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Article ; Online: Rabeprazole mitigates obesity-induced chronic inflammation and insulin resistance associated with increased M2-type macrophage polarization.

Li, Yunfang / Hao, Jiayue / Kong, Xianghui / Yuan, Weiyi / Shen, Yingying / Hui, Zhaoyuan / Lu, Xinliang

Biochimica et biophysica acta. Molecular basis of disease

2024 Volume 1870, Issue 5, Page(s) 167142

Abstract: Macrophage polarization is closely associated with obesity-induced chronic inflammation and insulin resistance. Proton pump inhibitor Rabeprazole has long been used to treat gastritis and gastric ulcers. However, whether Rabeprazole plays a role in ... ...

Abstract	Macrophage polarization is closely associated with obesity-induced chronic inflammation and insulin resistance. Proton pump inhibitor Rabeprazole has long been used to treat gastritis and gastric ulcers. However, whether Rabeprazole plays a role in macrophage polarization during obesity is unknown. Here, we show that Rabeprazole suppresses M1-type macrophage-mediated inflammation, leads to increased M2-type macrophages and alters the polarization status from M1 to M2 in vitro. Mechanistically, Rabe-regulated macrophage polarization is associated with inhibition of NF-κB and activation of STAT6 signaling pathways. Furthermore, Rabeprazole induces M2-type adipose tissue macrophages and alleviates chronic inflammation, improving glucose tolerance and insulin sensitivity in high-fat diet-fed mice. In addition, Rabeprazole increases CD206
Language	English
Publishing date	2024-03-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2024.167142
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Article ; Online: Metabolism of asparagine in the physiological state and cancer.

Yuan, Qiong / Yin, Liyang / He, Jun / Zeng, Qiting / Liang, Yuxin / Shen, Yingying / Zu, Xuyu

Cell communication and signaling : CCS

2024 Volume 22, Issue 1, Page(s) 163

Abstract: Asparagine, an important amino acid in mammals, is produced in several organs and is widely used for the production of other nutrients such as glucose, proteins, lipids, and nucleotides. Asparagine has also been reported to play a vital role in the ... ...

Abstract	Asparagine, an important amino acid in mammals, is produced in several organs and is widely used for the production of other nutrients such as glucose, proteins, lipids, and nucleotides. Asparagine has also been reported to play a vital role in the development of cancer cells. Although several types of cancer cells can synthesise asparagine alone, their synthesis levels are insufficient to meet their requirements. These cells must rely on the supply of exogenous asparagine, which is why asparagine is considered a semi-essential amino acid. Therefore, nutritional inhibition by targeting asparagine is often considered as an anti-cancer strategy and has shown success in the treatment of leukaemia. However, asparagine limitation alone does not achieve an ideal therapeutic effect because of stress responses that upregulate asparagine synthase (ASNS) to meet the requirements for asparagine in cancer cells. Various cancer cells initiate different reprogramming processes in response to the deficiency of asparagine. Therefore, it is necessary to comprehensively understand the asparagine metabolism in cancers. This review primarily discusses the physiological role of asparagine and the current progress in the field of cancer research.
MeSH term(s)	Animals ; Asparagine ; Neoplasms ; Leukemia ; Amino Acids ; Glucose ; Mammals
Chemical Substances	Asparagine (7006-34-0) ; Amino Acids ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-024-01540-x
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Article ; Online: Assessing radiation-induced carotid artery injury using ultrasound in patients with head and neck cancer.

Zheng, Zhuangzhuang / Shen, Yingying / Su, Jing / Ji, Xiaorui / Zhang, Qiang / Zhao, Qin / Jiang, Xin

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2024 Volume 196, Page(s) 110285

Abstract: Background and purpose: Radiotherapy (RT) can damage neck vessels in patients with head and neck cancer (HNC). This study investigated the early effects of RT on carotid artery, including the internal media thickness (IMT) and carotid plaques of the ... ...

