzzle of SLE and set the stage for groundbreaking gene-based therapeutic interventions and the advancement of precision medicine strategies tailored to SLE management.
Language	English
Publishing date	2024-02-29
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2052323-3
ISSN	1532-1770 ; 1521-6942
ISSN (online)	1532-1770
ISSN	1521-6942
DOI	10.1016/j.berh.2024.101937
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Se 1036: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A reciprocal association between interpersonal relationship quality and student's positive affect: A three-wave random intercept cross-lagged study in a Chinese primary mathematics learning context.

Cui, Tianxue / Liu, Qimeng / Shen, Nan

The British journal of educational psychology

2024 Volume 94, Issue 2, Page(s) 601–621

Abstract: Aim: This study adopted a three-wave random intercept cross-lagged panel model to explore the longitudinal reciprocal relationships between (a) the teacher-student relationship (TSR) quality and (b) the parent-child relationship (PCR) quality and ... ...

Abstract	Aim: This study adopted a three-wave random intercept cross-lagged panel model to explore the longitudinal reciprocal relationships between (a) the teacher-student relationship (TSR) quality and (b) the parent-child relationship (PCR) quality and positive affect among Chinese primary school students. Samples: Two primary school student samples, including 3505 and 2505 students, were tracked with their perceived relationship quality with math teachers and parents and their positive affect levels in mathematics learning over three academic years. Results: The results demonstrated that more closeness with parents could significantly predict students' subsequent higher level of positive affect in mathematics learning. However, more closeness with their math teachers did not show significant prediction. Meanwhile, more conflict with math teachers and parents could significantly predict their subsequent lower degree of perceived positive affect in mathematics learning. That is, a reciprocal association lines in the PCR quality and positive affect, whereas only a unidirectional association exists between the TSR and positive affect. The predictions of the experienced positive affect on their perceived interpersonal relationships with math teachers and parents were stronger than those in the reverse association. Conclusions: This study identifies that while the effects of closeness with math teachers and parents on positive affect in students' math learning differ, conflict with math teachers and parents indeed harms students' experienced positive affect in math learning. More attention should also be paid to fostering positive affect in math learning.
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1501130-6
ISSN	2044-8279 ; 0007-0998
ISSN (online)	2044-8279
ISSN	0007-0998
DOI	10.1111/bjep.12669
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Clinical and metagenomic characteristics of lymphadenopathy related to fever of unknown origin in children.

Zhou, Yajuan / Shen, Nan / Luo, Lijuan / Liu, Yandi / Cao, Qing

Pediatric research

2024

Abstract: Background: Diagnosis of fever of unknown origin remains challenge for pediatricians. Lymphadenopathy is a separate entity that mainly originates from infection or malignancy.: Methods: 168 patients with FUO accompanied by lymphadenectasis were ... ...

Abstract	Background: Diagnosis of fever of unknown origin remains challenge for pediatricians. Lymphadenopathy is a separate entity that mainly originates from infection or malignancy. Methods: 168 patients with FUO accompanied by lymphadenectasis were reviewed. 33 lymph node tissue samples were examined by mNGS. Differences in clinical characteristics were compared among different disease groups. The value of mNGS in diagnosing and improving the clinical situation was assessed. Results: Multivariate analysis revealed that hepatosplenomegaly and LDH levels were associated with infectious diseases. Arthralgia was correlated with non-infectious inflammatory diseases. Weight loss and a node located in supraclavicular region may indicate neoplastic diseases. mNGS-positive rate was 60.60%, higher than that obtained with traditional methods. Treatment for 3/4 patients was adjusted according to the pathogen detected by mNGS, and antibiotics uses was discontinued or degraded in over 1/2 of the patients according to mNGS results. Conclusions: Clinical characteristics of children with lymphadenopathy related to FUO have limited diagnostic value for distinguishing different kinds of diseases, while mNGS of lymph node tissue serves as a useful tool for identifying infectious diseases, especially those caused by rare pathogens. mNGS results can lead to not only adjustments in targeted treatment but also further confirmation of underlying diseases. Impact statement: 1. The clinical features of children with FUO and lymphadenopathy differ according to disease group,although multivariate analysis indicated little diagnostic value for these features. 2. mNGS on lymph node tissue from children with FUO may serve as a efficient tool for distinguishing infectious diseases from other diseases. This is especially useful when a diagnosis cannot be determined with traditional methods. 3. mNGS targeted treatment can be administered in a timely manner and some underlying diseases can be indicated.
Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-024-03187-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 373: Show issues

Order via subito

Details ▾

Article ; Online: Plot-based study to evaluate raindrop detachment capacity on moss-dominated biocrusted slope under simulated rainfall with different intensities

Guo, Qi / Wang, Zhanli / Shen, Nan

Catena. 2023 June, v. 226 p.107084-

2023

Abstract: Biocrusts play a critical role in prevention of erosion, but little is known on the relationship between biocrust cover and raindrop detachment capacity at the slope scale. Evaluating the raindrop detachment capacity on biocrusted slope is essential for ... ...

