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Article ; Online: Connexin 43 peptidic medicine for glioblastoma stem cells.

Sheng, Zhi

2021 Volume 64, Page(s) 103205

MeSH term(s)	Animals ; Brain Neoplasms/drug therapy ; Brain Neoplasms/etiology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; CSK Tyrosine-Protein Kinase/antagonists & inhibitors ; Connexin 43/chemistry ; Connexin 43/metabolism ; Glioblastoma/drug therapy ; Glioblastoma/etiology ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Peptides/pharmacology ; Peptides/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Chemical Substances	Connexin 43 ; Peptides ; Protein Kinase Inhibitors ; CSK Tyrosine-Protein Kinase (EC 2.7.10.2)
Language	English
Publishing date	2021-01-23
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2020.103205
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Article: Thermodynamic analysis of subcritical/transcritical ORCs with metal–organic heat carriers for efficient power generation from low-grade thermal energy

Li, Yang / Xu, Sheng-Zhi

Energy. 2022 Sept. 15, v. 255

2022

Abstract: Recovery of low-grade energy for power generation by organic Rankine cycle (ORC) can effectively alleviate energy crisis and reduce CO₂ emission, but the low heat source temperature severely affects the thermal efficiency and output power of the system. ... ...

Abstract	Recovery of low-grade energy for power generation by organic Rankine cycle (ORC) can effectively alleviate energy crisis and reduce CO₂ emission, but the low heat source temperature severely affects the thermal efficiency and output power of the system. Using new working fluids with enhanced thermal properties is one promising approach to improve cycle performance. Based on the concept of nanofluids with conventional refrigerants and metal–organic heat carriers (MOHCs), thermodynamic models of subcritical/transcritical basic ORC and regenerative ORC (RORC) with R134a/Cr-MIL-101 and R134a/Mg-MOF-74 nanofluids are constructed. Thermodynamic analysis results reveal that adsorption of R134a from MOFs increases pump work input and the turbine work output, while desorption increases the evaporator heat input. Also, MOHCs improve the thermal efficiency of both ORC and RORC, and the thermal efficiency improvement ratio of transcritical cycle is maximized at high evaporation pressure and low turbine inlet temperature. By adding a 0.9% mass fraction of Mg-MOF-74 to R134a, the maximum thermal efficiency of RORC is improved from 13.66% to 15.11%, and its maximum specific net work output is increased from 27.82 kJ/kg to 34.42 kJ/kg. Furthermore, both exergy efficiency and economic benefit are improved with MOHC-added systems.
Keywords	adsorption ; carbon dioxide ; desorption ; evaporation ; exergy ; financial economics ; heat ; nanofluids ; power generation ; temperature ; thermal energy
Language	English
Dates of publication	2022-0915
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2022.124519
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparative dose-response study on the infusion of norepinephrine combined with intravenous ondansetron versus placebo for preventing hypotension during spinal anesthesia for cesarean section: a randomised controlled trial.

Sheng, Zhi-Min / Sun, Heng-Qiu / Mao, Jun-Qin / Liu, Jie / Liang, Gang / Mei, Zhong

International journal of surgery (London, England)

2024 Volume 110, Issue 2, Page(s) 832–838

Abstract: Background: Ondansetron has been reported to attenuate the incidence of spinal anaesthesia-induced hypotension (SAIH) and norepinephrine requirement during caesarean section. However, no quantitative study has evaluated the extent of this effect. This ... ...

