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Book ; Online: Wind Turbine Aerodynamics II

Shen, Wen Zhong

2021

Keywords	Technology: general issues ; wind turbine aerodynamics ; actuator disc ; AD/NS ; tip loss correction ; blade element momentum ; orthopter ; vertical axis wind turbine ; power coefficient ; torque coefficient ; shear flow ; wind tunnel ; CFD ; delayed detached-eddy simulation ; wind turbine ; tilt angle ; unsteady aerodynamics ; computational fluid dynamics ; wind tunnel experiment ; wind turbine airfoil ; turbulence ; Gurney flap ; aerodynamic characteristics ; aeroacoustics ; noise modelling ; noise control ; coned rotor ; aerodynamics ; n/a
Size	1 electronic resource (144 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021291253
ISBN	9783036524733 ; 3036524738
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Wind Turbine Aerodynamics

Shen, Wen Zhong

2019

Abstract: Wind turbine aerodynamics is one of the central subjects of wind turbine technology. To reduce the levelized cost of energy (LCOE), the size of a single wind turbine has been increased to 12 MW at present, with further increases expected in the near ... ...

Abstract	Wind turbine aerodynamics is one of the central subjects of wind turbine technology. To reduce the levelized cost of energy (LCOE), the size of a single wind turbine has been increased to 12 MW at present, with further increases expected in the near future. Big wind turbines and their associated wind farms have many advantages but also challenges. The typical effects are mainly related to the increase in Reynolds number and blade flexibility. This Special Issue is a collection of 21 important research works addressing the aerodynamic challenges appearing in such developments. The 21 research papers cover a wide range of problems related to wind turbine aerodynamics, which includes atmospheric turbulent flow modeling, wind turbine flow modeling, wind turbine design, wind turbine control, wind farm flow modeling in complex terrain, wind turbine noise modeling, vertical axis wind turbine, and offshore wind energy. Readers from all over the globe are expected to greatly benefit from this Special Issue collection regarding their own work and the goal of enabling the technological development of new environmentally friendly and cost-effective wind energy systems in order to reach the target of 100% energy use from renewable sources, worldwide, by 2050
Keywords	Technology (General) ; Engineering (General). Civil engineering (General)
Size	1 electronic resource (410 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Document type	Book ; Online
Note	eng ; Open Access
HBZ-ID	HT020324008
ISBN	9783039215249 ; 9783039215256 ; 3039215248 ; 3039215256
DOI	10.3390/books978-3-03921-525-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Controversies in Thyroid Nodules and Differentiated Thyroid Cancer

Roman, Sanziana A. / Sosa, Julie Ann / Shen, Wen T.

A Case-Based Approach

2023

Author's details	Sanziana A. Roman, MD Professor University of California, San Francisco Department of Surgery Wen T. Shen MD MA Professor University of California, San Francisco Department of Surgery Julie Ann Sosa, MD MA Professor and Chair University of California, San Francisco Department of Surgery§
Keywords	fine-needleaspiration ; Low-RiskDTC ; PreoperativeLaryngoscopy ; RadiofrequencyAblation ; FamilialDTC ; IntraoperativeNerveMonitoring ; Fine-Needle Aspiration ; Low-Risk DTC ; Preoperative Laryngoscopy ; Radiofrequency Ablation ; Familial DTC ; Intraoperative Nerve Monitoring
Language	English
Size	224 p.
Edition	1
Publisher	Springer International Publishing
Document type	Book
Note	PDA Manuell_23
Format	160 x 241 x 17
ISBN	9783031371349 ; 3031371348
Database	PDA

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Article ; Online: Transdermal estrogen therapy in menopausal women at increased risk for thrombotic events: a scoping review.

Sobel, Talia H / Shen, Wen

Menopause (New York, N.Y.)

2022 Volume 29, Issue 4, Page(s) 483–490

Abstract: Importance and objective: It is estimated that over 45% of women in the United States are menopausal. Many of these women suffer from vasomotor symptoms of menopause, for which the gold standard treatment is menopause hormone therapy (MHT). However, MHT ...

