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Article: Sarcoidosis or Tuberculosis: Should Corticosteroids Be Used?

Shen, Yuting / Liu, Caihong / Zheng, Lan / Zhao, Yuliang

2023 Volume 15, Issue 10, Page(s) e47191

Abstract: Sarcoidosis shows high similarity with tuberculosis in clinical manifestations and imaging features. It is rarely reported whether sarcoidosis patients with suspected latent tuberculosis can be treated safely with immunosuppressive therapy. We reported ... ...

Abstract	Sarcoidosis shows high similarity with tuberculosis in clinical manifestations and imaging features. It is rarely reported whether sarcoidosis patients with suspected latent tuberculosis can be treated safely with immunosuppressive therapy. We reported on a 54-year-old man who presented with enlarged lymph nodes persisting for decades, accompanied by renal impairment and refractory hypercalcemia. The patient was diagnosed with sarcoidosis and suspected latent tuberculosis (as suggested by a positive tuberculin test and tuberculosis interferon-gamma release assays) and received prednisone under follow-up. The patient showed significant amelioration in hypercalcemia and shrinkage of lymph nodes, without evidence of developing active tuberculosis. For sarcoidosis patients with suspected latent tuberculosis, immunosuppressive agents can be utilized safely based on close monitoring. Further efforts are required to reveal whether sarcoidosis and tuberculosis can trigger similar immune responses and what the clinical implications are.
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47191
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Article ; Online: Shifting levels of peripheral inflammatory profiles as an indicator for comorbid multiple autoimmune diseases and bipolar disorder: a case report.

Shen, Yuting / Kong, Lingzhuo / Lai, Jianbo / Hu, Shaohua

BMC psychiatry

2023 Volume 23, Issue 1, Page(s) 375

Abstract: Autoimmune diseases (AID) cause inflammatory changes in the peripheral blood, which might be a predisposing factor for the development of comorbid bipolar disorder (BD). The levels of peripheral inflammatory indicators and cytokines may also serve as ... ...

Abstract	Autoimmune diseases (AID) cause inflammatory changes in the peripheral blood, which might be a predisposing factor for the development of comorbid bipolar disorder (BD). The levels of peripheral inflammatory indicators and cytokines may also serve as potential biomarkers for predicting BD susceptibility and the efficacy of antipsychotics in patients with AID. Herein, we present the case of a 43-year-old female who has suffered from AID for over 16 years and was recently diagnosed with "bipolar and related disorder due to another medical condition".
MeSH term(s)	Female ; Humans ; Adult ; Bipolar Disorder/complications ; Bipolar Disorder/diagnosis ; Antipsychotic Agents/therapeutic use ; Cytokines ; Biomarkers ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis
Chemical Substances	Antipsychotic Agents ; Cytokines ; Biomarkers
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-023-04820-x
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Article ; Online: Non-invasive imaging in the diagnosis of combined hepatocellular carcinoma and cholangiocarcinoma.

Shen, Yu-Ting / Yue, Wen-Wen / Xu, Hui-Xiong

Abdominal radiology (New York)

2023 Volume 48, Issue 6, Page(s) 2019–2037

Abstract: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare type of primary liver cancer. It is a complex "biphenotypic" tumor type consisting of bipotential hepatic progenitor cells that can differentiate into cholangiocytes subtype and hepatocytes ... ...

Abstract	Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare type of primary liver cancer. It is a complex "biphenotypic" tumor type consisting of bipotential hepatic progenitor cells that can differentiate into cholangiocytes subtype and hepatocytes subtype. The prognosis of patients with cHCC-CC is quite poor with its specific and more aggressive nature. Furthermore, there are no definite demographic or clinical features of cHCC-CC, thus a clear preoperative identification and accurate non-invasive imaging diagnostic analysis of cHCC-CC are of great value. In this review, we first summarized the epidemiological features, pathological findings, molecular biological information and serological indicators of cHCC-CC disease. Then we reviewed the important applications of non-invasive imaging modalities-particularly ultrasound (US)-in cHCC-CC, covering both diagnostic and prognostic assessment of patients with cHCC-CC. Finally, we presented the shortcomings and potential outlooks for imaging studies in cHCC-CC.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Bile Duct Neoplasms/pathology ; Cholangiocarcinoma/diagnostic imaging ; Cholangiocarcinoma/pathology ; Bile Ducts, Intrahepatic/pathology ; Retrospective Studies
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-023-03879-0
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Zs.A 1262: Show issues

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Article ; Online: The impact of quetiapine monotherapy or in combination with lithium on the thyroid function in patients with bipolar depression: A retrospective study.

Kong, Lingzhuo / Shen, Yuting / Hu, Shaohua / Lai, Jianbo

CNS neuroscience & therapeutics

2023 Volume 30, Issue 2, Page(s) e14342

Abstract: Objective: This study aims to investigate whether quetiapine monotherapy or in combination with lithium significantly disturbs thyroid function in depressed patients with bipolar disorder (BD), and whether difference exists in the post-treatment thyroid ...

Abstract	Objective: This study aims to investigate whether quetiapine monotherapy or in combination with lithium significantly disturbs thyroid function in depressed patients with bipolar disorder (BD), and whether difference exists in the post-treatment thyroid function between the two therapies. Methods: Based on the electric medical records, outpatients and inpatients with a current depressive episode of BD from January 2016 to December 2022 were screened. All patients were treated with quetiapine monotherapy or in combination with lithium. In addition to the demographic data and depression scale, thyroid profiles including total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and antithyroglobulin antibody (TGAb) were recorded, analyzed, and compared before and after the treatment. Results: Totally, 73 eligible patients were enrolled, including 53 in the monotherapy group (MG) and 20 in the combined therapy group (CG). No significant differences in thyroid profiles were detected between the two groups at the baseline (p > 0.05). After one-month treatment, in the MG, serum levels of TT4, TT3, FT4, and FT3 reduced significantly (p < 0.05), while TSH, TPOAb, and TGAb increased significantly (p < 0.05). In the CG, serum levels of TT4, TT3, and FT4 reduced and TSH increased following one-month treatment (p < 0.05), with no significant change in FT3, TPOAb, or TGAb (p > 0.05). After one-month treatment, no difference of TT4, TT3, FT4, FT3, and TSH was found between the two groups (p > 0.05). Conclusion: Both quetiapine monotherapy and a combined therapy with lithium significantly disturbed thyroid function in patients with bipolar depression, while quetiapine monotherapy seems to be associated with immune dysregulation in the thyroid.
MeSH term(s)	Humans ; Triiodothyronine ; Thyroid Gland/physiology ; Thyroxine/therapeutic use ; Retrospective Studies ; Lithium ; Bipolar Disorder/drug therapy ; Quetiapine Fumarate/therapeutic use ; Thyroid Function Tests ; Thyrotropin
Chemical Substances	Triiodothyronine (06LU7C9H1V) ; Thyroxine (Q51BO43MG4) ; Lithium (9FN79X2M3F) ; Quetiapine Fumarate (2S3PL1B6UJ) ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2023-07-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2423461-8
ISSN	1755-5949 ; 1755-5930
ISSN (online)	1755-5949
ISSN	1755-5930
DOI	10.1111/cns.14342
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Zs.A 4537: Show issues

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Article: Early prediction of acute kidney injury in patients with gastrointestinal bleeding admitted to the intensive care unit based on extreme gradient boosting.

Shi, Huanhuan / Shen, Yuting / Li, Lu

Frontiers in medicine

2023 Volume 10, Page(s) 1221602

Abstract: Background: Acute kidney injury (AKI) is a common and important complication in patients with gastrointestinal bleeding who are admitted to the intensive care unit. The present study proposes an artificial intelligence solution for acute kidney injury ... ...

Abstract	Background: Acute kidney injury (AKI) is a common and important complication in patients with gastrointestinal bleeding who are admitted to the intensive care unit. The present study proposes an artificial intelligence solution for acute kidney injury prediction in patients with gastrointestinal bleeding admitted to the intensive care unit. Methods: Data were collected from the eICU Collaborative Research Database (eICU-CRD) and Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. The prediction model was developed using the extreme gradient boosting (XGBoost) model. The area under the receiver operating characteristic curve, accuracy, precision, area under the precision-recall curve (AUC-PR), and F1 score were used to evaluate the predictive performance of each model. Results: Logistic regression, XGBoost, and XGBoost with severity scores were used to predict acute kidney injury risk using all features. The XGBoost-based acute kidney injury predictive models including XGBoost and XGBoost+severity scores model showed greater accuracy, recall, precision AUC, AUC-PR, and F1 score compared to logistic regression. Conclusion: The XGBoost model obtained better risk prediction for acute kidney injury in patients with gastrointestinal bleeding admitted to the intensive care unit than the traditional logistic regression model, suggesting that machine learning (ML) techniques have the potential to improve the development and validation of predictive models in patients with gastrointestinal bleeding admitted to the intensive care unit.
Language	English
Publishing date	2023-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1221602
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Article: [Determination of sulfation degree of heparin and low molecular weight heparins by capillary electrophoresis].

Shen, Yuting / Kang, Jingwu

Se pu = Chinese journal of chromatography

2021 Volume 38, Issue 10, Page(s) 1238–1242

Abstract: Heparin is composed of a highly sulfated linear saccharide and is widely used as an anticoagulant. Low molecular weight heparins (LMWHs) are derived from the unfractionated heparin (UFH) by enzymatic or chemical degradation. LMWHs have largely replaced ... ...

Abstract	Heparin is composed of a highly sulfated linear saccharide and is widely used as an anticoagulant. Low molecular weight heparins (LMWHs) are derived from the unfractionated heparin (UFH) by enzymatic or chemical degradation. LMWHs have largely replaced heparin as an anticoagulant for treatment and prevention of thrombosis because of the advantages of less bleeding, greater bioavailability, and more predictable anticoagulant effects in comparison to heparin. Enoxaparin, produced by the alkaline degradation of UFH through β-eliminative cleavage, represents the most commonly used LMWH. The structural characteristics of LMWHs differ from their parent heparin not only in terms of molecular weight but also in the sulfation degree as a result of losing the sulfate ester groups during the manufacturing process. The resulting compositional variation directly leads to a fluctuation in anticoagulant activity. In vitro functional assays showed that there is a wide variation in anticoagulant activity among the various LMWHs from different manufacturers owing to slight differences in the manufacturing process. This will directly affect heparin drug safety. In order to ensure the stability of product quality, it is necessary to develop a method for detecting the degree of heparin sulfation to monitor the stability of UFH and processing conditions. During the last two decades, various analytical methods based on chromatography or NMR have been developed for structural characterization of UFH and LMWHs. However, the reported methods require expensive equipment and professional data processing. These limitations make it difficult to apply the current methods to quality control via sulfation degree determination. Herein, we report a simple and robust method for the detection of the sulfation degree of UFH and LMWHs. The determination is based on the separation of building blocks of heparin obtained by exhaustive digestion of UFH and LMWHs in a mixture of heparinases. A mixed solution of heparinase Ⅰ, Ⅱ, and Ⅲ was prepared to give a final content of 0.13 IU/mL for each enzyme. The digestion of enoxaparin and heparin samples was performed at 25 ℃ for 48 h. By using a capillary electrophoresis (CE) method, a total of 18 oligosaccharides building blocks of heparin, including ten disaccharides, one trisaccharide, three tetrasaccharides, and four 1,6-anhydro derivatives, can be baseline separated. Then, the compositions of enoxaparin and UFH can be precisely determined. Based on the assumption that the molar extinction coefficient of each oligosaccharide at UV 232 nm is the same, the concentration of each oligosaccharide can be conveniently replaced by their peak area, and the accurate number of sulfate ester groups in each disaccharide unit can be determined, hence the average sulfation degree (SD). The developed method allows us to compare the sulfation degree data between the enoxaparin batches from the different manufacturers to evaluate the composition similarity. Herein, eight batches of commercially available enoxaparin from two manufacturers and four batches of UFH source materials were measured. Each sample was measured in triplicate, and the average values as well as the relative standard deviations (RSD) were calculated. The total sulfation degree (T-SD), the individual degree of
Language	Chinese
Publishing date	2021-07-02
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1000-8713
ISSN	1000-8713
DOI	10.3724/SP.J.1123.2020.05032
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Article ; Online: Progress and Implications from Genetic Studies of Bipolar Disorder.

Kong, Lingzhuo / Chen, Yiqing / Shen, Yuting / Zhang, Danhua / Wei, Chen / Lai, Jianbo / Hu, Shaohua

Neuroscience bulletin

2024

Abstract: With the advancements in gene sequencing technologies, including genome-wide association studies, polygenetic risk scores, and high-throughput sequencing, there has been a tremendous advantage in mapping a detailed blueprint for the genetic model of ... ...

Abstract	With the advancements in gene sequencing technologies, including genome-wide association studies, polygenetic risk scores, and high-throughput sequencing, there has been a tremendous advantage in mapping a detailed blueprint for the genetic model of bipolar disorder (BD). To date, intriguing genetic clues have been identified to explain the development of BD, as well as the genetic association that might be applied for the development of susceptibility prediction and pharmacogenetic intervention. Risk genes of BD, such as CACNA1C, ANK3, TRANK1, and CLOCK, have been found to be involved in various pathophysiological processes correlated with BD. Although the specific roles of these genes have yet to be determined, genetic research on BD will help improve the prevention, therapeutics, and prognosis in clinical practice. The latest preclinical and clinical studies, and reviews of the genetics of BD, are analyzed in this review, aiming to summarize the progress in this intriguing field and to provide perspectives for individualized, precise, and effective clinical practice.
Language	English
Publishing date	2024-01-11
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2419741-5
ISSN	1995-8218 ; 1673-7067
ISSN (online)	1995-8218
ISSN	1673-7067
DOI	10.1007/s12264-023-01169-9
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Zs.A 6734: Show issues

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Article ; Online: Gradient-based adaptive wavelet de-noising method for photoacoustic imaging in vivo.

Li, Xinke / Ge, Peng / Shen, Yuting / Gao, Feng / Gao, Fei

Journal of biophotonics

2023 Volume 17, Issue 2, Page(s) e202300289

Abstract: Photoacoustic imaging (PAI) has been applied to many biomedical applications over the past decades. However, the received PA signal usually suffers from poor SNR. Conventional solution of employing higher-power laser, or doing long-time signal averaging, ...

Abstract	Photoacoustic imaging (PAI) has been applied to many biomedical applications over the past decades. However, the received PA signal usually suffers from poor SNR. Conventional solution of employing higher-power laser, or doing long-time signal averaging, may raise the system cost, time consumption, and tissue damage. Another strategy is de-noising algorithm design. In this paper, we propose a gradient-based adaptive wavelet de-noising method, which sets the energy gradient mutation point of low-frequency wavelet components as the threshold. We conducted simulation, ex-vivo and in-vivo experiments using acoustic-resolution PAM. The quality of de-noised PA image/signal by our proposed algorithm has improved by at least 30%, in comparison to the traditional signal denoising algorithms, which produces better contrast and clearer details. Moreover, it produces good results when dealing with multi-layer structures. The proposed de-noising method provides potential to improve the SNR of PA signal under single-shot low-power laser illumination for biomedical applications in vivo.
MeSH term(s)	Photoacoustic Techniques ; Diagnostic Imaging ; Algorithms ; Computer Simulation
Language	English
Publishing date	2023-12-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2390063-5
ISSN	1864-0648 ; 1864-063X
ISSN (online)	1864-0648
ISSN	1864-063X
DOI	10.1002/jbio.202300289
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Zs.A 6723: Show issues

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Book ; Online: Non-line-of-sight photoacoustic imaging

Shen, Yuting / Feng, Xiaohua / Gao, Fei

2023

Abstract: Photoacoustic imaging is a promising imaging technique for human brain due to its high sensitivity and functional imaging ability. However, the skull would cause strong attenuation and distortion to the photoacoustic signals, which makes non-invasive ... ...

Abstract	Photoacoustic imaging is a promising imaging technique for human brain due to its high sensitivity and functional imaging ability. However, the skull would cause strong attenuation and distortion to the photoacoustic signals, which makes non-invasive transcranial imaging difficult. In this work, the temporal bone is selected as an imaging window to minimize the influence of the skull. Moreover, non-line-of-sight photoacoustic imaging is introduced to enhance the field of view, where the skull is considered as a reflector. Simulation studies are carried out to show that the image quality can be improved with reflected signal considered.
Keywords	Physics - Medical Physics ; Electrical Engineering and Systems Science - Image and Video Processing
Publishing date	2023-02-18
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In Situ Transmission Electron Microscopy Investigation on Oriented Attachment of Nanodiamonds.

Shen, Yuting / Su, Shi / Xu, Tao / Yin, Kuibo / Yang, Kaishuai / Sun, Litao

Nano letters

2023 Volume 23, Issue 20, Page(s) 9602–9608

Abstract: Oriented attachment (OA) plays an important role in the assembly of nanoparticles and the regulation of their size and morphology, which is expected to be an effective means to modulate the properties of nanodiamonds (NDs). However, there remains a ... ...

Abstract	Oriented attachment (OA) plays an important role in the assembly of nanoparticles and the regulation of their size and morphology, which is expected to be an effective means to modulate the properties of nanodiamonds (NDs). However, there remains a dearth of comprehensive investigation into the OA mechanism of NDs. Using in situ transmission electron microscopy, we conducted atomic-resolution investigation on the OA events of ND pairs under electron beam irradiation. The occurrence of an OA event is contingent upon the alignment between two ND surfaces, and the coalesced particles undergo recrystallization to form spherical shapes. Both experimental observations and molecular dynamics (MD) simulations reveal that ND pairs exhibit a preference for coalescing along the {111} surfaces. Additionally, MD simulations indicate that kinetic factors, such as contact surface area and contact angle, also influence the coalescence process.
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c03300
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