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Article ; Online: Chemical-free vacuum ultraviolet irradiation as ultrafiltration membrane pretreatment technique: Performance, mechanisms and DBPs formation.

Chen, Shengnan / Sheng, Xin / Zhao, Zhiwei / Cui, Fuyi

2023 Volume 351, Page(s) 119785

Abstract: Membrane fouling induced by natural organic matter (NOM) has seriously affected the further extensive application of ultrafiltration (UF). Herein, a simple, green and robust vacuum ultraviolet (VUV) technology was adopted as pretreatment before UF and ... ...

Abstract	Membrane fouling induced by natural organic matter (NOM) has seriously affected the further extensive application of ultrafiltration (UF). Herein, a simple, green and robust vacuum ultraviolet (VUV) technology was adopted as pretreatment before UF and ultraviolet (UV) technology was used for comparison. The results showed that control effect of VUV pretreatment on membrane fouling was better than that of UV pretreatment, as evidenced by the increase of normalized flux from 0.27 to 0.38 and 0.73 after 30 min UV or VUV pretreatment, respectively. This is related to the fact that VUV pretreatment exhibited stronger NOM degradation ability than UV pretreatment owing to the formation of HO•. The steady-state concentration of HO• was calculated as 3.04 × 10
MeSH term(s)	Disinfection ; Water Purification/methods ; Ultrafiltration/methods ; Vacuum ; Ultraviolet Rays ; Membranes, Artificial
Chemical Substances	Membranes, Artificial
Language	English
Publishing date	2023-12-10
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.119785
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Article ; Online: Climate shocks and wealth inequality in the UK: evidence from monthly data.

Sheng, Xin / Chisadza, Carolyn / Gupta, Rangan / Pierdzioch, Christian

Environmental science and pollution research international

2023 Volume 30, Issue 31, Page(s) 77771–77783

Abstract: This paper investigates both the linear and nonlinear effects of climate risk shocks on wealth inequality in the UK using the local projections (LPs) method, based on high-frequency, i.e., monthly data. The linear results show that climate risk shocks ... ...

Abstract	This paper investigates both the linear and nonlinear effects of climate risk shocks on wealth inequality in the UK using the local projections (LPs) method, based on high-frequency, i.e., monthly data. The linear results show that climate risk shocks lead to an increase in wealth inequality in the longer term. The nonlinear results present some evidence of heterogeneous responses of wealth inequality to climate risk variable shocks between high- and low-climate risk regimes. The findings highlight the disproportionate increased burden of climate change on households that are already experiencing poverty, particularly households in high-climate risk areas. As such, measures to mitigate the adverse effects of climate change need to be tailored so as not to overburden the poor.
MeSH term(s)	Family Characteristics ; Climate Change ; United Kingdom
Language	English
Publishing date	2023-06-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-27342-1
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Article ; Online: PRL-3 antibody combined with pemetrexed induces apoptosis of human lung adenocarcinoma cell line A549

SHENG Xin, LIU Dan, DENG Shu-kai

Jichu yixue yu linchuang, Vol 40, Iss 5, Pp 678-

2020 Volume 683

Abstract: Objective To investigate the effects of PRL-3 antibody and pemetrexed on proliferation, migration and apoptosis of A549 cells. Methods A549 cells were treated with PRL-3 antibody at different concentrations; CCK-8 method was used to measure the cell ... ...

Abstract	Objective To investigate the effects of PRL-3 antibody and pemetrexed on proliferation, migration and apoptosis of A549 cells. Methods A549 cells were treated with PRL-3 antibody at different concentrations; CCK-8 method was used to measure the cell proliferation of human lung adenocarcinoma A549 cells in each group; Transwell chamber assay was used to detect cell migration ability of A549 cells; Flow cytometry assay was used to measure the apoptosis rate of A549 cells; PRL-3, P-ERK and VEGF protein expressions of A549 cells were detected by Western bolt. Results 1)Compared with the control group, the inhibitory effect of PRL-3 antibody on proliferation of A549 cells increased with the increase of PRL-3 concentration (P＜0.05); 2)The inhibitory effect of the combination group on proliferation and migration ability of A549 cells was more significant than that of the monotheraphy group (P＜0.05); 3)The apoptosis rate of A549 cells in the combination group 34.63%±1.65% was better than that of PRL-3 antibody group 17.24%±1.15% and pemetrexed group 15.32%±1.82% (P＜0.05); 4)Compared with the monotheraphy group, the expressions of PRL-3, P-ERK and VEGF proteins in the combination group decreased more significantly (P＜0.05). Conclusions PRL-3 antibody combined with pemetrexed can inhibit the proliferation, migration and induce apoptosis of A549 cells as compared to the monotherapy group. The mechanism may be attributed to the inhibition of the expressions of PRL-3, P-ERK and VEGF protein.
Keywords	lung cancer\|pemetrexed\|prl-3\|p-erk\|vegf ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2020-05-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development.

Yan, Yu / Liu, Hongbo / Abedini, Amin / Sheng, Xin / Palmer, Matthew / Li, Hongzhe / Susztak, Katalin

Nature communications

2024 Volume 15, Issue 1, Page(s) 873

Abstract: Epigenetic changes may fill a critical gap in our understanding of kidney disease development, as they not only reflect metabolic changes but are also preserved and transmitted during cell division. We conducted a genome-wide cytosine methylation ... ...

Abstract	Epigenetic changes may fill a critical gap in our understanding of kidney disease development, as they not only reflect metabolic changes but are also preserved and transmitted during cell division. We conducted a genome-wide cytosine methylation analysis of 399 human kidney samples, along with single-nuclear open chromatin analysis on over 60,000 cells from 14 subjects, including controls, and diabetes and hypertension attributed chronic kidney disease (CKD) patients. We identified and validated differentially methylated positions associated with disease states, and discovered that nearly 30% of these alterations were influenced by underlying genetic variations, including variants known to be associated with kidney disease in genome-wide association studies. We also identified regions showing both methylation and open chromatin changes. These changes in methylation and open chromatin significantly associated gene expression changes, most notably those playing role in metabolism and expressed in proximal tubules. Our study further demonstrated that methylation risk scores (MRS) can improve disease state annotation and prediction of kidney disease development. Collectively, our results suggest a causal relationship between epigenetic changes and kidney disease pathogenesis, thereby providing potential pathways for the development of novel risk stratification methods.
MeSH term(s)	Humans ; DNA Methylation/genetics ; Chromatin/genetics ; Chromatin/metabolism ; Genome-Wide Association Study ; Kidney/metabolism ; Epigenesis, Genetic ; Renal Insufficiency, Chronic/pathology
Chemical Substances	Chromatin
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45295-y
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Article ; Online: Author Correction: Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development.

Yan, Yu / Liu, Hongbo / Abedini, Amin / Sheng, Xin / Palmer, Matthew / Li, Hongzhe / Susztak, Katalin

Nature communications

2024 Volume 15, Issue 1, Page(s) 2537

Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46661-6
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Article ; Online: The function of the ATG8 in the cilia and cortical microtubule maintenance of Euplotes amieti.

Wu, Junlin / Sheng, Yan / Mai, Shihuan / Zhong, Yanhao / Dai, Shengrong / Luo, Yupeng / Sheng, Xin

Protoplasma

2024

Abstract: Autophagy regulates the formation of primary cilia, which in turn affects autophagy. The relationship between autophagy and cilia is known to be bidirectional although the specific mechanisms involved have yet to be elucidated. In this study, we found ... ...

Abstract	Autophagy regulates the formation of primary cilia, which in turn affects autophagy. The relationship between autophagy and cilia is known to be bidirectional although the specific mechanisms involved have yet to be elucidated. In this study, we found for the first time that ATG8 protein localizes in the basal body of the dorsal kineties and the base of the ventral cirri in Euplotes amieti. ATG8 protein maintains the structural integrity of cilia and plays a role in the construction of the cortical ciliature and microtubule cytoskeleton associated with cilia. ATG8 gene interference leads to the degradation of IFT88, the transport protein in cilia, thus inhibiting the generation of cilia, and affecting the swing of cilia. This influences the swimming speed and cilia pattern, leading to death in Euplotes amieti.
Language	English
Publishing date	2024-05-20
Publishing country	Austria
Document type	Journal Article
ZDB-ID	123809-7
ISSN	1615-6102 ; 0033-183X
ISSN (online)	1615-6102
ISSN	0033-183X
DOI	10.1007/s00709-024-01957-8
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Article: Quasi-2D halide perovskite crystals and their optoelectronic applications

Sheng, Xin / Li, Yahui / Xia, Ming / Shi, Enzheng

Journal of materials chemistry A. 2022 Sept. 27, v. 10, no. 37

2022

Abstract: Due to the widely tunable and exceptional semiconductor properties, quasi-two-dimensional (2D) halide perovskites have been considered outstanding candidates for next-generation optoelectronic devices and have thus undergone rapid development over the ... ...

Abstract	Due to the widely tunable and exceptional semiconductor properties, quasi-two-dimensional (2D) halide perovskites have been considered outstanding candidates for next-generation optoelectronic devices and have thus undergone rapid development over the last decade. Their property tunability is intimately correlated with the quantum-well thickness (corresponding to the n value, the number of octahedral layers in each layer of quasi-2D halide perovskites). However, a systematic review of the relationship between the n value and the optoelectronic properties/applications of the quasi-2D perovskites is lacking. In this review, we begin with the n-dependent properties of quasi-2D perovskites, and move on to the synthesis of different forms of quasi-2D perovskite crystals. Afterwards, we focus on the existing optoelectronic applications using quasi-2D perovskites including light-emitting diodes, solar cells, lasers, and photodetectors. In the last section, we discuss the current challenges and a few promising directions with a special focus on the precise control of the n value. Moreover, the possible non-centrosymmetrical ordering of the organic ligands in quasi-2D halide perovskites provides new insights and opportunities to study the interaction between spontaneous polarization, photovoltaic effect, and carrier transport behaviors in the corresponding electronic and optoelectronic devices.
Keywords	chemistry ; ligands ; semiconductors ; systematic review
Language	English
Dates of publication	2022-0927
Size	p. 19169-19183.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/d2ta02219b
Database	NAL-Catalogue (AGRICOLA)