Abstract	Biocrusts play a critical role in prevention of erosion, but little is known on the relationship between biocrust cover and raindrop detachment capacity at the slope scale. Evaluating the raindrop detachment capacity on biocrusted slope is essential for better knowledge of the rainfall-induced erosion of biocrusted slope. Thus, laboratory simulated rainfall experiments were conducted on plots (140 × 120 cm) representing moss-dominated biocrusted slopes to measure the amounts of raindrop detachment under a complete combination of different biocrust cover (0%, 20%, 40%, 50%, 60%, and 80%) and rainfall intensities (42, 60, 90, 120, and 150 mm h⁻¹) at 26.79% slope gradient with two replications. The results showed that the biocrust cover, rainfall intensity, and their interaction all significantly affected the raindrop detachment modulus (RDm). The RDm in biocrust plot was significantly lower than in bare soil plot under rain events with the same rainfall intensities. The lower biocrust cover or the larger rainfall intensities led to higher RDm. Reduction benefit of raindrop detachment modulus (RB-RDm) were greater than its corresponding biocrust cover values. When the biocrust cover increased from 20% to 40%, the increase range and growth trend of RDm decreased with increasing rainfall intensity. Our results indicated that the development of biocrusts on slope is an effective way of reducing raindrop detachment by protecting soil in their covered area and increasing flow depth. When moss-dominated biocrust cover reached 40%, the raindrop detachment capacity effectively weakened even under rain events with large rainfall intensities. These findings may conducive to offer a scientific guidance for soil erosion control in the Loess Plateau and in other arid and semiarid regions.
Keywords	biological soil crusts ; catenas ; erosion control ; rain ; rain intensity ; rainfall simulation ; soil erosion ; China ; Raindrop detachment ; Biocrust cover ; Rainfall intensity ; Kinetic energy ; Detachment modulus reduction benefit
Language	English
Dates of publication	2023-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	519608-5
ISSN	1872-6887 ; 0008-7769 ; 0341-8162
ISSN (online)	1872-6887 ; 0008-7769
ISSN	0341-8162
DOI	10.1016/j.catena.2023.107084
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 3389: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants.

Vinuesa, Carola G / Shen, Nan / Ware, Thuvaraka

Nature reviews. Nephrology

2023 Volume 19, Issue 9, Page(s) 558–572

Abstract: The past few years have provided important insights into the genetic architecture of systemic autoimmunity through aggregation of findings from genome-wide association studies (GWAS) and whole-exome or whole-genome sequencing studies. In the prototypic ... ...

Abstract	The past few years have provided important insights into the genetic architecture of systemic autoimmunity through aggregation of findings from genome-wide association studies (GWAS) and whole-exome or whole-genome sequencing studies. In the prototypic systemic autoimmune disease systemic lupus erythematosus (SLE), monogenic disease accounts for a small fraction of cases but has been instrumental in the elucidation of disease mechanisms. Defects in the clearance or digestion of extracellular or intracellular DNA or RNA lead to increased sensing of nucleic acids, which can break B cell tolerance and induce the production of type I interferons leading to tissue damage. Current data suggest that multiple GWAS SLE risk alleles act in concert with rare functional variants to promote SLE development. Moreover, introduction of orthologous variant alleles into mice has revealed that pathogenic X-linked dominant and recessive SLE can be caused by novel variants in TLR7 and SAT1, respectively. Such bespoke models of disease help to unravel pathogenic pathways and can be used to test targeted therapies. Cell type-specific expression data revealed that most GWAS SLE risk genes are highly expressed in age-associated B cells (ABCs), which supports the view that ABCs produce lupus autoantibodies and contribute to end-organ damage by persisting in inflamed tissues, including the kidneys. ABCs have thus emerged as key targets of promising precision therapeutics.
MeSH term(s)	Animals ; Mice ; Genome-Wide Association Study ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/pathology ; Autoimmunity ; Autoantibodies ; DNA ; Genetic Predisposition to Disease
Chemical Substances	Autoantibodies ; DNA (9007-49-2)
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2490366-8
ISSN	1759-507X ; 1759-5061
ISSN (online)	1759-507X
ISSN	1759-5061
DOI	10.1038/s41581-023-00732-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6334: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 107: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Phen2Disease: a phenotype-driven model for disease and gene prioritization by bidirectional maximum matching semantic similarities.

Zhai, Weiqi / Huang, Xiaodi / Shen, Nan / Zhu, Shanfeng

Briefings in bioinformatics

2023 Volume 24, Issue 4

Abstract: Human Phenotype Ontology (HPO)-based approaches have gained popularity in recent times as a tool for genomic diagnostics of rare diseases. However, these approaches do not make full use of the available information on disease and patient phenotypes. We ... ...

