Article ; Online: Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency
Acta Chimica Slovenica, Vol 67, Iss 1, Pp 167-
2020 Volume 178
Abstract: A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding ... ...
| Abstract | A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding sulfadiazines 2–18 and hydrozaones 19a–h which were evaluated for their in vitro cytotoxicity versus four cancer cell lines. Compounds 3, 5, 19d and 19h were active against the tested cancer cells. |
|---|---|
| Keywords | anticancer ; sulfonamide ; oxadiazole ; pyridine ; thiazole ; Chemistry ; QD1-999 |
| Language | English |
| Publishing date | 2020-03-01T00:00:00Z |
| Publisher | Slovenian Chemical Society |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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