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  1. Article ; Online: Sports Participation and Physical Activity in Individuals with Heritable Thoracic Aortic Disease and Aortopathy Conditions.

    Sheppard, Mary B / Braverman, Alan C

    Clinics in sports medicine

    2022  Volume 41, Issue 3, Page(s) 511–527

    Abstract: The evaluation and management of athletes with HTAD and aortopathy conditions requires shared decision-making encompassing the underlying condition, family history, aortic diameter, and type and intensity of sports and exercise. Mouse models of thoracic ... ...

    Abstract The evaluation and management of athletes with HTAD and aortopathy conditions requires shared decision-making encompassing the underlying condition, family history, aortic diameter, and type and intensity of sports and exercise. Mouse models of thoracic aortic disease show that low-to-moderate-level aerobic exercise can maintain aortic architecture and attenuate pathologic aortic root dilation. Although controlled trials in human are lacking, recreational physical activities performed at a low-to-moderate aerobic pace are generally low risk for most individuals with aortopathy conditions. High-intensity, competitive, and contact sports or physical activities are generally prohibited in individuals with aortopathy conditions.
    MeSH term(s) Animals ; Aorta, Thoracic/pathology ; Aortic Diseases/genetics ; Aortic Diseases/pathology ; Aortic Diseases/therapy ; Athletes ; Exercise ; Humans ; Mice ; Sports
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 779944-5
    ISSN 1556-228X ; 0278-5919
    ISSN (online) 1556-228X
    ISSN 0278-5919
    DOI 10.1016/j.csm.2022.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Angiotensinogen as a Therapeutic Target for Cardiovascular and Metabolic Diseases.

    Daugherty, Alan / Sawada, Hisashi / Sheppard, Mary B / Lu, Hong S

    Arteriosclerosis, thrombosis, and vascular biology

    2024  Volume 44, Issue 5, Page(s) 1021–1030

    Abstract: AGT (angiotensinogen) is the unique precursor for the generation of all the peptides of the renin-angiotensin system, but it has received relatively scant attention compared to many other renin-angiotensin system components. Focus on AGT has increased ... ...

    Abstract AGT (angiotensinogen) is the unique precursor for the generation of all the peptides of the renin-angiotensin system, but it has received relatively scant attention compared to many other renin-angiotensin system components. Focus on AGT has increased recently, particularly with the evolution of drugs to target the synthesis of the protein. AGT is a noninhibitory serpin that has several conserved domains in addition to the angiotensin II sequences at the N terminus. Increased study is needed on the structure-function relationship to resolve many unknowns regarding AGT metabolism. Constitutive whole-body genetic deletion of
    MeSH term(s) Animals ; Humans ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/genetics ; Angiotensinogen/metabolism ; Angiotensinogen/genetics ; Metabolic Diseases/drug therapy ; Metabolic Diseases/metabolism ; Metabolic Diseases/genetics ; Renin-Angiotensin System/drug effects ; Molecular Targeted Therapy
    Chemical Substances Angiotensinogen (11002-13-4)
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.124.318374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Novel

    Sheppard, Mary B / Smith, Jeffrey D / Bergmann, Lisa L / Famulski, Jakub K

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1103784

    Abstract: In human, pathogenic variants in smad3 are one cause of familial aortopathy. We describe a ... ...

    Abstract In human, pathogenic variants in smad3 are one cause of familial aortopathy. We describe a novel
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1103784
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  4. Article ; Online: Assessment of gait mechanics and muscle strength in hypermobile Ehlers Danlos Syndrome.

    Ball, Lindsey N / Jacobs, Mariana V / McLouth, Christopher J / Clasey, Jody / Francomano, Clair / Sheppard, Mary B / Samaan, Michael A

    Clinical biomechanics (Bristol, Avon)

    2024  Volume 113, Page(s) 106210

    Abstract: Background: Hypermobile Ehlers Danlos Syndrome, a heritable connective tissue disorder, is associated with muscle dysfunction, joint subluxations and pain. The impact of hypermobile Ehlers Danlos Syndrome on musculoskeletal mechanics is understudied. ... ...

