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  1. Article ; Online: Consultation Section: Cornea. April consultation #5.

    Shen, Tueng T

    Journal of cataract and refractive surgery

    2017  Volume 43, Issue 4, Page(s) 575–576

    MeSH term(s) Cornea ; Corneal Topography ; Humans
    Language English
    Publishing date 2017-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632744-8
    ISSN 1873-4502 ; 0886-3350
    ISSN (online) 1873-4502
    ISSN 0886-3350
    DOI 10.1016/j.jcrs.2017.04.017
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography.

    Regnault, Gabriel / Kirby, Mitchell A / Wang, Ruikang K / Shen, Tueng T / O'Donnell, Matthew / Pelivanov, Ivan

    Biomedical optics express

    2023  Volume 14, Issue 9, Page(s) 5005–5021

    Abstract: Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave ... ...

    Abstract Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave propagation, depth dependent changes are still unclear if the cornea is not crosslinked through the whole depth. Here, phase-decorrelation measurements on optical coherence tomography (OCT) structural images are combined with acoustic micro-tapping (AµT) OCE to explore possible reconstruction of depth-dependent stiffness within crosslinked corneas in an
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.497970
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  3. Article ; Online: Non-contact acoustic micro-tapping optical coherence elastography for quantification of corneal anisotropic elasticity: in vivo rabbit study.

    Kirby, Mitchell A / Regnault, Gabriel / Pelivanov, Ivan / O'Donnell, Matthew / Wang, Ruikang K / Shen, Tueng T

    ArXiv

    2023  

    Abstract: Purpose: To demonstrate accurate measurement of corneal elastic moduli in vivo with non-contact and non-invasive optical coherence elastography.: Methods: Elastic properties (in-plane Young's modulus E and both in-plane, u, and out-of-plane, G, shear ...

    Abstract Purpose: To demonstrate accurate measurement of corneal elastic moduli in vivo with non-contact and non-invasive optical coherence elastography.
    Methods: Elastic properties (in-plane Young's modulus E and both in-plane, u, and out-of-plane, G, shear moduli) of rabbit cornea were quantified in vivo using non-contact dynamic Acoustic micro-Tapping Optical Coherence Elastography (AuT-OCE). The IOP-dependence of measured mechanical properties was explored in extracted whole globes following in vivo measurement. A nearly-incompressible transverse isotropic (NITI) model was used to reconstruct moduli from AuT-OCE data. Independently, cornea elastic moduli were also measured ex vivo with traditional, destructive mechanical tests (tensile extensometry and shear rheometry).
    Results: Our study demonstrates strong anisotropy of corneal elasticity in rabbits. The in-plane Young's modulus, computer as E=3u, was in the range of 20-44 MPa, whereas the out-of-plane shear modulus was in the range of 34-261 kPa. Both pressure-dependent ex vivo OCE and destructive mechanical tests performed on the same samples within an hour of euthanasia strongly support the results of AuT-OCE measurements.
    Conclusions: Non-contact AuT-OCE can non-invasively quantify cornea anisotropic elastic properties in vivo.
    Translational relevance: As OCT is broadly accepted in Ophthalmology, these results suggest the potential for rapid translation of AuT-OCE into clinical practice. In addition, AuT-OCE can likely improve diagnostic criteria of ectatic corneal diseases, leading to early diagnosis, reduced complications, customized surgical treatment, and personalized biomechanical models of the eye.
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
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  4. Article ; Online: Noncontact Acoustic Micro-Tapping Optical Coherence Elastography for Quantification of Corneal Anisotropic Elasticity: In Vivo Rabbit Study.

    Kirby, Mitchell A / Regnault, Gabriel / Pelivanov, Ivan / O'Donnell, Matthew / Wang, Ruikang K / Shen, Tueng T

    Translational vision science & technology

    2023  Volume 12, Issue 3, Page(s) 15

    Abstract: Purpose: The purpose of this study was to demonstrate accurate measurement of corneal elastic moduli in vivo with noncontact and noninvasive optical coherence elastography.: Methods: Elastic properties (in-plane Young's modulus, E, and both in-plane, ...

