LIVIVO - Search results -

Search results

Result 1 - 10 of total 152

Search options

Article ; Online: Acute effect of foot strike patterns on in vivo tibiotalar and subtalar joint kinematics during barefoot running

Dongqiang Ye / Lu Li / Shen Zhang / Songlin Xiao / Xiaole Sun / Shaobai Wang / Weijie Fu

Journal of Sport and Health Science, Vol 13, Iss 1, Pp 108-

2024 Volume 117

Abstract: Background: Foot kinematics, such as excessive eversion and malalignment of the hindfoot, are believed to be associated with running-related injuries. The majority of studies to date show that different foot strike patterns influence these specific foot ... ...

Abstract	Background: Foot kinematics, such as excessive eversion and malalignment of the hindfoot, are believed to be associated with running-related injuries. The majority of studies to date show that different foot strike patterns influence these specific foot and ankle kinematics. However, technical deficiencies in traditional motion capture approaches limit knowledge of in vivo joint kinematics with respect to rearfoot and forefoot strike patterns (RFS and FFS, respectively). This study uses a high-speed dual fluoroscopic imaging system (DFIS) to determine the effects of different foot strike patterns on 3D in vivo tibiotalar and subtalar joints kinematics. Methods: Fifteen healthy male recreational runners underwent foot computed tomography scanning for the construction of 3-dimensional models. A high-speed DFIS (100 Hz) was used to collect 6 degrees of freedom kinematics for participants’ tibiotalar and subtalar joints when they adopted RFS and FFS in barefoot condition. Results: Compared with RFS, FFS exhibited greater internal rotation at 0%–20% of the stance phase in the tibiotalar joint. The peak internal rotation angle of the tibiotalar joint under FFS was greater than under RFS (p < 0.001, Cohen's d = 0.92). RFS showed more dorsiflexion at 0%–20% of the stance phase in the tibiotalar joint than FFS. RFS also presented a larger anterior translation (p < 0.001, Cohen's d = 1.28) in the subtalar joint at initial contact than FFS. Conclusion: Running with acute barefoot FFS increases the internal rotation of the tibiotalar joint in the early stance. The use of high-speed DFIS to quantify the movement of the tibiotalar and subtalar joint was critical to revealing the effects of RFS and FFS during running.
Keywords	Foot strike patterns ; High-speed dual fluoroscopic imaging system ; In vivo kinematics ; Running ; Sports ; GV557-1198.995 ; Sports medicine ; RC1200-1245
Subject code	796
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Editorial

Shen Zhang / Hao Jiang / Qi Wu

Frontiers in Molecular Biosciences, Vol

Exploring the subcellular proteome and its post-translational modifications

2022 Volume 9

Keywords	subcellular ; proteomics ; proteome ; post-translational modification ; cell compartment ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Ticagrelor alleviates pyroptosis of myocardial ischemia reperfusion-induced acute lung injury in rats

Yi-Ning Dai / Li-Tao Wang / Ye-Shen Zhang / Ling Xue / Peng-Cheng He / Ning Tan / Yuan-Hui Liu

PeerJ, Vol 12, p e

a preliminary study

2024 Volume 16613

Abstract: Pulmonary infection is highly prevalent in patients with acute myocardial infarction undergoing percutaneous coronary intervention. However, the potential mechanism is not well characterized. Myocardial ischemia-reperfusion injury (MIRI) induces acute ... ...

Abstract	Pulmonary infection is highly prevalent in patients with acute myocardial infarction undergoing percutaneous coronary intervention. However, the potential mechanism is not well characterized. Myocardial ischemia-reperfusion injury (MIRI) induces acute lung injury (ALI) related to pulmonary infection and inflammation. Recent studies have shown that pyroptosis mediates ALI in several human respiratory diseases. It is not known whether MIRI induces pyroptosis in the lungs. Furthermore, ticagrelor is a clinically approved anti-platelet drug that reduces ALI and inhibits the expression levels of several pyroptosis-associated proteins, but the effects of ticagrelor on MIRI-induced ALI have not been reported. Therefore, we investigated whether ticagrelor alleviated ALI in the rat MIRI model, and its effects on pyroptosis in the lungs. Sprague-Dawley rats were randomly divided into four groups: control, MIRI, MIRI plus low ticagrelor (30 mg/kg), and MIRI plus high ticagrelor (100 mg/kg). Hematoxylin and Eosin (HE) staining was performed on the lung sections, and the HE scores were calculated to determine the extent of lung pathology. The wet-to-dry ratio of the lung tissues were also determined. The expression levels of pyroptosis-related proteins such as NLRP3, ASC, and Cleaved caspase-1 were estimated in the lung tissues using the western blot. ELISA was used to estimate the IL-1β levels in the lungs. Immunohistochemistry was performed to determine the levels of MPO-positive neutrophils as well as the total NLRP3-positive and Cleaved caspase-1-positive areas in the lung tissues. The lung tissues from the MIRI group rats showed significantly higher HE score, wet-to-dry ratio, and the MPO-positive area compared to the control group, but these effects were attenuated by pre-treatment with ticagrelor. Furthermore, lung tissues of the MIRI group rats showed significantly higher expression levels of pyroptosis-associated proteins, including NLRP3 (2.1-fold, P < 0.05), ASC (3.0-fold, P < 0.01), and Cleaved caspase-1 ...
Keywords	Myocardial ischemia-reperfusion injury ; Acute lung injury ; Pyroptosis ; NLRP3 ; Ticagrelor ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Prognostic Value of Tumor-microenvironment-associated Genes in Ovarian Cancer