Abstract	Importance and objective: It is estimated that over 45% of women in the United States are menopausal. Many of these women suffer from vasomotor symptoms of menopause, for which the gold standard treatment is menopause hormone therapy (MHT). However, MHT use has been controversial since the Women's Health Initiative (WHI) study in 2001. Transdermal MHT has been shown to be effective for treatment of vasomotor symptoms and does not increase the risk of venous thromboembolism (VTE) when used in healthy postmenopausal women. However, there is little data on its safety in women at increased risk for VTE such as women with prior VTE, increased body mass index, thrombophilia, tobacco use, autoimmune disease, chronic inflammatory disorders, recent surgery, trauma, or immobilization. This scoping review of the literature provides clinicians with an overview of the evidence on the risk profile of transdermal MHT use in these postmenopausal women at increased risk of VTE. Methods: We searched all published studies from 2000 to 2020 and included 13 primary articles on transdermal MHT use in postmenopausal women at increased risk of VTE. Discussion and conclusion: In women with prior VTE, two studies found a decrease in coagulability and no increased risk of recurrent VTE with transdermal MHT use. In women with increased body mass index, three studies found no increased VTE risk in transdermal MHT users. In women with prothrombotic genetic polymorphisms, three studies found minimal to no increased VTE risk in transdermal MHT users. In women with various proinflammatory comorbidities, five studies found an improved thrombotic profile and no increased VTE risk with transdermal MHT use. This scoping review provides data regarding the safety of transdermal MHT use in postmenopausal women with risk factors for VTE, and clinicians should have risk versus benefit discussions with each patient regarding its use.
MeSH term(s)	Administration, Cutaneous ; Estrogen Replacement Therapy/adverse effects ; Estrogens/adverse effects ; Female ; Hormone Replacement Therapy ; Humans ; Menopause
Chemical Substances	Estrogens
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000001938
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Quantifying the Possible Consequences of Parathyroidectomy on Hypertension in Patients With Primary Hyperparathyroidism: Bones, Kidneys, Brain-and Heart?

Shen, Wen T

JAMA surgery

2019 Volume 155, Issue 1, Page(s) 40

MeSH term(s)	Brain ; Humans ; Hyperparathyroidism, Primary/surgery ; Hypertension/etiology ; Kidney ; Parathyroidectomy
Language	English
Publishing date	2019-10-06
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2701841-6
ISSN	2168-6262 ; 2168-6254
ISSN (online)	2168-6262
ISSN	2168-6254
DOI	10.1001/jamasurg.2019.3961
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Article ; Online: MG53: A potential therapeutic target for kidney disease.

Ke, Ben / Shen, Wen / Song, Jianling / Fang, Xiangdong

Pharmacology research & perspectives

2023 Volume 11, Issue 1, Page(s) e01049

Abstract: Ensuring cell survival and tissue regeneration by maintaining cellular integrity is important to the pathophysiology of many human diseases, including kidney disease. Mitsugumin 53 (MG53) is a member of the tripartite motif-containing (TRIM) protein ... ...

Abstract	Ensuring cell survival and tissue regeneration by maintaining cellular integrity is important to the pathophysiology of many human diseases, including kidney disease. Mitsugumin 53 (MG53) is a member of the tripartite motif-containing (TRIM) protein family that plays an essential role in repairing cell membrane injury and improving tissue regeneration. In recent years, an increasing number of studies have demonstrated that MG53 plays a renoprotective role in kidney diseases. Moreover, with the beneficial effects of the recombinant human MG53 (rhMG53) protein in the treatment of kidney diseases in different animal models, rhMG53 shows significant therapeutic potential in kidney disease. In this review, we elucidate the role of MG53 and its molecular mechanism in kidney disease to provide new approaches to the treatment of kidney disease.
MeSH term(s)	Animals ; Humans ; Carrier Proteins/metabolism ; Carrier Proteins/pharmacology ; Cell Membrane/metabolism ; Wound Healing ; Cell Survival ; Kidney Diseases/drug therapy
Chemical Substances	Carrier Proteins
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2740389-0
ISSN	2052-1707 ; 2052-1707
ISSN (online)	2052-1707
ISSN	2052-1707
DOI	10.1002/prp2.1049
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A population-based model identifying optimal candidate for primary tumor resection in distant metastatic laryngeal carcinoma.