    Abstract Background: Hypermobile Ehlers Danlos Syndrome, a heritable connective tissue disorder, is associated with muscle dysfunction, joint subluxations and pain. The impact of hypermobile Ehlers Danlos Syndrome on musculoskeletal mechanics is understudied. Therefore, the aim of this study was to assess the effects of hypermobile Ehlers Danlos Syndrome on lower extremity gait mechanics and muscle strength.
    Methods: Eleven people with hypermobile Ehlers Danlos Syndrome and 11 asymptomatic controls underwent a 3D gait analysis and isometric hip and knee muscle strength assessment. Joint subluxations were self-reported by the hypermobile Ehlers Danlos syndrome group. Independent t-tests and Mann Whitney U tests were used to analyze joint mechanics, muscle strength, and patient report outcomes (p < 0.05).
    Findings: Both groups exhibited similar walking speeds as well as similar hip, knee, and ankle joint kinematics. The hypermobile Ehlers Danlos Syndrome group walked with a lower peak hip extensor moment (hypermobile Ehlers Danlos Syndrome: -0.52 ± 0.28 Nmˑkg
    Interpretation: Patients with hypermobile Ehlers Danlos Syndrome ambulated with altered hip extensor moments and exhibit hip extensor weakness. Future work should investigate the underlying mechanisms of hip extensor weakness and corresponding effects on joint health in people with hypermobile Ehlers Danlos Syndrome.
    MeSH term(s) Humans ; Ehlers-Danlos Syndrome ; Gait/physiology ; Joint Dislocations ; Muscle Strength/physiology ; Joint Instability
    Language English
    Publishing date 2024-02-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632747-3
    ISSN 1879-1271 ; 0268-0033
    ISSN (online) 1879-1271
    ISSN 0268-0033
    DOI 10.1016/j.clinbiomech.2024.106210
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  5. Article: A Comprehensive Research Schema for the Characterization of Aortic Aneurysms.

    Alslaim, Hossam / Sanampudi, Sreeja / Raissi, Driss / Fu, Weibo / Behr, Amanda Y / Issa, Mohamed / Sheppard, Mary B / Weintraub, Neal L / Winkler, Michael

    The International journal of angiology : official publication of the International College of Angiology, Inc

    2022  Volume 32, Issue 1, Page(s) 34–42

    Abstract: A robust, accurate, and standardized approach to measurement of the aorta is critical to improve the predictive accuracy of these aortic measurements, and to investigate other aortic imaging biomarkers. Developing a comprehensive and generic schema for ... ...

    Abstract A robust, accurate, and standardized approach to measurement of the aorta is critical to improve the predictive accuracy of these aortic measurements, and to investigate other aortic imaging biomarkers. Developing a comprehensive and generic schema for characterization of the aorta to enable investigators to standardize data that are collected across all aorta research. A systematic review of the literature was conducted to identify and assess schemata of aortic measurement and description. The schemata were reported and discussed to guide the synthesis of a comprehensive schema. We propose the International College of Angiology Aortic Research Schema as a comprehensive design that fills the gaps left behind by previously reported schemata. It is intended to be applicable for all clinically relevant purposes, including endograft development for aneurysm repair and for the accurate characterization of the aortic anatomy. This schema divides the aorta into 14 segments and 2 sections (thoracic and abdominal aortas). The segmentation proposed can be used in addition to specific measurements taken for any aneurysm including the neck, and maximal and minimal diameters of the aneurysm.
    Language English
    Publishing date 2022-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1144390-x
    ISSN 1061-1711
    ISSN 1061-1711
    DOI 10.1055/s-0042-1744275
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  6. Article ; Online: Hybrid Repair of Type B Aortic Dissection With Thoracoabdominal Aortic Aneurysmal Degeneration in the Setting of Marfan Syndrome.

