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Article ; Online: Gestational Diabetes Mellitus and Postpartum Hypertension: Evidence for a Tight Linkage Toward Women's Cardiovascular Health.

Shen, Yun / Hu, Gang

Hypertension (Dallas, Tex. : 1979)

2024 Volume 81, Issue 6, Page(s) 1269–1271

MeSH term(s)	Humans ; Female ; Pregnancy ; Diabetes, Gestational/epidemiology ; Diabetes, Gestational/physiopathology ; Hypertension/physiopathology ; Hypertension/epidemiology ; Postpartum Period ; Women's Health ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Puerperal Disorders/physiopathology ; Puerperal Disorders/etiology ; Puerperal Disorders/epidemiology
Language	English
Publishing date	2024-05-15
Publishing country	United States
Document type	Journal Article ; Review ; Editorial ; Comment
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.124.22919
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Zs.A 1488: Show issues

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Article ; Online: Letter to the Editor: Risk factors for obstetric anal sphincter injury recurrence: A systematic review and meta-analysis.

Shen, Yun / Wang, Jianing

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2023 Volume 162, Issue 2, Page(s) 777–778

MeSH term(s)	Pregnancy ; Female ; Humans ; Anal Canal/injuries ; Delivery, Obstetric/adverse effects ; Risk Factors ; Obstetric Labor Complications/etiology ; Fecal Incontinence/etiology
Language	English
Publishing date	2023-06-11
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Letter ; Comment
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.14939
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Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: System Design for Online Foreign Language Education Based on Blockchain Technology.

Song, Yuchen / Shen, Yun

publication RETRACTED

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 5180307

Abstract: This study aims to solve the problem that the traditional online foreign language teaching system focuses on function development, ignoring system security, and has certain risks. An online foreign language education system is designed and developed ... ...

Abstract	This study aims to solve the problem that the traditional online foreign language teaching system focuses on function development, ignoring system security, and has certain risks. An online foreign language education system is designed and developed based on the blockchain technology. First, the blockchain technology and key technologies of system design are described in detail. Second, the overall technical architecture of the system, functional modules, and business logic of each module are designed. Finally, the basic performance of the system is tested. The results show that the system can realize the user's unrestricted office work and zero maintenance of the system. The separation of presentation logic and business logic facilitates the development and maintenance of the system. The system mainly includes six functional modules: user management, course management, course order, course study, course certificate, and credit authentication. These modules are guaranteed for daily teaching use. The event processing success rate of the six functional modules of the system is greater than 99%, and the processing success rate is relatively high. The central processing unit (CPU) usage and memory usage are both below 30%. The host throughput of the six major modules is greater than 100 times/s when processing services. The average response time on the terminal side is maintained below 0.5 s. The average response time of business-side processing is maintained below 0.4 s, which is in line with the standard. The event processing success rate of the constructed system is 10.75% higher than that of other systems, and the average response time, CPU usage, and memory usage are 53.38%, 51.49%, and 50% lower than other systems, respectively. Therefore, the proposed system has better performance. To sum up, the designed system has excellent throughput, event processing capability, response speed, and low CPU and memory occupancy when processing business and is suitable for promotion and use in foreign language online education in colleges and universities. The use of the proposed system can improve its overall teaching efficiency and quality. The purpose is to provide important technical support for the improvement of the security of the online foreign language teaching system.
MeSH term(s)	Blockchain ; Education, Distance/methods ; Language ; Technology ; Universities
Language	English
Publishing date	2022-04-19
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/5180307
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Article: Development and validation of a risk prediction model for linezolid-induced thrombocytopenia in elderly patients.

Qin, Yan / Chen, Zhe / Gao, Shuai / Shen, Yun / Ye, Yanrong

European journal of hospital pharmacy : science and practice

2024 Volume 31, Issue 2, Page(s) 94–100

Abstract: Objectives: Linezolid is the first oxazolidinone antimicrobial agent developed for treating multi-drug-resistant gram-positive bacterial infections. The study aimed to investigate the risk factors of linezolid (LI)-induced thrombocytopenia (LI-TP) and ... ...