Shimei Li / Jiyi Yao / Shen Zhang / Xinchuan Zhou / Xinbao Zhao / Na Di / Shaoyun Hao / Hui Zhi

BIO Integration, Vol 4, Iss 3, Pp 84-

2023 Volume 96

Abstract: Background: Ovarian cancer (OV) is the fifth leading cause of cancer death among women. Growing evidence supports a key role of the tumor microenvironment in the growth, progression, and metastasis of OV. However, the prognostic effects of gene ... ...

Abstract	Background: Ovarian cancer (OV) is the fifth leading cause of cancer death among women. Growing evidence supports a key role of the tumor microenvironment in the growth, progression, and metastasis of OV. However, the prognostic effects of gene expression signatures associated with the OV microenvironment have not been well established. This study was aimed at applying the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) algorithm to identify tumor-microenvironment-associated genes that predict outcomes in patients with OV. Methods: The gene expression profiles of OV samples were downloaded from The Cancer Genome Atlas database. The immune and stromal scores of 469 OV samples on the basis of the ESTIMATE algorithm were available. To better understand the effects of gene expression signatures associated with the OV microenvironment on prognosis, we categorized these samples into groups with high and low ESTIMATE scores. A different OV cohort from the Gene Expression Omnibus (GEO) database and immunohistochemistry from The Human Protein Atlas database were used for external validation. Results: The molecular subtypes of patients with OV correlated with the stromal scores, and the mesenchymal subtype had the highest stromal scores. Patients with higher stromal scores had lower 5-year overall survival; 449 differentially expressed genes in the stromal score group were identified, 26 of which were significantly associated with poor prognosis in patients with OV (p < 0.05). In another OV cohort from the Gene Expression Omnibus database, six genes were further validated to be significantly associated with poor prognosis. Immunohistochemistry data from The Human Protein Atlas database confirmed the overexpression of CX3CR1, GFPT2, NBL1, TFPI2, and ZFP36 in OV tissues compared with normal tissues. Conclusion: Our findings suggest that CX3CR1, GFPT2, NBL1, TFPI2, and ZFP36 may be promising biomarkers for OV prognosis, with clinical implications for therapeutic ...
Keywords	ovarian cancer ; tumor microenvironment ; stromal scores ; prognosis ; tcga ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Compuscript Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The anesthesia management of totally thoracoscopic cardiac surgery

Hang Tian / Yan-jun Chen / He Tian / Xiao-shen Zhang / Hua Lu / Si Shen / Hao Wang

Heliyon, Vol 9, Iss 5, Pp e15737- (2023)

A single-center retrospective study

2023

Abstract: Anesthesia management of Totally thoracoscopic cardiac surgery (TTCS) has been the subject of much debate and discussion. In this single center retrospective study, we summarize the experience of clinical anesthesia management for TTCS by review the ... ...

Abstract	Anesthesia management of Totally thoracoscopic cardiac surgery (TTCS) has been the subject of much debate and discussion. In this single center retrospective study, we summarize the experience of clinical anesthesia management for TTCS by review the medical records of our medical center and look forward to its future development. In this retrospective study, 103 patients (49 male and 54 female) were enrolled, the mean age was 56.7 ± 14.4 years old. The participants underwent Mitral Valve Replacement (MVR) + Tricuspid Valve Annuloplasty (TVA) (42, 40.8%), Mitral Valve Annuloplasty (MVA) + TVA (38, 36.9%), MVA (21, 20.4%), and MVR (2, 1.9%)，respectively. Intraoperative hypoxemia, radiographic pulmonary infiltrates, and pneumonia were observed in 19 (18.4%), 84 (81.6%), and 13 (12.6%) patients, respectively. The LOS of ICU and POD were as follows: MVR + TVA (55.1 ± 25h, 9.9 ± 3.5 d), MVA + TVA (56.5 ± 28.4h, 9.4 ± 4.2d), MVA (37.9 ± 21.9h, 8.1 ± 2.3d) and MVR (48 ± 4.2h, 7.5 ± 2.1d). No reintubation, reoperations, postoperative cognitive dysfunction, 30-day mortality were observed in the present study. The present study demonstrated that applying this anesthesia management for TTCS associated with acceptable morbidity, intensive care unit and postoperative hospital lengths of stay. The finding from the present study might provide some new approach for Anesthesia management of TTCS.
Keywords	Totally thoracoscopic cardiac surgery ; Anesthesia management ; Perioperative complications ; Length of stay ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Preliminary Investigation into Ultrasound and MRI Presentation of Large-Cell Neuroendocrine Carcinomas of the Uterine Cervix