    Aru, Roberto G / Richie, Cheryl D / Badia, Daniel J / Romesberg, Amanda M / Sheppard, Mary B / Minion, David J / Tyagi, Sam

    Vascular and endovascular surgery

    2021  Volume 55, Issue 6, Page(s) 619–622

    Abstract: Aneurysmal degeneration of the thoracoabdominal aorta after aortic dissection is a well-documented sequela of Marfan syndrome (MFS). Hybrid technique (HT), an emerging treatment modality for complex aortic pathologies, decreases morbidity and mortality ... ...

    Abstract Aneurysmal degeneration of the thoracoabdominal aorta after aortic dissection is a well-documented sequela of Marfan syndrome (MFS). Hybrid technique (HT), an emerging treatment modality for complex aortic pathologies, decreases morbidity and mortality relative to open surgery. However, outcome data regarding HT in genetic aortopathies such as MFS is limited. We describe a case of a young male with hypertension and type B aortic dissection (AD) complicated by a symptomatic thoracoabdominal aortic aneurysm (TAAA). He underwent staged HT comprised of carotid-carotid transposition followed by zone 1 thoracic endovascular aortic repair and concurrent retrograde left subclavian stent graft placement. Genetic analysis was consistent with Marfan syndrome. Subsequent growth of his TAAA warranted open extent type IV TAAA repair with individual renovisceral and iliac bypasses. The patient recovered from the second surgery without further progression of disease or late complication.
    MeSH term(s) Adult ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/etiology ; Aneurysm, Dissecting/physiopathology ; Aneurysm, Dissecting/surgery ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/physiopathology ; Aorta, Thoracic/surgery ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/etiology ; Aortic Aneurysm, Thoracic/physiopathology ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/instrumentation ; Endovascular Procedures/instrumentation ; Humans ; Male ; Marfan Syndrome/complications ; Marfan Syndrome/diagnosis ; Stents ; Treatment Outcome ; Vascular Remodeling
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2076272-0
    ISSN 1938-9116 ; 1538-5744
    ISSN (online) 1938-9116
    ISSN 1538-5744
    DOI 10.1177/1538574420988279
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  7. Article: Insights into ascending aortic aneurysm pathogenesis using in vivo and ex vivo imaging systems in angiotensin II-infused mice.

    Sheppard, Mary B / Daugherty, Alan / Lu, Hong

    Journal of thoracic disease

    2016  Volume 8, Issue 8, Page(s) E822–4

    Language English
    Publishing date 2016-09-12
    Publishing country China
    Document type Comment ; Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2016.07.63
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  8. Article ; Online: Aortic Strain Correlates with Elastin Fragmentation in Fibrillin-1 Hypomorphic Mice.

    Chen, Jeff Z / Sawada, Hisashi / Moorleghen, Jessica J / Weiland, Mackenzie / Daugherty, Alan / Sheppard, Mary B

    Circulation reports

    2019  Volume 1, Issue 5, Page(s) 199–205

    Abstract: Background: High frequency ultrasound has facilitated in vivo measurements of murine ascending aortas, allowing aortic strains to be gleaned from two-dimensional images. Thoracic aortic aneurysms associated with mutations in fibrillin-1 (: Methods and ...

    Abstract Background: High frequency ultrasound has facilitated in vivo measurements of murine ascending aortas, allowing aortic strains to be gleaned from two-dimensional images. Thoracic aortic aneurysms associated with mutations in fibrillin-1 (
    Methods and results: Luminal diameters of the ascending aorta from wild type and FBN1 hypomorphic (
    Conclusions: FBN1
    Language English
    Publishing date 2019-04-27
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-18-0012
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  9. Article: A Comprehensive Research Schema for the Characterization of Aortic Aneurysms

    Alslaim, Hossam / Sanampudi, Sreeja / Raissi, Driss / Fu, Weibo / Behr, Amanda Y. / Issa, Mohamed / Sheppard, Mary B. / Weintraub, Neal L. / Winkler, Michael

    International Journal of Angiology

    2022  Volume 32, Issue 01, Page(s) 34–42

    Abstract: A robust, accurate, and standardized approach to measurement of the aorta is critical to improve the predictive accuracy of these aortic measurements, and to investigate other aortic imaging biomarkers. Developing a comprehensive and generic schema for ... ...

    Abstract A robust, accurate, and standardized approach to measurement of the aorta is critical to improve the predictive accuracy of these aortic measurements, and to investigate other aortic imaging biomarkers. Developing a comprehensive and generic schema for characterization of the aorta to enable investigators to standardize data that are collected across all aorta research. A systematic review of the literature was conducted to identify and assess schemata of aortic measurement and description. The schemata were reported and discussed to guide the synthesis of a comprehensive schema. We propose the International College of Angiology Aortic Research Schema as a comprehensive design that fills the gaps left behind by previously reported schemata. It is intended to be applicable for all clinically relevant purposes, including endograft development for aneurysm repair and for the accurate characterization of the aortic anatomy. This schema divides the aorta into 14 segments and 2 sections (thoracic and abdominal aortas). The segmentation proposed can be used in addition to specific measurements taken for any aneurysm including the neck, and maximal and minimal diameters of the aneurysm.
    Keywords abdominal aortic aneurysm ; endovascular repair ; hyopgastric aneurysm ; aortic dissection ; vessel repair ; thoracoabdominal aortic aneursym ; repair
    Language English
    Publishing date 2022-06-25
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1144390-x
    ISSN 1615-5939 ; 1061-1711
    ISSN (online) 1615-5939
    ISSN 1061-1711
    DOI 10.1055/s-0042-1744275
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  10. Article ; Online: Spontaneous Rupture of Mesenteric Vasculature Associated with Fibromuscular Dysplasia in a 28-Year-Old Male.

    Aru, Roberto G / Wallace, Jerald P / Bounds, Michael C / Sheppard, Mary B / Guney, Akif K / O'Connor, William N / Tyagi, Sam C

    Annals of vascular surgery

    2020  Volume 71, Page(s) 534.e13–534.e15

    Abstract: Spontaneous rupture of mesenteric vasculature associated with fibromuscular dysplasia is an unreported phenomenon. We describe a case in a 28-year-old male with a history of chronic abdominal pain who presented to our facility in hemorrhagic shock ... ...

    Abstract Spontaneous rupture of mesenteric vasculature associated with fibromuscular dysplasia is an unreported phenomenon. We describe a case in a 28-year-old male with a history of chronic abdominal pain who presented to our facility in hemorrhagic shock secondary to a ruptured transverse mesocolon middle colic aneurysm status postemergent transverse colectomy. He was found to have chronic vertebral, renovisceral, and iliac aneurysms as well as acute superior and inferior mesenteric artery dissection and chronic bilateral vertebral artery dissections. He subsequently developed disseminated intravascular coagulopathy, resulting in saddle pulmonary embolus as well as right renal artery and splenic artery thrombosis. Ultimately, the patient expired.
    MeSH term(s) Adult ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/etiology ; Aneurysm, Dissecting/surgery ; Aneurysm, Ruptured/diagnostic imaging ; Aneurysm, Ruptured/etiology ; Aneurysm, Ruptured/surgery ; Fatal Outcome ; Fibromuscular Dysplasia/complications ; Fibromuscular Dysplasia/diagnostic imaging ; Fibromuscular Dysplasia/surgery ; Humans ; Male ; Mesenteric Arteries/diagnostic imaging ; Mesenteric Arteries/surgery ; Rupture, Spontaneous ; Shock, Hemorrhagic/etiology ; Treatment Outcome
    Language English
    Publishing date 2020-09-16
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2020.08.157
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