Abstract	Background: Ondansetron has been reported to attenuate the incidence of spinal anaesthesia-induced hypotension (SAIH) and norepinephrine requirement during caesarean section. However, no quantitative study has evaluated the extent of this effect. This study aimed to determine the dose-response of prophylactic infusion of norepinephrine to prevent SAIH in parturients who received intravenous ondansetron or placebo before spinal anaesthesia for caesarean section. The median effective dose (ED 50 ) and 90% effective dose (ED 90 ) were compared to evaluate the effect of ondansetron versus placebo on the norepinephrine requirement. Materials and methods: One hundred fifty parturients undergoing caesarean section were randomized to receive either 0.1 mg/kg ondansetron (group O) or saline control (group C) 10 min before spinal anaesthesia. The parturients were randomly assigned to one of five different norepinephrine infusion groups: 0.02, 0.04, 0.06, 0.08 or 0.10 µg/kg/min. An effective infusion dose of norepinephrine was defined as non-occurrence of hypotension during the study period. The values for ED 50 and ED 90 of norepinephrine infusion were determined using probit regression. Differences between the two groups were evaluated by comparing the relative median potency with 95% CIs. Results: The ED 50 values were 0.033 (95% CIs, 0.024-0.043) µg/kg/min in group C and 0.021 (95% CIs, 0.013-0.029) µg/kg/min in group O. The ED 90 values were 0.091 (95% CIs 0.068-0.147) µg/kg/min in group C and 0.059 (95% CIs 0.044-0.089) µg/kg/min in group O, respectively. The estimate of the relative median potency for norepinephrine in group C versus group O was 0.643 (95% CIs, 0.363-0.956). The incidence of side effects was comparable between groups. No significant difference in neonatal outcomes. Conclusion: Intravenous ondansetron 0.1 mg/kg before spinal anaesthesia significantly reduced the dose requirement of prophylactic norepinephrine infusion in parturients undergoing elective caesarean section. This finding is potentially useful for clinical practice and further research.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Humans ; Female ; Ondansetron/therapeutic use ; Norepinephrine ; Cesarean Section/adverse effects ; Anesthesia, Spinal/adverse effects ; Hypotension/chemically induced ; Hypotension/prevention & control ; Double-Blind Method
Chemical Substances	Ondansetron (4AF302ESOS) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000000920
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Article ; Online: How positive mental well-being influences professional identity and the mediating mechanisms in Chinese nursing students.

Jilili, Ayisha / Weng, Xue / Zhao, Sheng Zhi / Wang, Lin / Fang, Qiong / Guo, Ningyuan

International nursing review

2024

Abstract: Aim: To examine the association between positive mental well-being and professional identity in nursing students. The mediating effects of resilience and nurse-patient relationship were explored.: Background: Professional identity of nursing students ...

Abstract	Aim: To examine the association between positive mental well-being and professional identity in nursing students. The mediating effects of resilience and nurse-patient relationship were explored. Background: Professional identity of nursing students can influence their pursuit of a nursing career. Negative mental health problems, such as anxiety, depression, and high stress, are known risk factors for professional identity. Few studies have examined the association of professional identity with positive mental well-being and underlying mechanisms. Methods: This was a cross-sectional study of Chinese nursing students on clinical placement. The Warwick-Edinburgh Mental Well-being Scale, Professional Identity Scale, Connor-Davidson Resilience Scale, Nurse-Patient Relationship Scale, and Patient Health Questionnaire were used, and demographic and study-related characteristics were measured. Multivariable linear regression and mediation analyses analyzed the associations. We followed the STROBE reporting guidelines. Results: Of 208 participants, the total scores of positive mental well-being and professional identity were at a moderate level. Positive mental well-being was associated with professional identity after adjusting for confounders including the main reason for choosing nursing and negative mental health. Resilience was a full mediator of the association between positive mental well-being and professional identity, whereas nurse-patient relationship was a partial mediator. Discussion and conclusion: Positive mental well-being was associated with professional identity in Chinese nursing students on clinical placement, mediated through resilience and nurse-patient relationship. Positive mental well-being can be a facilitator for the professional identity of nursing students, and resilience and nurse-patient relationship could be potential mechanisms for nurse professional development. Implications for nursing and/or health policy: Nurse researchers, educators, and policymakers are informed to increase the awareness of positive mental well-being and develop interventions targeting resilience and nurse-patient relationship for building a stable and satisfied nursing team.
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	80342-x
ISSN	1466-7657 ; 0020-8132
ISSN (online)	1466-7657
ISSN	0020-8132
DOI	10.1111/inr.12972
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Article ; Online: In vitro assessment of cytotoxicity of spent fluid catalytic cracking refinery catalysts on cell lines and identification of critical toxic metals.