Liu, Xiaobin / Lin, Peng / Shen, Wen / Yang, Yining

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2023 Volume 280, Issue 6, Page(s) 2885–2896

Abstract: Purpose: To developed a model to screen distant metastatic laryngeal carcinoma (DMLC) patients who would benefit from the primary tumor resection.: Methods: The propensity score matching (PSM) was utilized to avoid disproportionate distributions of ... ...

Abstract	Purpose: To developed a model to screen distant metastatic laryngeal carcinoma (DMLC) patients who would benefit from the primary tumor resection. Methods: The propensity score matching (PSM) was utilized to avoid disproportionate distributions of the confounding factors. We hypothesized that patients who underwent surgery would benefit from surgery by having a longer median cancer-specific survival (CSS) than patients without surgery. Multivariable Cox model was used to explore the independent factors of CSS and overall survival (OS) among PSM population. We used these factors to construct a nomogram to identify surgery benefit patients. The predictive performance and clinical practicability of the nomogram were determined by area under the curve (AUC), calibration curve, and decision curve. Results: The CSS and OS for patients who received primary tumor resection were significantly longer than those without resection (median CSS: 19 months vs. 10 months, P = 0.009; median OS: 21 months vs. 10 months, P = 0.001). The nomogram displayed a good degree of discrimination and calibration. The mean AUC of the nomogram was 0.70 (95% confidence interval [CI] 0.66-0.76) through threefold cross-validation. Conclusions: A predictive model was established and might be used to screen the optimal candidates for primary tumor surgery in DMLC patients.
MeSH term(s)	Humans ; Laryngeal Neoplasms/surgery ; Carcinoma ; Area Under Curve ; Nomograms ; Propensity Score
Language	English
Publishing date	2023-01-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-023-07851-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Retinal vascular remodeling in photoreceptor degenerative disease.

Nguyen, Matthew / Sullivan, James / Shen, Wen

Experimental eye research

2023 Volume 234, Page(s) 109566

Abstract: Abnormal vasculature in the retina, specifically tortuous vessels and capillary degeneration, is common in many of the most prevalent retinal degenerative diseases, currently affecting millions of people across the world. However, the formation and ... ...

Abstract	Abnormal vasculature in the retina, specifically tortuous vessels and capillary degeneration, is common in many of the most prevalent retinal degenerative diseases, currently affecting millions of people across the world. However, the formation and development of abnormal vasculature in the context of retinal degenerative diseases are still poorly understood. The FVB/N (rd1) and rd10 mice are well-studied animal models of retinal degenerative diseases, but how photoreceptor degeneration leads to vascular abnormality in the diseases remains to be elucidated. Here, we used advancements in confocal microscopy, immunohistochemistry, and image analysis software to systematically characterize the pathological vasculature in the FVB/N (rd1) and rd10 mice, known as a chronic, rapid and slower retinal degenerative model, respectively. We demonstrated that there was plexus-specific vascular degeneration in the retinal trilaminar vascular network paralleled to photoreceptor degeneration in the diseased retinas. We also quantitatively analyzed the vascular structural architecture in the wild-type and diseased retinas to provide valuable information on vascular remodeling in retinal degenerative disease.
MeSH term(s)	Mice ; Animals ; Vascular Remodeling ; Mice, Inbred C57BL ; Retina/pathology ; Photoreceptor Cells/pathology ; Retinal Degeneration/pathology ; Disease Models, Animal ; Photoreceptor Cells, Vertebrate/pathology
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2023.109566
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of non-supervised aerobic exercise on sleep quality and maternal-fetal attachment in pregnant women: A randomized controlled trial.

Shen, Wen-Chun / Chen, Chung-Hey

Complementary therapies in medicine

2021 Volume 57, Page(s) 102671

Abstract: Objectives: This study was designed to evaluate the effect in pregnant women of a non-supervised aerobic exercise intervention on sleep quality and maternal-fetal attachment.: Design: Pretest-posttest randomized controlled trial.: Setting: ... ...

Abstract	Objectives: This study was designed to evaluate the effect in pregnant women of a non-supervised aerobic exercise intervention on sleep quality and maternal-fetal attachment. Design: Pretest-posttest randomized controlled trial. Setting: Prenatal clinic of a medical center in southern Taiwan. Participants: One hundred and forty eligible, pregnant women were assigned systematically, at a random starting point, to either the experimental group (n = 70) or the control group (n = 70). Intervention: Participants in the experimental group received a 20-minute, low-impact aerobic exercise video on DVD and were instructed to exercise at home at least three times per week for a period of three months. Participants in the control group received routine prenatal care only. Main outcome measures: The Pittsburgh Sleep Quality Index and Modified Maternal-Fetal Attachment Scale were used to assess outcome measures before the intervention and at four and 12-weeks post-intervention. Results: The paired-sample t-tests revealed a significant improvement in sleep quality in the experimental group at 4-weeks posttest, which persisted through 12-weeks posttest. In addition, the experimental group reported a significantly higher mean score for maternal-fetal attachment at 4-weeks posttest than the control group. Conclusion: The results of this study indicate that performing aerobic exercise ameliorates the decline in sleep quality and improves maternal-fetal attachment in women who are pregnant. These findings may be used to encourage pregnant women to regularly perform low-impact aerobic exercise.
MeSH term(s)	Exercise ; Exercise Therapy ; Female ; Humans ; Pregnancy ; Pregnant Women ; Prenatal Care ; Sleep
Language	English
Publishing date	2021-01-21
Publishing country	Scotland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2021.102671
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Article: [Effect of MiR-142-3p Targeting HOXA5 on Proliferation, Cycle Arrest and Apoptosis of Acute B Lymphocytic Leukemia Cells].

Shen, Wen-Cui / Shi, Yu-Wei

Zhongguo shi yan xue ye xue za zhi

2021 Volume 29, Issue 4, Page(s) 1085–1092

Abstract: Objective: To investigate the effect and molecular mechanism of miR-142-3p to the proliferation, cycle and apoptosis of acute B lymphocytic leukemia (B-ALL) cells by regulating the homeobox gene 5 (HOXA5) expression.: Methods: Real-time fluorescence ... ...

Abstract	Objective: To investigate the effect and molecular mechanism of miR-142-3p to the proliferation, cycle and apoptosis of acute B lymphocytic leukemia (B-ALL) cells by regulating the homeobox gene 5 (HOXA5) expression. Methods: Real-time fluorescence quantitative PCR was used to detect the expression levels of miR-142-3p and HOXA5 in human B-ALL cell Nalm6 cell line and human B lymphoblast Hmy2-cir cells. Nalm6 was transfected by using liposome transfection technology, miR-142-3p mimic, pcDNA-HOXA5 overexpression plasmid, miR-142-3p mimic+pcDNA-HOXA5 overexpression plasmid, and control. The binding site of HOXA5 and miR-142-3p was predicted according to microRNA.org, and the targeting relationship between miR-142-3p and HOXA5 gene was detected by double luciferase reporter gene experiment. The effect of miR-142-3p to the proliferation of Nalm6 cells was detected using the Cell Counting Box-8 (CCK-8) method and cell clone formation experiments. Flow cytometry was used to detect the effects of miR-142-3p to cell cycle distribution and apoptosis of Nalm6 cells. The expression levels of cell cycle-related proteins, including G Results: Compared with Hmy2-cir cells, miR-142-3p showed low expression in Nalm6 cells and HOXA5 showed high expression (P<0.05). MiR-142-3p and HOXA5 3'-UTR showed complementary binding regions, the luciferase activity of miR-142-3p mimic and wild-type HOXA5 3'-UTR was significantly lower than that of miR-142-3p negative control and wild-type HOXA5 3'-UTR (P<0.05). The proliferation of Nalm6 cells and the number of cell clones could be inhibited by miR-142-3p mimic after 48 and 72 hours of transfection (P<0.05), which causing G Conclusion: MiR-142-3p can inhibit the proliferation of Nalm6 cells by targeting down-regulation the expression of HOXA5, arrest the G
MeSH term(s)	Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Genes, Homeobox ; Homeodomain Proteins/genetics ; Humans ; Leukemia, B-Cell/genetics ; MicroRNAs/genetics
Chemical Substances	HOXA5 protein, human ; Homeodomain Proteins ; MIRN142 microRNA, human ; MicroRNAs
Language	Chinese
Publishing date	2021-08-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2021.04.011
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