Abstract	Objectives: Linezolid is the first oxazolidinone antimicrobial agent developed for treating multi-drug-resistant gram-positive bacterial infections. The study aimed to investigate the risk factors of linezolid (LI)-induced thrombocytopenia (LI-TP) and to develop and validate a risk prediction model to identify elderly patients at high risk of developing LI-TP during linezolid therapy. Methods: A retrospective cohort study was performed at Zhongshan Hospital, FuDan University, China. The study involved elderly Chinese patients aged ≥65 years administered with linezolid (600 mg) twice a day between January 2015 and April 2021. We collected the patients' clinical characteristics and demographic data from electronic medical records, and compared the differences between LI-TP patients and those who had not developed thrombocytopenia (NO-TP) after linezolid treatment. The risk prediction model was developed based on the regression coefficient generated from logistic regression model. Results: A total of 343 inpatients were enrolled from January 2015 to August 2020 and were used as the training set. Among them, 67 (19.5%) developed LI-TP. Multivariate logistic regression analysis revealed that baseline platelet counts <150×10 Conclusions: These findings indicate that duration of linezolid therapy, age, eGFR, ICU admittance, baseline platelet counts, concomitant piperacillin-tazobactam were significantly associated with LI-TP in elderly patients. A risk prediction model based on these risk factors showed a good discriminative performance and may be useful for clinicians to identify patients at high risk of developing LI-TP.
MeSH term(s)	Aged ; Humans ; Linezolid/adverse effects ; Retrospective Studies ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis ; Thrombocytopenia/epidemiology ; Oxazolidinones/adverse effects ; Piperacillin, Tazobactam Drug Combination/adverse effects
Chemical Substances	Linezolid (ISQ9I6J12J) ; Oxazolidinones ; Piperacillin, Tazobactam Drug Combination (157044-21-8)
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2650179-X
ISSN	2047-9964 ; 2047-9956
ISSN (online)	2047-9964
ISSN	2047-9956
DOI	10.1136/ejhpharm-2022-003258
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Article ; Online: Association of single nucleotide polymorphisms of IL-6 gene with frailty in the Chinese Bai nationality.

Li, Xueqiong / Yang, Yan / Meng, Qi / Shen, Yun

Medicine

2023 Volume 102, Issue 36, Page(s) e35010

Abstract: To investigate the impact of 3 single nucleotide polymorphisms (SNPs) in the interleukin-6 (IL-6) gene and their interaction on susceptibility to frailty in the elderly in rural areas of China Bai nationality. Taking the Bai people in Dali, China as the ... ...

Abstract	To investigate the impact of 3 single nucleotide polymorphisms (SNPs) in the interleukin-6 (IL-6) gene and their interaction on susceptibility to frailty in the elderly in rural areas of China Bai nationality. Taking the Bai people in Dali, China as the research object, and according to the frailty phenotype scale, there were 2 groups: frail and non-frail. Basic information about the study participants was gathered using a questionnaire. Clinical biochemical indices were also evaluated and the Sanger method was used to identify the sequences of the IL-6 gene loci at rs1524107, rs1800796, and rs10499563. SHEsis online software was used to analyze the linkage disequilibrium of IL-6 gene sites and the relationship between haploids and frailty. The MDR software was used to analyze the 3 sites and their interactions. Among 231 rural Bai elderly people, 63 (27.3%) were frail and 168 (72.7%) were non-frail. The SNPs of rs1524107, rs1800796, and rs10499563 in the IL-6 gene were not associated with the occurrence of frailty, nor were they associated with clinical indicators such as grip strength and gait speed. After adjusting for age and gender, there was no significant difference in the distribution of the 3 genetic models composed of the 3 SNPs between frail and non-frail populations (all P > .05). The 3 haplotypes were not associated with the occurrence of frailty, and the interaction between the 3 loci was not associated with the susceptibility to frailty. The SNP of rs1524107, rs1800796, and rs10499563 sites of IL-6 gene may not be related to frailty susceptibility in Dali Bai people. Differences in frailty mechanisms among other populations at the gene level, which are of enormous significance for the prevention and treatment of frailty, require further research with larger samples and more gene loci.
MeSH term(s)	Humans ; East Asian People ; Ethnicity ; Frailty/ethnology ; Frailty/genetics ; Interleukin-6/genetics ; Polymorphism, Single Nucleotide ; China ; Aged ; Rural Population
Chemical Substances	Interleukin-6 ; IL6 protein, human
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000035010
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Article: Editorial: Exercise, diabetes and metabolic-associated fatty liver disease.