Abstract	Background and purpose: Radiotherapy (RT) can damage neck vessels in patients with head and neck cancer (HNC). This study investigated the early effects of RT on carotid artery, including the internal media thickness (IMT) and carotid plaques of the common carotid artery (CCA). Materials and methods: This study included 69 patients with HNC who underwent RT at the First Hospital of Jilin University from March 2017 to September 2022, and 69 healthy participants as controls. Color Doppler ultrasound (CDUS) of the carotid artery was used to measure the CCA IMT and plaques. Results: Left CCA IMT increased from 0.60 mm (0.60, 0.70) before RT to 0.70 mm (0.60, 1.20) after RT (P < 0.0001). Right CCA IMT changed from 0.60 mm (0.60, 0.71) before RT to 0.60 mm (0.60, 1.10) after RT (P = 0.0002). CCA IMT was 0.60 mm (0.60, 0.70) and 0.80 mm (0.60, 1.20) in the ≤40 Gy and >40 Gy groups (P = 0.0004). The CCA plaques number increased significantly after RT on both the left and right sides (P Conclusion: RT significantly increased CCA IMT, and the growth was related to the radiation dose. The number and volume of the CCA plaques also increased after RT.
Language	English
Publishing date	2024-04-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2024.110285
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Article: m5Cpred-XS: A New Method for Predicting RNA m5C Sites Based on XGBoost and SHAP.

Liu, Yinbo / Shen, Yingying / Wang, Hong / Zhang, Yong / Zhu, Xiaolei

Frontiers in genetics

2022 Volume 13, Page(s) 853258

Abstract: As one of the most important post-transcriptional modifications of RNA, 5-cytosine-methylation (m5C) is reported to closely relate to many chemical reactions and biological functions in cells. Recently, several computational methods have been proposed ... ...

Abstract	As one of the most important post-transcriptional modifications of RNA, 5-cytosine-methylation (m5C) is reported to closely relate to many chemical reactions and biological functions in cells. Recently, several computational methods have been proposed for identifying m5C sites. However, the accuracy and efficiency are still not satisfactory. In this study, we proposed a new method, m5Cpred-XS, for predicting m5C sites of
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.853258
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Article: Successful Treatment of an AML Patient Infected with Hypervirulent ST463 Pseudomonas Aeruginosa Harboring Rare Carbapenem-Resistant Genes blaAFM-1 and blaKPC-2 Following Allogeneic Hematopoietic Stem Cell Transplantation.

Shen, Yingying / Cao, Junmin / Hu, Tonglin / Yang, Xiawan / Zhao, Yuechao / Shen, Yiping / Ye, Baodong / Yu, Yunsong / Wu, Dijiong

Infection and drug resistance

2024 Volume 17, Page(s) 1357–1365

Abstract: Background: Carbapenem-resistant : Case presentation: The case is a 32-year-old acute myeloid leukemia (AML) patient with fever and septic shock during hematopoietic stem cell transplantation (HSCT), and the pathogen was finally identified as a ... ...

Abstract	Background: Carbapenem-resistant Case presentation: The case is a 32-year-old acute myeloid leukemia (AML) patient with fever and septic shock during hematopoietic stem cell transplantation (HSCT), and the pathogen was finally identified as a highly virulent sequence type 463 (ST463) Conclusion: This case emphasizes the importance of metagenomic next-generation sequencing (mNGS) and whole-genome sequencing (WGS) in identifying microbes with rare resistant genes, and managing CRPA, especially in immunocompromised patients.
Language	English
Publishing date	2024-04-06
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S455746
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Article ; Online: Research progress on the hematopoietic microenvironment in aplastic anemia.

Li, Hangchao / Zhou, Chenjie / Shen, Yingying / Xu, Min / Wu, Dijiong / Ye, Baodong

European journal of haematology

2023 Volume 111, Issue 2, Page(s) 172–180

Abstract: Aplastic anemia (AA) is a disease of bone marrow hematopoietic failure, and the main clinical manifestation is pancytopenia. Its pathogenesis is still unclear. In recent years, more research has been done on its immune abnormalities to explain its ... ...