Abstract	Human Phenotype Ontology (HPO)-based approaches have gained popularity in recent times as a tool for genomic diagnostics of rare diseases. However, these approaches do not make full use of the available information on disease and patient phenotypes. We present a new method called Phen2Disease, which utilizes the bidirectional maximum matching semantic similarity between two phenotype sets of patients and diseases to prioritize diseases and genes. Our comprehensive experiments have been conducted on six real data cohorts with 2051 cases (Cohort 1, n = 384; Cohort 2, n = 281; Cohort 3, n = 185; Cohort 4, n = 784; Cohort 5, n = 208; and Cohort 6, n = 209) and two simulated data cohorts with 1000 cases. The results of the experiments showed that Phen2Disease outperforms the three state-of-the-art methods when only phenotype information and HPO knowledge base are used, particularly in cohorts with fewer average numbers of HPO terms. We also observed that patients with higher information content scores have more specific information, leading to more accurate predictions. Moreover, Phen2Disease provides high interpretability with ranked diseases and patient HPO terms presented. Our method provides a novel approach to utilizing phenotype data for genomic diagnostics of rare diseases, with potential for clinical impact. Phen2Disease is freely available on GitHub at https://github.com/ZhuLab-Fudan/Phen2Disease.
MeSH term(s)	Humans ; Rare Diseases ; Semantics ; Genomics ; Biological Ontologies ; Phenotype
Language	English
Publishing date	2023-05-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068142-2
ISSN	1477-4054 ; 1467-5463
ISSN (online)	1477-4054
ISSN	1467-5463
DOI	10.1093/bib/bbad172
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6262: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Response of Soil Detachment Rate to Sediment Load and Model Examination: A Key Process Simulation of Rill Erosion on Steep Loessial Hillslopes.

Shen, Nan / Wang, Zhanli / Zhang, Fengbao / Zhou, Chunhong

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: The rate of soil detachment by water flow indicates soil erosion intensity directly. The exact relation between soil detachment rate and actual sediment load in water flow, however, is still unclear, and the existing relationships have not been ... ...

Abstract	The rate of soil detachment by water flow indicates soil erosion intensity directly. The exact relation between soil detachment rate and actual sediment load in water flow, however, is still unclear, and the existing relationships have not been adequately tested. The aims of the present study were to investigate the response of soil detachment rate to sediment load using rill flume data with loessial soil and to quantitatively examine the soil detachment equations in the WEPP and EUROSEM soil erosion models. Six slopes were combined with seven flow discharges to measure detachment rates under seven sediment loads using a rill flume with a soil-feeding hopper. Significant differences were found among the soil detachment rate by different sediment loads in low sediment load levels, but an insensitive response of soil detachment rate to sediment load was found under high levels of sediment load. The soil detachment rate was proved to be negatively linearly correlated with sediment load. The rill detachment equation in the WEPP model predicted the soil detachment rate by rill flow very well under our experiment condition. The soil detachment equation in the EUROSEM model underestimated the detachment rates under controlled conditions, but removing the setting velocity from the equation greatly improved prediction. Further experiments that could reflect the dynamic convective detachment and deposition process need to be conducted to compare with the present examination results and to further understand rill erosion processes.
MeSH term(s)	Soil ; Geologic Sediments ; Soil Erosion ; Computer Simulation ; Water
Chemical Substances	Soil ; Water (059QF0KO0R)
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20042839
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Quantifying interactions between slope gradient, slope length and rainfall intensity on sheet erosion on steep slopes using Multiple Linear Regression.

Shi, Fangying / Zhang, Fengbao / Shen, Nan / Yang, Mingyi

The Science of the total environment

2023 Volume 908, Page(s) 168090

Abstract: Understanding the interactions between influencing factors on sheet erosion is crucial for model development and mechanism elucidation. Simulation rainfall tests using a full-factorial design were conducted in 0.4 m wide flumes with five slope lengths (0. ...

Abstract	Understanding the interactions between influencing factors on sheet erosion is crucial for model development and mechanism elucidation. Simulation rainfall tests using a full-factorial design were conducted in 0.4 m wide flumes with five slope lengths (0.4, 0.8, 1.2, 1.6, and 2 m), five slope gradients (17.63, 26.79, 36.40, 46.63 and 57.74 %) and five rainfall intensities (48.0, 62.4, 102.0, 148.5, and 170.1 mm·h
Language	English
Publishing date	2023-10-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.168090
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 949: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Research in the application of artificial intelligence to lung cancer diagnosis.

Liu, Wenjuan / Shen, Nan / Zhang, Limin / Wang, Xiaoxi / Chen, Bainan / Liu, Zhuo / Yang, Chao

Frontiers in medicine

2024 Volume 11, Page(s) 1343485

Abstract: The morbidity and mortality rates in lung cancer are high worldwide. Early diagnosis and personalized treatment are important to manage this public health issue. In recent years, artificial intelligence (AI) has played increasingly important roles in ... ...

Abstract	The morbidity and mortality rates in lung cancer are high worldwide. Early diagnosis and personalized treatment are important to manage this public health issue. In recent years, artificial intelligence (AI) has played increasingly important roles in early screening, auxiliary diagnosis, and prognostic assessment. AI uses algorithms to extract quantitative feature information from high-volume and high-latitude data and learn existing data to predict disease outcomes. In this review, we describe the current uses of AI in lung cancer-focused pathomics, imageomics, and genomics applications.
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1343485
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito