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Article: Efficacy of arginine-enriched enteral formulas for the healing of pressure ulcers: a systematic review.

Liu, P / Shen, W-Q / Chen, H-L

2017 Volume 26, Issue 6, Page(s) 319–323

Abstract: Objective: Arginine improves healing and modulates inflammation and the immune response. This systematic review aimed to assess the effect of arginine-enriched enteral formulas in pressure ulcer (PU) healing.: Method: Systematic computerised searches ...

Abstract	Objective: Arginine improves healing and modulates inflammation and the immune response. This systematic review aimed to assess the effect of arginine-enriched enteral formulas in pressure ulcer (PU) healing. Method: Systematic computerised searches of PubMed, Web of Knowledge, Scopus, ENTRAL and CINAHL databases were performed from their inception to 20 January 2016. Randomised controlled trials (RCTs) were included in this systematic review. We used the Jadad scale as a quality assessment tool. Results: There were seven RCTs with 369 patients included in this systematic review; four RCTs assessed healing by PU area reduction. All of them reported arginine-enriched enteral nutrition led to a significant improved PU healing compared with standard hospital diet in 2-12 weeks follow-up. Among these four RCTs, one enrolled malnourished patients, one enrolled non-malnourished patients, and the other two studies did not restrict the nutritional status of the patients. Using the Pressure Ulcer Scale for Healing (PUSH) four RCTs assessed healing of PU, all reporting arginine-enriched enteral nutrition resulted in a significant PUSH score improvement compared with control at follow-up. Using the Pressure Sore Status Tool (PSST) one RCT assessed healing of PUs, finding patients receiving arginine had the lowest PSST scores compared with controls. An RCT compared healing with two doses of arginine (4.5g versus 9g), but no difference was found between the doses. Conclusion: Evidence showed that arginine-enriched enteral nutrition led to a significant improvement in PU healing. It was effective not only in malnourished patients, but also in non-malnourished patients.
MeSH term(s)	Arginine/therapeutic use ; Enteral Nutrition/methods ; Food, Formulated ; Humans ; Pressure Ulcer/diet therapy ; Wound Healing
Chemical Substances	Arginine (94ZLA3W45F)
Language	English
Publishing date	2017-06-08
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	1353951-6
ISSN	0969-0700
ISSN	0969-0700
DOI	10.12968/jowc.2017.26.6.319
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Zs.A 4572: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: FOXA1 promotes proliferation, migration and invasion by transcriptional activating KRT7 in human gastric cancer cells.

Liu, B L / Qin, J J / Shen, W Q / Liu, C / Yang, X Y / Zhang, X N / Hu, F / Liu, G M

Journal of biological regulators and homeostatic agents

2019 Volume 33, Issue 4, Page(s) 1041–1050

Abstract: Gastric cancer (GC) is the fourth leading cause of gynecological malignancies worldwide. 5-fluorouracil (5-FU)-mediated chemotherapy is the adjuvant treatment for patients with GC following surgical resection. Many studies have indicated the cancer-type ... ...

Abstract	Gastric cancer (GC) is the fourth leading cause of gynecological malignancies worldwide. 5-fluorouracil (5-FU)-mediated chemotherapy is the adjuvant treatment for patients with GC following surgical resection. Many studies have indicated the cancer-type specific roles of forkhead box protein A1 (FOXA1) and keratin 7 (KRT7) in human malignancies. However, the potential mechanism underlying the involvement of FOXA1 and KRT7 in the pathogenesis and chemoresistance of GC are still not entirely clear. In our study, gain- and loss-of-function experiments proved that FOXA1 promoted cell proliferation, migration and invasion in AGS and SGC-7901 cells. Consequently, KRT7 was identified to be transcriptional activated by FOXA1 using Dual luciferase reporter assay. Our results also indicated that FOXA1 exerted its functions in enhancing viability and invasion of AGS and SGC-7901 cells through activating KRT7. Finally, interference of FOXA1 or KRT7 increased the chemosensitivity of AGS and SGC-7901 cells to 5-fluorouracil (5-Fu) treatment by suppressing cell proliferation. In conclusion, these data indicate that FOXA1 promoted proliferation, migration, invasion, and decreased chemosensitivity of GC cells to 5-Fu treatment through transcriptional activator KRT7. The present study provides a novel therapeutic strategy for the enhancement of efficacy in GC treatment and provides important insights into the molecular mechanism underlying 5-FU-mediated chemoresistance.
MeSH term(s)	Cell Line, Tumor ; Cell Proliferation ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Humans ; Keratin-7/metabolism ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology
Chemical Substances	FOXA1 protein, human ; Hepatocyte Nuclear Factor 3-alpha ; KRT7 protein, human ; Keratin-7
Language	English
Publishing date	2019-07-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	639196-5
ISSN	1724-6083 ; 0393-974X
ISSN (online)	1724-6083
ISSN	0393-974X
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Article ; Online: Preliminary proteomic analysis of radiation response markers in rectal cancer patients.

Shen, W-Q / Rong, G-Q / Wu, Y / Pu, Y-W / Ye, Z-Y / Cao, C / Yang, X-D / Xing, C-G

European review for medical and pharmacological sciences

2019 Volume 23, Issue 20, Page(s) 8841–8851

Abstract: Objective: To provide biomarkers related to the radiation response of patients to avoid unnecessary side effects on those who were not sensitive to radiotherapy.: Patients and methods: In the present study, we compared the different four proteins ( ... ...

Abstract	Objective: To provide biomarkers related to the radiation response of patients to avoid unnecessary side effects on those who were not sensitive to radiotherapy. Patients and methods: In the present study, we compared the different four proteins (PDIA3, Vimentin, Galectin3, Dhe3) patterns in rectal tumor tissue before and after radiation therapy by using 2-D PAGE, mass spectrometry, and bioinformatics analysis. Results: The protein level of Galectin3 and PDIA3 were downregulated in rectal cancer patients before and after radiotherapy (1.42 folds); while Dhe3 protein and Vimentin were upregulated (1-2 folds), and we also revealed Vimentin as its role in the negative regulation of the well-known transcription factor ATF4. Conclusions: Our study showed that four candidate proteins, including PIDA3, Galectin3, Dhe3, and Vimentin, might be the potential biomarkers in the identification of radiation response in rectal cancer.
MeSH term(s)	Activating Transcription Factor 4/metabolism ; Adult ; Biomarkers, Tumor/metabolism ; Down-Regulation ; Female ; Galectin 3/metabolism ; Humans ; Male ; Middle Aged ; Protein Disulfide-Isomerases/metabolism ; Protein Interaction Maps ; Proteomics/methods ; Rectal Neoplasms/metabolism ; Rectal Neoplasms/pathology ; Rectal Neoplasms/radiotherapy ; Up-Regulation ; Vimentin/metabolism
Chemical Substances	Biomarkers, Tumor ; Galectin 3 ; Vimentin ; Activating Transcription Factor 4 (145891-90-3) ; Protein Disulfide-Isomerases (EC 5.3.4.1) ; PDIA3 protein, human (EC 5.3.4.1.)
Language	English
Publishing date	2019-11-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_201910_19279
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Article: [A comparison of measuring the systolic time interval and diastolic time interval by plethysmography and the cardiomechanogram].

Shen, W Q

Zhonghua xin xue guan bing za zhi

1984 Volume 12, Issue 3, Page(s) 209–211

MeSH term(s)	Adolescent ; Cardiography, Impedance ; Child ; Child, Preschool ; Diastole ; Electrocardiography ; Female ; Humans ; Kinetocardiography ; Male ; Myocardial Contraction ; Phonocardiography ; Plethysmography, Impedance ; Systole
Language	Chinese
Publishing date	1984-09
Publishing country	China
Document type	Comparative Study ; Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
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Article: Development of an efficient tissue culture protocol for callus formation and plant regeneration of wetland species Juncus effusus L

Xu, L / Najeeb, U / Raziuddin, R / Shen, W. Q / Shou, J. Y / Tang, G. X / Zhou, W. J

In vitro cellular & developmental biology. Plant. 2009 Oct., v. 45, no. 5

2009

Abstract: Wetland species mat rush (Juncus effusus L.) is an important economic plant, but no information is available regarding plant regeneration, callus induction, and its proliferation from in vitro seed grown plantlets. The present study investigates the ... ...

Abstract	Wetland species mat rush (Juncus effusus L.) is an important economic plant, but no information is available regarding plant regeneration, callus induction, and its proliferation from in vitro seed grown plantlets. The present study investigates the effects of growth regulator combinations and medium innovation on tissue culture system of five mat rush varieties. Addition of N6-benzyladenine (BA) and 2,4-dichlorophenoxyacetic acid (2,4-D) in Murashige and Skoog (MS) medium showed significantly positive effect on callus proliferation, plant regeneration, and its multiplication compared to the medium devoid of BA. The highest callus induction frequency (80.95%, 90.48%, 75.40%, 70.83%, and 83.33%) was observed in MS medium containing 0.5 mg L⁻¹ (2.2 μM) BA in Yinlin-1, Nonglin-4, Gangshan, Taicao, and Taiwan green, respectively. Various growth regulator combinations with successive subculture (medium replacement) were found essential to develop organogenic calluses and to regenerate shoots. The combination of 0.1 mg L⁻¹ BA (0.4 μM) and 2 mg L⁻¹ 2,4-D (9.0 μM) in MS medium was found best for callus proliferation for all the varieties under trial. The plant regeneration required two steps involving successive medium replacements as well as optimal hormonal balances. Successful plant regeneration (over 70%) was observed only by transferring the organogenic callus from regeneration medium I [MS medium containing 0.5 mg L⁻¹ BA (2. μM) and 1.0 mg L⁻¹ kinetin (KT; 4.6 μM)] to the regeneration medium II [MS medium containing 0.5 mg L⁻¹ BA (2.2 μM), 1.0 mg L⁻¹ KT (4.6 μM) and 3.0 mg L⁻¹ indoleacetic acid (IAA; 17.1 μM)]. Our results confirmed the importance of the ratio of auxin (IAA) to cytokinin (BA and KT) in the manipulation of shoot regeneration in J. effusus L. The maximum plant survival frequency and multiplication rates (90.97% and 5.40 and 94.23% and 8.25) were recorded in the presence of 0.5 mg L⁻¹ BA (2.2 μM) in the 1/2 MS multiplication medium for the varieties of Nonglin-4 and Taicao, respectively. About 100% survival rate was also observed for all the varieties in soil conditions. The efficient plant regeneration system developed here will be helpful for rapid micropropagation and further genetic improvement in J. effusus L.
Keywords	2,4-D ; Juncus effusus ; callus ; callus formation ; cytokinins ; genetic improvement ; indole acetic acid ; kinetin ; micropropagation ; shoots ; soil ; survival rate ; tissue culture ; Taiwan
Language	English
Dates of publication	2009-10
Size	p. 610-618.
Publisher	Springer-Verlag
Publishing place	New York
Document type	Article
ISSN	1054-5476
DOI	10.1007/s11627-009-9228-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Citric acid enhances the phytoextraction of manganese and plant growth by alleviating the ultrastructural damages in Juncus effusus L.

Najeeb, U / Xu, L / Ali, Shafaqat / Jilani, Ghulam / Gong, H J / Shen, W Q / Zhou, W J

Journal of hazardous materials

2009 Volume 170, Issue 2-3, Page(s) 1156–1163

Abstract: Chelate-assisted phytoextraction by high biomass producing plant species enhances the removal of heavy metals from polluted environments. In this regard, Juncus effusus a wetland plant has great potential. This study evaluated the effects of elevated ... ...

Abstract	Chelate-assisted phytoextraction by high biomass producing plant species enhances the removal of heavy metals from polluted environments. In this regard, Juncus effusus a wetland plant has great potential. This study evaluated the effects of elevated levels of manganese (Mn) on the vegetative growth, Mn uptake and antioxidant enzymes in J. effusus. We also studied the role of citric acid and EDTA on improving metal accumulation, plant growth and Mn toxicity stress alleviation. Three-week-old plantlets of J. effusus were subjected to various treatments in the hydroponics as: Mn (50, 100 and 500 microM) alone, Mn (500 microM) + citric acid (5 mM), and Mn (500 microM) + EDTA (5 mM). After 2 weeks of treatment, higher Mn concentrations significantly reduced the plant biomass and height. Both citric acid and EDTA restored the plant height as it was reduced at the highest Mn level. Only the citric acid (but not EDTA) was able to recover the plant biomass weight, which was also obvious from the microscopic visualization of mesophyll cells. There was a concentration dependent increase in Mn uptake in J. effusus plants, and relatively more deposition in roots compared to aerial parts. Although both EDTA and citric acid caused significant increase in Mn accumulation; however, the Mn translocation was enhanced markedly by EDTA. Elevated levels of Mn augmented the oxidative stress, which was evident from changes in the activities of antioxidative enzymes in plant shoots. Raised levels of lipid peroxidation and variable changes in the activities of antioxidant enzymes were recorded under Mn stress. Electron microscopic images revealed several modifications in the plants at cellular and sub-cellular level due to the oxidative damage induced by Mn. Changes in cell shape and size, chloroplast swelling, increased number of plastoglobuli and disruption of thylakoid were noticed. However, these plants showed a high degree of tolerance against Mn toxicity stress, and it removed substantial amounts of Mn from the media. The EDTA best enhanced the Mn uptake and translocation, while citric acid best recovered the plant growth.
MeSH term(s)	Antioxidants/metabolism ; Biomass ; Chelating Agents/pharmacology ; Chloroplasts/drug effects ; Chloroplasts/ultrastructure ; Citric Acid/chemistry ; Citric Acid/pharmacology ; Glutathione Reductase/chemistry ; Lipid Peroxidation ; Malondialdehyde ; Manganese/chemistry ; Manganese/isolation & purification ; Microscopy, Electron, Transmission ; Peroxidase/chemistry ; Plant Development ; Plant Shoots/drug effects ; Plant Shoots/growth & development ; Plant Shoots/ultrastructure ; Plants/metabolism ; Plants/ultrastructure ; Superoxide Dismutase/chemistry
Chemical Substances	Antioxidants ; Chelating Agents ; Citric Acid (2968PHW8QP) ; Manganese (42Z2K6ZL8P) ; Malondialdehyde (4Y8F71G49Q) ; Peroxidase (EC 1.11.1.7) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione Reductase (EC 1.8.1.7)
Language	English
Publishing date	2009-10-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2009.05.084
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Article: Induction of tetraploidy in Juncus effusus by colchicine

Xu, L / Najeeb, U / Naeem, M. S / Daud, M. K / Cao, J. S / Gong, H. J / Shen, W. Q / Zhou, W. J

Biologia plantarum. 2010 Dec., v. 54, no. 4

2010

Abstract: Tetraploidy was induced in vitro in mat rush (Juncus effusus L.) cultivar Nonglin-4 by exposure to colchicine (0, 50, 100 and 500 mg dm⁻³) for 6, 12 and 24 h. Flow cytometric analysis was used to confirm the ploidy level. Anatomical and ultrastructural ... ...

Abstract	Tetraploidy was induced in vitro in mat rush (Juncus effusus L.) cultivar Nonglin-4 by exposure to colchicine (0, 50, 100 and 500 mg dm⁻³) for 6, 12 and 24 h. Flow cytometric analysis was used to confirm the ploidy level. Anatomical and ultrastructural analyses at cellular and subcellular levels in tetraploid and diploid control plants revealed differences between diploid and tetraploid plants. The leaf epidermis had larger stomata but lower stomatal density in tetraploid plants. In addition, mesophyll cells in tetraploid plants appeared more compact and showed less intercellular spaces along with increased size of vascular bundles. However, a significant reduction of chlorophyll content was observed in tetraploid plants that might be the result of structural modification in the lamellar membranes of chloroplasts.
Keywords	chlorophyll ; diploidy
Language	English
Dates of publication	2010-12
Size	p. 659-663.
Publisher	Springer Netherlands
Publishing place	Dordrecht
Document type	Article
ZDB-ID	1496498-3
ISSN	1573-8264 ; 0006-3134
ISSN (online)	1573-8264
ISSN	0006-3134
DOI	10.1007/s10535-010-0117-9
Database	NAL-Catalogue (AGRICOLA)

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Book ; Conference proceedings: International Symposium on Heavy Ion Physics and its Application

Luo Yixao / Shen Wenqing / Luo, Y. X / Shen, W. Q

1991

Institution	Lan zhou zhong li zi yan jiu zhuang zhi
Event/congress	International Symposium on Heavy Ion Physics and its Application (1990.10.08-12, LanzhouChina)
Author's details	W. Q. Shen; Y. X. Luo [Hrsg.]. Heavy Ion Research Facility in Lanzhou
Language	Undetermined
Size	XVII, 545 S
Publisher	World Scientific
Publishing place	Singapore
Document type	Book ; Conference proceedings
ISBN	9810200307 ; 9789810200305
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Purification and characterization of a new peptide with analgesic effect from the scorpion Buthus martensi Karch.

Cao, Z-Y / Mi, Z-M / Cheng, G-F / Shen, W-Q / Xiao, X / Liu, X-M / Liang, X-T / Yu, D-Q

The journal of peptide research : official journal of the American Peptide Society

2004 Volume 64, Issue 1, Page(s) 33–41

Abstract: Anew peptide, designated as Buthus martensi Karch (BmK) AngM1, with an isoelectric point (pI) of 5.8 was purified and characterized from the venom of Buthus martensi Karch. The molecular mass was calculated as 7040.5 Da from multiple-charged ions by ... ...

Abstract	Anew peptide, designated as Buthus martensi Karch (BmK) AngM1, with an isoelectric point (pI) of 5.8 was purified and characterized from the venom of Buthus martensi Karch. The molecular mass was calculated as 7040.5 Da from multiple-charged ions by elelctrospray ionization mass spectroscopy (ESI/MS). The complete amino acid sequence of BmK AngM1 of 64 amino acid residues was determined by automatic sequencing of N-terminal part of the native peptide and the fragments of reduced and S-carboxymethylated (RCM)-peptide degraded by Staphylococcus aureaus V(8) protease and TPCK(N-p-Tosyl-L-phenylalanine chloromethyl ketone)-treated trypsin. Bioactivity tested using mouse-twisting model showed an evident analgesic effect with 63.0% (P < 0.001) inhibition efficiency at the dose of 0.8 mg/kg, but the LD(50) was larger than 50 mg/kg. Electrophysiological studies showed that BmK AngM1 at the concentration of 1 microm obviously inhibit voltage-dependent Na(+) current (I(Na)) and voltage-dependent delayed rectifier K(+) current (I(K)) but had no effects on transient K(+) current.
MeSH term(s)	Amino Acid Sequence ; Analgesics, Non-Narcotic/chemistry ; Analgesics, Non-Narcotic/isolation & purification ; Analgesics, Non-Narcotic/toxicity ; Animals ; Male ; Membrane Potentials/drug effects ; Mice ; Neurons/physiology ; Peptides/chemistry ; Peptides/isolation & purification ; Peptides/toxicity ; Potassium/metabolism ; Rats ; Rats, Wistar ; Scorpion Venoms/chemistry ; Scorpions/chemistry ; Sodium/metabolism ; Spectrometry, Mass, Electrospray Ionization
Chemical Substances	Analgesics, Non-Narcotic ; Peptides ; Scorpion Venoms ; Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2004-07
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1364582-1
ISSN	1397-002X
ISSN	1397-002X
DOI	10.1111/j.1399-3011.2004.00164.x
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Zs.A 703: Show issues

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Book ; Conference proceedings: Proceedings of the International Summer School on Heavy Ion Reaction Theory

Ge, L. X / Liu, J. Y / Shen, W. Q

Lanzhou, China, 10-18 August 1988

1989

Title variant	Heavy ion reaction theory
Institution	International Summer School on Heavy Ion Reaction Theory Lan zhou da xue Lanzhou-Wuli-Yanjiusuo Zhong guo yuan zi neng ke xue yan jiu yuan Zhong yang yan jiu yuan
Event/congress	International Summer School on Heavy Ion Reaction Theory (1988.08.10-18, Lanzhou)
Author's details	editors W. Q. Shen, J. Y. Liu, L. X. Ge ; Sponsors Institute of Modern Physics, Academia Sinica, Institute of Atomic Energy, Lanzhou University
Language	English
Size	xii, 302 Seiten, Illustrationen, Diagramme, 23 cm
Document type	Book ; Conference proceedings
Note	Literaturangaben
ISBN	9971509075 ; 9789971509071
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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