Sun, Yang / Sun, Chao / Hu, Gang / Shen, Yun

Frontiers in endocrinology

2023 Volume 14, Page(s) 1347458

MeSH term(s)	Humans ; Diabetes Mellitus ; Exercise ; Liver Diseases
Language	English
Publishing date	2023-12-19
Publishing country	Switzerland
Document type	Editorial ; Research Support, N.I.H., Extramural
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1347458
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Article ; Online: Expression, Significance, and Correlation of Histone Deacetylase 1/RE-1 Silencing Transcription Factor and Neuronal Markers in Glioma.

Shen, Yun / Ye, Yan-Rong / Tang, Zhao-Qi

World neurosurgery

2023 Volume 172, Page(s) e267–e277

Abstract: Background: Inducing the differentiation of glioma cells into neuron-like cells may be an effective strategy to combat glioma. The histone deacetylase 1/RE-1 silencing transcription factor (HDAC1/REST) complex regulates the expression of multiple ... ...

Abstract	Background: Inducing the differentiation of glioma cells into neuron-like cells may be an effective strategy to combat glioma. The histone deacetylase 1/RE-1 silencing transcription factor (HDAC1/REST) complex regulates the expression of multiple neuronal genes. In this study, we analyzed the presence and significance of this regulatory effect in glioma based on bioinformatics methods. Methods: The Human Protein Atlas database was used to obtain immunohistochemical staining images. The Gene Expression Profiling Interactive Analysis and Chinese Glioma Genome Atlas databases were used to analyze the expression of HDAC1/REST and neuronal markers in glioma, their effects on survival, and the association between HDAC1/REST and the expression of neuronal markers and stem cell markers. The differentially expressed genes between the high and low HDAC1/REST groups were explored. The Database for Annotation, Visualization and Integrated Discovery database was used for gene ontology and kyoto encyclopedia of genes and genomes pathway enrichment analysis. Results: The results showed that the expression of HDAC1 and REST increased with the grade of glioma, while the expression of neuronal markers decreased with the grade of glioma. High expression of HDAC1/REST and low expression of neuronal markers were associated with poor prognosis. HDAC1/REST expression was negatively correlated with the expression of neuronal markers, and positively correlated with the expression of neural stem cell markers. The genes up-regulated in the high HDAC1/REST group were mainly related to extracellular matrix and inflammation, and the down-regulated genes were mainly related to synapsis. Conclusions: This study suggested that HDAC1/REST may be involved in maintaining the malignant phenotype of glioma cells and the stem cell status of glioma stem cells by inhibiting the expression of neuronal markers, which promote the progression of glioma.
MeSH term(s)	Humans ; Gene Expression Regulation ; Glioma/pathology ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/metabolism ; Neurons/pathology ; Transcription Factors/genetics
Chemical Substances	Histone Deacetylase 1 (EC 3.5.1.98) ; Transcription Factors ; RE1-silencing transcription factor
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.01.007
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Article ; Online: Sodium Alginate Aerogel as a Carrier of Organogelators for Effective Oil Spill Solidification and Recovery.

Xue, Ying / Shen, Yun / Chen, Xiuping / Dong, Limei / Li, Junfeng / Guan, Yihao / Li, Yiming

Langmuir : the ACS journal of surfaces and colloids

2024 Volume 40, Issue 2, Page(s) 1515–1523

Abstract: Marine oil spills pose a serious threat to the marine ecological environment. Phase-selective organogelators (PSOGs) are ideal candidates for oil spill gelation when used in combination with a mechanical recovery method. However, the toxicity of an ... ...

Abstract	Marine oil spills pose a serious threat to the marine ecological environment. Phase-selective organogelators (PSOGs) are ideal candidates for oil spill gelation when used in combination with a mechanical recovery method. However, the toxicity of an organic solvent carrier has become a key problem when it is applied in the remediation of marine oil pollution. In this study, through an inexpensive and nontoxic ionic cross-linking and freeze-drying method, we successfully developed composite oil gelling agents that used a biomass sodium alginate aerogel as the carrier of 12-hydroxystearic acid (12-HSA). Simultaneously, carboxylated cellulose nanofibers (CNF-C) with large specific surface area and graphene oxide (GO) with excellent mechanical properties as reinforcing fillers were combined with an alginate matrix. 12-HSA, as a green and inexpensive organic gelator, was uniformly loaded on the aerogels by vacuum impregnation. The sodium alginate aerogel was capable of absorbing and storing oil due to its three-dimensional network skeleton and high porosity. Rheological studies have demonstrated that the organic gelator 12-HSA can be released from the aerogel substrate and self-assemble to form an oleogel with the absorbed oil quickly. The synergistic effect between absorption and congelation endows the composite oil gelling agent with efficient oil spill recovery capability. Based on eco-friendly, biodegradable, and simple synthesis methods, this composite oil gelling agent shows great potential for application in marine oil spill recovery.
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c03301
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Article ; Online: Association between weight-adjusted-waist index and depression in US adults: A cross-sectional study.

Shen, Yun / Wu, Yahui / Luo, Panru / Fu, Minghan / Zhu, Kai / Wang, Jinsheng

Journal of affective disorders

2024 Volume 355, Page(s) 299–307

Abstract: Background: Current evidence implicates a significant association between depression and obesity and related metabolic dysfunction. The weight-adjusted-waist index (WWI) was recently identified as an ideal index that integrates total body fat, muscle ... ...

Abstract	Background: Current evidence implicates a significant association between depression and obesity and related metabolic dysfunction. The weight-adjusted-waist index (WWI) was recently identified as an ideal index that integrates total body fat, muscle mass, and bone mass. This study investigated the relationship between WWI and depressive symptoms in adults. Methods: Participants from the National Health and Nutrition Examination Survey (2005-2018) were enrolled. Depressive symptom severity was measured with the Patient Health Questionnaire-9 (PHQ-9). Survey-weighted multivariable logistic regression, subgroup analysis, and generalized additive models were used to determine the relationship between WWI and depressive symptoms. Results: A total of 34,575 participants were included, with a mean WWI of 11.01; 2,979 participants were suspected of having depressive symptoms (PHQ-9 score ≥ 10). A significant positive association was identified between WWI and depressive symptoms (odds ratio = 1.416, 95 % confidence interval: 1.303-1.539, P < 0.0001). Subgroup analyses suggested that the association between WWI and depressive symptoms was stronger in individuals who were female, overweight, divorced, middle-aged or older (over 40 years old), and had diabetes. Furthermore, the non-linear multivariable regression revealed an inflection point for the WWI at 11.438, and the association was only significant when the WWI was higher than this point. Limitations: This study was retrospective and only included participants from the United States; therefore, further validation is needed from studies in other countries, especially middle-to-low-income countries, using longitudinal cohorts. Conclusions: This study identified a significant positive association between WWI and depressive symptoms.
MeSH term(s)	Adult ; Middle Aged ; Humans ; Female ; United States/epidemiology ; Male ; Depression/epidemiology ; Cross-Sectional Studies ; Nutrition Surveys ; Retrospective Studies ; Obesity/epidemiology ; Body Mass Index
Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.03.143
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Article ; Online: Ultralong-life and high-capacity magnesium/sodium hybrid-ion battery using a ternary CoSe/NiSe

Zhou, Ting / Zhu, Yajun / Shen, Yun / Qiu, Hui / Han, Tianli / Li, Jinjin / Liu, Jinyun

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 40, Page(s) 5338–5341

Abstract: An ultrahigh-performance magnesium/sodium hybrid-ion battery (MNHB) is developed using ternary CoSe/ ... ...

Abstract	An ultrahigh-performance magnesium/sodium hybrid-ion battery (MNHB) is developed using ternary CoSe/NiSe
Language	English
Publishing date	2024-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d4cc00623b
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