Wang, Yue-Jie / Sheng, Zhi-Guo / Li, Jun / Zhao, Zhen-Feng / Li, Ling-Ling / Shen, Chen

Toxicology in vitro : an international journal published in association with BIBRA

2024 Volume 97, Page(s) 105807

Abstract: The Purpose of the present study was to quantify the responses of ten cell lines (HeLa, HepG2, HEK293, MDA-MB-231, A498, A549, A357, 3 T3, BALB-C3 T3, and NIH-3 T3) to spent fluid catalytic cracking catalysts (SFCCCs) from different petroleum refineries, ...

Abstract	The Purpose of the present study was to quantify the responses of ten cell lines (HeLa, HepG2, HEK293, MDA-MB-231, A498, A549, A357, 3 T3, BALB-C3 T3, and NIH-3 T3) to spent fluid catalytic cracking catalysts (SFCCCs) from different petroleum refineries, and relate these responses to metal concentrations of SFCCC leachates (SFCCCLs). Cytotoxicity of SFCCCs were significantly different depending on cell lines. A357 and 3 T3 cell were the most sensitive, and A498 and HeLa cells were the least sensitive. HEK293 cells showed the least fluctuation in toxic response to different SFCCCLs among all cells. Cytotoxic IC
MeSH term(s)	Humans ; HeLa Cells ; HEK293 Cells ; Metals ; Hep G2 Cells ; Glutathione/metabolism
Chemical Substances	Metals ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2024.105807
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Article: Editorial: Assessment of osteoporotic fractures and risk prediction, volume II.

Xie, Dandan / Sheng, ZhiFeng / Wang, Xiangbing / Cheng, Xiaoguang

Frontiers in endocrinology

2023 Volume 14, Page(s) 1238237

MeSH term(s)	Humans ; Osteoporotic Fractures ; Osteoporosis/complications ; Bone Density
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1238237
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Article: Editorial: Assessment of osteoporotic fractures and risk prediction.

Cheng, Xiaoguang / Sheng, Zhi-Feng / Wang, Xiangbing

Frontiers in endocrinology

2022 Volume 13, Page(s) 1107678

MeSH term(s)	Humans ; Osteoporotic Fractures/epidemiology ; Osteoporosis/complications ; Osteoporosis/diagnosis ; Bone Density
Language	English
Publishing date	2022-12-19
Publishing country	Switzerland
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1107678
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Article ; Online: Research on the operation mechanism and winning mechanism of mosaic warfare

SUN Sheng-zhi / LIU Yu / SHENG Bi-qi / ZHENG Wei-juan

Zhihui kongzhi yu fangzhen, Vol 42, Iss 2, Pp 150-

2023 Volume 154

Abstract: With the development of science and technology, the Mosaics theory has been put forward and applied in practice gradually. This paper analyzes the basic characteristics of Mosaics, such as the plurality of subjects, the fusion of forms, the bewilderment ... ...

Abstract	With the development of science and technology, the Mosaics theory has been put forward and applied in practice gradually. This paper analyzes the basic characteristics of Mosaics, such as the plurality of subjects, the fusion of forms, the bewilderment of actions and the controllability of risks, it also researches the operation mechanism of Mosaics about the distributed decomposition of complex systems, networked integration of decomposition elements, intelligent aggregation of integrated systems and highly elastic self-healing of polymeric systems. This paper puts forward the Mosaic winning mechanism of distributed system winning, network system winning, intelligent system winning and high elastic system winning. This paper lays an important foundation for the in-depth study of the mechanism of winning the mosaic war and winning the initiative in the future war.
Keywords	mosaic warfare\|basic characteristics\|operations mechanism\|winning mechanism ; Military Science ; U
Language	Chinese
Publishing date	2023-04-01T00:00:00Z
Publisher	Editorial Office of Command Control and Simulation
Document type	Article ; Online
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Article ; Online: Enhancing potential of hydrofracturing in mylonitic coal by biocementation

Chenpeng Song / Sheng Zhi / Gan Feng / Junzhi Lin

Energy Science & Engineering, Vol 9, Iss 4, Pp 565-

2021 Volume 576

Abstract: Abstract Mylonite coal is a representative of tectonically deformed coal and is a result of crushing original coal into fine coal grains under strong shear or long‐low tectonic stress. Because of its granular nature and the resultant inferior mechanical ... ...