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Article: Exploring new ideas for sustainable development of urban agglomerations-based on the coupling of people’s livelihood and environmental governance

Huang, Qianqian / Peng, Benhong / Sheng, Xin / Wan, Anxia

Environment, development and sustainability. 2022 Aug., v. 24, no. 8

2022

Abstract: Peoples’ livelihood and environmental governance are interrelated and interact with each other, which is a new starting point for the study of sustainable development of urban agglomerations. Given the insufficient research on the combination of peoples’ ...

Abstract	Peoples’ livelihood and environmental governance are interrelated and interact with each other, which is a new starting point for the study of sustainable development of urban agglomerations. Given the insufficient research on the combination of peoples’ livelihood and environment in urban agglomerations. Therefore, this study analyzes the coupling relationship of environmental governance and peoples’ livelihood to achieve the objective of sustainable development of the Yangtze River urban agglomeration. The results found that from 2008 to 2017, the coupling of the peoples’ livelihood and the environment has significantly improved, and the high-coupling area was concentrated in the central part of the Yangtze River urban agglomeration. Moreover, with the rapid development of urban agglomerations, the gap between the development of peoples’ livelihood and environmental protection was not large and the correlation between the two sides is increasing. Finally, we propose to improve the development level of peoples’ livelihood and environment, focus on the relationship between peoples’ livelihood and environment related to promote the integration of peoples’ livelihood and environment development and other inspirations, to provide a reference for urban clusters to explore a sustainable development path.
Keywords	environment ; environmental governance ; environmental protection ; livelihood ; people ; sustainable development ; Yangtze River
Language	English
Dates of publication	2022-08
Size	p. 9985-10004.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1438730-x
ISSN	1387-585X
ISSN	1387-585X
DOI	10.1007/s10668-021-01853-8
Database	NAL-Catalogue (AGRICOLA)

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Article: The effects of climate risks on economic activity in a panel of US states: The role of uncertainty

Sheng, Xin / Gupta, Rangan / Çepni, Oğuzhan

Economics letters. 2022 Apr., v. 213

2022

Abstract: We analyse the impact of climate risks (temperature growth and its volatility) on the coincident indicator of the 50 US states in a panel data set-up, over the monthly period of March, 1984 to December, 2019. Using impulse response functions (IRFs) from ... ...

Abstract	We analyse the impact of climate risks (temperature growth and its volatility) on the coincident indicator of the 50 US states in a panel data set-up, over the monthly period of March, 1984 to December, 2019. Using impulse response functions (IRFs) from a linear local projections (LPs) model, we show that climate risks negatively impact economic activity to a similar degree, irrespective of whether such risks are due to changes in temperature growth or its volatility. More importantly, using a nonlinear LPs model, the IRFs reveal that the adverse effect of climate risks is contingent on the regimes of economic and policy-related uncertainty of the states, with the impact being significantly much stronger under relatively higher values of uncertainty, rather than lower values of the same. In addition to this, temperature growth volatility is found to contract economic activity nearly five times more compared to when temperature growth increases by a similar magnitude in the higher uncertainty-based regime of the nonlinear model. Understandably, our results have important policy implications.
Keywords	adverse effects ; climate ; economics ; issues and policy ; nonlinear models ; temperature ; uncertainty
Language	English
Dates of publication	2022-04
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0165-1765
DOI	10.1016/j.econlet.2022.110374
Database	NAL-Catalogue (AGRICOLA)

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Article: Persistence of state-level uncertainty of the United States: The role of climate risks

Sheng, Xin / Gupta, Rangan / Cepni, Oguzhan

Economics letters. 2022 June, v. 215

2022

Abstract: Recent theoretical developments tend to suggest that rare disaster risks enhance the persistence of uncertainty. Given this, we analyse the impact of climate risks (temperature growth or its volatility), as proxies for such unusual events, on the ... ...

Abstract	Recent theoretical developments tend to suggest that rare disaster risks enhance the persistence of uncertainty. Given this, we analyse the impact of climate risks (temperature growth or its volatility), as proxies for such unusual events, on the persistence of economic and policy-related uncertainty of the 50 US states in a panel data set-up, over the monthly period of 1984:03 to 2019:12. Using impulse response functions (IRFs) from a regime-based local projections (LPs) model, we show that the impact of an uncertainty shock on uncertainty itself is not only bigger in magnitude when the economy is in the upper-regime of temperature growth or its volatility, but is also, in line with theory, is more persistent. Our results have important policy implications.
Keywords	climate ; economics ; issues and policy ; models ; temperature ; uncertainty
Language	English
Dates of publication	2022-06
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0165-1765
DOI	10.1016/j.econlet.2022.110500
Database	NAL-Catalogue (AGRICOLA)

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