Abstract	Aplastic anemia (AA) is a disease of bone marrow hematopoietic failure, and the main clinical manifestation is pancytopenia. Its pathogenesis is still unclear. In recent years, more research has been done on its immune abnormalities to explain its pathogenesis and less on the hematopoietic microenvironment, but there are still some advances. This article summarizes the research on the hematopoietic microenvironment of AA in recent years to provide new ideas for the clinical treatment of AA.
MeSH term(s)	Humans ; Anemia, Aplastic/diagnosis ; Anemia, Aplastic/etiology ; Anemia, Aplastic/therapy ; Hematopoietic Stem Cells/pathology ; Pancytopenia/complications
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13991
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Article ; Online: Prolonged haematologic toxicity in CAR-T-cell therapy: A review.

Liu, Qi / Hu, Tonglin / Li, Hangchao / Shen, Yingying / Wu, Dijiong / Ye, Baodong

Journal of cellular and molecular medicine

2023 Volume 27, Issue 23, Page(s) 3662–3671

Abstract: Chimeric antigen receptor-T-cell (CAR-T-cell) therapy is a novel immunotherapy with encouraging results for treatment of relapsed/refractory haematologic malignancies. With increasing use, our understanding of immune-mediated side effects such as ... ...

Abstract	Chimeric antigen receptor-T-cell (CAR-T-cell) therapy is a novel immunotherapy with encouraging results for treatment of relapsed/refractory haematologic malignancies. With increasing use, our understanding of immune-mediated side effects such as cytokine release syndrome and neurotoxicity has improved; nevertheless, prolonged haematologic toxicity (PHT), with a high incidence rate, remains underrecognized. Owing to heterogeneity in populations, the CAR-T cells used and diseases treated as well as differences in the definition of PHT, its rate, risk factors and management vary across studies. In this review, we provide a narrative of PHT occurring in patients following CAR-T-cell therapy; evidence of PHT treatment strategies is also presented, with the aim of contributing to systematic understanding of PHT.
MeSH term(s)	Humans ; Receptors, Chimeric Antigen/genetics ; Neoplasm Recurrence, Local/drug therapy ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Immunotherapy ; Hematologic Neoplasms/therapy ; Cell- and Tissue-Based Therapy
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.17930
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Article: Application of Budyko framework to irrigation districts in China under various climatic conditions

Chen, Hang / Huo, Zailin / Zhang, Lu / Cui, Jing / Shen, Yingying / Han, Zhenzhong

Hydrological processes. 2022 Mar., v. 36, no. 3

2022

Abstract: Budyko's framework has been widely used to study basin‐scale water balance. In this study, we focus on the extended application of Fu's equation (one formulation of the Budyko‐type curves) to 371 large irrigation districts in China over a period of 2010– ... ...

Abstract	Budyko's framework has been widely used to study basin‐scale water balance. In this study, we focus on the extended application of Fu's equation (one formulation of the Budyko‐type curves) to 371 large irrigation districts in China over a period of 2010–2017. Water balance method was used to estimate actual evapotranspiration ET in the irrigated areas. Considering the contribution of shallow groundwater to ET, the water availability in the Budyko framework defined as equivalent precipitation Pe for irrigation areas is the sum of irrigation water I, precipitation P and groundwater evaporation ETgw. Results showed that the relationships between evapotranspiration ET, water availability Pe and energy supply ET0 can be accurately described by the Budyko's curves. The optimal values of Budyko parameter ω for each irrigation district was obtained with multi‐annual data using least square method. The Fu's equation performed better in humid and semi‐humid regions than arid and semi‐arid regions. The comparison between ∂ET/∂Pe and ∂ET/∂ET0 confirmed the relative effect of water availability and energy supply on ET according to the variation of climatic conditions. Normalized difference vegetation index (NDVI) and soil properties (denoted by the proportion of clay and sand) were selected to develop empirical equation for parameter ω using multiple linear regression analysis method. This study shows that the Budyko framework can be extended to irrigation areas and provides useful information on evapotranspiration to assist in water management in irrigation areas.
Keywords	clay ; energy ; equations ; evaporation ; evapotranspiration ; groundwater ; irrigation ; irrigation water ; normalized difference vegetation index ; regression analysis ; sand ; water management ; China
Language	English
Dates of publication	2022-03
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1479953-4
ISSN	1099-1085 ; 0885-6087
ISSN (online)	1099-1085
ISSN	0885-6087
DOI	10.1002/hyp.14542
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Unsupervised monitoring of vegetation in a surface coal mining region based on NDVI time series