Long Tan / Shi-Ji Wu / Ya Qiu / Yue Jie / Shen Zhang / Shang-Lan Zhou / Bao-Ming Luo / Na Di

BIO Integration, Vol 4, Iss 4, Pp 180-

2023 Volume 185

Abstract: Objective: The aim of this study was to analyze the ultrasound and MRI features of eight patients with cervical large-cell neuroendocrine carcinoma to improve awareness of this disease among sonographers, radiologists, and clinicians. Methods: Clinical ... ...

Abstract	Objective: The aim of this study was to analyze the ultrasound and MRI features of eight patients with cervical large-cell neuroendocrine carcinoma to improve awareness of this disease among sonographers, radiologists, and clinicians. Methods: Clinical data for eight patients with cervical large-cell neuroendocrine carcinoma confirmed by pathology at Sun Yat-sen Memorial Hospital of Sun Yat-sen University between February 2018 and April 2021 were retrospectively analyzed according to clinical, conventional ultrasound, contrast-enhanced ultrasound, and MRI characteristics. Results: Conventional ultrasound examination of the cervical large-cell neuroendocrine carcinoma lesions in the eight patients revealed two features: (1) irregular hypoechoic areas in the muscular layer, with slightly hyperechoic inlay streaks, and poorly delineated lesions, and (2) slightly abundant blood flow distribution in the lesions. The contrast-enhanced ultrasound showed a “fast-in and fast-out” mode; after subsidence, a “fence-like” change was observed, and the enhancement range was significantly greater than the range of two-dimensional ultrasound. In MRI, T1WI showed a low signal or isosignal; T2WI showed a high signal; DWI showed a high signal and low ADC value; and most of the enhanced MRI showed inhomogeneous hyperenhancement. Conclusion: Conventional ultrasound, contrast-enhanced ultrasound and MRI are complementary methods that provide additional imaging information for the diagnosis of cervical large-cell neuroendocrine carcinoma.
Keywords	cervical large celllarge-cell neuroendocrine carcinoma ; contrast-enhanced ultrasonography ; mri ; ultrasonography ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Compuscript Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Solid phase synthesis of alkoxyl tin and the role of alkyl for Multi-stage thermal decomposition of polyvinyl chloride

Shao-you Liu / Bao-shen Zhang / Yu-lin Ouyang / Li-hui Ou / Sheng-qiang Qiu / You Long / Shi-jie Xiong

Results in Chemistry, Vol 6, Iss , Pp 101101- (2023)

2023

Abstract: To prepare an innovative thermal stabilizer for polyvinyl chloride (PVC), the micro-nano powders of alkoxyl tin (RxOSn) were synthesized via a solid phase reaction at room temperature, using the surfactant sodium benzene sulfonate (SBS) as a catalyst. ... ...

Abstract	To prepare an innovative thermal stabilizer for polyvinyl chloride (PVC), the micro-nano powders of alkoxyl tin (RxOSn) were synthesized via a solid phase reaction at room temperature, using the surfactant sodium benzene sulfonate (SBS) as a catalyst. Theoretical calculation of deprotonation reaction energy of monobasic alcohol and tin chloride was performed with the framework of DFT, and their structures were characterized by XRD, SEM, FT-IR, XPS, and its surface wetting performance was carried out by contact angle (CA). Meanwhile, the multi-stage thermal stability of PVC with 10% RxOSn sample, and the role of alkyl groups (Rx, x = 2 ∼ 5) in the RxOSn/PVC were investigated. The results show that the RxOSn samples exhibit a microstructure akin to the rutile of SnO2. Multi-stage kinetic studies of exothermic reactions has confirmed that the alkoxyl wetting performance of stabilizers becomes a determining factor, while the variation in activation energy (Ea) values seems to be mainly influenced by the Rx alkyl groups in the RxOSn samples. Besides, the differences in the lattice parameter a of RxOSn were validated to have a certain impact on the stabilizing effect of PVC, and the Ea of PVC degradation is closely related to the relative value of exposed crystal surfaces (D(110)/D(101)). This series of materials is easily synthesized and can effectively enhance the thermal stability of PVC, offering a wide range of potential applications.
Keywords	Monobasic alcohol ; Alkoxyl tin ; PVC ; Multi-stage degradation ; Thermal stability ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Current status of traditional Chinese medicine therapy in treating tumor cachexia

