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Article ; Online: Dyspnea and Post-Pulmonary Embolism Syndrome after a Mild COVID-19 Infection.

Meda, Namratha S / Sherner, John H / Holley, Aaron B

2023 Volume 21, Issue 1, Page(s) 151–157

MeSH term(s)	Humans ; COVID-19/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/etiology ; Dyspnea/etiology ; Syndrome
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202304-332CC
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Article ; Online: Response.

Holley, Aaron B / McMahon, Michael J / Warren, Whittney A / Collen, Jacob F / Sherner, John H / Zeman, Joseph E / Morris, Michael J

Chest

2022 Volume 161, Issue 4, Page(s) e253–e254

Language	English
Publishing date	2022-03-23
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2021.10.042
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Article ; Online: Rapid response team implementation and hospital mortality rates.

Sherner, John H

JAMA

2009 Volume 301, Issue 16, Page(s) 1658–9; author reply 1660

MeSH term(s)	Cardiopulmonary Resuscitation/mortality ; Cardiopulmonary Resuscitation/statistics & numerical data ; Critical Care/organization & administration ; Heart Arrest/mortality ; Hospital Mortality ; Hospitals/statistics & numerical data ; Humans ; Outcome and Process Assessment (Health Care) ; Patient Care Team
Language	English
Publishing date	2009-04-22
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2009.528
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Article ; Online: Posttraumatic Stress Disorder Is Associated With a Decrease in Anaerobic Threshold, Oxygen Pulse, and Maximal Oxygen Uptake.

McMahon, Michael J / Holley, Aaron B / Warren, Whittney A / Collen, Jacob F / Sherner, John H / Zeman, Joseph E / Morris, Michael J

Chest

2021 Volume 160, Issue 3, Page(s) 1017–1025

Abstract: Background: Posttraumatic stress disorder (PTSD) has been linked to respiratory symptoms and functional limitations, but the mechanisms leading to this association are poorly defined.: Research question: What is the relationship between PTSD, lung ... ...

Abstract	Background: Posttraumatic stress disorder (PTSD) has been linked to respiratory symptoms and functional limitations, but the mechanisms leading to this association are poorly defined. Research question: What is the relationship between PTSD, lung function, and the cardiopulmonary response to exercise in combat veterans presenting with chronic respiratory symptoms? Study design and methods: This study prospectively enrolled military service members with respiratory symptoms following deployment to southwest Asia. All participants underwent a comprehensive evaluation that included pulmonary function testing and cardiopulmonary exercise testing. Pulmonary function test variables and cardiopulmonary response to exercise were compared in subjects with and without PTSD by using multivariable linear regression to adjust for confounders. Results: A total of 303 participants were included (PTSD, n = 70; non-PTSD, n = 233). Those with PTSD had a greater frequency of current respiratory symptoms. There were no differences in measures for airway disease or lung volumes, but patients with PTSD had a reduction in diffusing capacity that was eliminated following adjustment for differences in hemoglobin levels. Participants with PTSD had a lower anaerobic threshold (23.9 vs 26.4 cc/kg per minute; P = .004), peak oxygen pulse (19.7 vs 18.5 cc/beat; P = .03), and peak oxygen uptake (34.5 vs 38.8 cc/kg per minute; P < .001). No significant difference was observed in gas exchange, respiratory reserve, or effort at peak exercise between participants with and without PTSD. Interpretation: A diagnosis of PTSD was associated with a reduced anaerobic threshold, oxygen pulse, and peak oxygen uptake. This objective reduction in cardiopulmonary work is independent of baseline lung function, was not associated with abnormalities in gas exchange or respiratory reserve, and may be related to deconditioning.
MeSH term(s)	Adult ; Anaerobic Threshold ; Dyspnea/diagnosis ; Dyspnea/psychology ; Exercise/physiology ; Exercise/psychology ; Exercise Test/methods ; Female ; Humans ; Male ; Military Personnel/psychology ; Military Personnel/statistics & numerical data ; Oximetry/methods ; Oxygen Consumption ; Respiratory Function Tests/methods ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/physiopathology ; Symptom Assessment/methods ; Veterans Health
Language	English
Publishing date	2021-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2021.03.057
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Ui III Zs.45: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clinical Outcomes of Coronavirus Disease 2019 With Evidence-based Supportive Care.

Larson, Derek T / Sherner, John H / Gallagher, Kia M / Judy, Cynthia L / Paul, Madison B / Mahoney, Alexandra M / Weina, Peter J

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 74, Issue 1, Page(s) 133–135

Abstract: Calls for adherence to evidence-based medicine have emerged during the initial wave of the COVID-19 pandemic but reports of outcomes are lacking. This retrospective study of an institutional cohort including 135 patients with confirmed COVID-19 ... ...

Abstract	Calls for adherence to evidence-based medicine have emerged during the initial wave of the COVID-19 pandemic but reports of outcomes are lacking. This retrospective study of an institutional cohort including 135 patients with confirmed COVID-19 demonstrates positive outcomes when organizational standards of care consist of evidence-based supportive therapies.
MeSH term(s)	COVID-19 ; Cohort Studies ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa678
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Isolated Small Airway Dysfunction and Ventilatory Response to Cardiopulmonary Exercise Testing.

Holley, Aaron B / Mabe, Donovan L / Hunninghake, John C / Collen, Jacob F / Walter, Robert J / Sherner, John H / Huprikar, Nikhil A / Morris, Michael J

Respiratory care

2020 Volume 65, Issue 10, Page(s) 1488–1495

Abstract: Background: The effect of isolated small airway dysfunction (SAD) on exercise remains incompletely characterized. We sought to quantify the relationship between isolated SAD, identified with lung testing, and the respiratory response to exercise.: ... ...

Abstract	Background: The effect of isolated small airway dysfunction (SAD) on exercise remains incompletely characterized. We sought to quantify the relationship between isolated SAD, identified with lung testing, and the respiratory response to exercise. Methods: We conducted a prospective evaluation of service members with new-onset dyspnea. All subjects underwent plethysmography, diffusing capacity of the lung for carbon monoxide (D Results: We enrolled 121 subjects with normal basic spirometry (ie, FEV Conclusions: In 121 subjects with normal basic spirometry, D
MeSH term(s)	Adult ; Exercise Test ; Exercise Tolerance ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive ; Pulmonary Gas Exchange ; Spirometry
Language	English
Publishing date	2020-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.07424
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Article ; Online: Respiratory symptoms in service members returning from Afghanistan and Iraq.

Holley, Aaron B / Sobieszczyk, Michal / Sherner, John H / Perkins, Michael P

American journal of respiratory and critical care medicine

2014 Volume 190, Issue 9, Page(s) 1076–1077

MeSH term(s)	Environmental Exposure/adverse effects ; Female ; Humans ; Lung Diseases/diagnosis ; Male ; Military Personnel/statistics & numerical data ; Particulate Matter/adverse effects ; Respiration Disorders/diagnosis
Chemical Substances	Particulate Matter
Language	English
Publishing date	2014-11-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201408-1441LE
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Article ; Online: Clinical Evaluation of Deployed Military Personnel With Chronic Respiratory Symptoms: Study of Active Duty Military for Pulmonary Disease Related to Environmental Deployment Exposures (STAMPEDE) III.

Morris, Michael J / Walter, Robert J / McCann, Edward T / Sherner, John H / Murillo, Christina G / Barber, Brian S / Hunninghake, John C / Holley, Aaron B

Chest

2020 Volume 157, Issue 6, Page(s) 1559–1567

Abstract: Background: Chronic respiratory symptoms are frequently reported after Southwest Asia deployment in support of combat operations. The full spectrum of clinical lung diseases related to these deployments is not well characterized.: Methods: Military ... ...

Abstract	Background: Chronic respiratory symptoms are frequently reported after Southwest Asia deployment in support of combat operations. The full spectrum of clinical lung diseases related to these deployments is not well characterized. Methods: Military personnel with chronic symptoms, primarily exertional dyspnea, underwent a standardized cardiopulmonary evaluation at two tertiary medical centers. Pulmonary function testing consisted of spirometry, lung volume, diffusing capacity, impulse oscillometry, and bronchodilator testing. Further testing included methacholine challenge, exercise laryngoscopy, high-resolution CT scan, ECG, and transthoracic echocardiography. Results: A total of 380 participants with a mean age of 38.5 ± 8.4 years completed testing. Asthma was the most common diagnosis in 87 patients (22.9%) based on obstructive spirometry/impulse oscillometry and evidence of airway hyperreactivity, whereas another 57 patients (15.0%) had reactivity with normal spirometry. Airway disorders included 25 (6.6%) with laryngeal disorders and 16 (4.2%) with excessive dynamic airway collapse. Interstitial lung disease was identified in six patients (1.6%), whereas 11 patients (2.9%) had fixed obstructive lung disorders. Forty patients (10.5%) had isolated pulmonary function abnormalities and 16 (4.2%) had miscellaneous disorders. The remaining 122 patients (32.1%) with normal studies were classified as undiagnosed exertional dyspnea. Significant comorbidities identified included elevated BMI > 30 kg/m Conclusions: Postdeployment pulmonary evaluation should focus on common diseases, such as asthma and airway hyperreactivity, and include testing for upper airway disorders. Diffuse lung diseases were rarely diagnosed, whereas numerous comorbidities were common.
MeSH term(s)	Adult ; Bronchial Provocation Tests ; Environmental Exposure/adverse effects ; Exercise/physiology ; Female ; Follow-Up Studies ; Humans ; Lung/physiopathology ; Lung Diseases/diagnosis ; Lung Diseases/etiology ; Lung Diseases/physiopathology ; Male ; Military Personnel ; Prospective Studies ; United States
Language	English
Publishing date	2020-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2020.01.024
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Article ; Online: Optimizing routine screening for cardiac sarcoidosis through use of commonly available studies.

Holtzclaw, Arthur W / Mrsic, Zorana / Church, Tyler L / Shumar, John N / Liotta, Robert A / Aslam, Saira N / Fontana, Joseph R / Nations, Joel A / Lazarus, Angeline / Browning, Robert F / Holley, Aaron B / Sherner, John H / McKay, Sean A

Respiratory medicine

2021 Volume 178, Page(s) 106331

Abstract: Background: Sarcoidosis is a multisystem granulomatous disorder with unclear etiology. Morbidity and mortality vary based on organ involvement, with cardiac sarcoidosis (CS) associated with higher mortality; despite this, CS remains underdiagnosed. The ... ...

Abstract	Background: Sarcoidosis is a multisystem granulomatous disorder with unclear etiology. Morbidity and mortality vary based on organ involvement, with cardiac sarcoidosis (CS) associated with higher mortality; despite this, CS remains underdiagnosed. The Heart Rhythm Society (HRS) expert consensus statement recommends screening sarcoidosis patients for CS utilizing a symptom screen, EKG, and echocardiogram (TTE), while the American Thoracic Society (ATS) guideline recommends only EKG and symptom screening. These recommendations, however, are based on limited data with recommendations for further studies. Research question: The purpose is to evaluate the prevalence of abnormal screening tests in patients with sarcoidosis and the correlation of these tests with the subsequent diagnosis of CS. A specific emphasis was placed on evaluating the sensitivity of the recommendations versus the sensitivity of a modified criteria. Study design: and Methods: This study retrospectively evaluated a database of prospectively enrolled patients from a tertiary military academic center. All patients who underwent imaging with cardiac MRI and/or FDG-PET were identified. These results were correlated with screening studies (symptom screen, EKG, TTE, and ambulatory rhythm monitoring (ARM)) and used to calculate sensitivity, specificity, and positive and negative predictive values for each test. Using a clinical diagnosis of CS as the reference standard, the sensitivity and specificity of the HRS criteria were calculated and compared to a modified screening rubric developed a priori, consisting of minor changes to the criteria and the addition of ARM. Results: This study evaluated 114 patients with sarcoidosis with 132 advanced imaging events, leading to a diagnosis of CS in 36 patients. Utilizing HRS screening recommendations, the sensitivity for CS was 63.9%, while the modified criteria increased sensitivity to 94.4%. Interpretation: This study suggests that the HRS guidelines lack sensitivity to effectively screen for CS and that a modified screening model which includes ARM may be more effective.
MeSH term(s)	Cardiomyopathies/diagnosis ; Cardiomyopathies/diagnostic imaging ; Echocardiography, Transesophageal ; Electrocardiography, Ambulatory/methods ; Female ; Heart Rate ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Mass Screening/methods ; Positron-Emission Tomography/methods ; Predictive Value of Tests ; Retrospective Studies ; Sarcoidosis/diagnosis ; Sarcoidosis/diagnostic imaging ; Sensitivity and Specificity
Language	English
Publishing date	2021-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2021.106331
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Article: Clinical Outcomes of COVID-19 with Evidence-Based Supportive Care

Larson, Derek T / Sherner, John H / Gallagher, Kia M / Judy, Cynthia L / Paul, Madison B / Mahoney, Alexandra M / Weina, Peter J

Clin. infect. dis

Abstract: Calls for adherence to evidence-based medicine have emerged during the initial wave of the COVID-19 pandemic but reports of outcomes are lacking. This retrospective study of a single-institution cohort including 135 patients with confirmed COVID-19 ... ...

Abstract	Calls for adherence to evidence-based medicine have emerged during the initial wave of the COVID-19 pandemic but reports of outcomes are lacking. This retrospective study of a single-institution cohort including 135 patients with confirmed COVID-19 demonstrates positive outcomes when institutional standards of care consist of evidence-based supportive therapies.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32472675
Database	COVID19

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