    Abstract Purpose: The purpose of this study was to demonstrate accurate measurement of corneal elastic moduli in vivo with noncontact and noninvasive optical coherence elastography.
    Methods: Elastic properties (in-plane Young's modulus, E, and both in-plane, μ, and out-of-plane, G, shear moduli) of rabbit cornea were quantified in vivo using noncontact dynamic acoustic micro-tapping optical coherence elastography (AµT-OCE). The intraocular pressure (IOP)-dependence of measured mechanical properties was explored in extracted whole globes following in vivo measurement. A nearly incompressible transverse isotropic (NITI) model was used to reconstruct moduli from AµT-OCE data. Independently, cornea elastic moduli were also measured ex vivo with traditional, destructive mechanical tests (tensile extensometry and shear rheometry).
    Results: Our study demonstrates strong anisotropy of corneal elasticity in rabbits. The in-plane Young's modulus, computed as E = 3μ, was in the range of 20 MPa to 44 MPa, whereas the out-of-plane shear modulus was in the range of 34 kPa to 261 kPa. Both pressure-dependent ex vivo OCE and destructive mechanical tests performed on the same samples within an hour of euthanasia strongly support the results of AµT-OCE measurements.
    Conclusions: Noncontact AµT-OCE can noninvasively quantify cornea anisotropic elastic properties in vivo.
    Translational relevance: As optical coherence tomography (OCT) is broadly accepted in ophthalmology, these results suggest the potential for rapid translation of AµT-OCE into clinical practice. In addition, AµT-OCE can likely improve diagnostic criteria of ectatic corneal diseases, leading to early diagnosis, reduced complications, customized surgical treatment, and personalized biomechanical models of the eye.
    MeSH term(s) Animals ; Rabbits ; Elasticity Imaging Techniques/methods ; Anisotropy ; Elasticity ; Cornea/diagnostic imaging ; Acoustics
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.12.3.15
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  5. Article ; Online: Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography.

    Regnault, Gabriel / Kirby, Mitchell A / Wang, Ruikang K / Shen, Tueng T / O'Donnell, Matthew / Pelivanov, Ivan

    ArXiv

    2023  

    Abstract: Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave ... ...

    Abstract Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave propagation, depth dependent changes are still unclear if the cornea is not crosslinked through the whole depth. Here, phase-decorrelation measurements on optical coherence tomography (OCT) structural images are combined with acoustic micro-tapping (A$\mu$T) OCE to explore possible reconstruction of depth-dependent stiffness within crosslinked corneas in an ex vivo human cornea sample. Experimental OCT images are analyzed to define the penetration depth of CXL into the cornea. In a representative ex vivo human cornea sample, crosslinking depth varied from $\sim 100\mu m$ in the periphery to $\sim 150\mu m$ in the cornea center and exhibited a sharp in-depth transition between crosslinked and untreated areas. This information was used in an analytical two-layer guided wave propagation model to quantify the stiffness of the treated layer. We also discuss how the elastic moduli of partially CXL-treated cornea layers reflect the effective engineering stiffness of the entire cornea to properly quantify corneal deformation.
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
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  6. Article: Modified conjunctival flap as a primary procedure for nontraumatic acute corneal perforation.

    Sun, Yi-Chen / Kam, Jason P / Shen, Tueng T

    Ci ji yi xue za zhi = Tzu-chi medical journal

    2018  Volume 30, Issue 1, Page(s) 24–28

    Abstract: Objective: Appropriate management of nontraumatic acute corneal perforation is always a challenge even with the many advances in surgical materials and techniques. We reported the outcomes of a case series of acute corneal perforation repair using a ... ...

    Abstract Objective: Appropriate management of nontraumatic acute corneal perforation is always a challenge even with the many advances in surgical materials and techniques. We reported the outcomes of a case series of acute corneal perforation repair using a newly modified conjunctival flap with amniotic membrane transplant (AMT), fibrin glue, and a bandage soft contact lens (BCL).
    Materials and methods: A total of 13 consecutive referral cases with nontraumatic acute corneal perforation at the University of Washington were reviewed. All open globes were repaired by a combined surgery with a modified conjunctival flap, AMT, fibrin glue, and BCL. Visual acuity, a slit lamp examination, and the patient-reported pain level were collected preoperatively and postoperatively. Subsequent corneal surgeries to improve visual function were also reviewed.
    Results: All ocular surfaces of the 13 eyes were stable at postoperative follow-up. Eleven of the 13 patients had the same or worse visual acuity 1 week postoperatively. Nine of the 13 patients achieved better vision 6 months postoperatively. None of the patients developed perioperative or postoperative complications. Five patients with good visual potential underwent further corneal surgeries, including Boston keratoprosthesis and penetrating keratoplasty. The average referral distance was 217 miles and the median number of follow-up visits within 6 months was 4.
    Conclusions: The combination of a modified conjunctival flap, AMT, fibrin glue, and a BCL could provide a temporary method to stabilize and secure the integrity of the globe as well as the ocular surface after a nontraumatic acute corneal perforation. This approach allows easy follow-up and preserves the eye for future corneal surgery under optimal conditions.
    Language English
    Publishing date 2018-03-28
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    DOI 10.4103/tcmj.tcmj_191_17
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  7. Article ; Online: Acoustic Micro-Tapping Optical Coherence Elastography to Quantify Corneal Collagen Cross-Linking: An Ex Vivo Human Study.

    Kirby, Mitchell A / Pelivanov, Ivan / Regnault, Gabriel / Pitre, John J / Wallace, Ryan T / O'Donnell, Matthew / Wang, Ruikang K / Shen, Tueng T

    Ophthalmology science

    2022  Volume 3, Issue 2, Page(s) 100257

    Abstract: Purpose: To evaluate changes in the anisotropic elastic properties of ex vivo human cornea treated with ultraviolet cross-linking (CXL) using noncontact acoustic micro-tapping optical coherence elastography (AμT-OCE).: Design: Acoustic micro-tapping ... ...

    Abstract Purpose: To evaluate changes in the anisotropic elastic properties of ex vivo human cornea treated with ultraviolet cross-linking (CXL) using noncontact acoustic micro-tapping optical coherence elastography (AμT-OCE).
    Design: Acoustic micro-tapping OCE was performed on normal and CXL human donor cornea in an ex vivo laboratory study.
    Subjects: Normal human donor cornea (n = 22) divided into 4 subgroups. All samples were stored in optisol.
    Methods: Elastic properties (in-plane Young's,
    Main outcome measures: Corneal elastic moduli (in-plane Young's modulus,
    Results: Cross-linking induced a significant increase in both in-plane and out-of-plane elastic moduli in human cornea. The statistical mean in the paired study (presurgery and postsurgery, n = 7) of the in-plane Young's modulus,
    Conclusions: The human cornea is a highly anisotropic material where in-plane mechanical properties are very different from those out-of-plane. Noncontact AμT-OCE can measure changes in the anisotropic elastic properties in human cornea as a result of ultraviolet CXL.
    Language English
    Publishing date 2022-11-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-9145
    ISSN (online) 2666-9145
    DOI 10.1016/j.xops.2022.100257
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  8. Article ; Online: Correction to: The disposable bandage soft contact lenses therapy and anterior segment optical coherence tomography for management of ocular graft-versus-host disease.

    Sun, Yi-Chen / Inamoto, Yoshihiro / Wang, Ruikang K / Lee, Stephanie J / Hung, Kai-Feng / Shen, Tueng T

    BMC ophthalmology

    2022  Volume 22, Issue 1, Page(s) 38

    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-021-02225-6
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  9. Article ; Online: Refractive Surgery Preferred Practice Pattern®.

    Jacobs, Deborah S / Lee, Jimmy K / Shen, Tueng T / Afshari, Natalie A / Bishop, Rachel J / Keenan, Jeremy D / Vitale, Susan

    Ophthalmology

    2022  Volume 130, Issue 3, Page(s) P61–P135

    MeSH term(s) Humans ; Refractive Surgical Procedures ; Ophthalmology ; Practice Patterns, Physicians'
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Practice Guideline ; Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2022.10.032
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  10. Article ; Online: Refractive Errors Preferred Practice Pattern®.

    Jacobs, Deborah S / Afshari, Natalie A / Bishop, Rachel J / Keenan, Jeremy D / Lee, Jimmy / Shen, Tueng T / Vitale, Susan

    Ophthalmology

    2022  Volume 130, Issue 3, Page(s) P1–P60

    MeSH term(s) Humans ; Refractive Errors ; Sex Distribution
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Practice Guideline ; Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2022.10.031
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