Yang, Zhen / Shen, Yingying / Li, Jing / Jiang, Huawei / Zhao, Like

Environ Sci Pollut Res. 2022 Apr., v. 29, no. 18 p.26539-26548

2022

Abstract: Surface coal mining causes vegetation disturbance while providing an energy source. Thus, much attention is given to monitoring the vegetation of surface coal mining regions. Multitemporal satellite imagery, such as Landsat time-series imagery, is an ... ...

Abstract	Surface coal mining causes vegetation disturbance while providing an energy source. Thus, much attention is given to monitoring the vegetation of surface coal mining regions. Multitemporal satellite imagery, such as Landsat time-series imagery, is an operational environment monitoring service widely used to access vegetation traits and ensure vegetation surveillance across large areas. However, most of the previous studies have been conducted with change detection models or threshold-based methods that require multiple parameter settings or sample training. In this paper, we tried to analyze the change traits of vegetation in surface coal mining regions using shape-based clustering based on Normalized Difference Vegetation Index (NDVI) time series without multiple parameter settings and sample training. The shape-based clustering used in this paper applied shape-based distance (SBD) to obtain the distance between time series and used Dynamic Time Warping Barycenter Averaging (DBA) to generate cluster centroids. We applied the method to a stack of 19 NDVI images from 2000 to 2018 for a surface coal mining region located in North China. The results showed that the shape-based clustering used in this paper was appropriate for monitoring vegetation change in the region and achieved 79.0% overall accuracy in detecting disturbance-recovery trajectory types.
Keywords	Landsat ; coal ; energy ; monitoring ; normalized difference vegetation index ; remote sensing ; time series analysis ; vegetation ; China
Language	English
Dates of publication	2022-04
Size	p. 26539-26548.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17696-9
Database	NAL-Catalogue (AGRICOLA)

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Article: Severe Systemic Rash in the Treatment of Hairy Cell Leukemia with Cladribine: Case Report and Literature Review.

Dong, Huijie / Shen, Yingying / Shen, Yiping / Wu, Dijiong

International journal of general medicine

2020 Volume 13, Page(s) 1187–1192

Abstract: A 49-year-old male patient who had been diagnosed with variable hairy cell leukemia (HCL-V) was treated with interferon for half a year but exert no obvious effect. After two courses of chemotherapy with cladribine, he achieved remission, and ... ...

Abstract	A 49-year-old male patient who had been diagnosed with variable hairy cell leukemia (HCL-V) was treated with interferon for half a year but exert no obvious effect. After two courses of chemotherapy with cladribine, he achieved remission, and splenomegaly significantly improved (the length in craniocaudal dimension decreased from 15.8cm to 11.8cm). Four years later, the patient got disease relapse and was recommended for another cycle of cladribine (6mg for 7 days). On the last day of cladribine, the patient developed fever with needle-like red rashes on the face, limbs, and trunk. At the very beginning, the rash was lighter in color, sparsely distributed, and without obvious itching. Three days later, the rash gradually darkened, expanded and merged, with itching. With the application of high dose gamma globulin and corticosteroids (prednisolone combined with dexamethasone), the rash finally faded, and the patient was discharged. Rash caused by cladribine is not uncommon, such serious and widespread drug-induced rash is rare, and there are few reports. This article reviewed relevant studies and treatments.
Language	English
Publishing date	2020-11-19
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S281476
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