Abstract	Abstract Mylonite coal is a representative of tectonically deformed coal and is a result of crushing original coal into fine coal grains under strong shear or long‐low tectonic stress. Because of its granular nature and the resultant inferior mechanical property, it is difficult to initiate fluid‐driven fractures within mylonitic coal reservoirs for enhancing coalbed methane recovery. The following explores a biomineralization method of microbially mediated calcium carbonate precipitation (MICP) to enhance the structural integrity and mechanical strength of mylonitic coal, enabling potential success for hydrofracturing. The experimental results indicate that the mechanical properties of mylonite coal are significantly enhanced after a short period of MICP treatment with ten cycles of treatments yielding a maximum uniaxial compressive strength (UCS) of 8.7 MPa and a maximum brittleness index of 0.218 approaching that of the hard coal. The increments in UCS and brittleness of biocemented mylonite coal show a positive correlation with the generated calcium carbonate content. Scanning electron microscopy (SEM) imaging indicates that the generated calcium carbonate precipitates first randomly occur on the particle surfaces, and then occupies the interstitial space until particle‐particle bonds are developed. The irregular morphology of coal particles results in two contact relations between particles, point contact and planar contact, causing a significant difference in biocementation effectiveness. Two microfailure patterns of biocemented coal with uniaxial compression are observed. One is that the coal particles are crushed, and the other occurs at the biocemented interface between the coal particles and calcium carbonate crystals.
Keywords	biomineralization ; hydraulic fracturing ; microbial cementation ; microbially induced calcium carbonate precipitation ; mylonitic coal ; Technology ; T ; Science ; Q
Subject code	620
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Therapeutic strategies targeting the NLRP3‑mediated inflammatory response and pyroptosis in cerebral ischemia/reperfusion injury (Review).

Duan, Wan-Li / Wang, Xue-Jie / Ma, Ya-Ping / Sheng, Zhi-Mei / Dong, Hao / Zhang, Li-Ying / Zhang, Bao-Gang / He, Mao-Tao

Molecular medicine reports

2024 Volume 29, Issue 3

Abstract: Ischemic stroke poses a major threat to human health. Therefore, the molecular mechanisms of cerebral ischemia/reperfusion injury (CIRI) need to be further clarified, and the associated treatment approaches require exploration. The NOD‑like receptor ... ...

Abstract	Ischemic stroke poses a major threat to human health. Therefore, the molecular mechanisms of cerebral ischemia/reperfusion injury (CIRI) need to be further clarified, and the associated treatment approaches require exploration. The NOD‑like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome serves an important role in causing CIRI, and its activation exacerbates the underlying injury. Activation of the NLRP3 inflammasome triggers the maturation and production of the inflammatory molecules IL‑1β and IL‑18, as well as gasdermin‑D‑mediated pyroptosis and CIRI damage. Thus, the NLRP3 inflammasome may be a viable target for the treatment of CIRI. In the present review, the mechanisms of the NLRP3 inflammasome in the intense inflammatory response and pyroptosis induced by CIRI are discussed, and the therapeutic strategies that target the NLRP3‑mediated inflammatory response and pyroptosis in CIRI are summarized. At present, certain drugs have already been studied, highlighting future therapeutic perspectives.
MeSH term(s)	Humans ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Inflammasomes/metabolism ; Pyroptosis ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes
Language	English
Publishing date	2024-01-26
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2024.13170
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