Shen ZHANG

Journal of Integrative Medicine (JIM), Vol 7, Iss 9, Pp 873-

2009 Volume 877

Keywords	tumor ; cachexia ; traditional Chinese medicine ; therapy ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2009-09-01T00:00:00Z
Publisher	Journal of Chinese Integrative Medicine Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Numerical Investigation on the Effects of Dielectric Barrier on a Nanosecond Pulsed Surface Dielectric Barrier Discharge

Shen Zhang / Zhenli Chen / Binqian Zhang / Yingchun Chen

Molecules, Vol 24, Iss 21, p

2019 Volume 3933

Abstract: In order to understand the impacts of dielectric barrier on the discharge characteristics of a nanosecond pulsed surface dielectric barrier discharge (NS-DBD), the effects of dielectric constant and dielectric barrier thickness are numerically ... ...

Abstract	In order to understand the impacts of dielectric barrier on the discharge characteristics of a nanosecond pulsed surface dielectric barrier discharge (NS-DBD), the effects of dielectric constant and dielectric barrier thickness are numerically investigated by using a three-equation drift−diffusion model with a 4-species 4-reaction air chemistry. When the dielectric constant increases, while the dielectric barrier thickness is fixed, the streamer propagation speed ( V ), the maximum streamer length ( L ), the discharge energy ( <math display="inline"> <semantics> <msub> <mi>Q</mi> <mrow> <mi>D</mi> <mo>_</mo> <mi>e</mi> <mi>i</mi> </mrow> </msub> </semantics> </math> ), and the gas heating ( <math display="inline"> <semantics> <msub> <mi>Q</mi> <mrow> <mi>G</mi> <mi>H</mi> </mrow> </msub> </semantics> </math> ) of a pulse increase, but the plasma sheath thickness ( h ), the fast gas heating efficiency <math display="inline"> <semantics> <mi>η</mi> </semantics> </math> , and the charge densities on the wall surface decrease. When the dielectric barrier thickness increases, while the dielectric constant is fixed, V , L , <math display="inline"> <semantics> <msub> <mi>Q</mi> <mrow> <mi>D</mi> <mo>_</mo> <mi>e</mi> <mi>i</mi> </mrow> </msub> </semantics> </math> , and <math display="inline"> <semantics> <msub> <mi>Q</mi> <mrow> <mi>G</mi> <mi>H</mi> </mrow> </msub> </semantics> </math> of a pulse decrease, but h , <math display="inline"> <semantics> <mi>η</mi> </semantics> </math> , and the charge densities on the wall surface increase. It can be concluded that the ...
Keywords	nanosecond pulsed dielectric barrier discharge ; dielectric constant ; dielectric barrier thickness ; surface charge ; streamer characteristics ; gas heating ; Organic chemistry ; QD241-441
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum

Roger Shen Zhang / Kif Liakath-Ali / Thomas C Südhof

eLife, Vol

2020 Volume 9

Abstract: Latrophilin-2 (Lphn2) and latrophilin-3 (Lphn3) are adhesion GPCRs that serve as postsynaptic recognition molecules in CA1 pyramidal neurons of the hippocampus, where they are localized to distinct dendritic domains and are essential for different sets ... ...

Abstract	Latrophilin-2 (Lphn2) and latrophilin-3 (Lphn3) are adhesion GPCRs that serve as postsynaptic recognition molecules in CA1 pyramidal neurons of the hippocampus, where they are localized to distinct dendritic domains and are essential for different sets of excitatory synapses. Here, we studied Lphn2 and Lphn3 in the cerebellum. We show that latrophilins are abundantly and differentially expressed in the cerebellar cortex. Using conditional KO mice, we demonstrate that the Lphn2/3 double-deletion but not the deletion of Lphn2 or Lphn3 alone suppresses parallel-fiber synapses and reduces parallel-fiber synaptic transmission by ~50% without altering release probability. Climbing-fiber synapses, conversely, were unaffected. Even though ~50% of total cerebellar Lphn3 protein is expressed in Bergmann glia, Lphn3 deletion from Bergmann glia did not detectably impair excitatory or inhibitory synaptic transmission. Our studies demonstrate that Lphn2 and Lphn3 are selectively but redundantly required in Purkinje cells for parallel-fiber synapses.
Keywords	synaptic transmission ; synaptic organizers ; cerebellum ; adhesion GPCRs ; synapse specification ; latrophilins ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED